CN109010897A - A kind of preparation method of medical antibacterial gel dressing - Google Patents
A kind of preparation method of medical antibacterial gel dressing Download PDFInfo
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- CN109010897A CN109010897A CN201811046922.0A CN201811046922A CN109010897A CN 109010897 A CN109010897 A CN 109010897A CN 201811046922 A CN201811046922 A CN 201811046922A CN 109010897 A CN109010897 A CN 109010897A
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- gel dressing
- antibacterial gel
- starch
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- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 29
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- 229920002472 Starch Polymers 0.000 claims abstract description 22
- 239000008107 starch Substances 0.000 claims abstract description 22
- 235000019698 starch Nutrition 0.000 claims abstract description 22
- 239000003242 anti bacterial agent Substances 0.000 claims abstract description 21
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 42
- 238000003756 stirring Methods 0.000 claims description 33
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 23
- 239000008367 deionised water Substances 0.000 claims description 20
- 229910021641 deionized water Inorganic materials 0.000 claims description 20
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 16
- 238000002156 mixing Methods 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 13
- LRWZZZWJMFNZIK-UHFFFAOYSA-N 2-chloro-3-methyloxirane Chemical compound CC1OC1Cl LRWZZZWJMFNZIK-UHFFFAOYSA-N 0.000 claims description 12
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 12
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 claims description 12
- 239000003643 water by type Substances 0.000 claims description 12
- 230000008569 process Effects 0.000 claims description 11
- 229920000881 Modified starch Polymers 0.000 claims description 10
- 239000004368 Modified starch Substances 0.000 claims description 10
- 239000003093 cationic surfactant Substances 0.000 claims description 10
- 235000019426 modified starch Nutrition 0.000 claims description 10
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims description 10
- 229920002674 hyaluronan Polymers 0.000 claims description 9
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 8
- 239000011734 sodium Substances 0.000 claims description 8
- 229910052708 sodium Inorganic materials 0.000 claims description 8
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 7
- 229960003160 hyaluronic acid Drugs 0.000 claims description 7
- LTVDFSLWFKLJDQ-UHFFFAOYSA-N α-tocopherolquinone Chemical compound CC(C)CCCC(C)CCCC(C)CCCC(C)(O)CCC1=C(C)C(=O)C(C)=C(C)C1=O LTVDFSLWFKLJDQ-UHFFFAOYSA-N 0.000 claims description 7
- CSPHGSFZFWKVDL-UHFFFAOYSA-M (3-chloro-2-hydroxypropyl)-trimethylazanium;chloride Chemical class [Cl-].C[N+](C)(C)CC(O)CCl CSPHGSFZFWKVDL-UHFFFAOYSA-M 0.000 claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 239000006210 lotion Substances 0.000 claims description 6
- 230000001376 precipitating effect Effects 0.000 claims description 6
- 229910001961 silver nitrate Inorganic materials 0.000 claims description 6
- 239000000725 suspension Substances 0.000 claims description 6
- 238000010792 warming Methods 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 5
- 230000003213 activating effect Effects 0.000 claims description 2
- 239000002068 microbial inoculum Substances 0.000 claims description 2
- 230000004048 modification Effects 0.000 claims description 2
- 238000012986 modification Methods 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 abstract description 10
- 239000000463 material Substances 0.000 abstract description 10
- 230000035699 permeability Effects 0.000 abstract description 10
- 230000001580 bacterial effect Effects 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 5
- 241000894006 Bacteria Species 0.000 abstract description 4
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 abstract description 4
- 150000001768 cations Chemical class 0.000 abstract description 4
- 230000008859 change Effects 0.000 abstract description 3
- 230000002209 hydrophobic effect Effects 0.000 abstract description 3
- 208000031737 Tissue Adhesions Diseases 0.000 abstract description 2
- 125000000217 alkyl group Chemical group 0.000 abstract description 2
- 210000002421 cell wall Anatomy 0.000 abstract description 2
- 238000006243 chemical reaction Methods 0.000 abstract description 2
- 230000009089 cytolysis Effects 0.000 abstract description 2
- 230000034994 death Effects 0.000 abstract description 2
- 238000004090 dissolution Methods 0.000 abstract description 2
- 210000000416 exudates and transudate Anatomy 0.000 abstract description 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract description 2
- 239000001257 hydrogen Substances 0.000 abstract description 2
- 230000005764 inhibitory process Effects 0.000 abstract description 2
- 102000004169 proteins and genes Human genes 0.000 abstract description 2
- 108090000623 proteins and genes Proteins 0.000 abstract description 2
- 125000001453 quaternary ammonium group Chemical group 0.000 abstract description 2
- 239000004094 surface-active agent Substances 0.000 abstract description 2
- 239000000499 gel Substances 0.000 description 25
- 206010052428 Wound Diseases 0.000 description 17
- 208000027418 Wounds and injury Diseases 0.000 description 17
- 238000012360 testing method Methods 0.000 description 8
- 239000002253 acid Substances 0.000 description 3
- 210000000981 epithelium Anatomy 0.000 description 3
- 239000000017 hydrogel Substances 0.000 description 3
- 241000521257 Hydrops Species 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 230000006399 behavior Effects 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 238000002592 echocardiography Methods 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 231100000241 scar Toxicity 0.000 description 2
- 210000000717 sertoli cell Anatomy 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 230000029663 wound healing Effects 0.000 description 2
- VFKZECOCJCGZQK-UHFFFAOYSA-M 3-hydroxypropyl(trimethyl)azanium;chloride Chemical compound [Cl-].C[N+](C)(C)CCCO VFKZECOCJCGZQK-UHFFFAOYSA-M 0.000 description 1
- YWNYZQTZOONLGU-UHFFFAOYSA-N C(CC)Cl.[O] Chemical compound C(CC)Cl.[O] YWNYZQTZOONLGU-UHFFFAOYSA-N 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000001339 epidermal cell Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000003328 fibroblastic effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 238000005213 imbibition Methods 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000004202 respiratory function Effects 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 238000011895 specific detection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/48—Surfactants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a kind of preparation methods of medical antibacterial gel dressing, belong to medical macromolecular materials technical field.The present invention prepares quaternary ammonium cation starch, and the antibacterial agent in its area load Nano silver grain, as medical antibacterial gel dressing using quaternaries cation etherifying agent and starch reaction；The effects of antibacterial agent is mainly cation by hydrophobic binding between electrostatic force, hydrogen bond force and surfactant molecule and protein molecule, adsorbs electronegative bacterial body and is gathered on cell wall, generating chamber's inhibition effect causes bacterial growth suppressed and dead；Its hydrophobic alkyl and the hydrophilic group of bacterium act on, and lysis occurs, and destroy eucaryotic cell structure, cause the dissolution and death of cell；The medical antibacterial gel dressing permeability and mechanical strength of preparation are preferable, can provide wet tissue contact environment, have good cell compatibility, energy absorbing wound exudate, bring secondary damage when not with tissue adhesion to avoid more change dressings.
Description
Technical field
The present invention relates to a kind of preparation methods of medical antibacterial gel dressing, belong to medical macromolecular materials technical field.
Background technique
Treatment large-area burns at present, scald wound most efficient method are epidermizations, must using epidermization
Wound must be treated and be protected.It should be preferable guard method using gel overlay, medical gel dressing materials should have
There is following function: preventing the loss of moisture and body fluid；It covers and protects the surface of a wound not infected；Good biocompatibility；It is ventilative,
Moisture retention is good；There is preferable bonding force with the surface of a wound, is not deformed；There are enough mechanical strength sertoli cell differentiation to increase
It is raw；Surface has enough cell adsorption capacities, and the firewood for being conducive to cell echos growth；It can promote epithelial tissue and granulation
Normal growth promotes wound healing, preventing from scar；Material source is sufficient, is easy to make, process etc..In addition to this, it also to seek medical advice
It is nontoxic, non-stimulated and without sensitization with gel rubber material.But the preparation process of existing gel is complex, technique controlling difficulty
It is higher, it is therefore desirable to which that a kind of preparation method is relatively simple, while also with the medical gel material of preferable antibacterial effect.
General medical wound dressing gauze or non-woven fabrics and cotton are made with composite medicine, can protect the wound from mechanicalness
Damage, prevents wound infected, but the performances such as its antibacterial, imbibition, anti-inflammatory are not fully up to expectations.
Medical gel dressing materials should have following function: prevent the loss of moisture and body fluid；It covers and protects the surface of a wound not
It is infected；Good biocompatibility；Ventilative, moisture retention is good；There is preferable bonding force with the surface of a wound, is not deformed；Have
Enough mechanical strength sertoli cells break up hyperplasia；Surface has enough cell adsorption capacities, and the firewood for being conducive to cell echos
Growth；It can promote the normal growth of epithelial tissue and granulation, promote wound healing, preventing from scar；Material source is sufficient, is easy to
Production, processing etc..The main indicator for evaluating dressing performance is as follows: (1) mechanical performance；(2) bacterial barriers act on: the ideal surface of a wound
Dressing should be able to play the role of barrier to microorganism invasion, be effectively protected the surface of a wound, prevent from infecting.(3) adhesiveness: i.e. dressing is equal
Ability that is even, being closely adhere to the surface of a wound, is indicated with avulsion power.(4) absorptive capacity: i.e. dressing absorbs wound fluid and nocuousness
The ability of substance, the biggish dressing of absorptive capacity can prevent surface of a wound hydrops, bacterial growth be reduced, to promote to heal.(5) water
Vapor transmission rates: moisture-vapor transmission appropriate can make the surface of a wound keep an ideal humidity environment, while preventing hydrops
It is wet to be able to maintain the surface of a wound, may advantageously facilitate healing.(6) oxygen permeability: oxygen can be improved fibroblastic activity, favorably
In the synthesis of epithelial tissue composition collagen and the growth of epidermal cell.
Summary of the invention
The technical problems to be solved by the invention: for asking for existing medical gel dressing gas permeability and bad mechanical strength
Topic, provides a kind of preparation method of medical antibacterial gel dressing.
In order to solve the above technical problems, the technical solution adopted by the present invention is that:
(1) according to parts by weight, 100~120 parts of deionized waters are weighed respectively, 20~30 parts of mass fractions are 20% sodium hydroxide
Solution, 40~50 parts of starch, 10~22 parts of 3- chloro-2-hydroxypropyl-trimethyl ammonium chlorides, by deionized water, mass fraction 20%
Sodium hydroxide solution, starch, the mixing of 3- chloro-2-hydroxypropyl-trimethyl ammonium chloride, stir process obtain complex liquid, adjust pH value, obtain
Suspension filters to obtain filter residue, is washed with deionized 3~5 times, is placed in 60~70 DEG C of baking ovens and dries to constant weight, obtains modification
Starch；
(2) in mass ratio 2: 1: 1 modified starch, anhydrous methanol and mass fraction are mixed for 10% silver nitrate solution, is in revolving speed
It is protected from light 6~8h of stirring under 100~150r/min, obtains blend, addition mass fraction is 5% citric acid three sodium solution, at stirring
Reason, obtains mixed liquor, is centrifugated to obtain precipitating, be washed 3~5 times with dehydrated alcohol and deionized water respectively, and drying to constant weight must resist
Microbial inoculum；
(3) according to parts by weight, 20~40 parts of antibacterial agents, 1~10 part of quaternary ammonium salt cationic surfactant, 10 are weighed respectively
~16 parts of hyaluronic acids, 1~4 part of epoxychloropropane, 50~60 parts of deionized waters, by antibacterial agent, quaternary ammonium salt cationic surface
Activating agent, hyaluronic acid, epoxychloropropane and deionized water mixing, constant temperature stir process are cooled to room temperature to get medical antibacterial
Gel dressing.
It is that 20% sodium hydroxide solution and starch mix that stir process described in step (1), which is by deionized water, mass fraction,
It closes, is that 200~300r/min is stirred evenly at room temperature in revolving speed, obtains lotion, 3- chloro-2-hydroxypropyl-trimethyl ammonium chloride is added,
Continue 5~10min of stirring, is warming up to 40~50 DEG C and is stirred to react 8~12h.
Adjusting pH described in step (1) be with mass fraction be 7% hydrochloric acid solution adjust pH value be 5.5~6.5.
Stirring is protected from light described in step (2) to be protected from light 6~8h of stirring in the case where revolving speed is 100~150r/min.
Mass fraction described in step (2) is that the mass ratio of 5% citric acid three sodium solution and blend is 1: 10.
Stir process described in step (2) is that 30~50min is stirred at 400~500r/min.
It is 60~80 DEG C that constant temperature stir process described in step (3), which is in temperature, and revolving speed is to stir under 800~1000r/min
Mix 2~4h.
The present invention is compared with other methods, and advantageous effects are:
(1) present invention use quaternaries cation etherifying agent, prepared under the action of catalyst with starch reaction quaternary ammonium type sun from
Sub- starch, and in its area load Nano silver grain, as the antibacterial agent of medical antibacterial gel dressing, the antibacterial agent of preparation is main
It the effects of being cation by hydrophobic binding between electrostatic force, hydrogen bond force and surfactant molecule and protein molecule, inhales
Attached electronegative bacterial body, is gathered on cell wall, and generating chamber's inhibition effect causes bacterial growth suppressed and dead；It is hated simultaneously
Water alkyl can also be acted on the hydrophilic group of bacterium, change the permeability of film, and lysis then occurs, and destroyed eucaryotic cell structure, drawn
Play the dissolution and death of cell；Nano silver grain may be interfered by attaching to the surface of cell membrane cell permeability and its
Respiratory function；In the case where phase homogenous quantities, nano-Ag particles can possess bigger surface area than other bulky grains, to have
The bigger space with microbial interaction；Silver nano-grain can interact with the prot th that contains on bacterial membrane,
It also interacts simultaneously with the phosphorus-containing compound on DNA, to make inactivation of bacteria；Nano-Ag particles can be released inside bacterium
Silver ion is put, its antibacterial activity can be improved；
(2) medical antibacterial gel dressing material prepared by the present invention can provide wet tissue contact environment, have good thin
Cell phase capacitive, energy absorbing wound exudate, bring secondary damage when not with tissue adhesion to avoid more change dressings, antibacterial agent
In starch be used as pore creating material again during the preparation process, using epoxychloropropane as starch crosslinking agent, so that the gel of preparation is deposited
Expect good permeability, mechanical strength is preferable.
Specific embodiment
According to parts by weight, 100~120 parts of deionized waters are weighed respectively, 20~30 parts of mass fractions are 20% sodium hydroxide
Solution, 40~50 parts of starch, 10~22 parts of 3- chloro-2-hydroxypropyl-trimethyl ammonium chlorides, by deionized water, mass fraction 20%
Sodium hydroxide solution and starch mixing are that 200~300r/min is stirred evenly at room temperature in revolving speed, obtain lotion, the chloro- 2- of 3- is added
Hydroxypropyl-trimethyl ammonium chloride continues 5~10min of stirring, is warming up to 40~50 DEG C and is stirred to react 8~12h, obtains complex liquid, uses
Mass fraction is that 7% hydrochloric acid solution adjusting pH value is 5.5~6.5, obtains suspension, filters to obtain filter residue, be washed with deionized 3~5
It is secondary, it is placed in 60~70 DEG C of baking ovens and dries to constant weight, obtain modified starch；In mass ratio 2: 1: 1 by modified starch, anhydrous methanol
It is the mixing of 10% silver nitrate solution with mass fraction, is protected from light 6~8h of stirring in the case where revolving speed is 100~150r/min, obtains blend,
In mass ratio 1: 10 is added mass fraction as 5% citric acid three sodium solution, and 30~50min is stirred at 400~500r/min, is obtained
Mixed liquor is centrifugated to obtain precipitating, be washed 3~5 times with dehydrated alcohol and deionized water respectively, and drying to constant weight obtains antibacterial agent；
According to parts by weight, 20~40 parts of antibacterial agents, 1~10 part of quaternary ammonium salt cationic surfactant, 10~16 parts are weighed respectively
Hyaluronic acid, 1~4 part of epoxychloropropane, 50~60 parts of deionized waters, by antibacterial agent, quaternary ammonium salt cationic surfactant,
Hyaluronic acid, epoxychloropropane and deionized water mixing are 60~80 DEG C in temperature, and revolving speed is to stir under 800~1000r/min
2~4h is cooled to room temperature to get medical antibacterial gel dressing.
According to parts by weight, 100 parts of deionized waters are weighed respectively, 20 parts of mass fractions are 20% sodium hydroxide solution, 40 parts
Deionized water, mass fraction are 20% sodium hydroxide solution and starch by starch, 10 parts of 3- chloro-2-hydroxypropyl-trimethyl ammonium chlorides
Mixing is that 200r/min is stirred evenly at room temperature in revolving speed, obtains lotion, 3- chloro-2-hydroxypropyl-trimethyl ammonium chloride is added, continue
Stir 5min, be warming up to 40 DEG C and be stirred to react 8h, obtain complex liquid, with mass fraction be 7% hydrochloric acid solution adjust pH value be 5.5, obtain
Suspension filters to obtain filter residue, is washed with deionized 3 times, is placed in 60 DEG C of baking ovens and dries to constant weight, obtains modified starch；It presses
Mass ratio 2: 1: 1 mixes modified starch, anhydrous methanol and mass fraction for 10% silver nitrate solution, is 100r/min in revolving speed
Under be protected from light stirring 6h, obtain blend, in mass ratio 1: 10 mass fraction is added is 5% citric acid three sodium solution, at 400r/min
30min is stirred, mixed liquor is obtained, precipitating is centrifugated to obtain, is washed 3 times with dehydrated alcohol and deionized water respectively, it is dry to constant weight
Obtain antibacterial agent；According to parts by weight, weigh respectively 20 parts of antibacterial agents, 1 part of quaternary ammonium salt cationic surfactant, 10 parts it is transparent
Matter acid, 1 part of epoxychloropropane, 50 parts of deionized waters, by antibacterial agent, quaternary ammonium salt cationic surfactant, hyaluronic acid, ring
Oxygen chloropropane and deionized water mixing are 60 DEG C in temperature, and revolving speed is to stir 2h under 800r/min, are cooled to room temperature to get doctor
With antibacterial gel dressing.
According to parts by weight, 110 parts of deionized waters are weighed respectively, 25 parts of mass fractions are 20% sodium hydroxide solution, 45 parts
Deionized water, mass fraction are 20% sodium hydroxide solution and starch by starch, 16 parts of 3- chloro-2-hydroxypropyl-trimethyl ammonium chlorides
Mixing is that 250r/min is stirred evenly at room temperature in revolving speed, obtains lotion, 3- chloro-2-hydroxypropyl-trimethyl ammonium chloride is added, continue
Stir 7min, be warming up to 45 DEG C and be stirred to react 10h, obtain complex liquid, with mass fraction be 7% hydrochloric acid solution adjust pH value be 6.0,
Suspension is obtained, filter residue is filtered to obtain, is washed with deionized 4 times, is placed in 65 DEG C of baking ovens and dries to constant weight, obtain modified starch；
In mass ratio 2: 1: 1 mix modified starch, anhydrous methanol and mass fraction for 10% silver nitrate solution, are 125r/ in revolving speed
It is protected from light stirring 7h under min, obtains blend, in mass ratio 1: 10 is added mass fraction for 5% citric acid three sodium solution, in 450r/
40min is stirred under min, obtains mixed liquor, is centrifugated to obtain precipitating, be washed 4 times with dehydrated alcohol and deionized water respectively, drying is extremely
Constant weight obtains antibacterial agent；According to parts by weight, 30 parts of antibacterial agents, 5 parts of quaternary ammonium salt cationic surfactants, 13 parts are weighed respectively
Hyaluronic acid, 2 parts of epoxychloropropane, 55 parts of deionized waters, by antibacterial agent, quaternary ammonium salt cationic surfactant, hyalomitome
Acid, epoxychloropropane and deionized water mixing are 70 DEG C in temperature, and revolving speed is to stir 3h under 900r/min, are cooled to room temperature, i.e.,
Obtain medical antibacterial gel dressing.
According to parts by weight, 120 parts of deionized waters are weighed respectively, 30 parts of mass fractions are 20% sodium hydroxide solution, 50 parts
Deionized water, mass fraction are 20% sodium hydroxide solution and starch by starch, 22 parts of 3- chloro-2-hydroxypropyl-trimethyl ammonium chlorides
Mixing is that 300r/min is stirred evenly at room temperature in revolving speed, obtains lotion, 3- chloro-2-hydroxypropyl-trimethyl ammonium chloride is added, continue
Stir 10min, be warming up to 50 DEG C and be stirred to react 12h, obtain complex liquid, with mass fraction be 7% hydrochloric acid solution adjust pH value be 6.5,
Suspension is obtained, filter residue is filtered to obtain, is washed with deionized 5 times, is placed in 70 DEG C of baking ovens and dries to constant weight, obtain modified starch；
In mass ratio 2: 1: 1 mix modified starch, anhydrous methanol and mass fraction for 10% silver nitrate solution, are 150r/ in revolving speed
It is protected from light stirring 8h under min, obtains blend, in mass ratio 1: 10 is added mass fraction for 5% citric acid three sodium solution, in 500r/
50min is stirred under min, obtains mixed liquor, is centrifugated to obtain precipitating, be washed 5 times with dehydrated alcohol and deionized water respectively, drying is extremely
Constant weight obtains antibacterial agent；According to parts by weight, 40 parts of antibacterial agents, 10 parts of quaternary ammonium salt cationic surfactants, 16 are weighed respectively
Part hyaluronic acid, 4 parts of epoxychloropropane, 60 parts of deionized waters, by antibacterial agent, quaternary ammonium salt cationic surfactant, transparent
Matter acid, epoxychloropropane and deionized water mixing are 80 DEG C in temperature, and revolving speed is to stir 4h under 1000r/min, are cooled to room
Temperature is to get medical antibacterial gel dressing.
Medical antibacterial gel dressing prepared by the present invention and commercially available antibacterial gel dressing are detected, specific detection is such as
Under:
Mechanical strength test:
Compressive Mechanical test is carried out using hydrogel sample of the omnipotent mechanics tester to different parameters, with the rate of 1mm/min
It is compressed, until sample is broken.
Swelling behavior test: the hydrogel sample prepared is soaked in the centrifuge tube containing 15mLPBS, then is placed in 37
DEG C, the constant humidity culture shaking table of 70rpm, carry out swelling behavior test, taken out after 1h, suck surface moisture with filter paper and weigh.It is molten
After swollen experiment, hydrogel is taken out and is freeze-dried, weighing obtains the quality of dry state gel.
The calculation formula of swellbility is as follows: swellbility=(Wi-Wd)/Wd
Wherein WiFor the quality of swollen gel after water suction, WdFor the quality of dry state gel.
Permeability test: using computermatic air permeability test instrument measurement medical antibacterial gel dressing gas permeability, set pressure difference as
100.0Pa test area 20cm2, nozzle number is 0.8.
Specific test result such as table 1.
1 performance characterization contrast table of table
| Project | Example 1 | Example 2 | Example 3 | Reference examples |
| Tangent modulus (MPa) | 211 | 213 | 209 | 185 |
| Swellbility (%) | 3000 | 3400 | 3200 | 4000 |
| Air penetrability (%) | 2.81 | 2.75 | 2.77 | 1.98 |
As shown in Table 1, medical antibacterial gel dressing mechanical strength prepared by the present invention is good, and good permeability, has wide answer
Use prospect.
Claims (7)
1. a kind of preparation method of medical antibacterial gel dressing, it is characterised in that specific preparation step are as follows:
(1) according to parts by weight, 100~120 parts of deionized waters are weighed respectively, 20~30 parts of mass fractions are 20% sodium hydroxide
Solution, 40~50 parts of starch, 10~22 parts of 3- chloro-2-hydroxypropyl-trimethyl ammonium chlorides, by deionized water, mass fraction 20%
Sodium hydroxide solution, starch, the mixing of 3- chloro-2-hydroxypropyl-trimethyl ammonium chloride, stir process obtain complex liquid, adjust pH value, obtain
Suspension filters to obtain filter residue, is washed with deionized 3~5 times, is placed in 60~70 DEG C of baking ovens and dries to constant weight, obtains modification
Starch；
(2) in mass ratio 2: 1: 1 modified starch, anhydrous methanol and mass fraction are mixed for 10% silver nitrate solution, is in revolving speed
It is protected from light 6~8h of stirring under 100~150r/min, obtains blend, addition mass fraction is 5% citric acid three sodium solution, at stirring
Reason, obtains mixed liquor, is centrifugated to obtain precipitating, be washed 3~5 times with dehydrated alcohol and deionized water respectively, and drying to constant weight must resist
Microbial inoculum；
(3) according to parts by weight, 20~40 parts of antibacterial agents, 1~10 part of quaternary ammonium salt cationic surfactant, 10 are weighed respectively
~16 parts of hyaluronic acids, 1~4 part of epoxychloropropane, 50~60 parts of deionized waters, by antibacterial agent, quaternary ammonium salt cationic surface
Activating agent, hyaluronic acid, epoxychloropropane and deionized water mixing, constant temperature stir process are cooled to room temperature to get medical antibacterial
Gel dressing.
2. a kind of preparation method of medical antibacterial gel dressing according to claim 1, it is characterised in that: step (1) institute
The stir process stated is by deionized water, mass fraction is 20% sodium hydroxide solution and starch mixing, revolving speed be 200~
300r/min is stirred evenly at room temperature, obtains lotion, and 3- chloro-2-hydroxypropyl-trimethyl ammonium chloride is added, continues 5~10min of stirring,
It is warming up to 40~50 DEG C and is stirred to react 8~12h.
3. a kind of preparation method of medical antibacterial gel dressing according to claim 1, it is characterised in that: step (1) institute
The adjusting pH stated be with mass fraction be 7% hydrochloric acid solution adjust pH value be 5.5~6.5.
4. a kind of preparation method of medical antibacterial gel dressing according to claim 1, it is characterised in that: step (2) institute
That states is protected from light stirring to be protected from light 6~8h of stirring in the case where revolving speed is 100~150r/min.
5. a kind of preparation method of medical antibacterial gel dressing according to claim 1, it is characterised in that: step (2) institute
The mass fraction stated is that the mass ratio of 5% citric acid three sodium solution and blend is 1: 10.
6. a kind of preparation method of medical antibacterial gel dressing according to claim 1, it is characterised in that: step (2) institute
The stir process stated is that 30~50min is stirred at 400~500r/min.
7. a kind of preparation method of medical antibacterial gel dressing according to claim 1, it is characterised in that: step (3) institute
It is 60~80 DEG C that the constant temperature stir process stated, which is in temperature, and revolving speed is that 2~4h is stirred under 800~1000r/min.
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