CN113025703A - 用于治疗、诊断和监控狼疮的方法 - Google Patents

用于治疗、诊断和监控狼疮的方法 Download PDF

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Publication number
CN113025703A
CN113025703A CN202110273784.5A CN202110273784A CN113025703A CN 113025703 A CN113025703 A CN 113025703A CN 202110273784 A CN202110273784 A CN 202110273784A CN 113025703 A CN113025703 A CN 113025703A
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China
Prior art keywords
variation
locus
lupus
subject
snp
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CN202110273784.5A
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English (en)
Chinese (zh)
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T·W·伯伦斯
R·R·格拉姆
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Hoffmann La Roche Inc
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Hoffmann La Roche Inc
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Priority claimed from CN201080055282.5A external-priority patent/CN102803509B/zh
Publication of CN113025703A publication Critical patent/CN113025703A/zh
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN202110273784.5A 2009-10-07 2010-10-06 用于治疗、诊断和监控狼疮的方法 Pending CN113025703A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27851009P 2009-10-07 2009-10-07
US61/278,510 2009-10-07
CN201080055282.5A CN102803509B (zh) 2009-10-07 2010-10-06 用于治疗、诊断和监控狼疮的方法

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201080055282.5A Division CN102803509B (zh) 2009-10-07 2010-10-06 用于治疗、诊断和监控狼疮的方法

Publications (1)

Publication Number Publication Date
CN113025703A true CN113025703A (zh) 2021-06-25

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CN202110273784.5A Pending CN113025703A (zh) 2009-10-07 2010-10-06 用于治疗、诊断和监控狼疮的方法
CN201611005880.7A Pending CN106929568A (zh) 2009-10-07 2010-10-06 用于治疗、诊断和监控狼疮的方法

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US (3) US20130034544A1 (2)
EP (3) EP2486152B1 (2)
JP (2) JP5937008B2 (2)
KR (2) KR101824744B1 (2)
CN (2) CN113025703A (2)
BR (1) BR112012007778A2 (2)
CA (1) CA2777055C (2)
RU (2) RU2596391C2 (2)
WO (1) WO2011044205A1 (2)

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CN113025703A (zh) * 2009-10-07 2021-06-25 弗·哈夫曼-拉罗切有限公司 用于治疗、诊断和监控狼疮的方法
US20130310266A1 (en) * 2010-09-03 2013-11-21 Immport Therapeutics, Inc. Methods and Compositions For The Diagnosis And Treatment Of Cancer and Autoimmune Disorders
KR20140034529A (ko) 2012-09-12 2014-03-20 삼성전기주식회사 전기 동도금 장치
KR101491214B1 (ko) * 2012-10-10 2015-02-06 가톨릭대학교 산학협력단 １ｑ２５．１(RABGAP1L) 위치, 6p21.32 (C4) 위치 및 １０ｑ２１．３위치의 ＤＮＡ 복제 수 변이 검출용 프라이머를 포함하는 전신성 홍반성 루푸스 발병 위험도 예측용 조성물
WO2014058254A1 (ko) * 2012-10-10 2014-04-17 가톨릭대학교 산학협력단 １ｑ２５．１(RABGAP1L) 위치, 6P21.32 (C4) 위치 및 １０ｑ２１．３위치의 ＤＮＡ 복제 수 변이 검출용 프라이머를 포함하는 전신성 홍반성 루푸스 발병 위험도 예측용 조성물
SG11201606843SA (en) * 2014-03-21 2016-10-28 Agency Science Tech & Res Fusion genes in cancer
DE102017107661A1 (de) 2017-04-10 2018-10-11 Universität Rostock SH2B-Adapterprotein-3 für die Vorhersage einer Knochenmarkantwort und Immunantwort
KR20190034511A (ko) 2019-03-22 2019-04-02 아주대학교산학협력단 Aimp1을 포함하는 전신 홍반성 루프스 진단용 바이오마커 조성물 및 이를 이용한 전신 홍반성 루프스 진단 방법
WO2021127589A1 (en) * 2019-12-18 2021-06-24 The Children's Hospital Of Philadelphia Novel druggable targets for the treatment of inflammatory diseases such as systemic lupus erythematosus (sle) and methods for diagnosis and treatment using the same
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Also Published As

Publication number Publication date
US20160273044A1 (en) 2016-09-22
CN106929568A (zh) 2017-07-07
RU2012118596A (ru) 2013-11-20
EP3219813A3 (en) 2018-01-10
CA2777055A1 (en) 2011-04-14
EP3839068A3 (en) 2021-10-20
JP2013507127A (ja) 2013-03-04
US20130034544A1 (en) 2013-02-07
EP2486152B1 (en) 2017-12-06
EP3219813A2 (en) 2017-09-20
KR20120100969A (ko) 2012-09-12
CN102803509A (zh) 2012-11-28
CA2777055C (en) 2021-04-06
EP3219813B1 (en) 2020-11-18
HK1176384A1 (zh) 2013-07-26
JP6321717B2 (ja) 2018-05-09
EP3839068A2 (en) 2021-06-23
RU2596391C2 (ru) 2016-09-10
EP2486152A1 (en) 2012-08-15
US10053734B2 (en) 2018-08-21
JP5937008B2 (ja) 2016-06-22
JP2017012158A (ja) 2017-01-19
US20190211398A1 (en) 2019-07-11
BR112012007778A2 (pt) 2020-08-11
KR20180012344A (ko) 2018-02-05
RU2016131167A (ru) 2018-12-07
KR101953075B1 (ko) 2019-02-27
EP2486152A4 (en) 2013-05-22
WO2011044205A1 (en) 2011-04-14
KR101824744B1 (ko) 2018-03-15

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Application publication date: 20210625