CN110051702A - 一种防治手足口病、流感的益生菌配方 - Google Patents
一种防治手足口病、流感的益生菌配方 Download PDFInfo
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- 239000006041 probiotic Substances 0.000 title claims abstract description 55
- 235000018291 probiotics Nutrition 0.000 title claims abstract description 55
- 206010022000 influenza Diseases 0.000 title claims abstract description 43
- 230000000529 probiotic effect Effects 0.000 title claims abstract description 40
- 208000020061 Hand, Foot and Mouth Disease Diseases 0.000 title claims abstract description 35
- 208000025713 Hand-foot-and-mouth disease Diseases 0.000 title claims abstract description 35
- 238000009472 formulation Methods 0.000 title claims abstract description 33
- 239000000203 mixture Substances 0.000 title claims abstract description 33
- 230000002265 prevention Effects 0.000 claims abstract description 21
- 241000186000 Bifidobacterium Species 0.000 claims abstract description 3
- 240000001046 Lactobacillus acidophilus Species 0.000 claims abstract description 3
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 claims abstract description 3
- 241000186604 Lactobacillus reuteri Species 0.000 claims abstract description 3
- 241000218588 Lactobacillus rhamnosus Species 0.000 claims abstract description 3
- 241001465754 Metazoa Species 0.000 claims abstract description 3
- 229940039695 lactobacillus acidophilus Drugs 0.000 claims abstract description 3
- 229940001882 lactobacillus reuteri Drugs 0.000 claims abstract description 3
- 244000052769 pathogen Species 0.000 abstract description 6
- 230000003449 preventive effect Effects 0.000 abstract description 3
- 230000001225 therapeutic effect Effects 0.000 abstract description 3
- 230000000968 intestinal effect Effects 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 230000031068 symbiosis, encompassing mutualism through parasitism Effects 0.000 description 3
- 201000004624 Dermatitis Diseases 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 208000010668 atopic eczema Diseases 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 208000019902 chronic diarrheal disease Diseases 0.000 description 2
- 241000700605 Viruses Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000037111 immune power Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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Abstract
本发明涉及一种益生菌配方,尤其涉及一种防治手足口病、流感的益生菌配方。本发明的益生菌配方,每0.05毫升的益生菌配方溶液中含有:动物双歧杆菌Bb‑12:1.5~2.0亿个;嗜酸乳杆菌:1.5~2.0亿个;鼠李糖乳杆菌:1.5~2.0亿个;罗伊乳杆菌:0~2.0亿个。本发明的益生菌组合能够共生共存,可以诱导机体产生非特异性抗体,提高机体抵抗力;并可诱导机体产生对手足口病和流感的主要病原体产生特异性抗体,对手足口病和流感有一定的防治作用。
Description
技术领域
本发明涉及一种益生菌配方,尤其涉及一种防治手足口病、流感的益生菌配方。
背景技术
益生菌指可改善宿主肠内微生态的平衡,并对宿主有正面效益的活性微生物。益生菌有帮助营养物质的消化吸收;产生重要的营养物质;抵抗细菌病毒的感染,提升免疫力,可清除有害菌对身体的伤害等功能。
由于现在市场上的益生菌只是非特异性地在一定程度上提高机体抵抗力,并不能针对手足口病和流感的主要病原体产生特异性抗体,因此对这些疾病的防治并没有太明显的影响。
本发明专门研究并选择可诱导机体产生对手足口病和流感的主要病原体产生特异性抗体的益生菌进行组合,并保证这些益生菌能够共存共生。
发明内容
(1)要解决的技术问题
本发明为了克服现在市场上的益生菌只是非特异性地在一定程度上提高机体抵抗力,并不能针对手足口病和流感的主要病原体产生特异性抗体的缺点,本发明要解决的技术问题是提供一种防治手足口病、流感的益生菌配方。
(2)技术方案
为了解决上述技术问题,本发明提供了这样一种防治手足口病、流感的益
生菌配方,每0.05毫升的益生菌配方溶液中含有:
动物双歧杆菌Bb-12: 1.5~2.0亿个;
嗜酸乳杆菌: 1.5~2.0亿个;
鼠李糖乳杆菌: 1.5~2.0亿个;
罗伊乳杆菌: 0~2.0亿个。
优选地,每0.05毫升的益生菌配方溶液中含有:
优选地,每0.05毫升的益生菌配方溶液中含有:
优选地,每0.05毫升的益生菌配方溶液中含有:
本发明的上述益生菌是从肠道内500-1000种的益生菌中选择,选择已经证明是有益于人类生命和健康的益生菌,并且选择对流感或手足口病防治有帮助的益生菌,同时选择的上述益生菌能够共生共存。
本发明的益生菌配方的适应症有:
≤3岁的肠道菌群系统“成人化”前;
65岁后肠道菌群显著变化后;
慢性腹泻者;
长期服用抗生素者;
湿疹,过敏等。
在流感季节前1-2个月开始服用防治流感的益生菌组合,每天服用1滴,一滴即0.05毫升,连续服用2-3周。
在手足口病季节前1-2个月开始服用防治手足口病的益生菌组合,每天服用1滴,一滴即0.05毫升,连续服用3-5周。
(3)有益效果
本发明的益生菌组合能够共存共生,诱导机体提高非特异性抗体,提高机体抵抗力。
诱发机体产生对手足口病和流感的主要病原体产生特异性抗体,对手足口病和流感有一定的防治作用。
具体实施方式
实施例1
一种防治手足口病、流感的益生菌配方,每0.05毫升的益生菌配方溶液中含有:
用上述配方防治流感(甲流、乙流)。
实施例2
一种防治手足口病、流感的益生菌配方,每0.05毫升的益生菌配方溶液中含有:
用上述配方防治流感(甲流、乙流)和手足口病。
实施例3
一种防治手足口病、流感的益生菌配方,每0.05毫升的益生菌配方溶液中含有:
用上述配方防治流感(甲流、乙流)和手足口病。
实施例4
一种防治手足口病、流感的益生菌配方,每0.05毫升的益生菌配方溶液中含有:
用上述配方防治流感(甲流、乙流)和手足口病。
实施例5
一种防治手足口病、流感的益生菌配方,每0.05毫升的益生菌配方溶液中含有:
用上述配方防治流感(甲流、乙流)和手足口病。
本发明的上述益生菌是从肠道内500-1000种的益生菌中选择,选择已经证明是有益于人类生命和健康的益生菌,并且选择对流感或手足口病防治有帮助的益生菌,同时选择的上述益生菌能够共生共存。
本发明的益生菌配方的适应症有:
≤3岁的肠道菌群系统“成人化”前;
65岁后肠道菌群显著变化后;
流感(甲流、乙流);
手足口病;
慢性腹泻者;
长期服用抗生素者;
湿疹,过敏等。
在流感季节前1-2个月开始服用防治流感的益生菌组合,每天服用1滴,一滴即0.05毫升,连续服用2-3周。
在手足口病季节前1-2个月开始服用防治手足口病的益生菌组合,每天服用1滴,一滴即0.05毫升,连续服用3-5周。
本发明的益生菌组合能够共存共生,帮助机体提高非特异性抗体,提高机体抵抗力。诱发机体产生对手足口病和流感的主要病原体产生特异性抗体,对手足口病和流感有一定的防治作用。
以上所述实施例仅表达了本发明的优选实施方式,其描述较为具体和详细,但并不能因此而理解为对本发明专利范围的限制。应当指出的是,对于本领域的普通技术人员来说,在不脱离本发明构思的前提下,还可以做出若干变形、改进及替代,这些都属于本发明的保护范围。因此,本发明专利的保护范围应以所附权利要求为准。
Claims (4)
1.一种防治手足口病、流感的益生菌配方,其特征在于,每0.05毫升的益生菌配方溶液中含有:
动物双歧杆菌Bb-12: 1.5~2.0亿个;
嗜酸乳杆菌: 1.5~2.0亿个;
鼠李糖乳杆菌: 1.5~2.0亿个;
罗伊乳杆菌: 0~2.0亿个。
2.根据权利要求1所述的一种防治手足口病、流感的益生菌配方,其特征在于,每0.05毫升的益生菌配方溶液中含有:
3.根据权利要求1所述的一种防治手足口病、流感的益生菌配方,其特征在于,每0.05毫升的益生菌配方溶液中含有:
4.根据权利要求1所述的一种防治手足口病、流感的益生菌配方,其特征在于,每0.05毫升的益生菌配方溶液中含有:
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101031313A (zh) * | 2004-11-16 | 2007-09-05 | 安尼德拉尔有限公司 | 基于益生菌的组合物及其在预防和/或治疗呼吸性病变和/或感染以及改善肠功能中的用途 |
| CN101336938A (zh) * | 2007-07-02 | 2009-01-07 | 青岛东海药业有限公司 | 益生菌在制备治疗与预防手足口病组合物中的应用 |
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2019
- 2019-06-06 CN CN201910491110.5A patent/CN110051702A/zh active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101031313A (zh) * | 2004-11-16 | 2007-09-05 | 安尼德拉尔有限公司 | 基于益生菌的组合物及其在预防和/或治疗呼吸性病变和/或感染以及改善肠功能中的用途 |
| CN101336938A (zh) * | 2007-07-02 | 2009-01-07 | 青岛东海药业有限公司 | 益生菌在制备治疗与预防手足口病组合物中的应用 |
Non-Patent Citations (3)
| Title |
|---|
| GAREAU MG等: "Probiotics and the gut microbiota in intestinal health and disease", 《NAT REV GASTROENTEROL HEPATOL》 * |
| 尹斐弘等: "儿童重症手足口病肠道菌群和肠道黏膜通透性的研究进展", 《中国微生态学杂志》 * |
| 邹杨等: "益生菌防治呼吸道感染的研究进展", 《中国当代医药》 * |
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