CN113827784A - Medical nano heat-non-conductive composite material and preparation method and application thereof - Google Patents
Medical nano heat-non-conductive composite material and preparation method and application thereof Download PDFInfo
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- CN113827784A CN113827784A CN202111133775.2A CN202111133775A CN113827784A CN 113827784 A CN113827784 A CN 113827784A CN 202111133775 A CN202111133775 A CN 202111133775A CN 113827784 A CN113827784 A CN 113827784A
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- 239000002131 composite material Substances 0.000 title claims abstract description 71
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 238000002679 ablation Methods 0.000 claims abstract description 50
- 239000004005 microsphere Substances 0.000 claims abstract description 43
- 108010022355 Fibroins Proteins 0.000 claims abstract description 30
- 229920000954 Polyglycolide Polymers 0.000 claims abstract description 22
- 235000018936 Vitellaria paradoxa Nutrition 0.000 claims abstract description 22
- 241001135917 Vitellaria paradoxa Species 0.000 claims abstract description 22
- 239000004633 polyglycolic acid Substances 0.000 claims abstract description 22
- -1 polytetrafluoroethylene Polymers 0.000 claims abstract description 22
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims abstract description 22
- 239000004810 polytetrafluoroethylene Substances 0.000 claims abstract description 22
- 239000000843 powder Substances 0.000 claims abstract description 22
- 229940057910 shea butter Drugs 0.000 claims abstract description 22
- 238000000034 method Methods 0.000 claims abstract description 9
- 239000000839 emulsion Substances 0.000 claims abstract description 8
- 239000012460 protein solution Substances 0.000 claims abstract description 8
- 238000003756 stirring Methods 0.000 claims description 12
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 8
- 239000011248 coating agent Substances 0.000 claims description 8
- 238000000576 coating method Methods 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 239000002245 particle Substances 0.000 claims description 6
- 238000005507 spraying Methods 0.000 claims description 6
- 239000005018 casein Substances 0.000 claims description 5
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims description 5
- 235000021240 caseins Nutrition 0.000 claims description 5
- 239000004408 titanium dioxide Substances 0.000 claims description 4
- 235000013399 edible fruits Nutrition 0.000 abstract description 9
- 229920005989 resin Polymers 0.000 abstract description 9
- 239000011347 resin Substances 0.000 abstract description 9
- 206010067484 Adverse reaction Diseases 0.000 abstract description 2
- 230000006838 adverse reaction Effects 0.000 abstract description 2
- 238000003745 diagnosis Methods 0.000 abstract description 2
- 201000010099 disease Diseases 0.000 abstract description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 230000017525 heat dissipation Effects 0.000 description 3
- 238000011161 development Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 238000010317 ablation therapy Methods 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L31/125—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/1815—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/005—Ingredients of undetermined constitution or reaction products thereof
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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- A—HUMAN NECESSITIES
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L31/125—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L31/129—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix containing macromolecular fillers
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
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Abstract
The invention discloses a medical nano heat-non-conductive composite material, a preparation method and application thereof, wherein the medical nano heat-non-conductive composite material contains polytetrafluoroethylene, polyglycolic acid, biological nano microspheres, silk fibroin powder and shea butter fruit resin, and does not aim at diagnosis or treatment of diseases. The medical nano heat-non-conductive composite material is prepared by adding the biological nano microspheres into silk fibroin protein solution prepared by silk fibroin protein powder and adding polyglycolic acid, shea butter fruit resin and polytetrafluoroethylene emulsion, has good heat-non-conductive performance, simultaneously has good biocompatibility, does not produce toxic action on human bodies, can inhibit bacteria, does not cause adverse reaction after being coated on a microwave ablation needle, can ensure that the needle body of the ablation needle cannot be overheated and burn healthy cells, can always keep the low-temperature characteristic, has the advantages of thin thickness, no occupation of overlarge space, simple process and suitability for industrial popularization and use.
Description
Technical Field
The invention belongs to the technical field of medical non-heat-conducting materials, and particularly relates to a medical nano non-heat-conducting composite material, and a preparation method and application thereof.
Background
With the continuous development of medical technology, microwave ablation needles for ablation therapy are continuously developed and improved, wherein the microwave ablation mainly utilizes an antenna to radiate microwaves to enable ions or polar water molecules in tissues to rotate, vibrate and rub with each other to generate a heat effect, so that a treatment area quickly reaches a high temperature, tumor cells are inactivated, and the purpose of treating tumors is further achieved. The existing microwave ablation needle is narrow in internal space, the heat dissipation structure arranged inside is complex, the heat dissipation efficiency is low, a built-in cable cannot be well cooled through heat dissipation, safety accidents of the microwave ablation needle are easily caused, and the development of the microwave ablation needle is limited.
Disclosure of Invention
In order to solve the problems in the prior art, the invention aims to provide a medical nano heat-non-conductive composite material, a preparation method and application thereof.
In order to achieve the purpose and achieve the technical effect, the invention adopts the technical scheme that:
a medical nanometer composite material without heat conduction comprises polytetrafluoroethylene, polyglycolic acid, biological nanometer microsphere, silk fibroin powder and shea butter fruit resin.
Further, the paint comprises the following components in parts by weight: 5-10 parts of polytetrafluoroethylene, 1-10 parts of polyglycolic acid, 1.2-18 parts of biological nano microspheres, 1-20 parts of silk fibroin powder and 0.1-2 parts of shea butter.
Furthermore, the particle size of the biological nano-microsphere is 140-200 nm.
Further, the biological nano-microspheres are casein nano-microspheres or titanium dioxide nano-microspheres.
The invention discloses a preparation method of a medical nano heat-non-conductive composite material, which comprises the following steps:
adding the biological nano microspheres into silk fibroin protein solution prepared from silk fibroin protein powder, uniformly stirring, then adding polyglycolic acid and shea butter, uniformly stirring again, adding polytetrafluoroethylene emulsion, and uniformly mixing to obtain the required medical nano heat-non-conductive composite material.
The invention discloses application of a medical nano heat-non-conductive composite material in a microwave ablation needle.
The invention discloses an application method of a medical nano heat-non-conductive composite material, which comprises the following steps:
coating or spraying the medical nano heat-non-conductive composite material on the inner wall and/or the surface of the needle body of the microwave ablation needle, or immersing the inner wall and/or the surface of the needle body of the microwave ablation needle in the medical nano heat-non-conductive composite material, standing for 10-35s, then taking out the microwave ablation needle, ensuring that the medical nano heat-non-conductive composite material is uniformly coated on the inner wall and/or the surface of the needle body of the microwave ablation needle, drying at 40-45 ℃, repeating the steps for 2-5 times, controlling the thickness of the medical nano heat-non-conductive composite material on the inner wall of the needle body of the microwave ablation needle to be within 920 mu m, and controlling the thickness of the medical nano heat-non-conductive composite material on the surface of the needle body of the microwave ablation needle to be within 1200 mu m.
Compared with the prior art, the invention has the beneficial effects that:
the invention discloses a medical nano heat-non-conductive composite material, a preparation method and application thereof, wherein the medical nano heat-non-conductive composite material contains five components of polytetrafluoroethylene, polyglycolic acid, biological nano microspheres, silk fibroin powder and shea butter fruit resin, and does not aim at diagnosis or treatment of diseases. The medical nano heat-non-conductive composite material is prepared by adding biological nano microspheres into silk fibroin protein solution prepared by silk fibroin protein powder and adding polyglycolic acid, shea butter fruit resin and polytetrafluoroethylene emulsion, has good heat-non-conductive performance, good biocompatibility, no toxic effect on human bodies and bacteriostasis, can not cause adverse reactions after being coated on a microwave ablation needle, can ensure that the needle body of the ablation needle cannot be overheated, can not burn healthy cells, can always keep the low-temperature characteristic, has the advantages of over-thin thickness and no occupation of too large space, has simple process, and is suitable for industrial popularization and use.
Detailed Description
The following detailed description of the embodiments of the present invention is provided to enable those skilled in the art to more easily understand the advantages and features of the present invention, and to clearly and clearly define the scope of the present invention.
A medical nano heat-non-conductive composite material contains five components of polytetrafluoroethylene, polyglycolic acid, biological nano microspheres, silk fibroin powder and shea butter fruit resin, and specifically comprises the following components in parts by weight: 5-10 parts of polytetrafluoroethylene, 1-10 parts of polyglycolic acid, 1.2-18 parts of biological nano microspheres, 1-20 parts of silk fibroin powder and 0.1-2 parts of shea butter.
The particle size of the biological nano-microsphere is 140-200nm, preferably, the biological nano-microsphere is casein nano-microsphere or titanium dioxide nano-microsphere
The invention discloses a preparation method of a medical nano heat-non-conductive composite material, which comprises the following steps:
adding the biological nano microspheres into silk fibroin protein solution prepared from silk fibroin protein powder, uniformly stirring, then adding polyglycolic acid and shea butter, uniformly stirring again, adding polytetrafluoroethylene emulsion, and uniformly mixing to obtain the required medical nano heat-non-conductive composite material.
The invention discloses application of a medical nano heat-non-conductive composite material in a microwave ablation needle.
The invention discloses an application method of a medical nano heat-non-conductive composite material, which comprises the following steps:
coating or spraying a medical nano heat-non-conductive composite material on the inner wall and/or surface of a microwave ablation needle body, or immersing the inner wall and/or surface of the microwave ablation needle body in the medical nano heat-non-conductive composite material, standing for 10-35s, then taking out the microwave ablation needle, ensuring that the medical nano heat-non-conductive composite material is uniformly coated on the inner wall and/or surface of the microwave ablation needle body, drying at 40-45 ℃, repeating the steps for 2-5 times, controlling the thickness of the medical nano heat-non-conductive composite material on the inner wall of the microwave ablation needle body within 920 mu m, and controlling the thickness of the medical nano heat-non-conductive composite material on the surface of the microwave ablation needle body within 1200 mu m.
Example 1
A medical nano heat-non-conductive composite material contains five components of polytetrafluoroethylene, polyglycolic acid, biological nano microspheres, silk fibroin powder and shea butter fruit resin, and specifically comprises the following components in parts by weight: 5 parts of polytetrafluoroethylene, 9 parts of polyglycolic acid, 16 parts of biological nano microspheres, 20 parts of silk fibroin powder and 2 parts of shea butter.
The particle size of the biological nano-microsphere is 160-180nm, and the biological nano-microsphere is casein nano-microsphere or nano hollow sphere.
A preparation method of a medical nano heat-non-conductive composite material comprises the following steps:
adding the biological nano microspheres into silk fibroin protein solution prepared from silk fibroin protein powder, uniformly stirring, then adding polyglycolic acid and shea butter, uniformly stirring again, adding polytetrafluoroethylene emulsion, and uniformly mixing to obtain the required medical nano heat-non-conductive composite material.
An application method of a medical nano heat-non-conductive composite material comprises the following steps:
coating or spraying the medical nano heat-non-conductive composite material on the inner wall or the surface of the needle body of the microwave ablation needle, or immersing the inner wall or the surface of the needle body of the microwave ablation needle in the medical nano heat-non-conductive composite material, standing for 30s, then taking out the microwave ablation needle, ensuring that the medical nano heat-non-conductive composite material is uniformly coated on the inner wall or the surface of the needle body of the microwave ablation needle, drying at 45 ℃, repeating the steps for 3 times, controlling the thickness of the medical nano heat-non-conductive composite material on the inner wall of the needle body of the microwave ablation needle to be 800 microns, and controlling the thickness of the medical nano heat-non-conductive composite material on the surface of the needle body of the microwave ablation needle to be 1000 microns.
Example 2
A medical nano heat-non-conductive composite material contains five components of polytetrafluoroethylene, polyglycolic acid, biological nano microspheres, silk fibroin powder and shea butter fruit resin, and specifically comprises the following components in parts by weight: 9 parts of polytetrafluoroethylene, 2 parts of polyglycolic acid, 1.2 parts of biological nano microspheres, 1 part of silk fibroin powder and 0.2 part of shea butter.
The particle size of the biological nano-microspheres is 170-185nm, and the biological nano-microspheres are casein nano-microspheres.
A preparation method of a medical nano heat-non-conductive composite material comprises the following steps:
adding the biological nano microspheres into silk fibroin protein solution prepared from silk fibroin protein powder, uniformly stirring, then adding polyglycolic acid and shea butter, uniformly stirring again, adding polytetrafluoroethylene emulsion, and uniformly mixing to obtain the required medical nano heat-non-conductive composite material.
An application method of a medical nano heat-non-conductive composite material comprises the following steps:
coating or spraying the medical nano heat-non-conductive composite material on the inner wall and the surface of the needle body of the microwave ablation needle, or immersing the inner wall and the surface of the needle body of the microwave ablation needle in the medical nano heat-non-conductive composite material, standing for 35s, then taking out the microwave ablation needle, ensuring that the medical nano heat-non-conductive composite material is uniformly coated on the inner wall and the surface of the needle body of the microwave ablation needle, drying at 40 ℃, repeating the steps for 5 times, controlling the thickness of the medical nano heat-non-conductive composite material on the inner wall of the needle body of the microwave ablation needle to be 900 microns, and controlling the thickness of the medical nano heat-non-conductive composite material on the surface of the needle body of the microwave ablation needle to be 1200 microns.
The same as in example 1.
Example 3
A medical nano heat-non-conductive composite material contains five components of polytetrafluoroethylene, polyglycolic acid, biological nano microspheres, silk fibroin powder and shea butter fruit resin, and specifically comprises the following components in parts by weight: 8 parts of polytetrafluoroethylene, 8 parts of polyglycolic acid, 10 parts of biological nano microspheres, 16 parts of silk fibroin powder and 1 part of shea butter.
The particle size of the biological nano-microspheres is 170nm, and the biological nano-microspheres are titanium dioxide nano-microspheres.
A preparation method of a medical nano heat-non-conductive composite material comprises the following steps:
adding the biological nano microspheres into silk fibroin protein solution prepared from silk fibroin protein powder, uniformly stirring, then adding polyglycolic acid and shea butter, uniformly stirring again, adding polytetrafluoroethylene emulsion, and uniformly mixing to obtain the required medical nano heat-non-conductive composite material.
An application method of a medical nano heat-non-conductive composite material comprises the following steps:
coating or spraying the medical nano heat-non-conductive composite material on the inner wall and/or the surface of the needle body of the microwave ablation needle, or immersing the inner wall and/or the surface of the needle body of the microwave ablation needle in the medical nano heat-non-conductive composite material, standing for 30s, then taking out the microwave ablation needle, ensuring that the medical nano heat-non-conductive composite material is uniformly coated on the inner wall and/or the surface of the needle body of the microwave ablation needle, drying at 45 ℃, repeating the steps for 3 times, controlling the thickness of the medical nano heat-non-conductive composite material on the inner wall of the needle body of the microwave ablation needle to be 600 mu m, and controlling the thickness of the medical nano heat-non-conductive composite material on the surface of the needle body of the microwave ablation needle to be 900 mu m.
The same as in example 1.
And (3) performance testing:
the performance test of the medical nano heat-non-conductive composite material coating on the microwave ablation needle obtained in the embodiment 1-3 shows that the coating of the embodiment 1-3 has good compactness, no shedding phenomenon and the like after bending, does not conduct heat, can keep the low-temperature characteristic of the body of the microwave ablation needle, and avoids medical safety accidents.
The parts of the invention not specifically described can be realized by adopting the prior art, and the details are not described herein.
The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications of equivalent structures and equivalent processes, which are made by the present specification, or directly or indirectly applied to other related technical fields, are included in the scope of the present invention.
Claims (7)
1. A medical nanometer heat-non-conductive composite material is characterized by comprising five components of polytetrafluoroethylene, polyglycolic acid, biological nanometer microspheres, silk fibroin protein powder and shea butter.
2. The medical nanometer heat-nonconducting composite material as claimed in claim 1, comprises the following components in parts by weight: 5-10 parts of polytetrafluoroethylene, 1-10 parts of polyglycolic acid, 1.2-18 parts of biological nano microspheres, 1-20 parts of silk fibroin powder and 0.1-2 parts of shea butter.
3. The medical nano heat-non-conductive composite material as claimed in claim 1 or 2, wherein the particle size of the bio-nano microsphere is 140-200 nm.
4. The medical nano heat-non-conductive composite material as claimed in claim 3, wherein the bio-nano microsphere is a casein nano microsphere or a titanium dioxide nano microsphere.
5. The preparation method of the medical nano heat-nonconducting composite material as claimed in any one of claims 1 to 4, comprising the steps of:
adding the biological nano microspheres into silk fibroin protein solution prepared from silk fibroin protein powder, uniformly stirring, then adding polyglycolic acid and shea butter, uniformly stirring again, adding polytetrafluoroethylene emulsion, and uniformly mixing to obtain the required medical nano heat-non-conductive composite material.
6. The use of a medical nano heat-non-conductive composite material according to any one of claims 1 to 4 in a microwave ablation needle.
7. The application method of the medical nano heat-nonconducting composite material as claimed in claim 6, comprising the steps of:
coating or spraying the medical nano heat-non-conductive composite material of any one of claims 1 to 4 on the inner wall and/or surface of the needle body of the microwave ablation needle, or immersing the inner wall and/or surface of the needle body of the microwave ablation needle in the medical nano heat-non-conductive composite material of any one of claims 1 to 4, standing for 10 to 35s, then taking out the microwave ablation needle, ensuring that the medical nano heat-non-conductive composite material uniformly covers the inner wall and/or surface of the needle body of the microwave ablation needle, drying at 40 to 45 ℃, repeating the steps for 2 to 5 times, controlling the thickness of the medical nano heat-non-conductive composite material on the inner wall of the needle body of the microwave ablation needle to be within 920 microns, and controlling the thickness of the medical nano heat-non-conductive composite material on the surface of the needle body of the microwave ablation needle to be within 1200 microns.
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