CN108743473A - A kind of mouthrinse composition, preparation method and application - Google Patents
A kind of mouthrinse composition, preparation method and application Download PDFInfo
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- CN108743473A CN108743473A CN201810684705.8A CN201810684705A CN108743473A CN 108743473 A CN108743473 A CN 108743473A CN 201810684705 A CN201810684705 A CN 201810684705A CN 108743473 A CN108743473 A CN 108743473A
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- 239000000203 mixture Substances 0.000 title claims abstract description 50
- 239000002324 mouth wash Substances 0.000 title claims abstract description 43
- 238000002360 preparation method Methods 0.000 title claims description 7
- 229940027779 persimmon extract Drugs 0.000 claims abstract description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
- 229940065115 grapefruit extract Drugs 0.000 claims abstract description 21
- 239000008367 deionised water Substances 0.000 claims abstract description 19
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 19
- 229920003169 water-soluble polymer Polymers 0.000 claims abstract description 19
- 244000246386 Mentha pulegium Species 0.000 claims description 12
- 235000016257 Mentha pulegium Nutrition 0.000 claims description 12
- 235000004357 Mentha x piperita Nutrition 0.000 claims description 12
- 235000001050 hortel pimenta Nutrition 0.000 claims description 12
- 239000012459 cleaning agent Substances 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 7
- 229920000642 polymer Polymers 0.000 claims description 7
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 5
- 239000000661 sodium alginate Substances 0.000 claims description 5
- 235000010413 sodium alginate Nutrition 0.000 claims description 5
- 229940005550 sodium alginate Drugs 0.000 claims description 5
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- 229920001285 xanthan gum Polymers 0.000 claims description 4
- 229920002907 Guar gum Polymers 0.000 claims description 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 3
- 239000000665 guar gum Substances 0.000 claims description 3
- 235000010417 guar gum Nutrition 0.000 claims description 3
- 229960002154 guar gum Drugs 0.000 claims description 3
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 3
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 3
- -1 alkenyl methylether maleic acid anhydride Chemical compound 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 abstract description 14
- 231100000252 nontoxic Toxicity 0.000 abstract description 4
- 230000003000 nontoxic effect Effects 0.000 abstract description 4
- 230000001835 salubrious effect Effects 0.000 abstract description 3
- 230000000052 comparative effect Effects 0.000 description 12
- 206010006326 Breath odour Diseases 0.000 description 10
- 208000032139 Halitosis Diseases 0.000 description 10
- 229940051866 mouthwash Drugs 0.000 description 10
- 230000000694 effects Effects 0.000 description 9
- 241000894006 Bacteria Species 0.000 description 7
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 6
- 230000001408 fungistatic effect Effects 0.000 description 5
- 244000005700 microbiome Species 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 241000628997 Flos Species 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 230000008676 import Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 210000003296 saliva Anatomy 0.000 description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 240000000560 Citrus x paradisi Species 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 240000009164 Petroselinum crispum Species 0.000 description 1
- 235000002770 Petroselinum crispum Nutrition 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 235000020710 ginseng extract Nutrition 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 229940117336 parsley extract Drugs 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229940083542 sodium Drugs 0.000 description 1
- 235000015424 sodium Nutrition 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8164—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical, and containing at least one other carboxyl radical in the molecule, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers, e.g. poly (methyl vinyl ether-co-maleic anhydride)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- Health & Medical Sciences (AREA)
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- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Medicinal Chemistry (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Microbiology (AREA)
- Mycology (AREA)
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- Oral & Maxillofacial Surgery (AREA)
- Botany (AREA)
- Biotechnology (AREA)
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Abstract
The present invention provides a kind of mouthrinse compositions, including：0.1~5 parts by weight of water-soluble polymer；0.1~1 parts by weight of persimmon extract；0.1~2 parts by weight of grape fruit extract；90~99 parts by weight of deionized water；Tasty and refreshing dose of 0.1~1 parts by weight.Water-soluble polymer, persimmon extract and the grape fruit extract that the present invention is matched by specified weight act synergistically, and can effectively improve the bacteriostasis in oral cavity, remove oral peculiar smell.Said components are nontoxic simultaneously, edible, safe and secure, while by tasty and refreshing dose of addition, coordinating with extract and making taste salubrious, fragrant.
Description
Technical field
The present invention relates to field of material technology, more particularly, to a kind of mouthrinse composition, preparation method and application.
Background technology
Usual mouthwash is used as the chemicals detergent being administered orally.When as dentilave, pass through removal
Bacterium and virus in oral cavity eliminate oral peculiar smell, typically no serious problem.But when water constituent of gargling contains chemical drugs
As accidentally intake has that there are insulting risks when object.To the mouthwash composition of the safe handling chemicals effect of human body
It does not assume that the case where eating by mistake, can cause to keep tissue impaired because eating chemicals ingredient by mistake.
Therefore, exploitation is a kind of allows to be eaten by mistake, has and comfortably feels, is different from the composition of traditional mouthwash, energy
The harmful bacteria for causing to be grown in oral cavity is effectively killed, the mouthwash for removing oral peculiar smell is very necessary.
Invention content
In view of this, the technical problem to be solved in the present invention is to provide a kind of mouthrinse composition, it is provided by the invention
Mouthrinse composition is permissible to be eaten by mistake, can effectively kill the harmful bacteria for causing to grow in oral cavity, and oral peculiar smell is removed.
The present invention provides a kind of mouthrinse compositions, including：
Preferably, the mouthrinse composition includes：
Preferably, the mouthrinse composition includes：
Preferably, the mouthrinse composition includes：
Preferably, the water-soluble polymer include methoxy ethylene-maleic anhydride polymer, sodium carboxymethylcellulose,
One or more of sodium alginate, guar gum and xanthans.
Preferably, described tasty and refreshing dose is peppermint.
The preparation method for the mouthrinse composition that the present invention provides a kind of as described in above-mentioned technical proposal, including：
By water-soluble polymer, persimmon extract, grape fruit extract, deionized water and tasty and refreshing dose of mixing, stir to get
Mouthrinse composition.
Preferably, the mixing time is 3~5 hours；The speed of agitator is 30 revs/min.
The present invention also provides application of the composition described in above-mentioned technical proposal in preparing cleaning agent for mouth cavity.
The present invention also provides a kind of cleaning agent for mouth cavity, including the composition described in above-mentioned technical proposal.
Compared with prior art, the present invention provides a kind of mouthrinse compositions, including：0.1~5 weight of water-soluble polymer
Measure part；0.1~1 parts by weight of persimmon extract；0.1~2 parts by weight of grape fruit extract；90~99 parts by weight of deionized water；It is refreshing
Mouth 0.1~1 parts by weight of agent.Water-soluble polymer, persimmon extract and the grape fruit extraction that the present invention is matched by specified weight
Object acts synergistically, and can effectively improve the bacteriostasis in oral cavity, removes oral peculiar smell.Said components are nontoxic simultaneously,
It is edible, safe and secure, while by tasty and refreshing dose of addition, coordinating with extract and making taste salubrious, fragrant.
Specific implementation mode
The present invention provides a kind of mouthrinse composition, those skilled in the art can use for reference present disclosure, be suitably modified
Formula and component are realized.In particular, it should be pointed out that all similar substitutions and modifications are aobvious for a person skilled in the art
And be clear to, they shall fall within the protection scope of the present invention.The method of the present invention and application are carried out by preferred embodiment
Description, related personnel can obviously not depart from the content of present invention, change to methods herein and application in spirit and scope
It moves or suitably changes and combine, to realize and apply the technology of the present invention.
The present invention provides a kind of mouthrinse compositions, including：
Mouthrinse composition provided by the invention includes the water-soluble polymer of 0.1~5 parts by weight；Preferably include 0.5~4
The water-soluble polymer of parts by weight；More preferably include the water-soluble polymer of 0.7~3 parts by weight；It most preferably include 0.7~2 weight
Measure the water-soluble polymer of part.
Water-soluble polymer of the present invention preferably includes methoxy ethylene-maleic anhydride polymer, carboxymethyl cellulose
One or more of sodium, sodium alginate, guar gum and xanthans.
The present invention for above-mentioned water-soluble polymer source without limit, it is commercially available.
Mouthrinse composition provided by the invention includes the persimmon extract of 0.1~1 parts by weight；Preferably include 0.2~0.9
The persimmon extract of parts by weight；More preferably include the persimmon extract of 0.3~0.8 parts by weight；It most preferably include 0.3~0.6 weight
Measure the persimmon extract of part.
The present invention for the persimmon extract source without limit, it is commercially available.It is preferred that import canal can be selected
The persimmon extract of road purchase.
Mouthrinse composition provided by the invention includes the grape fruit extract of 0.1~2 parts by weight；Preferably include 0.2~
The grape fruit extract of 1.5 parts by weight；More preferably include the grape fruit extract of 0.3~1.3 parts by weight；Most preferably include 0.3
The grape fruit extract of~1.1 parts by weight.
The present invention for the grape fruit extract source without limit, it is commercially available.It is preferred that import can be selected
The grape fruit extract of channel purchase.
The present invention selects above two extract, is the collaboration for specific extract on the basis of numerous experiments
Cooperation, in combination with special ratios, can be only achieved effect of the present invention.
The present invention passes through the synergistic effect of above-mentioned water-soluble polymer, persimmon extract and grape fruit extract, Ke Yiyou
The raising of effect is to the antibacterial level in oral cavity, while said components are safe and non-toxic, and use is safer, to human body and without eating
It is without side-effects.
Mouthrinse composition provided by the invention includes the deionized water of 90~99 parts by weight；Preferably include 91~99 weight
The deionized water of part；More preferably include 92~98 parts by weight；Most preferably include 93~98 parts by weight.
The present invention for the deionized water source without limit, it is commercially available.
Deionized water of the present invention as dissolving and can carry antibacterial and fresh breath medium, while also act as clear
Clean effect.
Mouthrinse composition provided by the invention includes tasty and refreshing dose of 0.1~1 parts by weight；Preferably include 0.1~0.9 weight
Tasty and refreshing dose of part；More preferably include tasty and refreshing dose of 0.1~0.8 parts by weight；Most preferably include tasty and refreshing dose of 0.1~0.6 parts by weight.
Tasty and refreshing dose of the present invention is peppermint.By the cooperation of peppermint and specific extraction object, fresh breath, gas can be played
The effect of taste fragrance.
In a portion preferred embodiment of the present invention, the mouthrinse composition includes：
In a portion preferred embodiment of the present invention, the mouthrinse composition includes：
In a portion preferred embodiment of the present invention, the mouthrinse composition includes：
The present invention provides a kind of mouthrinse compositions, including：0.1~5 parts by weight of water-soluble polymer；Persimmon extract
0.1~1 parts by weight；0.1~2 parts by weight of grape fruit extract；90~99 parts by weight of deionized water；Tasty and refreshing dose of 0.1~1 weight
Part.Water-soluble polymer, persimmon extract and the grape fruit extract that the present invention is matched by specified weight act synergistically,
The bacteriostasis in oral cavity can be effectively improved, oral peculiar smell is removed.Said components are nontoxic simultaneously, edible, put safely
The heart, while by tasty and refreshing dose of addition, coordinating with extract and making taste salubrious, fragrant.
The preparation method for the mouthrinse composition that the present invention provides a kind of as described in above-mentioned technical proposal, including：
By water-soluble polymer, persimmon extract, grape fruit extract, deionized water and tasty and refreshing dose of mixing, stir to get
Mouthrinse composition.
The present invention is above-mentioned for water-soluble polymer, persimmon extract, grape fruit extract, deionized water and tasty and refreshing dose
Composition and proportioning have been clearly described, and details are not described herein.
The present invention for it is described mixing and stirring concrete mode without limit, it is well known to those skilled in the art i.e.
It can.
In the present invention, the mixing time is preferably 3~5 hours；The speed of agitator is preferably 30 revs/min.
The present invention also provides application of the composition described in above-mentioned technical proposal in preparing cleaning agent for mouth cavity.
Mouthrinse composition of the present invention can be used for oral cleaning, reach good cleaning effect, while environmentally friendly nothing
Poison, safety are without side-effects.
The present invention also provides a kind of cleaning agent for mouth cavity, including the composition described in above-mentioned technical proposal.
Cleaning agent for mouth cavity of the present invention can be prepared by above-mentioned composition, can also include the present composition or
Remaining additive well known to those skilled in the art of person, the present invention is to this without limiting.
In order to further illustrate the present invention, with reference to embodiments to a kind of mouthrinse composition progress provided by the invention
Detailed description.
Embodiment 1
Following component is bound together to form mouthwash (quality %)
Methoxy ethylene-maleic anhydride polymer 0.7%
Persimmon extract 0.5%
Grape fruit extract 0.5%
Deionized water 98%
Peppermint 0.3%
Embodiment 2
Following component is bound together to form mouthwash (quality %)
Sodium carboxymethylcellulose 1.1%
Persimmon extract 0.3%
Grape fruit extract 0.6%
Deionized water 98%
Peppermint 0.3%
Embodiment 3
Sodium alginate 1.7%
Persimmon extract 0.4%
Grape fruit extract 0.8%
Deionized water 97%
Peppermint 0.1%
Embodiment 4
Xanthans 3.7%
Persimmon extract 0.4%
Grape fruit extract 0.8%
Deionized water 95%
Peppermint 0.1%
Comparative example 1
Sodium alginate 0.7%
Persimmon extract 0.5%
Grape fruit extract 0.5%
Deionized water 98%
Peppermint 0.3%
Comparative example 2
Methoxy ethylene-maleic anhydride polymer 0.7%
Ginseng extract 0.5%；
Flos Caryophylli extract 0.5%
Deionized water 98%
Peppermint 0.3%
Comparative example 3
Methoxy ethylene-maleic anhydride polymer 0.7%
Flos Chrysanthemi Indici extract 0.5%
Sheep's-parsley extract 0.5%
Deionized water 98%
Peppermint 0.3%
Comparative example 4
Methoxy ethylene-maleic anhydride polymer 0.7%
Persimmon extract 1%
Deionized water 98%
Peppermint 0.3%
5 fungistatic effect of embodiment is tested
1min is kept using water is first contained before gargling, then water is spat and dilutes ten times in collection vessel to obtain saliva dilute
Liquid is released, each 5mL of mouthwash of Example 1~4 and comparative example 1~4 is mixed with to obtain 8 groups of culture mediums with MC culture mediums,
Each 1ml of saliva dilution is taken respectively, is inoculated in the culture medium containing Examples 1 to 4 and comparative example 1~4, in 25 DEG C of conditions
Lower constant temperature incubation preserves, respectively at the total content of microorganisms of 5min, 30min, 1h, 12h detection sample, to judge its antibacterial energy
Power, experimental result are as follows.
Wherein, bacteriostasis calculation formula is as follows：
Wherein, Ao is the content of microorganism in mouthwash when being initially added microorganism；An is different detection time microorganisms
Content；If bacterium declines 99.9%, if can maintain total plate count in 12h, judgement sample in total plate count in 30min
Fungistatic effect is notable.
Total plate count declines 99.9% and can maintain 12h in the notable 30min of Examples 1 to 4 fungistatic effect, and comparative example 1 presses down
Total plate count declines 99.9% and can maintain 6h in the fine 30min of bacterium effect, bacterium colony in the fine 30min of 2 fungistatic effect of comparative example
Sum declines 99.9% and can maintain 6h, and total plate count declines 99.9% and energy in the notable 30min of 3~4 fungistatic effect of comparative example
Maintain 6h.
6 breath freshening of embodiment is tested
Halitosis is classified：Halitosis is divided into six grades using direct smell method, standard at different levels is：Level-one：Without halitosis；Two level：
Very slight halitosis；Three-level：Slight halitosis；Level Four：Moderate halitosis；Pyatyi：Strong halitosis；Six grades：Halitosis strongly.
Test method：
There is the volunteer of level Four or more halitosis each in the mouthwash with Examples 1 to 4 and comparative example 1~4
Again receive halitosis classified estimation after 30s, 2h, it is effective that rank, which reduces two level or more person,；It is effective to reduce level-one；It is unchanged
It is invalid.As a result it is that the reduction of example 1~4 two level is effective, the reduction of comparative example 1 level-one is effective, and the reduction of comparative example 2 two level is effective, right
It is effective that ratio 3~4 reduces level-one.
This mouthwash forms the sense of discomfort for eliminating mouth-taste, can containing the natural materials for eliminating oral cavity harmful bacteria
Oral cleaning for children and the elderly.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (10)
1. a kind of mouthrinse composition, including：
2. composition according to claim 1, which is characterized in that the mouthrinse composition includes：
3. composition according to claim 1, which is characterized in that the mouthrinse composition includes：
4. composition according to claim 1, which is characterized in that the mouthrinse composition includes：
5. according to the composition described in Claims 1 to 4 any one, which is characterized in that the water-soluble polymer includes second
One or more of alkenyl methylether maleic acid anhydride polymer, sodium carboxymethylcellulose, sodium alginate, guar gum and xanthans.
6. according to the composition described in Claims 1 to 4 any one, which is characterized in that described tasty and refreshing dose is peppermint.
7. a kind of preparation method of mouthrinse composition as described in claim 1, including：
By water-soluble polymer, persimmon extract, grape fruit extract, deionized water and tasty and refreshing dose of mixing, stirs to get and gargle
Water composition.
8. preparation method according to claim 7, the mixing time is 3~5 hours；The speed of agitator be 30 turns/
Point.
9. application of the composition described in claim 1~6 any one in preparing cleaning agent for mouth cavity.
10. a kind of cleaning agent for mouth cavity, including the composition described in claim 1~6 any one.
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| CN110897953A (en) * | 2019-12-09 | 2020-03-24 | 南通优护优家卫生用品有限公司 | Breath freshener containing plant extract for relieving oral odor |
| CN114652475A (en) * | 2022-03-23 | 2022-06-24 | 上海歌鹭日化科技有限公司 | Screening method, development method, and usage method of mouthwash suitable for irrigator |
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