CN1097601A - 治疗脚癣病的药物及其制备工艺 - Google Patents
治疗脚癣病的药物及其制备工艺 Download PDFInfo
- Publication number
- CN1097601A CN1097601A CN93108743A CN93108743A CN1097601A CN 1097601 A CN1097601 A CN 1097601A CN 93108743 A CN93108743 A CN 93108743A CN 93108743 A CN93108743 A CN 93108743A CN 1097601 A CN1097601 A CN 1097601A
- Authority
- CN
- China
- Prior art keywords
- gram
- medicine
- acid
- tinea pedis
- propolis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 27
- 201000004647 tinea pedis Diseases 0.000 title claims abstract description 12
- 238000005516 engineering process Methods 0.000 title claims abstract description 9
- 238000002360 preparation method Methods 0.000 title abstract description 7
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims abstract description 20
- 241000241413 Propolis Species 0.000 claims abstract description 11
- 229940069949 propolis Drugs 0.000 claims abstract description 11
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229960004889 salicylic acid Drugs 0.000 claims abstract description 10
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 claims abstract description 8
- 229960004125 ketoconazole Drugs 0.000 claims abstract description 8
- 239000000203 mixture Substances 0.000 claims abstract description 7
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 14
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 12
- 239000005711 Benzoic acid Substances 0.000 claims description 7
- 235000010233 benzoic acid Nutrition 0.000 claims description 7
- TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 claims description 6
- 239000001263 FEMA 3042 Substances 0.000 claims description 6
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 claims description 6
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims description 6
- 239000004327 boric acid Substances 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- 239000011780 sodium chloride Substances 0.000 claims description 6
- 235000015523 tannic acid Nutrition 0.000 claims description 6
- 229920002258 tannic acid Polymers 0.000 claims description 6
- 229940033123 tannic acid Drugs 0.000 claims description 6
- 230000008014 freezing Effects 0.000 claims description 3
- 238000007710 freezing Methods 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 2
- 235000015110 jellies Nutrition 0.000 claims 2
- 239000008274 jelly Substances 0.000 claims 2
- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 claims 2
- 241000894006 Bacteria Species 0.000 abstract description 4
- 208000002474 Tinea Diseases 0.000 abstract description 4
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 4
- -1 Alumen Chemical compound 0.000 abstract description 3
- 241001480043 Arthrodermataceae Species 0.000 abstract description 3
- 241000130764 Tinea Species 0.000 abstract description 3
- 230000036592 analgesia Effects 0.000 abstract description 3
- 230000037304 dermatophytes Effects 0.000 abstract description 3
- 230000002147 killing effect Effects 0.000 abstract description 3
- 231100000252 nontoxic Toxicity 0.000 abstract description 3
- 230000003000 nontoxic effect Effects 0.000 abstract description 3
- 208000003251 Pruritus Diseases 0.000 abstract description 2
- 238000009472 formulation Methods 0.000 abstract description 2
- 210000003701 histiocyte Anatomy 0.000 abstract description 2
- 230000005764 inhibitory process Effects 0.000 abstract description 2
- 230000008929 regeneration Effects 0.000 abstract description 2
- 238000011069 regeneration method Methods 0.000 abstract description 2
- 210000003491 skin Anatomy 0.000 description 9
- 241000256836 Apis Species 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 229940079593 drug Drugs 0.000 description 6
- 230000001139 anti-pruritic effect Effects 0.000 description 4
- 239000003908 antipruritic agent Substances 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- LRBQNJMCXXYXIU-QWKBTXIPSA-N gallotannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@H]2[C@@H]([C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-QWKBTXIPSA-N 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 229940109850 royal jelly Drugs 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- OOCCDEMITAIZTP-QPJJXVBHSA-N (E)-cinnamyl alcohol Chemical compound OC\C=C\C1=CC=CC=C1 OOCCDEMITAIZTP-QPJJXVBHSA-N 0.000 description 2
- 206010017533 Fungal infection Diseases 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 208000031888 Mycoses Diseases 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 description 2
- 206010047601 Vitamin B1 deficiency Diseases 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 208000002894 beriberi Diseases 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 206010025482 malaise Diseases 0.000 description 2
- 230000036407 pain Effects 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 229940098465 tincture Drugs 0.000 description 2
- QAIPRVGONGVQAS-DUXPYHPUSA-N trans-caffeic acid Chemical compound OC(=O)\C=C\C1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-DUXPYHPUSA-N 0.000 description 2
- QHBZHVUGQROELI-SOFGYWHQSA-N (E)-10-hydroxydec-2-enoic acid Chemical compound OCCCCCCC\C=C\C(O)=O QHBZHVUGQROELI-SOFGYWHQSA-N 0.000 description 1
- ACEAELOMUCBPJP-UHFFFAOYSA-N (E)-3,4,5-trihydroxycinnamic acid Natural products OC(=O)C=CC1=CC(O)=C(O)C(O)=C1 ACEAELOMUCBPJP-UHFFFAOYSA-N 0.000 description 1
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 description 1
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
- YJCJVMMDTBEITC-UHFFFAOYSA-N 10-hydroxycapric acid Chemical compound OCCCCCCCCCC(O)=O YJCJVMMDTBEITC-UHFFFAOYSA-N 0.000 description 1
- 241000256844 Apis mellifera Species 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 description 1
- 206010011409 Cross infection Diseases 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- BYBLEWFAAKGYCD-UHFFFAOYSA-N Miconazole Chemical compound ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 BYBLEWFAAKGYCD-UHFFFAOYSA-N 0.000 description 1
- 206010029803 Nosocomial infection Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 description 1
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 description 1
- QHBZHVUGQROELI-UHFFFAOYSA-N Royal Jelly acid Natural products OCCCCCCCC=CC(O)=O QHBZHVUGQROELI-UHFFFAOYSA-N 0.000 description 1
- ZONYXWQDUYMKFB-UHFFFAOYSA-N SJ000286395 Natural products O1C2=CC=CC=C2C(=O)CC1C1=CC=CC=C1 ZONYXWQDUYMKFB-UHFFFAOYSA-N 0.000 description 1
- 206010040840 Skin erosion Diseases 0.000 description 1
- 241000219784 Sophora Species 0.000 description 1
- 241000053227 Themus Species 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 241000223238 Trichophyton Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- OOCCDEMITAIZTP-UHFFFAOYSA-N allylic benzylic alcohol Natural products OCC=CC1=CC=CC=C1 OOCCDEMITAIZTP-UHFFFAOYSA-N 0.000 description 1
- 229940037003 alum Drugs 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 239000003659 bee venom Substances 0.000 description 1
- 229960004365 benzoic acid Drugs 0.000 description 1
- 229960002645 boric acid Drugs 0.000 description 1
- 235000004883 caffeic acid Nutrition 0.000 description 1
- 229940074360 caffeic acid Drugs 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 235000013985 cinnamic acid Nutrition 0.000 description 1
- 229930016911 cinnamic acid Natural products 0.000 description 1
- QAIPRVGONGVQAS-UHFFFAOYSA-N cis-caffeic acid Natural products OC(=O)C=CC1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-UHFFFAOYSA-N 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 230000001877 deodorizing effect Effects 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 235000001785 ferulic acid Nutrition 0.000 description 1
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 description 1
- 229940114124 ferulic acid Drugs 0.000 description 1
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 description 1
- 229930003949 flavanone Natural products 0.000 description 1
- 150000002207 flavanone derivatives Chemical class 0.000 description 1
- 235000011981 flavanones Nutrition 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002212 flavone derivatives Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- HVQAJTFOCKOKIN-UHFFFAOYSA-N flavonol Natural products O1C2=CC=CC=C2C(=O)C(O)=C1C1=CC=CC=C1 HVQAJTFOCKOKIN-UHFFFAOYSA-N 0.000 description 1
- 150000007946 flavonol Chemical class 0.000 description 1
- 235000011957 flavonols Nutrition 0.000 description 1
- 210000002683 foot Anatomy 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 239000007952 growth promoter Substances 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000002690 local anesthesia Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
- 239000011812 mixed powder Substances 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 230000001473 noxious effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 235000005875 quercetin Nutrition 0.000 description 1
- 229960001285 quercetin Drugs 0.000 description 1
- 230000003716 rejuvenation Effects 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 230000007958 sleep Effects 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
一种治疗脚癣病的药物及其制备工艺，以蜂胶、
蜂王浆、蜂毒为主要成分，再配以酮康唑、明矾、水杨
酸等组成。本药物具有安全无毒、无刺激性、抑制癣
菌生长、消炎止痒镇痛、促进组织细胞再生功能，对皮
肤真菌有极强的杀灭作用。其制备工艺简单、价格低
廉、使用方便、施药量小，适合于所有脚癣病患者使
用，并有特殊疗效。
Description
本发明涉及一种治疗脚癣病的药物及其制备工艺，属于药品制造领域。
脚癣（俗称脚气、香港脚）是一种发病率很高的多发性皮肤病，尤其是井下工人、部队战士、运动员、钢铁工人、南方广大城乡、亚热带、热带的人群发病率更为集中和居高。加上公共浴池、公用拖鞋等的交叉传染，致使60-70%的人患有此病。患病初期脚趾间瘙痒难忍，抓破皮肤后水血津流若有细菌感染则患处潮湿糜烂、脚趾浮肿、流出浓血水并有臭味。此病给患者的生活、工作及学习带来很大影响，严重时还得住院治疗，但没有特殊效果。我国传统医学认为此病因脾胃两经湿热下注而成或久居湿地、或水浆浸渍，湿毒浸淫肌肤所致。西医则认为是由真菌感染而引起的。目前临床常用“脚癣一次净”“脚气灵”、“足光粉”、“达克宁”、“脚气膏”、“土槿皮酊”等药物治疗，虽能暂时止痒、减缓症状，用量较大，短期内还有复发。加之有些药物如“土槿皮酊”、“脚癣一次净”等刺激性较大，使用时疼痛难忍，给患者带来很大痛苦。迄今为止还没见到治疗该病的特效药物。
本发明的目的就是针对上述背景技术中的不足，而提供一种用量较少、价格较低，能抑制真菌感染，抗菌消炎、止痒除臭的治疗脚癣病的药物及其制备工艺。
实现本发明目的的技术解决方案是这样的：本发明所述的药物中含有蜂胶2.5-5.0克、蜂王浆0.8-3.0克、酮康唑0.8-3.0克、苯甲酸3.0-7.0克、硼酸10.0-19.0克、明矾10.0-19.0克、鞣酸10.0-19.0克、氯化钠15.0-27.0克、水杨酸15.0-27.0克、蜂毒0.001-0.005克。其制备工艺是按用量将蜂胶在-8℃-0℃的温度内冷冻5-16小时后研粉过120目筛，再按量加入酮康唑、苯甲酸、硼酸、明矾、鞣酸、氯化钠、水杨酸研粉混合，再加入冻干王浆和蜂毒细粉研磨均匀封装即可。
以下结合实施例对本发明做一说明。
首先将2.5-5.0克的蜂胶在-8℃-0℃的温度下冷冻7-12小时，使其硬脆后进行研磨并过120目筛，再将0.9-2.8克的酮康唑、3.2-6.7克的苯甲酸、10.5-18.0克的硼酸、10.5-18.0克的明矾、10.5-18.0克的鞣酸、15.2-25.0克的氯化钠、15.5-25.0克的水杨酸细粉加入并搅拌混合，再在以上的混合粉中加入冻干王浆0.8-3.0克和蜂毒0.001-0.005克、细粉混合均匀后封装即可。
本药物中所含各成份的功效：
蜂胶：含有黄酮、黄烷醇、黄烷酮、槲皮素、肉桂酸、肉桂醇、香草醛、咖啡酸及5-羟基2-7-二甲氧基黄酮、5-7-二羟基-2，4-二甲氧基黄酮及阿魏酸等。蜂胶对细菌、真菌、病毒具有抑制及其杀灭作用，还能消炎、镇痛、止痒、促进组织再生。
蜂王浆：含有10-羟基癸烯酸（又名王浆酸）及活性多肽等。蜂王浆具有促进生长发育和复壮作用，能使衰老和受损的组织细胞被新细胞所代替，使细胞功能正常化。
苯甲酸、硼酸、水杨酸、鞣酸：均有抗癣菌、抑制其生长的作用，并可软化角质层细胞。
氯化钠：可防腐消炎。
明矾：具有收涩、抑菌作用。
酮康唑：能抑制癣菌生长，治疗皮肤真菌性感染。
蜂毒：可以使局部麻醉，并能增加抗体。
本发明所述的药物经陕西省中医药研究院进行的各项实验结果如下：
一、急性毒性实验：取18-22克的ICR品系小白鼠雌雄各10只禁食（不禁水）过夜后按0.2毫升/20克（相当于成人用药量的100倍）灌胃，观察7天皆无异常反应。经解剖观察心、肝、脾、肺、肾等重要脏器皆无异常发现。
二、药效学实验：
1、按常规实验方法用鼠背部皮肤进行刺激及过敏实验，该药物不引起皮肤红斑、水肿，不引起皮肤糜烂。用家兔进行皮肤急性毒性实验亦无毒性反应。
2、对外伤（手术划痕）后的破损皮肤无刺激作用，并有迅速止血、促进皮肤愈合的作用。
3、用浸湿纸片粘附该药物贴敷于接种各种细菌的培养皿上培养24小时，结论是能抑制自脚癣患者皮肤分离出的白色表皮毛癣菌作用。
4、用小白鼠醋酸扭体法实验证明该药物具有显著的镇痛作用。
临床应用共观察158例，显效率为98%，用药后迅速痊愈，一年内无复发。表现为止痒、止痛、止渗出，破损皮肤很快愈合，一周内蜕皮病好转、痊愈。患者睡前洗净双脚，将该药物粉末涂摸于患处。轻者用药1克，重者用药2-4克即可痊愈。
本发明由于采用了蜜蜂系列产品如蜂胶、蜂王浆及蜂毒为主要成份，再配以酮康唑、明矾、水杨酸等药物，具有安全无毒、无刺激性、抑制癣菌生长、防腐消炎、除臭、收涩止痒镇痛、促进组织细胞再生功能、对皮肤真菌有极强的杀灭作用。本药物制备工艺简单、价格低廉、施药量少、使用方便，适合于所有脚癣病患者作用，并有特殊的疗效。
Claims (3)
1、一种治疗脚癣病的药物，其中包括苯甲酸、水杨酸，本发明的特征在于该药物中含有蜂胶2.5-5.0克、蜂王浆0.8-3.0克、酮康唑0.8-3.0克、苯甲酸3.0-7.0克、硼酸10.0-19.0克、明矾10.0-19.0克、鞣酸10.0-19.0克、氯化钠15.0-27.0克、水杨酸15.0-27.0克、蜂毒0.001-0.005克。
2、根据权利要求1所述的药物，其特征是所述的蜂胶为冻干蜂胶;蜂王浆为冻干蜂王浆。
3、一种制备治疗脚癣病的药物的工艺，包括混合、研粉工序，其特征是将2.5-5.0克的蜂胶在-8℃-0℃的温度中冷冻5-16小时后研粉过120目筛，再加入酮康唑0.8-3.0克、苯甲酸3.0-7.0克、硼酸10.0-19.0克、明矾10.0-19.0克、鞣酸10.0-19.0克、氯化钠15.0-27.0克、水杨酸15.0-27.0克研粉并混合，最后加入冻干蜂王浆0.8-3.0克和蜂毒0.001-0.005克细粉研磨均匀。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93108743A CN1097601A (zh) | 1993-07-17 | 1993-07-17 | 治疗脚癣病的药物及其制备工艺 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93108743A CN1097601A (zh) | 1993-07-17 | 1993-07-17 | 治疗脚癣病的药物及其制备工艺 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1097601A true CN1097601A (zh) | 1995-01-25 |
Family
ID=4987280
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN93108743A Pending CN1097601A (zh) | 1993-07-17 | 1993-07-17 | 治疗脚癣病的药物及其制备工艺 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1097601A (zh) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1088994C (zh) * | 1999-05-14 | 2002-08-14 | 乔顺朝 | 一种治疗足癣的药物组合物 |
| CN101129409B (zh) * | 2007-08-30 | 2011-06-01 | 程贵昌 | 一种抗真菌类外用药 |
| EP2863907A1 (de) * | 2012-06-26 | 2015-04-29 | Universitätsklinikum Freiburg | Pharmazeutische zusammensetzung mit synergistischer wirkung von direkten katalaseinhibitoren und zur katalasezerstörung führenden modulatoren des no-stoffwechsels oder der extrazellulären superoxidanionenproduktion |
| CN111450128A (zh) * | 2020-06-01 | 2020-07-28 | 王刚建 | 一种用于治疗脚气的药物 |
-
1993
- 1993-07-17 CN CN93108743A patent/CN1097601A/zh active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1088994C (zh) * | 1999-05-14 | 2002-08-14 | 乔顺朝 | 一种治疗足癣的药物组合物 |
| CN101129409B (zh) * | 2007-08-30 | 2011-06-01 | 程贵昌 | 一种抗真菌类外用药 |
| EP2863907A1 (de) * | 2012-06-26 | 2015-04-29 | Universitätsklinikum Freiburg | Pharmazeutische zusammensetzung mit synergistischer wirkung von direkten katalaseinhibitoren und zur katalasezerstörung führenden modulatoren des no-stoffwechsels oder der extrazellulären superoxidanionenproduktion |
| CN111450128A (zh) * | 2020-06-01 | 2020-07-28 | 王刚建 | 一种用于治疗脚气的药物 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0279984B1 (en) | Pharmaceutical use of graminaceous extracts | |
| JP2009269904A (ja) | 外傷、褥瘡の治療用漢方薬組成物及びその製剤の製造方法 | |
| JPH08511283A (ja) | 皮膚再生および治療用製造物、その製造方法およびその使用 | |
| CN112245497A (zh) | 一种杀菌消炎、促进伤口愈合的中药制剂及其制备方法 | |
| CN111297961A (zh) | 一种促进伤口愈合的侗药 | |
| US20020182263A1 (en) | Pharmaceutical composition comprising dimethylsulfoxide and ozone | |
| CN1097601A (zh) | 治疗脚癣病的药物及其制备工艺 | |
| CN103690903B (zh) | 一种治疗烧烫伤褥疮等外伤疾病的复方中药制剂 | |
| CN101332286B (zh) | 一种治疗皮肤病的中药组合物及其制备方法 | |
| CN1284494A (zh) | 竹红菌提取物及其制备方法和应用 | |
| CN1072499C (zh) | 一种治疗人体体表慢性溃疡的外用药 | |
| CN1186068C (zh) | 具有消炎生肌止痒止痛作用的外用中成药及其制备方法 | |
| CN1274596A (zh) | 复方蜂毒搽剂及其制备方法 | |
| CN108126109A (zh) | 创伤烧伤抑菌药及其加工方法 | |
| CN107982300B (zh) | 一种喷雾剂及其制备方法和应用 | |
| CN100402074C (zh) | 一种促进痔瘘术后创面愈合的中药膏剂及其制备方法 | |
| CN104055720A (zh) | 止痒护肤水 | |
| CN1167430C (zh) | 一种广谱抗菌治疗深度烧烫伤的药膏 | |
| CN1062456C (zh) | 一种治疗粉刺、痤疮的药物的制作方法 | |
| CN1100527C (zh) | 护肤保健液 | |
| CN115463077A (zh) | 一种紧致修护精华液及其制备方法 | |
| CN1236789C (zh) | 治疗真菌感染型脚气病的药物 | |
| CN1064534C (zh) | 一种用于皮肤病治疗的药剂 | |
| CN105920103A (zh) | 一种治疗脚气的外用喷剂及其制备方法 | |
| RU2614392C1 (ru) | Комбинация для лечения угревой болезни и способ ее применения |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |