CN110772434A - A kind of attapulgite oral cleaning product and preparation method and application thereof - Google Patents

Abstract

The invention belongs to the field of oral care products. The attapulgite oral cleaning product comprises, by weight, 10-20 parts of attapulgite, 1-5 parts of enzymes, 5-10 parts of salt, 8-15 parts of glycerol, 1-5 parts of cyclodextrin, 2-8 parts of cocamidopropyl betaine, 1-1.5 parts of sodium citrate, 2-8 parts of a thickening agent, 2-4 parts of a flavoring agent and 30-50 parts of water. The components of the attapulgite oral cavity cleaning product provided by the invention interact with each other to deeply clean the oral cavity, and the attapulgite oral cavity cleaning product has the effects of thoroughly cleaning the oral cavity and protecting the health of the oral cavity for a long time.

Description

A kind of attapulgite oral cleaning product and preparation method and application thereof

technical field

The invention relates to the field of oral care products, in particular to an attapulgite oral cleaning product and a preparation method and application thereof.

Background technique

The protein, bacteria and food debris in saliva form a sticky film on the tooth surface, which becomes an environment for bacteria to grow and multiply, which is called dental plaque. The bacteria in dental plaque are the main cause of dental caries and periodontal disease. Plaque tends to settle in certain deep pits and fissures on the tooth surface, in the spaces adjacent to the teeth, or in places that are not easily cleaned by brushing. Substances such as sugar in food enter the plaque and are fermented by bacteria to produce acid, which can dissolve the minerals in the teeth, thereby causing "tooth decay" (dental caries). The foods we eat every day are rich in nutrients that give our body the energy it needs every day, but if left in the mouth they can also become the main source of energy for bacteria to multiply. Therefore, good oral hygiene after meals is of great significance to oral health and dental care.

At present, the main cleaning method of the oral cavity is brushing teeth. The function of brushing teeth is to remove food debris, soft scale, dental plaque, etc. However, it is not enough to clean the oral cavity only. Therefore, toothpastes with various functions have appeared on the market, such as: fluoride toothpaste, Chinese herbal toothpaste, anti-inflammatory toothpaste, hypoallergenic toothpaste, descaling and whitening toothpaste, etc. These toothpastes are mainly for targeted treatment of oral diseases that have appeared. And the effectiveness of toothpaste is also affected by factors such as brushing method and brushing time.

Nowadays, young people also tend to only use mouthwash to achieve the purpose of oral cleaning. In fact, simply using mouthwash can only remove food debris floating on the surface of the teeth, and some food debris and deposits in hidden parts, such as between teeth It is not easy to remove the object, so you can not simply use mouthwash instead of brushing your teeth. Some people think that using oral cleaning mouthwash can make the mouth clean. In fact, although mouthwash has antibacterial and bactericidal function, if you use mouthwash without brushing your teeth first, then the effect of mouthwash to prevent tooth decay is very limited. Bacteria that remain in the interdental spaces and gingival sulcus or periodontal pockets can still multiply rapidly. In addition, some mouthwashes contain higher pharmaceutical ingredients than toothpastes. Commonly used mouthwashes may lead to imbalance of oral flora, which may lead to more oral diseases.

SUMMARY OF THE INVENTION

The purpose of the present invention is to provide an attapulgite oral cleaning product and its preparation method and application. The attapulgite oral cleaning product of the present invention can be blended into mouthwash and or used in conjunction with toothpaste, used for daily oral care, and can effectively prevent Oral problems.

In order to achieve the above object of the invention, the present invention provides the following technical solutions: a kind of attapulgite oral cleaning product, comprising the following raw materials by weight: 10-20 parts of attapulgite, 1-5 parts of enzymes, 5-10 parts of salt, 8-15 parts of glycerin, 1-5 parts of cyclodextrin, 2-8 parts of cocamidopropyl betaine, 1-1.5 parts of sodium citrate, 2-8 parts of thickener, 2-4 parts of flavoring agent, water 30-50 servings.

Preferably: attapulgite 12-18 parts, enzymes 2-4 parts, salt 6-9 parts, glycerol 7-14 parts, cyclodextrin 1.5-4 parts, cocamidopropyl betaine 3-7 parts, 1.1-1.4 parts of sodium citrate, 3-7 parts of thickener, 2.3-3.8 parts of flavoring agent, 35-45 parts of water;

More preferably: attapulgite 13-16 parts, enzymes 2.5-3.5 parts, salt 7-8 parts, glycerol 8-12 parts, cyclodextrin 2-3.5 parts, cocamidopropyl betaine 4-6 parts , 1.2-1.3 parts of sodium citrate, 4-6 parts of thickener, 2.5-3.2 parts of flavoring agent, 38-42 parts of water;

Still more preferably: attapulgite 15 parts, enzymes 3 parts, salt 7.5 parts, glycerin 10 parts, cyclodextrin 3 parts, cocamidopropyl betaine 5 parts, sodium citrate 1.2 parts, thickener 5 parts parts, 3 parts of fragrance, 40 parts of water;

The particle size ranges of the attapulgite in the present invention are 50-100 nm, 200-500 nm and 800-1000 nm.

Further, the particle size ranges of the attapulgite are 50-100 nm, 200-500 nm and 800-1000 nm.

Preferably, the particle size ranges of the attapulgite are 60-90 nm, 250-450 nm, and 850-950 nm.

Further, the particle size range of the attapulgite is 70-80nm, 300-400nm, 880-920nm, and then

Further, the particle size ranges of the attapulgite are 75 nm, 350 nm and 900 nm.

Further, the dosage ratio of the particle size in each range of the attapulgite is 1-3:5-7:1-2.

Preferably, the dosage ratio of the attapulgite in each range of particle size is 1.5-2.5:5.5-6.5:1.2-1.8.

Preferably, the dosage ratio of the attapulgite in each range of particle size is 2:6:1.5.

Further, the enzymes are one or a mixture of two or more of protease, cellulase, and amylase.

Further, the thickener is carboxymethyl cellulose and/or carrageenan;

Further, described fragrance agent is a kind of in wintergreen oil, peppermint oil, spearmint oil and clove oil;

The invention provides a preparation method of attapulgite oral cleaning products, comprising the following steps:

(1) Take 10-20 parts of attapulgite, 5-10 parts of table salt, 1-5 parts of cyclodextrin, 2-8 parts of cocamidopropyl betaine, 1-1.5 parts of sodium citrate , Mix 2-4 parts of flavoring agent evenly, then add 8-15 parts of glycerin and 30-50 parts of water to fully dissolve;

(2) Take 1-5 parts of enzymes and 2-8 parts of thickeners, add them to the solution in step (1), stir evenly, and prepare attapulgite oral cleaning products.

Application of the attapulgite oral cleaning product of the present invention as mouthwash.

Preferably, the oral cleaning product is added with 10-20 times the volume of water of the oral cleaning product, and mixed thoroughly to obtain a mouthwash.

Preferably, when the mouthwash is used, gargle for 20-30s and repeat 2-3 times.

The application of the attapulgite oral cleaning product of the present invention in combination with toothpaste.

Preferably, the attapulgite oral cleaning product and toothpaste are used in a volume ratio of 1:3-5.

Compared with the prior art, the present invention has the following beneficial effects:

1. Attapulgite refers to a clay mineral with attapulgite as its main component. Attapulgite is a crystalline hydrated magnesium-aluminosilicate mineral with a unique layer-chain structure. There is lattice replacement in its structure, and its ideal chemical formula is: Mg ₅ Si ₈ O ₂₀ (OH) ₂ (OH ₂ ) ₄ ·4H ₂ O. Has an intermediate structure between a chain-like structure and a layered structure. Rod crystals contain a variable amount of Na ⁺ , Ca ²⁺ , Fe ³⁺ , Al ³⁺ , and the crystals are needle-like, fibrous or fibrous aggregates. Attapulgite has good colloidal properties such as unique dispersion, high temperature resistance, salt and alkali resistance, high adsorption and decolorization ability, and has certain plasticity and cohesive force. It is applied to the preparation of oral cleaning products. The food residues in the teeth are well removed; with attapulgite with different particle size ranges, it can absorb impurities of different particle sizes, and can go deep into different spaces for cleaning, so as to achieve good cleaning of teeth and oral cavity. The purpose of deep cleaning; in addition, the special structure of attapulgite can also interact with cyclodextrin to form a specific structural cavity, which can further encapsulate impurities and make cleaning more thorough;

2. Enzymes can degrade debris in some deep pits and fissures on the tooth surface and in the gap between teeth, and cooperate with attapulgite to further adsorb and remove food debris; cocamidopropyl betaine is an extremely mild The amphoteric surfactant has no harmful effect on teeth, has good foaming and thickening properties, and its foam is stable and delicate, which can improve the adhesion of attapulgite;

3. The lubricating effect of glycerin can not only care for the gums, but also lubricate food debris, and also play a synergistic role to facilitate the deep adsorption and removal of attapulgite;

4. Enzymes, salt and glycerin have a long-term effect on oral care. The lubricating effect of glycerin and the bactericidal effect of salt can provide long-term care for oral health, while enzymes can further degrade oral residues into small molecular substances, making them It is excreted from the oral environment with saliva, drinking water, etc., so as to maintain oral health for a long time;

To sum up, the interaction between the components of the attapulgite oral cleaning product provided by the present invention can deeply clean the oral cavity, and has the functions of thoroughly cleaning the oral cavity and protecting the oral health for a long time.

Detailed ways

A kind of attapulgite oral cleaning product provided by the present invention will be described in detail below with reference to the examples, but they should not be construed as limiting the protection scope of the present invention.

The following table is the preparation ratio of the attapulgite involved in the following examples

Attapulgite particle size (nm) Mixing ratio of attapulgite with different particle sizes Example 1 50/200/800 1:5:1 Example 2 60/250/850 1:6:1 Example 3 70/300/800 1.5:6:1.5 Example 4 75/350/900 2:6:1.5 Example 5 80/400/920 2:7:2 Example 6 90/450/950 2:7:1 Example 7 100/500/1000 3:7:2

Example 1

The present embodiment provides an attapulgite oral cleaning product, and its preparation steps are as follows: take 10 parts of attapulgite, 6 parts of table salt, 1 part of cyclodextrin, 7 parts of cocamidopropyl betaine, Mix 1.1 parts of sodium citrate and 2.3 parts of wintergreen oil evenly, then add 5 parts of glycerin and 35 parts of water to fully dissolve; then take 5 parts of enzymes and 2 parts of carboxymethyl cellulose and add them to the step In the solution, stir evenly to prepare attapulgite oral cleaning products.

When the product of this example is used as a mouthwash, add 10 times the volume of water to dilute the product, gargle for 20-30s, spit it out, and repeat 2-3 times.

When the product of this embodiment is used in combination with toothpaste, squeeze it onto the toothbrush together with the toothpaste in a volume ratio of 1:3 with the toothpaste, and just brush the teeth normally.

Example 2

The present embodiment provides an attapulgite oral cleaning product, and its preparation steps are as follows: take 12 parts of attapulgite, 8 parts of table salt, 4 parts of cyclodextrin, 3 parts of cocamidopropyl betaine, 1.3 parts of sodium citrate and 2 parts of peppermint oil are mixed evenly, then 7 parts of glycerin and 30 parts of water are added to fully dissolve; 2.5 parts of enzymes and 8 parts of carrageenan are added to the solution in the step , stir evenly, and prepare attapulgite oral cleaning products.

When the product of this example is used as a mouthwash, add 20 times the volume of water to dilute the product, gargle for 20-30s, spit it out, and repeat 2-3 times.

When the product of this embodiment is used in combination with toothpaste, squeeze it onto the toothbrush together with the toothpaste in a volume ratio of 1:5 with the toothpaste, and then brush the teeth normally.

Example 3

The present embodiment provides an attapulgite oral cleaning product, and its preparation steps are as follows: take 16 parts of attapulgite, 9 parts of table salt, 5 parts of cyclodextrin, 2 parts of cocamidopropyl betaine, 1.4 parts of sodium citrate and 3.2 parts of spearmint oil were mixed evenly, then 8 parts of glycerin and 50 parts of water were added to fully dissolve; 1 part of enzymes and 3 parts of carboxymethyl cellulose were added to the step In the solution in , stir evenly to prepare attapulgite oral cleaning products.

When the product of this example is used as a mouthwash, add 12 times the volume of water to dilute it, gargle for 20-30s, spit it out, and repeat 2-3 times.

When the product of this embodiment is used in combination with toothpaste, squeeze it onto the toothbrush together with the toothpaste in a volume ratio of 1:3.5 with the toothpaste, and then brush the teeth normally.

Example 4

The present embodiment provides an attapulgite oral cleaning product, and its preparation steps are as follows: take 13 parts of attapulgite, 5 parts of table salt, 3.5 parts of cyclodextrin, 4 parts of cocamidopropyl betaine, 1.5 parts of sodium citrate and 2.5 parts of clove oil are mixed evenly, then 12 parts of glycerin and 38 parts of water are added to fully dissolve; 4 parts of enzymes and 7 parts of carboxymethyl cellulose are added to the step In the solution, stir evenly to prepare attapulgite oral cleaning products.

When the product of this example is used as a mouthwash, add 18 times the volume of water to dilute the product, gargle for 20-30s, spit it out, and repeat 2-3 times.

When the product of this embodiment is used in combination with toothpaste, squeeze it onto the toothbrush together with the toothpaste in a volume ratio of 1:4.5 with the toothpaste, and then brush your teeth normally.

Example 5

The present embodiment provides an attapulgite oral cleaning product, and the preparation steps are as follows: take 15 parts of attapulgite, 7.5 parts of table salt, 3 parts of cyclodextrin, 5 parts of cocamidopropyl betaine, 1.2 parts of sodium citrate and 3 parts of peppermint oil are mixed evenly, then 10 parts of glycerin and 40 parts of water are added to fully dissolve; then 3 parts of enzymes and 5 parts of carboxymethyl cellulose are added to the steps In the solution, stir evenly to prepare attapulgite oral cleaning products.

When the product of this example is used as a mouthwash, add 15 times the volume of water to dilute the product, rinse the mouth for 20-30s, spit it out, and repeat 2-3 times.

When the product of this embodiment is used in combination with toothpaste, squeeze it onto the toothbrush together with the toothpaste in a volume ratio of 1:4 with the toothpaste, and then brush the teeth normally.

Example 6

The present embodiment provides an attapulgite oral cleaning product, and its preparation steps are as follows: take 20 parts of attapulgite, 10 parts of table salt, 2 parts of cyclodextrin, 6 parts of cocamidopropyl betaine, 1 part of sodium citrate and 3.8 parts of clove oil are mixed evenly, then 14 parts of glycerin and 42 parts of water are added to fully dissolve; 2 parts of enzymes and 4 parts of carrageenan are added to the solution in the step , stir evenly, and prepare attapulgite oral cleaning products.

When the product of this example is used as a mouthwash, add 13 times the volume of water to dilute the product, gargle for 20-30s, spit it out, and repeat 2-3 times.

When the product of this embodiment is used in combination with toothpaste, squeeze it onto the toothbrush together with the toothpaste in a volume ratio of 1:3 with the toothpaste, and just brush the teeth normally.

Example 7

The present embodiment provides an attapulgite oral cleaning product, and its preparation steps are as follows: take 18 parts of attapulgite, 7 parts of table salt, 1.5 parts of cyclodextrin, 8 parts of cocamidopropyl betaine, 1.2 parts of sodium citrate and 4 parts of peppermint oil were mixed evenly, and then 15 parts of glycerin and 45 parts of water were added to fully dissolve; 3.5 parts of enzymes and 6 parts of carrageenan were added to the solution in the step , stir evenly, and prepare attapulgite oral cleaning products.

When the product of this example is used as a mouthwash, add 14 times the volume of water to dilute it, gargle for 20-30s, spit it out, and repeat 2-3 times.

When the product of this embodiment is used in combination with toothpaste, squeeze it onto the toothbrush together with the toothpaste in a volume ratio of 1:5 with the toothpaste, and then brush the teeth normally.

Comparative Example 1

The present embodiment provides an oral cleaning product, the preparation steps of which are as follows: take 7.5 parts of table salt, 3 parts of cyclodextrin, 5 parts of cocamidopropyl betaine, 1.2 parts of sodium citrate, 3 parts of Mix peppermint oil evenly, then add 10 parts of glycerin and 40 parts of water to fully dissolve; then take 3 parts of enzymes and 5 parts of carboxymethyl cellulose, add them to the solution in the step, stir evenly, and prepare concave-convex Stick soil oral cleaning supplies.

When the product of this comparative example is used as a mouthwash, add 15 times the volume of water to dilute the product, gargle for 20-30s, spit it out, and repeat 2-3 times.

When the product of this embodiment is used in combination with toothpaste, squeeze it onto the toothbrush together with the toothpaste in a volume ratio of 1:4 with the toothpaste, and then brush the teeth normally.

Comparative Example 2

The present embodiment provides an oral cleaning product, the preparation steps of which are as follows: take 15 parts of attapulgite, 7.5 parts of table salt, 3 parts of cyclodextrin, 5 parts of cocamidopropyl betaine, 1.2 parts of Mix sodium citrate and 3 parts of peppermint oil evenly, then add 10 parts of glycerin and 40 parts of water to fully dissolve; then take 5 parts of carboxymethyl cellulose, add it to the solution in the step, stir evenly, and prepare Get attapulgite oral hygiene products.

When the product of this example is used as a mouthwash, add 15 times the volume of water to dilute the product, rinse the mouth for 20-30s, spit it out, and repeat 2-3 times.

When the product of this embodiment is used in combination with toothpaste, squeeze it onto the toothbrush together with the toothpaste in a volume ratio of 1:4 with the toothpaste, and then brush the teeth normally.

Comparative Example 3

The present embodiment provides an oral cleaning product, the preparation steps of which are as follows: take 15 parts of attapulgite, 7.5 parts of table salt, 3 parts of cyclodextrin, 5 parts of cocamidopropyl betaine, 1.2 parts of Sodium citrate and 3 parts of peppermint oil are mixed evenly, then 40 parts of water are added to fully dissolve; then 3 parts of enzymes and 5 parts of carboxymethyl cellulose are added to the solution in the step, stirred evenly, and prepared Get attapulgite oral hygiene products.

When the product of this example is used as a mouthwash, add 15 times the volume of water to dilute the product, rinse the mouth for 20-30s, spit it out, and repeat 2-3 times.

When the product of this embodiment is used in combination with toothpaste, squeeze it onto the toothbrush together with the toothpaste in a volume ratio of 1:4 with the toothpaste, and then brush the teeth normally.

Comparative Example 4

The present embodiment provides an oral cleaning product, the preparation steps of which are as follows: take 15 parts of attapulgite, 3 parts of cyclodextrin, 5 parts of cocamidopropyl betaine, 1.2 parts of sodium citrate, 3 parts of Mix 10 parts of peppermint oil evenly, then add 10 parts of glycerin and 40 parts of water to fully dissolve; then take 3 parts of enzymes and 5 parts of carboxymethyl cellulose, add them to the solution in the step, stir evenly, and prepare Get attapulgite oral hygiene products.

When the product of this example is used as a mouthwash, add 15 times the volume of water to dilute the product, rinse the mouth for 20-30s, spit it out, and repeat 2-3 times.

When the product of this embodiment is used in combination with toothpaste, squeeze it onto the toothbrush together with the toothpaste in a volume ratio of 1:4 with the toothpaste, and then brush the teeth normally.

Experiment 1: For the examples and comparative examples of the present invention and the two existing mouthwashes on the market (the main formula components are water, glycerol, sorbitol, ethanol, tea extract, propolis extract, citric acid, sodium citrate and Caprylyl glycol) to test the degree of cleaning.

For each example, comparative example and two selected mouthwash products in this experiment, 10 volunteers aged 23-27 were randomly selected for postprandial oral cleanliness test and comfort test (the test results were divided into refreshing and comfortable and uncomfortable two).

In this experiment, the control of the mouthwash group was water; the control of the combination group with toothpaste was toothpaste; the rinsing time of each product was 30s, and the number of rinsing was 2 times.

Note: In the above experiment, when experimenting with the toothpaste combination group, the examples 1-7 were squeezed onto the toothpaste in a volume ratio of 1:4 with the toothpaste, and the teeth were brushed normally.

According to the test results of Experiment 1, it can be known that the attapulgite oral cleaning product provided by the present invention can bring a refreshing and comfortable taste, and has a strong ability to remove food debris, especially food fibers, left in the oral cavity after meals. Therefore, the attapulgite oral cleaning product of the present invention can achieve deep cleaning of the oral cavity. It can also be seen from the experimental results that the best embodiment of the present invention is Embodiment 5.

Experiment 2:

The patient brushes his teeth with the attapulgite oral cleaning product of Example 5 and toothpaste in the morning and evening, and rinses his mouth with the mouthwash mixed with the attapulgite oral cleaning product of Example 5 after meals, and carries out the efficacy test after two weeks.

According to the test results of Experiment 2, the attapulgite oral cleaning product of the present invention has a certain improvement effect on the problems of gums and teeth, and has obvious curative effect on the problem of bad breath. The invention mainly realizes the nursing effect on the oral cavity through deep cleaning and thorough cleaning of the oral cavity, and has a long-term effect on the prevention of oral diseases.

It can be seen from the above examples that the present invention provides an attapulgite oral cleaning product and its preparation method and application, especially the postprandial oral cleaning product and its preparation method and application, and its use as a toothpaste additive. Applications. The interaction between the components of the attapulgite oral cleaning product provided by the present invention can deeply clean the oral cavity, and has the functions of thoroughly cleaning the oral cavity and protecting the oral health for a long time.

The above are only the preferred embodiments of the present invention. It should be pointed out that for those skilled in the art, without departing from the principles of the present invention, several improvements and modifications can be made. It should be regarded as the protection scope of the present invention.

Claims (10)

1. The attapulgite oral cleaning product is characterized by comprising, by weight, 10-20 parts of attapulgite, 1-5 parts of enzymes, 5-10 parts of salt, 8-15 parts of glycerol, 1-5 parts of cyclodextrin, 2-8 parts of cocamidopropyl betaine, 1-1.5 parts of sodium citrate, 2-8 parts of a thickening agent, 2-4 parts of a flavoring agent and 30-50 parts of water.

2. The attapulgite oral cavity cleaning article as claimed in claim 1, wherein the particle size of the attapulgite is in the range of 50-100nm, 200-500nm and 800-1000 nm.

3. The attapulgite oral cleaning product according to claim 2, wherein the attapulgite has a particle size ratio of 1-3:5-7:1-2 in each range.

4. The oral cleaning product of claim 1, wherein the enzyme is one or a mixture of two or more of protease, cellulase and amylase.

5. The method for preparing an attapulgite oral cleaning product according to any one of claims 1 to 4, comprising the steps of:

uniformly mixing 10-20 parts of attapulgite, 5-10 parts of salt, 1-5 parts of cyclodextrin, 2-8 parts of cocamidopropyl betaine, 1-1.5 parts of sodium citrate and 2-4 parts of flavoring agent, adding 8-15 parts of glycerol and 30-50 parts of water, and fully dissolving;

and (2) adding 1-5 parts of enzyme and 2-8 parts of thickening agent into the solution obtained in the step (1), and uniformly stirring to obtain the attapulgite oral cleaning product.

6. Use of the attapulgite clay oral cleaning product of claim 5 as a mouthwash.

7. The use of claim 6, wherein the oral cleaning article is used as a mouthwash by adding an amount of water in the range of 10 to 20 times the volume of the oral cleaning article and mixing thoroughly to obtain the mouthwash.

8. The use of claim 7, wherein the mouthwash is applied by rinsing for 20-30 seconds, repeated 2-3 times.

9. Use of the attapulgite clay oral cleaning product of claim 5 in combination with toothpaste.

10. The use according to claim 9 wherein the attapulgite oral cleaning product is mixed with toothpaste in a ratio of 1: 3-5 volume ratio.