CN110201246A - 抗血栓形成移植物 - Google Patents

抗血栓形成移植物 Download PDF

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Publication number
CN110201246A
CN110201246A CN201910658935.1A CN201910658935A CN110201246A CN 110201246 A CN110201246 A CN 110201246A CN 201910658935 A CN201910658935 A CN 201910658935A CN 110201246 A CN110201246 A CN 110201246A
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CN
China
Prior art keywords
decellularized
layer
tissue
coating
heparin
Prior art date
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Pending
Application number
CN201910658935.1A
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English (en)
Chinese (zh)
Inventor
S·蒂米卓吾思嘉
L·尼克拉森
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Yale University
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Yale University
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Publication of CN110201246A publication Critical patent/CN110201246A/zh
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/507Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727Heparin; Heparan
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28Materials for coating prostheses
    • A61L27/34Macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3625Vascular tissue, e.g. heart valves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52Hydrogels or hydrocolloids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005Use of materials characterised by their function or physical properties
    • A61L33/0011Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005Use of materials characterised by their function or physical properties
    • A61L33/0011Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0029Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using an intermediate layer of polymer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005Use of materials characterised by their function or physical properties
    • A61L33/0064Hydrogels or hydrocolloids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06Use of macromolecular materials
    • A61L33/08Polysaccharides
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05DPROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D7/00Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials
    • B05D7/50Multilayers
    • B05D7/52Two layers
    • B05D7/54No clear coat specified
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09DCOATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D105/00Coating compositions based on polysaccharides or on their derivatives, not provided for in groups C09D101/00 or C09D103/00
    • C09D105/08Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09DCOATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D105/00Coating compositions based on polysaccharides or on their derivatives, not provided for in groups C09D101/00 or C09D103/00
    • C09D105/10Heparin; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/44Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23Carbohydrates
    • A61L2300/236Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/42Anti-thrombotic agents, anticoagulants, anti-platelet agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606Coatings
    • A61L2300/608Coatings having two or more layers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00Materials or methods for coatings medical devices
    • A61L2420/02Methods for coating medical devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00Materials or methods for coatings medical devices
    • A61L2420/08Coatings comprising two or more layers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/40Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Materials Engineering (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
CN201910658935.1A 2013-05-20 2014-05-19 抗血栓形成移植物 Pending CN110201246A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361825256P 2013-05-20 2013-05-20
US61/825,256 2013-05-20
CN201480029024.8A CN105228665A (zh) 2013-05-20 2014-05-19 抗血栓形成移植物

Related Parent Applications (1)

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CN201480029024.8A Division CN105228665A (zh) 2013-05-20 2014-05-19 抗血栓形成移植物

Publications (1)

Publication Number Publication Date
CN110201246A true CN110201246A (zh) 2019-09-06

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Family Applications (2)

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CN201910658935.1A Pending CN110201246A (zh) 2013-05-20 2014-05-19 抗血栓形成移植物
CN201480029024.8A Pending CN105228665A (zh) 2013-05-20 2014-05-19 抗血栓形成移植物

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Application Number Title Priority Date Filing Date
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Country Status (9)

Country Link
US (2) US9981066B2 (fr)
EP (1) EP2999494B1 (fr)
CN (2) CN110201246A (fr)
AU (2) AU2014268778B2 (fr)
CA (1) CA2912664C (fr)
DK (1) DK2999494T3 (fr)
ES (1) ES2829412T3 (fr)
HK (1) HK1219242A1 (fr)
WO (1) WO2014189835A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110732041A (zh) * 2019-10-12 2020-01-31 广东省人民医院(广东省医学科学院) 一种脱细胞小口径血管支架及其制备方法
CN115109293A (zh) * 2022-07-26 2022-09-27 浙江硕华生命科学研究股份有限公司 一种血沉试验管及其制备方法

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014189835A2 (fr) * 2013-05-20 2014-11-27 Yale University Greffons anti-thrombose
WO2016154070A1 (fr) 2015-03-20 2016-09-29 William Marsh Rice University Bioimpression hypothermique en 3d de tissus vivants supportée par un système vasculaire pouvant être perfusé
AU2016248234B2 (en) 2015-04-16 2020-07-02 Hollister Incorporated Hydrophilic coatings and methods of forming the same
US12551509B2 (en) 2015-11-18 2026-02-17 Lucina Patent Holdco, Llc Acellular regenerative products and methods of their manufacture
EP3448310B1 (fr) 2016-04-27 2024-07-31 Yale University Compositions et procédés pour greffons modifiés avec une matrice extracellulaire dérivée de cellules non thrombogènes et promigratoires
CN106267369B (zh) * 2016-08-05 2019-05-31 华中科技大学同济医学院附属协和医院 一种人造血管及其制备方法
CN107412865A (zh) * 2016-10-27 2017-12-01 浙江保尔曼生物科技有限公司 高强度的具有抗凝血功能的去细胞化肾脏生物支架及制备方法
US11628239B2 (en) * 2016-11-04 2023-04-18 University Of Delaware Method for protecting skeletonized blood vessels
WO2019006430A1 (fr) * 2017-06-30 2019-01-03 Vascudyne Inc Implants en tissu régénératif et en tissu naturel
WO2019075213A1 (fr) 2017-10-11 2019-04-18 Northwestern University Héparine conjuguée à des peptides se liant au collagène pour cibler des tissus biologiques et synthétiques
US12186452B2 (en) 2017-10-23 2025-01-07 Yale University Compositions and methods useful in regenerative medicine
JP7418363B2 (ja) 2018-06-21 2024-01-19 イエール ユニバーシティ バイオ人工血管膵臓
IL280610B2 (en) * 2018-08-31 2024-08-01 Wisconsin Alumni Res Found Fabrication of vascular grafts seeded with arterial endothelial cells
EP3846867B1 (fr) 2018-09-06 2025-02-19 Biomodics APS Dispositif tubulaire médical
EP3927385A1 (fr) * 2019-02-19 2021-12-29 Tc1 Llc Greffon vasculaire et procédés de scellement d'un greffon vasculaire
CN110354311A (zh) * 2019-08-30 2019-10-22 青岛大学 细胞外基质复合透明质酸凝胶及其制备方法、应用和生物材料
WO2021113584A1 (fr) * 2019-12-04 2021-06-10 Yale University Greffons vasculaires de génie tissulaire ayant une résistance mécanique avancée
WO2023086925A1 (fr) * 2021-11-15 2023-05-19 The Texas A&M University System Greffons vasculaires acellulaires anticoagulants et méthodes associées
CN115920130B (zh) * 2022-12-29 2024-07-16 季华实验室 基于prp活化剂-肝素处理的血管材料及其制备方法
CN116271251B (zh) * 2023-03-22 2024-12-10 中国人民解放军陆军军医大学 一种组织工程小口径人工血管移植物及其制备方法和应用
US20240408286A1 (en) * 2023-06-08 2024-12-12 Becton, Dickinson And Company Tissue-plasminogen activator coated catheter with hydrogel-controlled elution
PL446936A1 (pl) * 2023-11-30 2024-10-21 Uniwersytet Mikołaja Kopernika W Toruniu Proteza do odprowadzenia moczu u pacjentów pozbawionych pęcherza moczowego oraz sposób jej wytwarzania

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010044654A1 (en) * 2000-04-28 2001-11-22 Changyi Chen Decellularized vascular prostheses resistant to thrombus occlusion and immunologic rejection
US20030048796A1 (en) * 2000-11-24 2003-03-13 Toshiyasu Yabe Relay device
US20030161938A1 (en) * 2002-02-22 2003-08-28 Bo Johnson Composition and method for coating medical devices
CN1455687A (zh) * 2000-10-24 2003-11-12 韩国美大富历寿株式会社 疏水性多组分肝素结合物,其制备方法及其应用
US20040038934A1 (en) * 2001-02-22 2004-02-26 Anika Therapeutics, Inc. Thiol-modified hyaluronan
CN101066477A (zh) * 2007-05-17 2007-11-07 中国人民解放军第三军医大学 能在体捕获内皮祖细胞的生物人工血管
CN101249285A (zh) * 2007-02-21 2008-08-27 科迪斯公司 用于具有抗血栓形成共轭物的医疗装置的涂层
CN101703813A (zh) * 2009-11-25 2010-05-12 南开大学 利用内源性no供体构建抗凝血性血管支架材料的方法
CN101745327A (zh) * 2009-12-29 2010-06-23 浙江大学 一种在聚合物微孔膜表面固定生物分子的方法
US20130023507A1 (en) * 2004-04-30 2013-01-24 Advanced Cardiovascular Systems, Inc. Hyaluronic acid based copolymers

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030187515A1 (en) * 2002-03-26 2003-10-02 Hariri Robert J. Collagen biofabric and methods of preparing and using the collagen biofabric
ES2548518T3 (es) * 2005-11-23 2015-10-19 Ventana Medical Systems, Inc. Conjugado molecular
WO2014189835A2 (fr) * 2013-05-20 2014-11-27 Yale University Greffons anti-thrombose

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010044654A1 (en) * 2000-04-28 2001-11-22 Changyi Chen Decellularized vascular prostheses resistant to thrombus occlusion and immunologic rejection
CN1455687A (zh) * 2000-10-24 2003-11-12 韩国美大富历寿株式会社 疏水性多组分肝素结合物,其制备方法及其应用
US20030048796A1 (en) * 2000-11-24 2003-03-13 Toshiyasu Yabe Relay device
US20040038934A1 (en) * 2001-02-22 2004-02-26 Anika Therapeutics, Inc. Thiol-modified hyaluronan
US6884788B2 (en) * 2001-02-22 2005-04-26 Anika Therapeutics, Inc. Thiol-modified hyaluronan
US20030161938A1 (en) * 2002-02-22 2003-08-28 Bo Johnson Composition and method for coating medical devices
US20130023507A1 (en) * 2004-04-30 2013-01-24 Advanced Cardiovascular Systems, Inc. Hyaluronic acid based copolymers
CN101249285A (zh) * 2007-02-21 2008-08-27 科迪斯公司 用于具有抗血栓形成共轭物的医疗装置的涂层
CN101066477A (zh) * 2007-05-17 2007-11-07 中国人民解放军第三军医大学 能在体捕获内皮祖细胞的生物人工血管
CN101703813A (zh) * 2009-11-25 2010-05-12 南开大学 利用内源性no供体构建抗凝血性血管支架材料的方法
CN101745327A (zh) * 2009-12-29 2010-06-23 浙江大学 一种在聚合物微孔膜表面固定生物分子的方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DAN LIAO等: "Covalent linkage of heparin provides a stable anti-coagulation surface of decellularized porcine arteries", 《J. CELL. MOL. MED.》 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110732041A (zh) * 2019-10-12 2020-01-31 广东省人民医院(广东省医学科学院) 一种脱细胞小口径血管支架及其制备方法
CN115109293A (zh) * 2022-07-26 2022-09-27 浙江硕华生命科学研究股份有限公司 一种血沉试验管及其制备方法
CN115109293B (zh) * 2022-07-26 2023-10-27 浙江硕华生命科学研究股份有限公司 一种血沉试验管及其制备方法

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US20160058913A1 (en) 2016-03-03
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