CN108697601A - A kind of cosmetic composition containing antioxidant - Google Patents

A kind of cosmetic composition containing antioxidant Download PDF

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Publication number
CN108697601A
CN108697601A CN201780004912.8A CN201780004912A CN108697601A CN 108697601 A CN108697601 A CN 108697601A CN 201780004912 A CN201780004912 A CN 201780004912A CN 108697601 A CN108697601 A CN 108697601A
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CN
China
Prior art keywords
curcumin
fluorophenyl
fluorine
propenone
antioxidant
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CN201780004912.8A
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Chinese (zh)
Inventor
赵文忠
洪盛杰
林学镁
谷志静
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LAF INTERNATIONAL GROUP Ltd
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LAF INTERNATIONAL GROUP Ltd
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Publication of CN108697601A publication Critical patent/CN108697601A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/004—Aftersun preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A61K2800/522—Antioxidants; Radical scavengers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Cosmetics (AREA)

Abstract

A kind of cosmetic composition containing antioxidant, removes cosmetically acceptable carrier such as emulsifier, ultra-violet absorber, thickener, polyalcohol, suitable chelating agent, and preservative outside essence and deionized water, contains:1, the curcumin of composition weight 0.05-0.6% is accounted for;2, the curcumin analogue of composition weight 0.05-1.0% is accounted for, the curcumin analogue is fluorine-containing curcumin.Contained curcumin and fluorine-containing curcumin complex have excellent antioxidant effect, can capture harmful oxygen radical, have good synergy especially in terms of the promotion of sun care preparations SPF.There is certain maintenance effect for the skin being damaged after drying and solarization, for air pollutants such as smog, flue dust, the pollutant component in air, free radical and ultraviolet light have the function of defending.

Description

A kind of cosmetic composition containing antioxidant
Technical field
The invention belongs to daily chemicals fields, and in particular to a kind of cosmetic composition containing antioxidant.
Background technology
In cosmetic technical field, antioxidant is the composition often applied.One can prevent and delay to make up The metachromasia of other active materials in product, two can prevent the oxidative rancidity etc. of grease used.The antioxidant being frequently used Such as, Butylated Hydroxytoluene BHT, Butylated Hydroxyanisole BHA, Alpha's tocopherol or Alpha's tocopherol acetate such as vitamin E, ascorbic acid And its derivative is also vitamin C etc., these antioxidants largely are used for preventing oxidation and the acid of base material of cosmetics at present It loses, play preservation, vitamin E and ascorbic collocation use has synergy to skin-whitening.
The composition of many plant origins has stronger anti-oxidation characteristics such as:Curcumin, ferulic acid, hesperetin, tomato red Element, green tea, grape pip, niacinamide etc., wherein curcumin are with its high-strength anti-oxidation characteristics better than the antioxidant that tradition uses And by extensive concern, curcumin also causes many research fields in the application in cosmetics and is formulated the emerging of engineer Interest.
Curcumin belongs to plant polyphenol, is a kind of orange-yellow crystalline powder extracted from fresh ginger Huang and turmeric volatile-oil, Its structure is as shown in formula I.
Curcumin be also referred to as curcumin have a variety of good bioactivity, long-term nontoxicity side effect, have it is anti-inflammatory, Anti-oxidant equal pharmacological actions, but structure is not sufficiently stable, and is easily decomposed, poorly water-soluble, blood concentration is low, make its bioavailability compared with Low, stability is poor, and color is heavier, using there is certain difficulty in cosmetics.
Tetrahydro curcumin is the curcumin (curcumin) isolated in zingiberaceous plant turmeric (curcuma longa) rhizome Dehydrogenation and to be usually used in whitening, nti-freckle, oxidation resistant all kinds of skin care item.
The stability of curcumin structure does not have an impact people and studies it, and according to the design feature of curcumin, synthesis is new Curcumin derivate or the like, probe into its physico property and bioactivity, become the hot spot of recent research.Numerous studies Show:Numerous curcumin derivates or the like have bioactivity more stronger than curcumin.
It is therefore desirable to comprehensively utilize curcumin and its derivative, the anti-oxidant and stability of curcumin analogue is combined Advantage.
Invention content
The object of the present invention is to provide a kind of cosmetic compositions with preferable antioxidant effect.
The object of the present invention is achieved like this:A kind of cosmetic composition containing antioxidant, except cosmetics can connect The carrier received:Outside emulsifier, ultra-violet absorber, thickener, polyalcohol, chelating agent, preservative, essence and deionized water, Contain:
A, the curcumin of composition weight 0.05-0.6% is accounted for;
B, the curcumin analogue of composition weight 0.05-1.0% is accounted for, the curcumin analogue is fluorine-containing curcumin.
Technical scheme of the present invention includes:The curcumin is tetrahydro curcumin.
Technical scheme of the present invention includes:The fluorine-containing curcumin is 1- (4- fluorophenyls) -3- (2- fluorophenyls)-propylene The mixture of ketone, 1- (4- fluorophenyls) -3- (3- fluorophenyls)-propenone, 1- (4- fluorophenyls) -3- (4- fluorophenyls)-propenone, And three kinds of mixture weight ratio 1- (4- fluorophenyls) -3- (2- fluorophenyls)-propenone:1- (4- fluorophenyls) -3- (3- fluorophenyls) - Propenone:1- (4- fluorophenyls) -3- (4- fluorophenyls)-propenone is 1:1:1.
A kind of cosmetic composition containing antioxidant, component and content are:
Advantage of the present invention:Contained curcumin and fluorine-containing curcumin complex and conventional vitamin C, vitamin in the present invention E is compared with the compound of ferulic acid, has more excellent antioxidant effect, harmful oxygen radical can be captured, especially sun-proof There is good synergy in terms of the promotion of cosmetics SPF.Have centainly for the skin being damaged after drying and solarization Maintenance effect, for the pollutant component in air pollutants such as smog, flue dust, air, free radical and ultraviolet light have defence Effect.
Specific implementation mode
With reference to embodiment to this further detailed description of the invention.
A kind of cosmetic composition containing antioxidant of the present invention can be a kind of gel, frost, lotion, Essence, spray The dosage forms such as mist, oil-in-water emulsion or water-in-oil emulsion, ultra light sun block lotion are presented.
In order to illustrate that the purpose of the present invention, a kind of cosmetic composition containing antioxidant of the present invention are a kind of containing anti-oxidant The ultra light sun block lotion of agent, the anti-oxidant composition are curcumin and curcumin analogue.
A kind of cosmetics containing antioxidant contain anti-oxidant composition as described below:
(1) curcumin:The present invention is tetrahydro curcumin;
(2) curcumin analogue:Including fluorine-containing curcumin A1, fluorine-containing curcumin curcumin A2 and fluorine-containing curcumin A3;
(3) mixture of (1) (2).
A kind of cosmetics containing antioxidant also contain the acceptable ingredient of cosmetics such as:Emulsifier, grease, thickener, Preservative and essence.
Tetrahydro curcumin:Tetrahydro curcumin, by the turmeric isolated in zingiberaceous plant turmeric (curcuma longa) rhizome Plain (curcumin) hydrogenation.White powder, content 95%, molecular weight:372.2 CAS is numbered:36062-04-1.It can be effective Inhibit the generation of oxygen radical and the free radical formed can be removed, there is apparent antioxidation, such as human body skin Aging, reparation, desalination pigment, nti-freckle etc., are used as antioxidant in the present invention.
Curcumin analogue (fluorine-containing curcumin):Fluorine-containing curcumin A1 (see formula III) is 1- (4- fluorophenyls) -3- (2- fluorobenzene Base)-propenone, light yellow crystal, chemical formula:C15H10F2O, molecular weight 244.24.80.6~81.1 DEG C of melting range.Water is slightly soluble in, Organic solvent is dissolved in, is stablized under normal condition.
Fluorine-containing curcumin A2 (see formula IV) compounds A2:1- (4- fluorophenyls) -3- (3- fluorophenyls)-propenone, it is faint yellow Crystal, chemical formula:C15H10F2O, molecular weight 244.24.86.4~87.2 DEG C of melting range.It is slightly soluble in water, dissolves in organic solvent, just Stablize under the conditions of often.
Fluorine-containing curcumin A3 (see formula V) compound A-13:1- (4- fluorophenyls) -3- (4- fluorophenyls)-propenone, it is faint yellow Crystal, chemical formula:C15H10F2O, molecular weight 244.24,108~109.2 DEG C of melting range are slightly soluble in water, dissolve in organic solvent, just Stablize under the conditions of often.
Emulsifier:Emulsifier can be anion, cation, both sexes and nonionic emulsifier, the present invention it is preferred it is cloudy from Subclass emulsifier such as, phosphoric acid ester such as laruyl alcohol phosphate potassium, C20-22 alcohol phosphates, or nonionic class emulsifier. The nonionic emulsifier can be glyceride type such as stearine, can be for polyglycerol ester class such as:Natrulon H-10 is stearic Acid esters, -6 oleate of polyglycereol, -3 certain herbaceous plants with big flowers acid esters of polyglycereol, -4 certain herbaceous plants with big flowers acid esters of polyglycereol etc., polysorbate esters are such as:Poly- sorbic alcohol Ester -20, poly- sorbic alcohol ester -60, poly- sorbic alcohol ester -80 etc.;Polyethers are such as:Ceteareth -25, cetostearyl alcohol are poly- Ether -6 etc..Preferred -3 certain herbaceous plants with big flowers acid esters of polyglycereol of emulsifier of the present invention and ceteareth -25, wherein -3 certain herbaceous plants with big flowers acid esters of polyglycereol and Ceteareth -25 accounts for cosmetics weight 1% of the present invention respectively.
Thickener:Thickener of the present invention can be selected from card wave class such as:Card wave 934, card wave 940, card wave 980, polyacrylamide Amine such as matches 305 (polyacrylamides/C13-14 isoparaffins/laureth -7) of Bick, thickener used in the present invention For:Polyacrylic acid amide class 305 (SEPPIGEL 305), 305 thickeners account for weight 0.5-3.0% of the present invention, advanced optimize For 0.6-1.5%, other thickeners further include:Stearic acid, cetostearyl alcohol, aluminum magnesium silicate, hydroxyethyl cellulose, xanthan gum etc. It is one such or a variety of.
Polyalcohol:Polyalcohol may include glycerine, 1,3 butanediols, dipropylene glycol, preferably 1,3 butanediols of the invention.1,3 Butanediol weight percent in cosmetics of the present invention is 3%.
Ultra-violet absorber:Cosmetics of the present invention can include more than one sun-screening agents or UV ultraviolet when being used as day cream Light absorbers.Its absorbing wavelength of sun-screening agent at least one compound used in the regions UVB (absorbing wavelength be 290-320 nanometers), In addition also at least also include that a kind of absorbing wavelength in the regions UVA, (for 320-400 receive by absorbing wavelength as selectable sun-screening agent Rice) compound.Therefore, ultra-violet absorber used in the present invention accounts for cosmetics weight percent about 2-20% of the present invention, into one Step is optimized for 10-15%, wherein butylmethoxydibenzoylmethane accounts for cosmetics weight 0.5-2% of the present invention, salicylic acid Ethylhexyl accounts for cosmetics weight 3-5% of the present invention, and Octocrilene accounts for cosmetics weight 6-8% of the present invention.Remaining can be selected Ultra-violet absorber such as:Benzophenone 2-10%, ethylhexyl methoxy cinnamate 2-10%, PAPA and own ester 1-8%, Benzylidene camphor sulfonic acid 1-6%, p-aminobenzoic acid 1-5%, Uvinul T 150 1-5%, Phenylbenzimidazolesulfonic acid and Its potassium, sodium and triethanolamine salt 1-8%, titanium dioxide 1-25%, zinc oxide 1-25% etc..
Preservative:In cosmetics health specification conventional use of preservative such as, imidazolidinyl urea, parabens such as oxybenzene first Ester and Nipasol, Phenoxyethanol, disodium EDTA (chelating agent) etc., the preferably suitable parabens of the present invention and Phenoxyethanol, chelating agent are disodium EDTA.
Embodiment:I, II, III, VI and VII is comparative example (doing Experimental comparison's use) in embodiment;In addition, embodiment IV, embodiment V, embodiment VIII, embodiment Ⅸ, embodiment Ⅹ are the embodiment of the present invention.
Comparative example:Comparative example I is basic cosmetic formulations, except can be connect containing ultra-violet absorber and cosmetics Outside the carrier received, any other anti-oxidation active substance is not contained,
Four comparative examples are such as:Comparative example II, comparative example III, comparative example VI and comparative example VII, it is to add antioxidant such as on the basis of comparative example I:L-Ascorbic Acid L-O-Phosphate, vitamin e acetate and Three kinds of antioxidant contents such as ferulic acid.
Embodiment IV, V, V, VIII, Ⅸ, Ⅹ.
The embodiment of the present invention is respectively for totally 5 embodiment IV, embodiment V, embodiment VIII, embodiment Ⅸ, embodiment Ⅹ.
The embodiment of the present invention is that curcumin is increased on the basis of comparative example I, fluorine-containing curcumin A1, fluorine-containing turmeric Four kinds of antioxidant contents such as plain A2 and fluorine-containing curcumin A3.
Efficacy assessments
Antioxidant and ultraviolet light contained by a kind of cosmetic composition test present invention containing antioxidant of the present invention The cooperative synergism effect of absorbent, it is curcumin that the present invention, which has cooperative synergism effect antioxidant, fluorine-containing curcumin A1, is contained The mixture of fluorine curcumin A2 and fluorine-containing curcumin A3, and such as with the antioxidant used in comparative example, vitamin C phosphorus The mixture of acid esters magnesium, what ferulic acid of vitamin e acetate is compared;Through the embodiment of the present invention with comparative example SPF The comparison of value is judged the cooperative synergism effect of front and back two groups of antioxidant blends and ultra-violet absorber.
Embodiment I-V
Wherein:* tetrahydro curcumin, * * 1- (4- fluorophenyls) -3- (2- fluorophenyls)-propenone, * * * 1- (4- fluorophenyls) - 3- (3- fluorophenyls)-propenone, * * * * 1- (4- fluorophenyls) -3- (4- fluorophenyls)-propenone.
Embodiment VI-Ⅹ
Wherein:* tetrahydro curcumin, * * 1- (4- fluorophenyls) -3- (2- fluorophenyls)-propenone, * * * 1- (4- fluorophenyls) - 3- (3- fluorophenyls)-propenone, * * * * 1- (4- fluorophenyls) -3- (4- fluorophenyls)-propenone.
The spf value test result of embodiment I-Ⅹ
Embodiment SPF SPF
I comparison 13
II comparison 13.5
III comparison 13.8
Ⅳ 15
Ⅴ 16
VI comparison 13.8
VII comparison 14
Ⅷ 16.3
Ⅸ 17
Ⅹ 17
SPF test specifications:I, II, III, VI and VII is wherein real for comparative example (doing Experimental comparison's use) in embodiment It applies example I and had not both contained curcumin and fluorine-containing curcumin complex or without containing conventional vitamin C, vitamin E and ferulic acid Compound, the spf value measured (human body method) are 13.8;Other four are implemented for example, comparative example II, comparative example III, the compound of comparative example VI and comparative example VII containing vitamin C, vitamin E and ferulic acid, but without containing this Invention curcumin and fluorine-containing curcumin complex, the spf value of this four comparative examples are respectively that comparative example II is 13.5, comparative example III is 13.8, and comparative example VI is 13.8, and comparative example VII is 14);In addition, embodiment IV, Embodiment V, embodiment VIII, embodiment Ⅸ and embodiment Ⅹ are the embodiment of the present invention and contain curcumin and fluorine-containing curcumin Compound, measured spf value are respectively SPF15, SPF16, SPF16.3, SPF17, SPF17.
By the above embodiment of the present invention (embodiment IV, embodiment V, embodiment VIII, embodiment Ⅸ, embodiment Ⅹ) with Comparative example it was found that the embodiment of the present invention SPF present gradient promoted and embodiment Ⅸ resultant effect Preferably, the SPF increasing degree of 5 comparative examples (I, II, III, VI and VII) is little.
Conclusion:The SPF test datas of I-Ⅹ embodiment find out that the present invention contains curcumin and fluorine-containing turmeric through the invention Containing vitamin E used in the compound cosmetics of element and routine, vitamin C is compared with the cosmetics of ferulic acid compound, The cosmetics SPF for the compound that the present invention contains curcumin and fluorine-containing curcumin is above gives birth to containing conventional use of dimension Plain E, the SPF of vitamin C and ferulic acid compound cosmetics.Illustrate that curcumin and fluorine-containing curcumin have in the present invention More excellent antioxidant effect, and be used together to have with Orangic sunscreen and cooperate with enhancing cosmetics (sunscreen) sun-proof finger Several effects.
Highly preferred embodiment of the present invention is embodiment Ⅸ (a kind of cosmetic composition containing antioxidant)
* tetrahydro curcumin, * * 1- (4- fluorophenyls) -3- (2- fluorophenyls)-propenone, * * * 1- (4- fluorophenyls) -3- (3- Fluorophenyl)-propenone
* * * 1- (4- fluorophenyls) -3- (4- fluorophenyls)-propenone

Claims (4)

1.一种含有抗氧化剂的化妆品组合物，除化妆品可接受的载体：乳化剂、紫外线吸收剂、增稠剂、多元醇，适量的螯合剂、防腐剂、香精、以及去离子水外，还含有：1. A cosmetic composition containing an antioxidant, except a cosmetically acceptable carrier: an emulsifier, an ultraviolet absorber, a thickener, a polyhydric alcohol, an appropriate amount of a chelating agent, an antiseptic, an essence, and deionized water, and contain: A、占组合物重量0.05-0.6％的姜黄素；A, account for the curcumin of composition weight 0.05-0.6%; B、占组合物重量0.05-1.0％的姜黄素类似物，所述姜黄素类似物为含氟姜黄素。B. Accounting for 0.05-1.0% of the curcumin analog by weight of the composition, the curcumin analog is fluorine-containing curcumin. 2.根据权利要求1所述组合物，所述姜黄素为四氢姜黄素。2. composition according to claim 1, described curcumin is tetrahydrocurcumin. 3.根据权利要求1所述组合物，所述含氟姜黄素为1-(4-氟苯基)-3-(2-氟苯基)-丙烯酮、1-(4-氟苯基)-3-(3-氟苯基)-丙烯酮、1-(4-氟苯基)-3-(4-氟苯基)-丙烯酮的混合物；且三种混合物重量比1-(4-氟苯基)-3-(2-氟苯基)-丙烯酮:1-(4-氟苯基)-3-(3-氟苯基)-丙烯酮:1-(4-氟苯基)-3-(4-氟苯基)-丙烯酮为1:1:1。3. according to the composition described in claim 1, described fluorine-containing curcumin is 1-(4-fluorophenyl)-3-(2-fluorophenyl)-propenone, 1-(4-fluorophenyl) -A mixture of 3-(3-fluorophenyl)-propenone and 1-(4-fluorophenyl)-3-(4-fluorophenyl)-propenone; and the weight ratio of the three mixtures is 1-(4- Fluorophenyl)-3-(2-fluorophenyl)-propenone: 1-(4-fluorophenyl)-3-(3-fluorophenyl)-propenone: 1-(4-fluorophenyl) -3-(4-fluorophenyl)-propenone is 1:1:1. 4.一种含有抗氧化剂的化妆品组合物，其组分及含量为：4. A cosmetic composition containing antioxidant, its components and content are:
CN201780004912.8A 2017-09-05 2017-09-05 A kind of cosmetic composition containing antioxidant Pending CN108697601A (en)

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Application publication date: 20181023