CN110325209A - 能够结合cd137和肿瘤抗原的双特异性结合分子及其用途 - Google Patents

能够结合cd137和肿瘤抗原的双特异性结合分子及其用途 Download PDF

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CN110325209A
CN110325209A CN201880013509.6A CN201880013509A CN110325209A CN 110325209 A CN110325209 A CN 110325209A CN 201880013509 A CN201880013509 A CN 201880013509A CN 110325209 A CN110325209 A CN 110325209A
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cdr
seq
mab
variable domains
heavy
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刘丽勤
C·K·兰姆
G·迪德里奇
莱斯利·S·约翰逊
保罗·A·摩尔
埃兹奥·泊韦尼
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Macro Gene Co Ltd
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Macro Gene Co Ltd
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CN201880013509.6A 2017-02-24 2018-02-22 能够结合cd137和肿瘤抗原的双特异性结合分子及其用途 Pending CN110325209A (zh)

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US201762463353P 2017-02-24 2017-02-24
US62/463,353 2017-02-24
US201762597594P 2017-12-12 2017-12-12
US62/597,594 2017-12-12
PCT/US2018/019188 WO2018156740A1 (en) 2017-02-24 2018-02-22 Bispecific binding molecules that are capable of binding cd137 and tumor antigens, and uses thereof

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EP (2) EP4389226A3 (2)
JP (1) JP7132232B2 (2)
KR (1) KR102585848B1 (2)
CN (1) CN110325209A (2)
AU (1) AU2018224094B2 (2)
BR (1) BR112019017628A2 (2)
CA (1) CA3053803A1 (2)
IL (1) IL268836B2 (2)
MA (1) MA47612A (2)
MX (1) MX2019009967A (2)
SG (1) SG11201907753TA (2)
TW (1) TWI788327B (2)
WO (1) WO2018156740A1 (2)
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CN112119977A (zh) * 2020-10-15 2020-12-25 中国人民解放军军事科学院军事医学研究院 Cd317诱导的抑郁和记忆损伤的小鼠模型的构建方法及其应用
WO2021104326A1 (zh) * 2019-11-25 2021-06-03 苏州星湾生物科技有限公司 Car-t细胞的检测用单克隆抗体、试剂盒及应用
WO2022002063A1 (zh) * 2020-06-30 2022-01-06 和铂医药(上海)有限责任公司 一种4-1bb结合蛋白及其应用
CN115279403A (zh) * 2020-02-21 2022-11-01 宏观基因有限公司 Cd137结合分子及其用途
CN115368465A (zh) * 2022-07-19 2022-11-22 合肥天港免疫药物有限公司 双特异性抗体及其应用
CN115427059A (zh) * 2020-01-31 2022-12-02 达因疗法公司 抗转铁蛋白受体（tfr）抗体及其用途
CN116693684A (zh) * 2023-04-19 2023-09-05 浙江正熙生物技术有限公司 一种抗人cd8抗体及其制备方法和应用
CN117007808A (zh) * 2022-04-27 2023-11-07 洛阳中科生物芯片技术有限公司 非洲猪瘟病毒CD2v蛋白阻断生物芯片抗体检测试剂盒
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CN120795136A (zh) * 2025-09-11 2025-10-17 华中农业大学 猪德尔塔冠状病毒单克隆抗体及其在制备抗原检测试纸条中的应用

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TWI825046B (zh) 2017-12-19 2023-12-11 英商拜西可泰克斯有限公司 Epha2特用之雙環胜肽配位基
CN111902429A (zh) 2018-02-23 2020-11-06 拜斯科技术开发有限公司 多聚体双环肽配体
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CN112739339B (zh) 2018-07-23 2024-12-27 海德堡医药研究有限责任公司 抗cd137抗体药物缀合物(adc)在同种异体细胞疗法中的用途
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TWI839395B (zh) * 2018-10-09 2024-04-21 瑞士商Ｎｕｍａｂ治療公司 靶向cd137的抗體及其使用方法
JP7596263B2 (ja) * 2018-10-10 2024-12-09 ザイムワークス ビーシー インコーポレイテッド ４－１ｂｂ及び腫瘍関連抗原に結合する抗体構築物ならびにその使用
JP7410143B2 (ja) * 2018-11-01 2024-01-09 山▲東▼新▲時▼代▲薬▼▲業▼有限公司 二重特異性抗体及びその用途
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KR20220145859A (ko) * 2020-02-28 2022-10-31 상하이 헨리우스 바이오테크, 인크. 항cd137 작제물, 다중 특이적 항체 및 그 용도
US20230265202A1 (en) * 2020-04-15 2023-08-24 Zymeworks Inc. Antibody constructs binding 4-1bb and folate receptor alpha and uses thereof
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