CN109071509B - 作为ROR-γ的调节剂的苯并咪唑衍生物 - Google Patents
作为ROR-γ的调节剂的苯并咪唑衍生物 Download PDFInfo
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- CN109071509B CN109071509B CN201780009016.0A CN201780009016A CN109071509B CN 109071509 B CN109071509 B CN 109071509B CN 201780009016 A CN201780009016 A CN 201780009016A CN 109071509 B CN109071509 B CN 109071509B
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- imidazole
- difluorobenzo
- dioxol
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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| CN202111366970.XA CN114230523A (zh) | 2016-01-29 | 2017-01-27 | 作为ROR-γ的调节剂的苯并咪唑衍生物 |
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| US62/320,893 | 2016-04-11 | ||
| PCT/US2017/015220 WO2017132432A1 (en) | 2016-01-29 | 2017-01-27 | Benzimidazole derivatives as modulators of ror-gamma |
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| AU2015210833B2 (en) | 2014-02-03 | 2019-01-03 | Vitae Pharmaceuticals, Llc | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| US9663515B2 (en) | 2014-11-05 | 2017-05-30 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| SI3294713T1 (sl) | 2015-05-15 | 2021-08-31 | Aurigene Discovery Technologies Limited, | Nadomeščene spojine tetrahidrokinolinona kot ROR gama modulatorji |
| DK3331876T3 (da) | 2015-08-05 | 2021-01-11 | Vitae Pharmaceuticals Llc | Modulators of ror-gamma |
| MA53943A (fr) | 2015-11-20 | 2021-08-25 | Vitae Pharmaceuticals Llc | Modulateurs de ror-gamma |
| TWI757266B (zh) | 2016-01-29 | 2022-03-11 | 美商維它藥物有限責任公司 | ROR-γ調節劑 |
| WO2019018975A1 (en) | 2017-07-24 | 2019-01-31 | Vitae Pharmaceuticals, Inc. | INHIBITORS OF ROR GAMMA |
| CN115650976A (zh) | 2017-07-24 | 2023-01-31 | 生命医药有限责任公司 | RORγ的抑制剂 |
| CN109593068B (zh) * | 2017-09-30 | 2022-12-27 | 广东东阳光药业有限公司 | 一种RORγ抑制剂的中间体及其制备方法 |
| KR102709804B1 (ko) * | 2018-05-03 | 2024-09-25 | 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 | 레티노이드-관련 희귀 수용체 감마(RORγ)의 조절제로서 벤즈이미다졸 유도체 및 이의 약학적 용도 |
| CN110483437B (zh) * | 2018-05-14 | 2022-12-06 | 嘉兴维眸生物科技有限公司 | 一种含五元环的化合物及其制备和应用 |
| CN112601745B (zh) * | 2018-10-24 | 2023-06-27 | 上海和誉生物医药科技有限公司 | 一种氮杂芳基酰胺衍生物及其制备方法和应用 |
| CN111320609A (zh) | 2018-12-13 | 2020-06-23 | 拓臻股份有限公司 | 一种THRβ受体激动剂化合物及其制备方法和用途 |
| AU2020336272A1 (en) | 2019-08-23 | 2022-04-14 | Terns Pharmaceuticals, Inc. | Thyroid hormone receptor beta agonist compounds |
| WO2021050945A1 (en) | 2019-09-12 | 2021-03-18 | Terns, Inc. | Thyroid hormone receptor beta agonist compounds |
| KR20220093340A (ko) * | 2019-10-31 | 2022-07-05 | 지앙수 헨그루이 메디슨 컴퍼니 리미티드 | RORγ 조절제의 산부가염 |
| CN112745268B (zh) * | 2019-10-31 | 2022-09-16 | 江苏恒瑞医药股份有限公司 | 苯并咪唑衍生物的晶型及制备方法 |
| TW202136237A (zh) | 2020-01-06 | 2021-10-01 | 大陸商廣東東陽光藥業有限公司 | RORγt抑制劑及其製備方法和用途 |
| CN111333552B (zh) * | 2020-04-09 | 2021-07-20 | 广州安岩仁医药科技有限公司 | β-苯并氨基酸类化合物的合成方法 |
| CN111606868B (zh) * | 2020-06-23 | 2023-02-17 | 温州大学新材料与产业技术研究院 | 一种双齿噁唑啉手性配体的制备方法 |
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- 2017-01-27 JP JP2018539070A patent/JP6948333B2/ja not_active Expired - Fee Related
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- 2017-01-27 UY UY0001037098A patent/UY37098A/es not_active Application Discontinuation
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2018
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2020
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|---|---|
| MX2018009257A (es) | 2018-11-09 |
| UY37098A (es) | 2017-08-31 |
| BR112018015273A2 (pt) | 2018-12-18 |
| US10829481B2 (en) | 2020-11-10 |
| EP3408268A1 (en) | 2018-12-05 |
| SA518392101B1 (ar) | 2022-03-16 |
| JP6948333B2 (ja) | 2021-10-13 |
| RU2760366C2 (ru) | 2021-11-24 |
| TW202220968A (zh) | 2022-06-01 |
| RU2021133444A (ru) | 2021-11-29 |
| CA3011838A1 (en) | 2017-08-03 |
| WO2017132432A8 (en) | 2017-08-31 |
| JP2021193131A (ja) | 2021-12-23 |
| RU2018127360A (ru) | 2020-03-02 |
| MX381313B (es) | 2025-03-12 |
| MA45646A (fr) | 2021-03-24 |
| US20190352286A1 (en) | 2019-11-21 |
| JP2019503385A (ja) | 2019-02-07 |
| CN109071509A (zh) | 2018-12-21 |
| EP3939974A1 (en) | 2022-01-19 |
| CN114230523A (zh) | 2022-03-25 |
| TW201734001A (zh) | 2017-10-01 |
| US20210094940A1 (en) | 2021-04-01 |
| EP3408268B1 (en) | 2021-08-04 |
| RU2018127360A3 (2) | 2020-04-06 |
| WO2017132432A1 (en) | 2017-08-03 |
| TWI757266B (zh) | 2022-03-11 |
| AU2017212577B2 (en) | 2021-05-13 |
| AU2017212577A1 (en) | 2018-08-02 |
| EP3408268B8 (en) | 2023-12-06 |
| KR20180100697A (ko) | 2018-09-11 |
| MA55328A (fr) | 2022-01-19 |
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