CN108640916A - 一类具有抗癌活性的硫代吲嗪类化合物及其衍生物 - Google Patents

一类具有抗癌活性的硫代吲嗪类化合物及其衍生物 Download PDF

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Publication number
CN108640916A
CN108640916A CN201810583904.XA CN201810583904A CN108640916A CN 108640916 A CN108640916 A CN 108640916A CN 201810583904 A CN201810583904 A CN 201810583904A CN 108640916 A CN108640916 A CN 108640916A
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CN
China
Prior art keywords
cancer
substituted
unsubstituted
pharmaceutically acceptable
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201810583904.XA
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English (en)
Chinese (zh)
Inventor
曹华
李彬
陈伟鑫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guangdong Pharmaceutical University
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Guangdong Pharmaceutical University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Guangdong Pharmaceutical University filed Critical Guangdong Pharmaceutical University
Priority to CN201810583904.XA priority Critical patent/CN108640916A/zh
Priority to PCT/CN2018/000246 priority patent/WO2019232665A1/fr
Publication of CN108640916A publication Critical patent/CN108640916A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201810583904.XA 2018-06-07 2018-06-07 一类具有抗癌活性的硫代吲嗪类化合物及其衍生物 Pending CN108640916A (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201810583904.XA CN108640916A (zh) 2018-06-07 2018-06-07 一类具有抗癌活性的硫代吲嗪类化合物及其衍生物
PCT/CN2018/000246 WO2019232665A1 (fr) 2018-06-07 2018-07-04 Composé d'indolizine thiolisé à activité anticancéreuse et son dérivé

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810583904.XA CN108640916A (zh) 2018-06-07 2018-06-07 一类具有抗癌活性的硫代吲嗪类化合物及其衍生物

Publications (1)

Publication Number Publication Date
CN108640916A true CN108640916A (zh) 2018-10-12

Family

ID=63751896

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201810583904.XA Pending CN108640916A (zh) 2018-06-07 2018-06-07 一类具有抗癌活性的硫代吲嗪类化合物及其衍生物

Country Status (2)

Country Link
CN (1) CN108640916A (fr)
WO (1) WO2019232665A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117265556A (zh) * 2023-10-09 2023-12-22 上海陶术生物科技有限公司 1,3-二芳巯基中氮茚衍生物的电化学制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102458580A (zh) * 2009-04-21 2012-05-16 诺瓦提斯公司 作为mek抑制剂的杂环化合物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102458580A (zh) * 2009-04-21 2012-05-16 诺瓦提斯公司 作为mek抑制剂的杂环化合物

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
COLONNA, MARTINO等: "Electron-transfer processes. Trans-sulfenylation of electron-rich systems with sulfonamides", 《GAZZETTA CHIMICA ITALIANA》 *
LI, BIN 等: "Transition-Metal-Free Regioselective Cross-Coupling: Controlled Synthesis of Mono- or Dithiolation Indolizines", 《ORG. LETT.》 *
MIREK, JULIAN 等: "The reaction of indolizines and acetylindolizines with trifluoromethylsulfenyl chloride", 《JOURNAL OF FLUORINE CHEMISTRY》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117265556A (zh) * 2023-10-09 2023-12-22 上海陶术生物科技有限公司 1,3-二芳巯基中氮茚衍生物的电化学制备方法和应用

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Publication number Publication date
WO2019232665A1 (fr) 2019-12-12

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