CN111065731B - 血管类器官、产生和使用所述类器官的方法 - Google Patents
血管类器官、产生和使用所述类器官的方法 Download PDFInfo
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- CN111065731B CN111065731B CN201880040207.8A CN201880040207A CN111065731B CN 111065731 B CN111065731 B CN 111065731B CN 201880040207 A CN201880040207 A CN 201880040207A CN 111065731 B CN111065731 B CN 111065731B
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/069—Vascular Endothelial cells
- C12N5/0691—Vascular smooth muscle cells; 3D culture thereof, e.g. models of blood vessels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
- A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/165—Vascular endothelial growth factor [VEGF]
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/54—Collagen; Gelatin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Vascular Medicine (AREA)
- Developmental Biology & Embryology (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- General Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Gynecology & Obstetrics (AREA)
- Immunology (AREA)
- Virology (AREA)
- Materials For Medical Uses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Prostheses (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17176335 | 2017-06-16 | ||
| EP17176335.2 | 2017-06-16 | ||
| PCT/EP2018/065949 WO2018229251A1 (fr) | 2017-06-16 | 2018-06-15 | Organoïde de vaisseau sanguin, procédés de production et d'utilisation desdits organoïdes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111065731A CN111065731A (zh) | 2020-04-24 |
| CN111065731B true CN111065731B (zh) | 2024-03-12 |
Family
ID=59239786
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880040207.8A Active CN111065731B (zh) | 2017-06-16 | 2018-06-15 | 血管类器官、产生和使用所述类器官的方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20200199541A1 (fr) |
| EP (1) | EP3638773A1 (fr) |
| JP (2) | JP2020523027A (fr) |
| KR (1) | KR102656200B1 (fr) |
| CN (1) | CN111065731B (fr) |
| AU (2) | AU2018285579B2 (fr) |
| CA (1) | CA3066959A1 (fr) |
| WO (1) | WO2018229251A1 (fr) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011140441A2 (fr) | 2010-05-06 | 2011-11-10 | Children's Hospital Medical Center | Procédés et systèmes de conversion de cellules précurseurs en tissus intestinaux par différenciation dirigée |
| EP3712254A1 (fr) | 2014-05-28 | 2020-09-23 | Children's Hospital Medical Center | Procédés et systèmes de conversion de cellules précurseurs dans des tissus gastriques à travers la différenciation dirigée |
| SG11201903697WA (en) | 2016-11-04 | 2019-05-30 | Childrens Hospital Med Ct | Liver organoid compositions and methods of making and using same |
| EP3609997A4 (fr) | 2017-04-14 | 2021-03-03 | Children's Hospital Medical Center | Compositions de cellules souches issues de multiples cellules donneuses et leurs procédés de préparation |
| US12297457B2 (en) | 2017-10-10 | 2025-05-13 | Children's Hospital Medical Center | Esophageal tissue and/or organoid compositions and methods of making same |
| EP3727394A4 (fr) | 2017-12-21 | 2021-09-08 | Children's Hospital Medical Center | Organoïdes humains numérisés et méthodes d'utilisation de ceux-ci |
| US12421500B2 (en) | 2018-07-26 | 2025-09-23 | Children's Hospital Medical Center | Hepato-biliary-pancreatic tissues and methods of making same |
| JP2021535753A (ja) | 2018-09-12 | 2021-12-23 | チルドレンズ ホスピタル メディカル センター | 造血幹細胞およびその派生体の生成のためのオルガノイド組成物 |
| CN111494711B (zh) * | 2019-01-31 | 2023-06-23 | 华东理工大学 | 干细胞发生器产生的干细胞用于治疗造血损伤 |
| WO2020160371A1 (fr) | 2019-02-01 | 2020-08-06 | The University Of Hong Kong | Compositions d'organoïdes innervés et leurs procédés de fabrication |
| CN113631034B (zh) * | 2019-03-29 | 2024-04-26 | 公立大学法人横滨市立大学 | 基质组合物 |
| JPWO2020217409A1 (fr) * | 2019-04-25 | 2020-10-29 | ||
| CN114174494A (zh) | 2019-05-31 | 2022-03-11 | 儿童医院医学中心 | 产生和扩增造血干细胞的方法 |
| CA3141814A1 (fr) | 2019-05-31 | 2020-12-03 | Children's Hospital Medical Center | Compositions organoides faconnees et leurs procedes de fabrication |
| CA3140249A1 (fr) * | 2019-06-24 | 2020-12-30 | Upm-Kymmene Corporation | Composition de cellules transplantables comprenant des cellules eucaryotes dans un hydrogel de cellulose nanofibrillaire, son procede de preparation et utilisation de cellulose na nofibrillaire |
| KR102218303B1 (ko) * | 2019-08-26 | 2021-02-23 | 연세대학교 산학협력단 | 혈관 조직을 포함하는 오가노이드의 제조 방법 및 이의 용도 |
| EP3884957A1 (fr) * | 2020-03-26 | 2021-09-29 | The University of British Columbia | Procédés de traitement de virus et procédés de criblage de réactif anti-virus à l'aide d'organoïdes |
| CA3182887A1 (fr) * | 2020-05-13 | 2021-11-18 | Pfizer Inc. | Methodes, therapies et utilisations pour le traitement du cancer |
| EP4222246A1 (fr) * | 2020-09-30 | 2023-08-09 | Corning Incorporated | Récipients de culture contenant des substrats de culture cellulaire 3d avec des structures de diffusion |
| JP7808832B2 (ja) * | 2021-04-20 | 2026-01-30 | 国立大学法人東京農工大学 | ネコ乳腺腫瘍オルガノイド培地用組成物及びネコ乳腺腫瘍オルガノイドの製造方法 |
| WO2023286832A1 (fr) * | 2021-07-15 | 2023-01-19 | アステラス製薬株式会社 | Cellules de type péricyte exprimant le facteur de croissance endothéliale vasculaire (vegf) à un niveau élevé |
| WO2023286834A1 (fr) * | 2021-07-15 | 2023-01-19 | アステラス製薬株式会社 | Cellule de type péricyte exprimant le facteur de croissance endothéliale vasculaire (vegf) à un niveau élevé |
| US20250145961A1 (en) * | 2022-02-15 | 2025-05-08 | The University Of Birmingham | Generating bone marrow organoids |
| CN114540278B (zh) * | 2022-03-25 | 2023-11-21 | 青岛大学 | 微血管体外培养方法及培养液 |
| CN116203237B (zh) * | 2022-12-05 | 2026-03-27 | 中国人民解放军陆军军医大学第一附属医院 | 一种用于检测周细胞的特异性单重生物标志物ndufa4l2及其应用 |
| CN116376809A (zh) * | 2023-04-24 | 2023-07-04 | 辽宁博奥晶典启衡颐加生物工程有限公司 | 一种血管化肠类器官的制备方法及应用 |
| CN116875535B (zh) * | 2023-07-19 | 2024-07-12 | 首都医科大学附属北京天坛医院 | 一种烟雾病血管类器官模型及其构建方法 |
| KR20250062598A (ko) * | 2023-10-31 | 2025-05-08 | 서울대학교산학협력단 | 내분비 오가노이드 이식용 혈관화 시스템 |
| CN118718096A (zh) * | 2024-05-29 | 2024-10-01 | 广东省人民医院 | 一种胰岛细胞外基质支架及其仿生胰岛类器官的制备方法和应用 |
| CN120137886A (zh) * | 2025-03-07 | 2025-06-13 | 南京医科大学 | 一种模拟寄生虫感染的血管类器官模型及其应用 |
| CN120519372B (zh) * | 2025-07-23 | 2026-04-03 | 国科大杭州高等研究院 | 基于人多能干细胞诱导的静脉血管类器官及其构建方法 |
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2018
- 2018-06-15 AU AU2018285579A patent/AU2018285579B2/en active Active
- 2018-06-15 US US16/623,319 patent/US20200199541A1/en active Pending
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- 2018-06-15 CN CN201880040207.8A patent/CN111065731B/zh active Active
- 2018-06-15 KR KR1020197036235A patent/KR102656200B1/ko active Active
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| KR20200018779A (ko) | 2020-02-20 |
| US20200199541A1 (en) | 2020-06-25 |
| AU2018285579B2 (en) | 2024-10-24 |
| JP2023126246A (ja) | 2023-09-07 |
| JP2020523027A (ja) | 2020-08-06 |
| CA3066959A1 (fr) | 2018-12-20 |
| WO2018229251A1 (fr) | 2018-12-20 |
| CN111065731A (zh) | 2020-04-24 |
| AU2025200408A1 (en) | 2025-03-27 |
| AU2018285579A1 (en) | 2019-12-12 |
| KR102656200B1 (ko) | 2024-04-12 |
| EP3638773A1 (fr) | 2020-04-22 |
| WO2018229251A9 (fr) | 2019-12-19 |
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