CN112741836A - 用于运动机能亢进性运动障碍的治疗的vmat2抑制剂 - Google Patents

用于运动机能亢进性运动障碍的治疗的vmat2抑制剂 Download PDF

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Publication number
CN112741836A
CN112741836A CN202011483141.5A CN202011483141A CN112741836A CN 112741836 A CN112741836 A CN 112741836A CN 202011483141 A CN202011483141 A CN 202011483141A CN 112741836 A CN112741836 A CN 112741836A
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China
Prior art keywords
htbz
isoquinolin
pyrido
hexahydro
dimethoxy
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Pending
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CN202011483141.5A
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English (en)
Chinese (zh)
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克里斯托弗·F·奥布赖恩
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Neurocrine Biosciences Inc
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Neurocrine Biosciences Inc
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Publication of CN112741836A publication Critical patent/CN112741836A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychology (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CN202011483141.5A 2014-05-06 2015-05-06 用于运动机能亢进性运动障碍的治疗的vmat2抑制剂 Pending CN112741836A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461989240P 2014-05-06 2014-05-06
US61/989,240 2014-05-06
CN201580023821.XA CN106456629A (zh) 2014-05-06 2015-05-06 用于运动机能亢进性运动障碍的治疗的vmat2抑制剂

Related Parent Applications (1)

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CN201580023821.XA Division CN106456629A (zh) 2014-05-06 2015-05-06 用于运动机能亢进性运动障碍的治疗的vmat2抑制剂

Publications (1)

Publication Number Publication Date
CN112741836A true CN112741836A (zh) 2021-05-04

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CN202011483141.5A Pending CN112741836A (zh) 2014-05-06 2015-05-06 用于运动机能亢进性运动障碍的治疗的vmat2抑制剂
CN201580023821.XA Pending CN106456629A (zh) 2014-05-06 2015-05-06 用于运动机能亢进性运动障碍的治疗的vmat2抑制剂
CN202011483135.XA Pending CN112741835A (zh) 2014-05-06 2015-05-06 用于运动机能亢进性运动障碍的治疗的vmat2抑制剂

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CN201580023821.XA Pending CN106456629A (zh) 2014-05-06 2015-05-06 用于运动机能亢进性运动障碍的治疗的vmat2抑制剂
CN202011483135.XA Pending CN112741835A (zh) 2014-05-06 2015-05-06 用于运动机能亢进性运动障碍的治疗的vmat2抑制剂

Country Status (24)

Country Link
US (3) US20170071932A1 (2)
EP (3) EP4389227A3 (2)
JP (4) JP6635945B2 (2)
KR (5) KR20240011255A (2)
CN (3) CN112741836A (2)
AU (1) AU2015256012B2 (2)
CA (1) CA2947736C (2)
CY (1) CY1125058T1 (2)
DK (2) DK3139925T3 (2)
ES (2) ES2976207T3 (2)
FI (1) FI3936130T3 (2)
HR (2) HRP20220025T1 (2)
HU (2) HUE057839T2 (2)
IL (1) IL248745B (2)
LT (2) LT3936130T (2)
MX (1) MX387625B (2)
NZ (1) NZ725826A (2)
PL (2) PL3936130T3 (2)
PT (2) PT3936130T (2)
RS (2) RS62782B1 (2)
RU (1) RU2753740C2 (2)
SI (2) SI3139925T1 (2)
SM (2) SMT202400199T1 (2)
WO (1) WO2015171802A1 (2)

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JP6869988B2 (ja) 2015-12-23 2021-05-12 ニューロクライン バイオサイエンシーズ，インコーポレイテッド （Ｓ）−（２Ｒ，３Ｒ，１１ｂＲ）−３−イソブチル−９，１０−ジメトキシ−２，３，４，６，７，１１ｂ−ヘキサヒドロ−１Ｈ−ピリド［２，１−ａ］イソキノリン−２−イル２−アミノ−３−メチルブタノエートジ（４−メチルベンゼンスルホネート）の調製のための合成方法
US10442800B2 (en) 2016-06-29 2019-10-15 Crystal Pharmaceutical (Suzhou) Co., Ltd. Crystal forms of NBI-98854, preparation method and use thereof
WO2018102673A1 (en) * 2016-12-02 2018-06-07 Neurocrine Biosciences, Inc. Use of valbenazine for treating schizophrenia or schizoaffective disorder
US10703750B2 (en) 2017-01-10 2020-07-07 Sandoz Ag Crystalline valbenazine free base
CA3051830A1 (en) 2017-01-27 2018-08-02 Neurocrine Bioscienes, Inc. Methods for the administration of certain vmat2 inhibitors
EP3585787A1 (en) 2017-02-27 2020-01-01 Sandoz AG Crystalline forms of valbenazine salts
WO2018164996A1 (en) * 2017-03-06 2018-09-13 Neurocrine Biosciences, Inc. Dosing regimen for valbenazine
GB201705303D0 (en) 2017-04-01 2017-05-17 Adeptio Pharmaceuticals Ltd Pharmaceutical compositions
GB201705304D0 (en) 2017-04-01 2017-05-17 Adeptio Pharmaceuticals Ltd Pharmaceutical compositions
GB201705306D0 (en) 2017-04-01 2017-05-17 Adeptio Pharmaceuticals Ltd Pharmaceutical compositions
CN110678181A (zh) * 2017-04-01 2020-01-10 阿德普蒂奥制药有限公司 (+)-α-二氢丁苯那嗪在治疗运动障碍中的用途
US20190111035A1 (en) * 2017-04-01 2019-04-18 Adeptio Pharmaceuticals Limited Pharmaceutical compositions
GB201705305D0 (en) * 2017-04-01 2017-05-17 Adeptio Pharmaceuticals Ltd Pharmaceutical compositions
GB201705302D0 (en) 2017-04-01 2017-05-17 Adeptio Pharmaceuticals Ltd Pharmaceutical compositions
AU2018241940B2 (en) * 2017-04-01 2023-09-28 Adeptio Pharmaceuticals Limited Dihydrotetrabenazine for use in the treatment a movement disorder
WO2018200605A1 (en) * 2017-04-26 2018-11-01 Neurocrine Biosciences, Inc. Use of valbenazine for treating levodopa-induced dyskinesia
CA3076000A1 (en) 2017-09-21 2019-03-28 Neurocrine Biosciences, Inc. High dosage valbenazine formulation and compositions, methods, and kits related thereto
JP2021502959A (ja) 2017-10-10 2021-02-04 ニューロクライン バイオサイエンシーズ，インコーポレイテッド 特定のｖｍａｔ２インヒビターを投与するための方法
KR20250070134A (ko) 2017-10-10 2025-05-20 뉴로크린 바이오사이언시즈 인코퍼레이티드 특정 vmat2 억제제의 투여 방법
SG11202004165UA (en) * 2017-11-08 2020-06-29 Yuhua Li Esters of dihydrotetrabenazine
JP7212958B2 (ja) 2017-12-26 2023-01-26 ▲蘇▼州科睿思制▲葯▼有限公司 バルベナジントシル酸塩の結晶形及びその製造方法並びに用途
CA3097189A1 (en) * 2018-04-25 2019-10-31 Shinkei Therapeutics Llc Tetrabenazine transdermal delivery device
GB201808464D0 (en) 2018-05-23 2018-07-11 Adeptio Pharmaceuticals Ltd Pharmaceutical compounds for use in treating huntington's disease
AU2019287524A1 (en) 2018-06-14 2020-12-24 Neurocrine Biosciences, Inc. VMAT2 inhibitor compounds, compositions, and methods relating thereto
MA53239A (fr) 2018-08-15 2022-05-04 Neurocrine Biosciences Inc Procédés d'administration de certains inhibiteurs de vmat2
EP3860599B1 (en) 2018-10-04 2024-05-15 Adeptio Pharmaceuticals Limited (+)-alpha-dihydrotetrabenazine dosage regimen for treating movement disorders
MA55893A (fr) * 2019-05-09 2022-03-16 Neurocrine Biosciences Inc Procédés d'administration de certains inhibiteurs de vmat2
US10940141B1 (en) 2019-08-23 2021-03-09 Neurocrine Biosciences, Inc. Methods for the administration of certain VMAT2 inhibitors

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IL248745A0 (en) 2017-01-31
AU2015256012B2 (en) 2020-07-23
RS62782B1 (sr) 2022-01-31
SI3936130T1 (sl) 2024-05-31
CN106456629A (zh) 2017-02-22
CA2947736C (en) 2023-04-18
RU2016147523A (ru) 2018-06-08
DK3936130T3 (da) 2024-03-25
KR20220140647A (ko) 2022-10-18
HUE066361T2 (hu) 2024-07-28
RU2753740C2 (ru) 2021-08-23
CA2947736A1 (en) 2015-11-12
EP3139925B1 (en) 2021-12-01
PL3936130T3 (pl) 2024-06-10
LT3936130T (lt) 2024-04-25
US20200101063A1 (en) 2020-04-02
MX387625B (es) 2025-03-18
PT3139925T (pt) 2022-01-26
KR20250029267A (ko) 2025-03-04
KR20160147044A (ko) 2016-12-21
CY1125058T1 (el) 2023-06-09
HRP20220025T1 (hr) 2022-04-01
EP3139925A1 (en) 2017-03-15
EP3936130A1 (en) 2022-01-12
EP3936130B1 (en) 2024-02-14
US20210196702A1 (en) 2021-07-01
PT3936130T (pt) 2024-04-17
RS65359B1 (sr) 2024-04-30
ES2976207T3 (es) 2024-07-26
US20170071932A1 (en) 2017-03-16
HUE057839T2 (hu) 2022-06-28
JP2024153782A (ja) 2024-10-29
HRP20240459T1 (hr) 2024-06-21
SMT202200193T1 (it) 2022-07-21
FI3936130T3 (fi) 2024-04-23
MX2016014429A (es) 2017-04-06
EP4389227A3 (en) 2024-09-04
NZ725826A (en) 2023-05-26
LT3139925T (lt) 2022-01-25
JP2019218407A (ja) 2019-12-26
WO2015171802A1 (en) 2015-11-12
JP2017514850A (ja) 2017-06-08
RU2016147523A3 (2) 2018-12-28
AU2015256012A1 (en) 2016-11-24
ES2904526T3 (es) 2022-04-05
KR20240011255A (ko) 2024-01-25
SMT202400199T1 (it) 2024-07-09
EP4389227A2 (en) 2024-06-26
JP2021191799A (ja) 2021-12-16
IL248745B (en) 2022-07-01
SI3139925T1 (sl) 2022-04-29
KR20200133003A (ko) 2020-11-25
CN112741835A (zh) 2021-05-04
DK3139925T3 (da) 2021-12-20
JP6635945B2 (ja) 2020-01-29
PL3139925T3 (pl) 2022-03-21

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