CN109875615A - A kind of subsidiary conduit - Google Patents
A kind of subsidiary conduit Download PDFInfo
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- CN109875615A CN109875615A CN201910121894.2A CN201910121894A CN109875615A CN 109875615 A CN109875615 A CN 109875615A CN 201910121894 A CN201910121894 A CN 201910121894A CN 109875615 A CN109875615 A CN 109875615A
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- guiding catheter
- subsidiary conduit
- body portion
- seal wire
- coil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/09—Guide wires
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Abstract
本发明涉及一种辅助导管，所述辅助导管包括体部以及分别位于所述体部两端的头端和尾柄；所述体部伸入指引导管的内腔中，所述体部的外侧壁与所述指引导管的内侧壁相互贴合；所述头端具有圆锥状结构，并由所述指引导管的远端向外伸出；所述尾柄由所述指引导管的近端向外伸出；所述辅助导管的内部设置有用于导丝通过的导丝通道；所述辅助导管的外侧壁上设有第一开口，所述导丝能够从所述第一开口中脱出。本发明所述的辅助导管能够辅助指引导管快速通过狭窄段，明显缩短介入时间；显著减少桡动脉并发症。
The invention relates to an auxiliary catheter. The auxiliary catheter comprises a body part, a head end and a tail handle respectively located at both ends of the body part; the body part extends into the inner cavity of the guiding catheter, and the outer wall of the body part Fitted with the inner side wall of the guiding catheter; the head end has a conical structure, and extends outward from the distal end of the guiding catheter; the tail handle extends outward from the proximal end of the guiding catheter A guide wire channel for the guide wire to pass through is arranged inside the auxiliary conduit; a first opening is arranged on the outer side wall of the auxiliary conduit, and the guide wire can be pulled out from the first opening. The auxiliary catheter of the present invention can assist the guiding catheter to quickly pass through the stenosis section, significantly shorten the intervention time, and significantly reduce radial artery complications.
Description
Technical field
The present invention relates to field of medical technology, are related to a kind of conduit, in particular to angiocarpy, the cerebrovascular, peripheral blood vessel, disappear
Change the subsidiary conduit applied in the treatment or diagnosis of road, respiratory tract, the urinary tract, genital tract, particularly through radial artery, ulnar artery,
The diagnosis of arteria brachialis and Femoral Approaches or therapeutic process.
Background technique
In organism, the especially intracorporal angiocarpy of people, the cerebrovascular, peripheral blood vessel, respiratory tract, alimentary canal, genital tract etc.
Lumen, is frequently present of local stenosis, and conduit passes through difficult situation.
In recent years, with the deep and percutaneous coronary intervention device that people recognize coronary heart disease
The maturation of tool and skill, percutaneous coronary intervene the essential therapeutic arsenals for having become contemporary coronary heart disease.With through femoral artery way
Diameter is compared, and the Vascular Complications of Punctured Spots of Transradial Approach operation significantly reduces, this is exactly patients underwent intervention therapy via radial artery
(TRI) huge clinical advantage.
1989, Canadian doctor Campeau reported the first Experience of Transradial and carries out coronarography, discovery
It can the significant incidence for reducing complication compared with Femoral Approaches.The change of approach not only increases the safety of operation,
And patient it is postoperative can immediately out-of-bed activity become big advantage.
Holland doctor Kiemeniji in 1992 and 1993 reports the first Transradial Approach in succession and carries out percutaneous intracavitary hat
Shape arterioplasty (PTCA) and stent endoprosthesis, lead Interventional cardiology to enter another developing stage.
" the cardiovascular report 2016 of China " display 2015, China row coronary intervention patient reaches 567583,
Middle to use radial artery interventional therapy Proportion of patients for 89.45%, army's data show that radial artery intervenes path ratio 91%.
But since that there are blood vessels is tiny tortuous for radial artery, state's human radial artery internal diameter is averagely only 2.2-2.7 millimeters, together
When radial artery anatomic characteristic or limitation, during completing percutaneous coronary intervention (pci), angiocarpy intervention doctor's warp
It is difficult to be commonly encountered some practical operations.One of the most common is Radial artery spasm, and incidence is up to 5-10%, in Chang Shu in short-term
Between occur, and it is difficult to predict with evade.
Especially after completing coronary angiography, when quasi- replacement guiding catheter, most easily occurs, cause guiding catheter can not before give,
Patient's upper arm severe pain.Once it is as follows that similar situation solution occurs:
1, it replaces intervention approach: being changed to Femoral Approaches, dramatically increase patient suffering, extend intervention time, increase treatment
Expense, and there is severe complication ratio and obviously increases compared with radial artery in femoral artery
2, trans-radial sheath injects drug: including nitroglycerin, Verapamil, and the anti-spasms drug such as thiazolone, still
This method uncertain therapeutic efficacy is cut, the relevant side effect of drug, waiting for a long time, spasm again when reusing guiding catheter uplink
3, guiding catheter rotates ascending method: guiding catheter prolongs guiding wire, and left and right is light to turn push, this method success rate is low, and
Often result in radial artery inner film injury, the postoperative serious hemotoncus of Chang Qianbi, pain, vagus-pressor response increases Radial artery occlusion probability, seriously
When may occur in which osteofascial compartment syndrome.
4, subsidiary conduit guidance method: 0.014 seal wire prolongs seal wire and is sent into subsidiary conduit, until guiding catheter head by radial artery
End, after gradually expanding before give, this method obviously increases about 5000 yuan of patient's expense, and the intervention time for exposure extends.
Summary of the invention
To overcome defect and deficiency existing in the prior art, the invention discloses a kind of subsidiary conduit and there is auxiliary to lead
Conduit tube component of pipe and preparation method thereof.
The invention is realized by the following technical scheme:
A kind of subsidiary conduit, the subsidiary conduit include body portion and the head end and tail for being located at body portion both ends
Handle；The body portion protrudes into the inner cavity of guiding catheter, and the lateral wall in the body portion is mutually pasted with the inner sidewall of the guiding catheter
It closes；The head end has cone-shaped structure, and protruding by the distal end of the guiding catheter；The caudal peduncle is led by the guide
The proximal end of pipe is protruding；The subsidiary conduit is internally provided with the silk guide passage passed through for seal wire；The subsidiary conduit
Lateral wall be equipped with first opening, the seal wire can from it is described first opening in deviate from.
Further, first opening extends to the medium position in the body portion by the caudal peduncle；Or, described
One opening extends to the head end by the caudal peduncle.
Further, first opening is any one in the first opening of threadiness or the opening of strip first.
Further, the diameter of the head end gradually subtracts from one end close to the body portion to one end far from the body portion
It is small；The head end is from one end close to the body portion to one end far from the body portion gradually to the side far from the body axis
To deflection.
Further, inner tube is set in the inner cavity in the body portion, and the seal wire runs through said inner tube；The outside of said inner tube
Wall is connect by several connection wall with the inner sidewall in the body portion；The lateral wall of said inner tube is equipped with the second opening；Institute
Seal wire is stated by the first opening and the second opening, is interconnected with the inner cavity of the guiding catheter.
A kind of conduit tube component for the treatment of intravascular bifurcated lesions, including subsidiary conduit, guiding catheter and seal wire, it is described
Subsidiary conduit protrudes into the guiding catheter, and the seal wire protrudes into the subsidiary conduit, and the subsidiary conduit includes body portion and divides
Not Wei Yu body portion both ends head end and caudal peduncle；The body portion protrudes into the inner cavity of guiding catheter, the lateral wall in the body portion
It is bonded to each other with the inner sidewall of the guiding catheter；The head end has cone-shaped structure, and by the distal end of the guiding catheter
It is protruding；The caudal peduncle is protruding by the proximal end of the guiding catheter；The subsidiary conduit is internally provided with for leading
The silk guide passage that silk passes through；The lateral wall of the subsidiary conduit is equipped with the first opening；The seal wire includes core material and coil, institute
Stating core material includes front end, rear end.
Further, the core material is made of stainless steel material and/or nickel-titanium alloy material, and the coil uses NiTi
Alloy material is made；The outer peripheral edge of the rear end is coated with cyclic resin layer；The outer peripheral edge of the front end is coated with
Silver-colored strontium alloy layer；The outer peripheral edge of the coil is coated with layered double-hydroxide layer.
A kind of preparation method of the conduit tube component for the treatment of intravascular bifurcated lesions, the conduit tube component include that auxiliary is led
Pipe, guiding catheter and seal wire, the subsidiary conduit protrude into the guiding catheter, and the seal wire protrudes into the subsidiary conduit, described
Subsidiary conduit includes body portion and the head end and caudal peduncle for being located at body portion both ends；
The body portion protrudes into the inner cavity of guiding catheter, the inner sidewall phase of the lateral wall and the guiding catheter in the body portion
Mutually fitting；
The head end has cone-shaped structure, and protruding by the distal end of the guiding catheter；
The caudal peduncle is protruding by the proximal end of the guiding catheter；
The subsidiary conduit is internally provided with the silk guide passage passed through for seal wire；
The lateral wall of the subsidiary conduit is equipped with the first opening；The seal wire includes core material and coil, the core material packet
Include front end, rear end；
The core material is made of stainless steel material and/or nickel-titanium alloy material, and the coil uses nickel-titanium alloy material
It is made；
The outer peripheral edge of the rear end is coated with cyclic resin layer；The front end outer peripheral edge is coated with silver-colored strontium alloy
Layer；
The outer peripheral edge of the coil is coated with layered double-hydroxide layer；
The seal wire is prepared by following steps:
S1. resin cladding pretreatment is carried out to the rear end；
S2. metal sputter-deposition pretreatment is carried out to the integrally formed front end；
S3. the cladding pretreatment of layered double-hydroxide layer is carried out to the coil；
S4. the front end and rear end are interconnected and fixed using solder by laser welding；
S5. the Inside coil is wound in the outer peripheral edge of the front end, by one end of the Inside coil with
First joint portion is welded to each other, and the other end of the Inside coil and third joint portion are welded to each other；
S6., the external coil is wound in the outside of the Inside coil, by one end of the external coil and first
Joint portion is welded to each other, and the other end of the external coil and the second joint portion are welded to each other.
A kind of application method of subsidiary conduit, the subsidiary conduit is in radial artery, ulnar artery, arteria brachialis and femoral artery
The bifurcated lesions treatment of any one.
Compared with prior art, the present invention the advantage is that: subsidiary conduit of the present invention can assist guiding catheter
Quickly through narrow section, hence it is evident that shorten intervention time；Substantially reduce radial artery complication；And do not change intervention approach (to be not required to
Want femoral artery puncture)；In addition, the subsidiary conduit of the invention is cheap.
In addition, seal wire is guided not need all to withdraw, guiding catheter damaged coronary is avoided；When lesion complexity needs heavy caliber
It when guiding catheter, can routinely pass through Transradial Artery, avoid femoral artery puncture, reduce injury of radial artery.When guiding catheter, auxiliary
After conduit and seal wire reach the designated position of coronary opening entirely through artery, the caudal peduncle of hand-held subsidiary conduit can be first passed through,
It is peelled off by gradually tearing except subsidiary conduit from guiding catheter, seal wire still retains original position at this time.Why not by seal wire with it is auxiliary
It is because preventing guiding catheter port damaged coronary under the constraint of not seal wire that the assistant director of a film or play, which manages while withdrawing from, this is also of the invention
Another important beneficial effect.
Detailed description of the invention
First schematic diagram of Fig. 1 subsidiary conduit of the present invention；
Second schematic diagram of Fig. 2 subsidiary conduit of the present invention；
The third schematic diagram of Fig. 3 subsidiary conduit of the present invention；
The schematic diagram of Fig. 4 caudal peduncle of the present invention；
The cross-sectional view of Fig. 5 seal wire of the present invention, subsidiary conduit, guiding catheter；
The schematic diagram of Fig. 6 seal wire of the present invention；
First welding schematic diagram of Fig. 7 seal wire of the present invention；
Second welding schematic diagram of Fig. 8 seal wire of the present invention；
The coil schematic diagram of Fig. 9 seal wire of the present invention；
The partial enlargement diagram of the coil of Figure 10 seal wire of the present invention.
Description of symbols:
Subsidiary conduit -1, guiding catheter -2, seal wire -3, body portion -11, head end -12, caudal peduncle -13, the first opening -15 are interior
Pipe -16, connection wall -17, the second opening -18, core material -31, front end -311, stepped cylindrical boss -3111, rear end -312,
Hollow circuit cylinder boss -3121, coil -32, Inside coil -321, the engagement of external coil -322, the first joint portion -331, the second
Portion -332, third joint portion -333, solder -34.
Specific embodiment
In order to enable the purposes, technical schemes and advantages of technical solution of the present invention are clearer, below in conjunction with this
The technical solution of the embodiment of the present invention is clearly and completely described in the attached drawing of invention specific embodiment.Before reconcilable
It puts, the technical characteristic in each embodiment of the present invention can be combined with each other.
Referring to attached drawing 1-10, the embodiment of the invention provides a kind of subsidiary conduit, the subsidiary conduit 1 include body portion 11 with
And it is located at the head end 12 and caudal peduncle 13 at 11 both ends of body portion；The body portion 11 protrudes into the inner cavity of guiding catheter 2, described
The lateral wall in body portion 11 and the inner sidewall of the guiding catheter 2 are bonded to each other；The head end 12 has cone-shaped structure, and by institute
The distal end for stating guiding catheter 2 is protruding；The caudal peduncle 13 is protruding by the proximal end of the guiding catheter 2；The auxiliary is led
Pipe 1 is internally provided with the silk guide passage passed through for seal wire 3；The lateral wall of the subsidiary conduit 1 is equipped with the first opening 15,
The seal wire 3 can be deviate from from first opening 15.The length of the subsidiary conduit 1 is greater than the length of the guiding catheter 2
Degree.Specifically, the length of the subsidiary conduit 1 is 0.5-50 centimetres longer than the length of the guiding catheter 2, it is preferred that described auxiliary
The length of assistant director of a film or play's pipe 1 is 1-25 centimetres longer than the length of the guiding catheter 2, it is further preferred that the length of the subsidiary conduit 1
Length than the guiding catheter 2 is 3-20 centimetres long.The length of the subsidiary conduit 1 is 90-150 centimetres, it is preferred that described auxiliary
The length of assistant director of a film or play's pipe 1 is 100-125 centimetres.
In use, subsidiary conduit 1 provided in an embodiment of the present invention is through in the inner cavity of the guiding catheter 2, it is described to lead
Silk 3 is by the silk guide passage, through in the inner cavity of the subsidiary conduit 1.In surgical procedure, grasped by hand by doctor
Make, or control corresponding instrument and operated, by the seal wire 3, subsidiary conduit 1 and guiding catheter 2 via human vas, to lesion
Position conveying.Wherein, the operating side of doctor is defined as proximal end or rear end by the present invention, by the lesion end of patient be defined as distal end or
Front end.When conveying, the seal wire 3 is located at the front of the guiding catheter 2, and the body portion 11 protrudes into the inner cavity of guiding catheter 2,
The lateral wall in the body portion 11 and the inner sidewall of the guiding catheter 2 are bonded to each other；The head end 12 has cone-shaped structure, and
Distal end by the guiding catheter 2 is protruding.Since the head end 12 has cone-shaped structure, the guide can avoid
The front end of conduit 2 damages vascular wall, effectively reduces damage.In addition, the lateral wall of the subsidiary conduit 1 is equipped with first
Opening 15.In some embodiments of the invention, first opening 15 extends to the body portion 11 by the caudal peduncle 13
Medium position；Or, first opening 15 extends to the head end 12 by the caudal peduncle 13.First opening 15 is
Threadiness first opening or strip first opening in any one.After the guiding catheter 2 reaches target position, pass through torsion
Turn to tear the subsidiary conduit 1, the subsidiary conduit 1 is separated by the first opening 15 with through its internal seal wire 3, thus
The subsidiary conduit 1 can be easily withdrawn from, continues to play therapeutic effect in lesions position without influencing seal wire 3 and subsidiary conduit 1.
The diameter of the head end 12 is gradually reduced from one end close to the body portion 11 to one end far from the body portion 11；
The head end 12 is from one end close to the body portion 11 to one end far from the body portion 11 gradually to far from 11 axis of body portion
The direction of line deflects.People's body vessel can be better conformed to the head end 12 far from axle center gradually deflection structure, is had good
Good operability and flexibility.
In some embodiments of the invention, inner tube 16 is set, the seal wire 3 runs through institute in the inner cavity in the body portion 11
State inner tube 16；The lateral wall of said inner tube 16 is connect by several connection wall 17 with the inner sidewall in the body portion 11；It is described
The lateral wall of inner tube 16 is equipped with the second opening 18；The seal wire 3 is and described by first opening 15 and the second opening 18
The inner cavity of guiding catheter 2 is interconnected.In the prior art, conduit is admitted in patient vessel under the guidance of seal wire, due to leading
The mobile steering of pipe in the blood vessels is difficult to control, therefore, uncontrollable factor in art higher to the skilled operation degree of doctor
It is also larger with accident probability of happening.In order to avoid the above problem, the present invention is provided with the setting of said inner tube 16, described interior
The diameter of pipe 16 is bigger with the seal wire 3, and due to the inner sidewall phase of the lateral wall in the body portion 11 and the guiding catheter 2
Mutually fitting, by above structure, enables the surgeon to the feeding and steering that easily control the guiding catheter 2, improves operation
Efficiency, the difficulty for reducing operation improve safety, and avoid unnecessary injury of blood vessel.After the completion of use, doctor passes through rotation
It stretches, can be separated the subsidiary conduit 1 and seal wire 3 by first opening 15 and the second opening 18, it is easy to operate.
In some embodiments of the invention, the seal wire 3 includes core material 31 and coil 32, before the core material 31 includes
End 311, rear end 312；The outer peripheral edge of the front end 311 is wound with coil 32.The rear end 312 has cylinder
Structure；The front end 311 has from one end close to the rear end 312 to one end diameter far from the rear end 312
The conical structure being gradually reduced.The front end 311 is equipped with stepped cylindrical boss 3111；The rear end 312 is equipped with hollow
Cylinder boss 3121；After the stepped cylindrical boss 3111 is partially protruded into the hollow circuit cylinder boss 3121, using solder 34
The stepped cylindrical boss 3111 and hollow circuit cylinder boss 3121 are connected fixation by laser welding.
The coil 32 includes the Inside coil 321 and external coil 322 of coaxial arrangement, and the external coil 322 surrounds
In the outside of the Inside coil 321；One end of the external coil 322 passes through the first joint portion 331 and the front end 311
It is welded to each other connection, the other end is welded to each other with the front end 311 by the second joint portion 332 and is connect；The Inside coil
321 one end is welded to each other with the front end 311 by the first joint portion 331 and is connect, and the other end passes through third joint portion 333
It is welded to each other and connect with front end 311；The diameter of the external coil 322 from close to first joint portion 331 one end to
One end close to second joint portion 332 is gradually increased；The diameter of the Inside coil 321 is from close to first joint portion
331 one end is gradually reduced to one end close to the third joint portion 333.
The core material 31 is made of stainless steel material and/or nickel-titanium alloy material, and the coil 32 uses Nitinol
Material is made；The outer peripheral edge of the rear end 312 is coated with cyclic resin layer；The outer peripheral edge of the front end 311 coats
There is silver-colored strontium alloy layer；The outer peripheral edge of the coil 32 is coated with layered double-hydroxide layer.
Specifically, the seal wire 33 is prepared by following steps:
S1. resin cladding pretreatment is carried out to the rear end 312；
S2. metal sputter-deposition pretreatment is carried out to the integrally formed front end 311；
S3. the cladding pretreatment of layered double-hydroxide layer is carried out to the coil 32；
S4. the front end 311 and rear end 312 are interconnected and fixed using solder 34 by laser welding；
S5. the Inside coil 321 is wound in the outer peripheral edge of the front end 311, by the Inside coil 321
One end be welded to each other with the first joint portion 331, and it is the other end of the Inside coil 321 and third joint portion 333 is mutual
Welding；
S6., the external coil 322 is wound in the outside of the Inside coil 321, by the one of the external coil 322
End is welded to each other with the first joint portion 331, and the other end of the external coil 322 and the second joint portion 332 are welded to each other.
The seal wire 3 provided in an embodiment of the present invention can be more easier to pass through at bifurcated lesions position；Also, it is treating
When complicated bifurcated lesions, the surface of preforming seal wire is smooth, seal wire internal stress and stable structure, is not susceptible to fracture and right
The scuffing of blood vessel；In addition, the present invention can be improved procedure efficiency, the time of patient's shaped by hand seal wire repeatedly is reduced, operation is shortened
Time reduces branch's occlusion, reduces complication.Finally, preforming seal wire can also be further processed, adapt to various special
The particular/special requirement of branch's lesion.
The Inside coil 321 and external coil 322 gradually changed respectively by diameter, can be improved the front end 311
Flexibility and restoring type make it particularly suitable for the treatment of bifurcated lesions.Further, since the preforming seal wire of the embodiment of the present invention
Flexibility it is higher, thus its is easy to operate, and a possibility that being strayed into blood vessel substantially reduces.Due to 311 rigidity of the front end compared with
Low, flexible relative, the double layer design of Inside coil 321 and external coil 322 can avoid the front end 311 and plasticity shape occur
Become, improve its safety, and avoid replacing seal wire in surgical procedure, reduces operation cost, improve procedure efficiency.
In some embodiments of the invention, the core material 31 uses stainless steel material and/or nickel-titanium alloy material system
At the coil 32 is made of nickel-titanium alloy material.The outer peripheral edge of the rear end 312 is coated with cyclic resin layer；Institute
The outer peripheral edge for stating front end 311 is coated with silver-colored strontium alloy layer；The outer peripheral edge of the coil 32 is coated with the double hydroxides of stratiform
Nitride layer.The reason of outer peripheral edge in the rear end 312 coats cyclic resin layer is: institute can be improved by cyclic resin layer
The hydrophily and pliability for stating the outer peripheral edge of rear end 312 make under the premise of not reducing rigidity and push torsion is handling
It is with good flexibility, elasticity and biocompatibility, to reduce the friction occurred with blood vessel wall surface and and damage blood vessel
A possibility that wall.Be in the reason of outer peripheral edge coated with silver strontium alloy layer of the front end 311: nickel-titanium alloy material although
With good shape memory effect, but its enter human body after can discharge toxic free nickel ion so that preforming seal wire
Biological safety reduces, and easily causes allergy and postoperative infection, therefore, by the front end of nickel-titanium alloy material
311 outer peripheral edge coated with silver strontium alloy layer, can inhibit the precipitation of free nickel ion, and silver-colored strontium alloy itself has good in addition
Antibacterial bacteriostatic performance, thus can effectively reduce allergy and postoperative infection risk.In the outer peripheral edge of the coil 32, i.e. inner wire
The reason of outer peripheral edge of circle 321 and external coil 322 is coated with layered double-hydroxide layer is: firstly, free nickel ion
Can reduce by biocompatibility and the safety of 32 part of coil, and layered double-hydroxide have unique anion exchange capacity and
Biocompatibility is excellent, thus its biocompatibility that 32 part of low coil not only can be improved, and applies also for the load of drug.
Specifically, the preforming seal wire is obtained by following steps:
S1. resin cladding pretreatment is carried out to the rear end 312；
S2. metal sputter-deposition pretreatment is carried out to the integrally formed front end 311；
S3. the cladding pretreatment of layered double-hydroxide layer is carried out to the coil 32；
S4. the front end 311 and rear end 312 are interconnected and fixed using solder 34 by laser welding, specifically
, after the stepped cylindrical boss 3111 is partially protruded into the hollow circuit cylinder boss 3121, using solder 34 along not extending into
The external stepped cylindrical boss 3111 that is exposed to of the hollow circuit cylinder boss 3121 carries out laser welding, by the front end 311
It is fixedly connected with rear end 12；
S5. the Inside coil 21 is wound in the outer peripheral edge of the front end 311, by the Inside coil 321
One end be welded to each other with the first joint portion 331, and the other end of the Inside coil 321 and third joint portion 33 are mutually welded
It connects；
S6., the external coil 322 is wound in the outside of the Inside coil 321, by the one of the external coil 322
End is welded to each other with the first joint portion 331, and the other end of the external coil 322 and the second joint portion 332 are welded to each other.
In step sl, resin cladding pretreatment is carried out to the rear end 312 by the following method:
S1-1. by the rear end 312 in the aqueous hydrochloric acid solution that concentration is 10wt%-20wt% and 30 DEG C -40 DEG C
40min-60min is impregnated under the conditions of temperature；
S1-2. by the rear end 312 by step S1-1 processing in the sodium bicarbonate that concentration is 5wt%-15wt%
80min-120min is impregnated in aqueous solution and under the conditions of 50 DEG C -60 DEG C of temperature；
S1-2. 10min- will be impregnated in the polyamide of flowing by the rear end 312 of step S1-2 processing
It is taken out after 20min.
In step s 2, metal sputter-deposition is carried out to the integrally formed front end 311 by the following method to locate in advance
Reason:
S2-1., the integrally formed front end 311 is put into the indoor tubular of vacuum of plasma alloying equipment
In sample stage, the silver-colored strontium alloy target containing 2-5% mass fraction silver is placed horizontally on tubular sample stage, adjusts silver-colored strontium alloy target
The distance between integrally formed described front end 11 is 20cm-40cm；
S2-2. the air pressure of vacuum chamber is evacuated to vacuum by venthole with vacuum evacuation device, then by air inlet to true
Argon gas is passed through in empty room, the flow of argon gas is controlled by flowmeter；When the stable gas pressure in vacuum chamber is in 10Pa-20Pa, open
Voltage is simultaneously added slowly to 450V-500V by power supply, is acted on by the bombardment of argon plasma, is made the integrally formed front end
The temperature in portion 311 is maintained at 800-840 DEG C, at this point, under the bombardment effect of argon plasma, Si and Ag in silver-colored strontium target
Element is deposited on the surface alloying of the front end 311 by sputtering effect, forms silver-colored Strontium Alloying layer, and alloying time is
1.5h-2h。
In step s3, the cladding pretreatment of layered double-hydroxide layer is carried out to the coil 32 by the following method:
S3-1. the coil 32 is put into reaction kettle, is 4wt%- with concentration under the conditions of 80 DEG C -100 DEG C of temperature
The sodium hydroxide of 6wt% carries out hydro-thermal reaction, reaction time 6h-8h；
S3-2. to the coil 32 by step S3-1 processing in the aqueous hydrochloric acid solution that concentration is 2wt%-4wt%,
With impregnate 180min-250min under normal temperature condition；
S3-3. the kayexalate and chlorination to the coil 32 by step S3-2 processing at 80 DEG C -90 DEG C
40min-60min is impregnated in the mixed aqueous solution of sodium, wherein the concentration of kayexalate and sodium chloride is respectively 2g/L-
4g/L and 6g/L-12g/L.
The present invention discloses the application method of the subsidiary conduit 1 and conduit tube component by following embodiment and treatment is imitated
Fruit.
Embodiment 1
Women, 75 years old, coronary heart disease, diabetes, hypertension, trans-radial row coronarography prompted right hat severe narrow
It is narrow by 90%；The conventional J-type that retains guides seal wire to aortic sinus；It is sent near guiding catheter 2 to radial artery along seal wire 3, high-drag, disease
The severe pain of people's forearm, withdraws from guiding catheter, pain relief.It is judged as Radial artery spasm.
1. subsidiary conduit 1 is inserted into guiding catheter 2 through 2 tail end of guiding catheter (Y-valve), 1 head end of subsidiary conduit is beyond guide
The length of conduit 2 is 5 centimetres；
2. prolonging before seal wire 3 synchronizes entirety and sending, pass through radial artery narrow section the guiding catheter 2 assembled and subsidiary conduit 1
Reach aorta ascendens；
3. fixed seal wire 3, subsidiary conduit 1 of dropping back, quickly withdraw from, and guiding catheter 2 and seal wire 3 remain stationary；
4. guiding catheter 2 smoothly reaches right the first opening of hat, Percutaneous Coronary Intervention is completed；
5. routine pressure dressing at puncture, forearm is without swelling, without bright after smoothly removing guiding catheter 2 and radial artery sheath
Aobvious pain；
6. after 48 hours, forearm is without swelling, without obvious pain.
Embodiment 2
Male, 38 years old, coronary heart disease, angina pectoris, hypertension, hyperlipemia；Trans-radial row coronarography, before prompt
Descending branch severe stenosis 99%；90% severe stenosis of distal end in right hat；
Row coronary intervention after three days, along instructing silk 3 that guiding catheter 2 is sent nearby to be hampered to radial artery, patient's forearm is acute
Strong pain withdraws from guiding catheter 2, pain relief.It is judged as Radial artery spasm.
1. subsidiary conduit 1 is inserted into guiding catheter 2 through 2 tail end of guiding catheter (Y-valve), 1 head end of subsidiary conduit is beyond guide
10 centimetres of 2 length of conduit；
2. prolonging before seal wire 3 synchronizes entirety and sending the guiding catheter 2 assembled and subsidiary conduit 1, pass through radial artery resistance section
Reach aorta ascendens；
3. fixed seal wire 3, subsidiary conduit 1 of dropping back are removed subsidiary conduit 1 along the line of rabbet joint, are quickly withdrawn from, and 2 He of guiding catheter
Seal wire 3 is guided to remain stationary；
4. guiding catheter 2 smoothly reaches left the first opening of hat, Percutaneous Coronary Intervention is completed；
5. routine pressure dressing at puncture, forearm is without swelling, without bright after smoothly removing guiding catheter 2 and radial artery sheath
Aobvious pain；
6. after 48 hours, forearm is without swelling, without obvious pain.
Obviously, above-described embodiment is only a part of the embodiments of the present invention, instead of all the embodiments.Based on the present invention
In embodiment, those of ordinary skill in the art without creative efforts to these embodiments carry out it is various
Variation, modification, replacement and improvement, should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of subsidiary conduit, it is characterised in that: the subsidiary conduit (1) includes body portion (11) and is located at the body portion
(11) head end (12) and caudal peduncle (13) at both ends；The body portion (11) is protruded into the inner cavity of guiding catheter (2), the body portion (11)
The inner sidewall of lateral wall and the guiding catheter (2) be bonded to each other；The head end (12) has cone-shaped structure, and by described
The distal end of guiding catheter (2) is protruding；The caudal peduncle (13) is protruding by the proximal end of the guiding catheter (2).
2. subsidiary conduit according to claim 1, it is characterised in that: being internally provided with for subsidiary conduit (1) is used for
The silk guide passage that seal wire (3) passes through；The lateral wall of the subsidiary conduit (1) is equipped with the first opening (15), seal wire (3) energy
Enough abjections from first opening (15).
3. subsidiary conduit according to claim 1, it is characterised in that: first opening (15) is by the caudal peduncle (13)
Place, extends to the medium position of the body portion (11)；Or, first opening (15) extends to institute by the caudal peduncle (13)
State head end (12).
4. subsidiary conduit according to claim 1, it is characterised in that: it is described first opening (15) be threadiness first opening or
Strip first opening in any one.
5. subsidiary conduit described in any one of -3 according to claim 1, it is characterised in that: the diameter of the head end (12) by
It is gradually reduced close to one end of the body portion (11) to one end far from the body portion (11)；The head end (12) is by close to described
The one end in body portion (11) is gradually deflected to the direction far from body portion (11) axis to one end far from the body portion (11).
6. subsidiary conduit described in any one of -3 according to claim 1, it is characterised in that: in the inner cavity of the body portion (11)
It is arranged inner tube (16), the seal wire (3) runs through said inner tube (16)；The connection that the lateral wall of said inner tube (16) passes through several
Wall (17) is connect with the inner sidewall of the body portion (11)；The lateral wall of said inner tube (16) is equipped with the second opening (18)；It is described
Seal wire (3) is interconnected by first opening (15) and the second opening (18) with the inner cavity of the guiding catheter (2).
7. a kind of conduit tube component for the treatment of intravascular bifurcated lesions, including subsidiary conduit (1), guiding catheter (2) and seal wire
(3), the subsidiary conduit (1) is protruded into the guiding catheter (2), and the seal wire (3) protrudes into the subsidiary conduit (1), feature
Be: the subsidiary conduit (1) includes body portion (11) and the head end (12) and caudal peduncle for being located at body portion (11) both ends
(13)；The body portion (11) is protruded into the inner cavity of guiding catheter (2), the lateral wall and the guiding catheter of the body portion (11)
(2) inner sidewall is bonded to each other；The head end (12) has cone-shaped structure, and outside by the distal end of the guiding catheter (2)
It stretches out；The caudal peduncle (13) is protruding by the proximal end of the guiding catheter (2)；Subsidiary conduit (1) is internally provided with
The silk guide passage passed through for seal wire (3)；The lateral wall of the subsidiary conduit (1) is equipped with the first opening (15)；The seal wire
It (3) include core material (31) and coil (32), the core material (31) includes front end (311), rear end (312).
8. the conduit tube component according to claim 6 for the treatment of intravascular bifurcated lesions, it is characterised in that: the core material
(31) it is made of stainless steel material and/or nickel-titanium alloy material, the coil (32) is made of nickel-titanium alloy material；It is described
The outer peripheral edge of rear end (312) is coated with cyclic resin layer；Front end (311) outer peripheral edge is coated with silver-colored strontium alloy
Layer；The outer peripheral edge of the coil (32) is coated with layered double-hydroxide layer.
9. a kind of preparation method of the conduit tube component for the treatment of intravascular bifurcated lesions, which is characterized in that
The conduit tube component includes subsidiary conduit (1), guiding catheter (2) and seal wire (3), and the subsidiary conduit (1) is protruded into described
Guiding catheter (2), the seal wire (3) are protruded into the subsidiary conduit (1), and the subsidiary conduit (1) includes body portion (11) and divides
Not Wei Yu body portion (11) both ends head end (12) and caudal peduncle (13)；
The body portion (11) is protruded into the inner cavity of guiding catheter (2), the lateral wall of the body portion (11) and the guiding catheter (2)
Inner sidewall be bonded to each other；
The head end (12) has cone-shaped structure, and protruding by the distal end of the guiding catheter (2)；
The caudal peduncle (13) is protruding by the proximal end of the guiding catheter (2)；
The subsidiary conduit (1) is internally provided with the silk guide passage passed through for seal wire (3)；
The lateral wall of the subsidiary conduit (1) is equipped with the first opening (15)；The seal wire (3) includes core material (31) and coil
(32), the core material (31) includes front end (311), rear end (312)；
The core material (31) is made of stainless steel material and/or nickel-titanium alloy material, and the coil (32) uses Nitinol
Material is made；
The outer peripheral edge of the rear end (312) is coated with cyclic resin layer；Front end (311) outer peripheral edge is coated with silver
Strontium alloy layer；
The outer peripheral edge of the coil (32) is coated with layered double-hydroxide layer；
The seal wire (3) is prepared by following steps:
S1. resin cladding pretreatment is carried out to the rear end (312)；
S2. metal sputter-deposition pretreatment is carried out to the front end (311)；
S3. the cladding pretreatment of layered double-hydroxide layer is carried out to the coil (32)；
S4. the front end (311) and rear end (312) are interconnected and fixed using solder (34) by laser welding；
S5. the Inside coil (321) is wound in the outer peripheral edge of the front end (311), by the Inside coil
(321) one end is welded to each other with the first joint portion (331), and the other end of the Inside coil (321) is engaged with third
Portion (333) is welded to each other；
S6., the external coil (322) is wound in the outside of the Inside coil (321), by the external coil (322)
One end is welded to each other with the first joint portion (331), and by the other end of the external coil (322) and the second joint portion (332)
It is welded to each other.
10. a kind of application method of the subsidiary conduit as described in any one of claim 1-6, the subsidiary conduit is used for oar
The cardiovascular treatment of any one in artery, ulnar artery, arteria brachialis and femoral artery.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2019/000066 WO2019196520A1 (en) | 2018-04-12 | 2019-04-12 | Auxiliary catheter |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2018103244148 | 2018-04-12 | ||
| CN201810324414 | 2018-04-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109875615A true CN109875615A (en) | 2019-06-14 |
| CN109875615B CN109875615B (en) | 2021-04-16 |
Family
ID=66928358
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910121894.2A Active CN109875615B (en) | 2018-04-12 | 2019-02-18 | an auxiliary catheter |
| CN201920212359.3U Active CN210409198U (en) | 2018-04-12 | 2019-02-18 | Auxiliary catheter and catheter assembly for treatment of intravascular bifurcation lesions |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201920212359.3U Active CN210409198U (en) | 2018-04-12 | 2019-02-18 | Auxiliary catheter and catheter assembly for treatment of intravascular bifurcation lesions |
Country Status (2)
| Country | Link |
|---|---|
| CN (2) | CN109875615B (en) |
| WO (1) | WO2019196520A1 (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111135431A (en) * | 2020-01-17 | 2020-05-12 | 科塞尔医疗科技（苏州）有限公司 | Balloon catheter for anchoring guide wire and connector assembly |
| CN112336964A (en) * | 2020-11-24 | 2021-02-09 | 郑州四环医药用品有限公司 | Catheter with antibacterial coating |
| CN112386776A (en) * | 2019-08-12 | 2021-02-23 | 唐熠达 | Improved auxiliary catheter |
| CN115297921A (en) * | 2019-12-09 | 2022-11-04 | 克利夫兰临床基金会 | Apparatus and method for using fluid flow devices |
| CN116850430A (en) * | 2023-09-05 | 2023-10-10 | 易生科技(北京)有限公司 | Guide wire |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113559389A (en) * | 2021-07-26 | 2021-10-29 | 上海志心健康咨询事务所 | Dilating tube for coronary artery stent implantation operation |
| CN113707272B (en) * | 2021-08-02 | 2024-02-02 | 复旦大学附属中山医院 | Model for evaluating suitable crowd for interventional therapy of radial artery access liver cancer and construction method |
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| CN205698858U (en) * | 2016-04-08 | 2016-11-23 | 上海庆之医疗科技有限公司 | Conduit |
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- 2019-02-18 CN CN201910121894.2A patent/CN109875615B/en active Active
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| EP0965363A1 (en) * | 1994-06-24 | 1999-12-22 | Schneider (Europe) GmbH | Medical appliance for the treatment of a portion of body vessel by ionizing radiation |
| US20090198153A1 (en) * | 2008-01-31 | 2009-08-06 | Shriver Edgar L | Steering, piercing, anchoring, distending extravascular guidewire |
| CN201453804U (en) * | 2009-07-06 | 2010-05-12 | 成正辉 | Conveying and recovering duct of remote end protector inside blood vessel |
| CN102294071A (en) * | 2010-06-25 | 2011-12-28 | 朝日英达科株式会社 | Balloon catheter |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112386776A (en) * | 2019-08-12 | 2021-02-23 | 唐熠达 | Improved auxiliary catheter |
| CN115297921A (en) * | 2019-12-09 | 2022-11-04 | 克利夫兰临床基金会 | Apparatus and method for using fluid flow devices |
| CN115297921B (en) * | 2019-12-09 | 2024-07-30 | 克利夫兰临床基金会 | Apparatus and method for using a fluid flow device |
| CN111135431A (en) * | 2020-01-17 | 2020-05-12 | 科塞尔医疗科技（苏州）有限公司 | Balloon catheter for anchoring guide wire and connector assembly |
| CN111135431B (en) * | 2020-01-17 | 2020-12-01 | 科塞尔医疗科技（苏州）有限公司 | Balloon catheter for anchoring guide wire and connector assembly |
| CN112336964A (en) * | 2020-11-24 | 2021-02-09 | 郑州四环医药用品有限公司 | Catheter with antibacterial coating |
| CN112336964B (en) * | 2020-11-24 | 2021-06-04 | 郑州四环医药用品有限公司 | Catheter with antibacterial coating |
| CN116850430A (en) * | 2023-09-05 | 2023-10-10 | 易生科技(北京)有限公司 | Guide wire |
Also Published As
| Publication number | Publication date |
|---|---|
| CN210409198U (en) | 2020-04-28 |
| WO2019196520A1 (en) | 2019-10-17 |
| CN109875615B (en) | 2021-04-16 |
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