CN1138472C - 二肽型编程性细胞死亡抑制剂及其用途 - Google Patents

二肽型编程性细胞死亡抑制剂及其用途 Download PDF

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CN1138472C
CN1138472C CNB988100223A CN98810022A CN1138472C CN 1138472 C CN1138472 C CN 1138472C CN B988100223 A CNB988100223 A CN B988100223A CN 98810022 A CN98810022 A CN 98810022A CN 1138472 C CN1138472 C CN 1138472C
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cbz
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cell death
val
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CN1301131A (zh
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Jfw
J·F·W·克阿纳
蔡遂雄
J·古阿斯特拉
杨武
J·A·德里威
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Cytovia Therapeutics LLC
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    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
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    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
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    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
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    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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    • C12N2810/40—Vectors comprising a peptide as targeting moiety, e.g. a synthetic peptide, from undefined source

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CNB988100223A 1997-10-10 1998-10-09 二肽型编程性细胞死亡抑制剂及其用途 Expired - Fee Related CN1138472C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6167697P 1997-10-10 1997-10-10
US60/061,676 1997-10-10

Publications (2)

Publication Number Publication Date
CN1301131A CN1301131A (zh) 2001-06-27
CN1138472C true CN1138472C (zh) 2004-02-18

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CNB988100223A Expired - Fee Related CN1138472C (zh) 1997-10-10 1998-10-09 二肽型编程性细胞死亡抑制剂及其用途

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EP (1) EP1033910A4 (fr)
JP (1) JP4439111B2 (fr)
KR (1) KR100580333B1 (fr)
CN (1) CN1138472C (fr)
AU (1) AU741203B2 (fr)
BR (1) BR9814817A (fr)
CA (1) CA2306692C (fr)
EA (1) EA200000409A1 (fr)
NO (1) NO20001323L (fr)
WO (1) WO1999018781A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106317161A (zh) * 2015-06-29 2017-01-11 深圳翰宇药业股份有限公司 一种氟甲基酮肽系列化合物的制备方法

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KR20010041905A (ko) * 1998-03-16 2001-05-25 시토비아 인크. 디펩티드 카스파제 억제제 및 이의 용도
DE69932434D1 (de) 1998-05-29 2006-08-31 Mochida Pharm Co Ltd Prophylaxe und Behandlung von autoimmunen Entmyelinisierungserkrankungen durch Fas-antagonisten
US7488590B2 (en) 1998-10-23 2009-02-10 Amgen Inc. Modified peptides as therapeutic agents
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
MEP42108A (en) 1998-10-23 2011-02-10 Kiren Amgen Inc Dimeric thrombopoietin peptide mimetics binding to mp1 receptor and having thrombopoietic activity
WO2000044216A2 (fr) 1999-02-01 2000-08-03 Cytovia Inc Acide de gomme-gute,. analogues et derives en tant qu'activateurs de caspases et inducteurs d'apoptose
AU3876600A (en) 1999-03-16 2000-10-04 Cytovia, Inc. Substituted 2-aminobenzamide caspase inhibitors and the use thereof
US6355618B1 (en) * 1999-04-09 2002-03-12 Cytovia, Inc. Caspase inhibitors and the use thereof
US6495522B1 (en) 1999-08-27 2002-12-17 Cytovia, Inc. Substituted alpha-hydroxy acid caspase inhibitors and the use thereof
US6566338B1 (en) 1999-10-12 2003-05-20 Cytovia, Inc. Caspase inhibitors for the treatment and prevention of chemotherapy and radiation therapy induced cell death
US6303374B1 (en) 2000-01-18 2001-10-16 Isis Pharmaceuticals Inc. Antisense modulation of caspase 3 expression
DE10006889A1 (de) * 2000-02-16 2001-09-06 Procorde Gmbh Verwendung von Inhibitoren von Caspase-3 oder der Caspase-aktivierten Desoxyribonuclease (CAD) zur Behandlung von Herzerkrankungen
EP1923386A3 (fr) 2000-03-29 2008-05-28 Vertex Pharmceuticals Incorporated Dérivés de carbamates en tant qu'inhibiteurs de caspase et leurs utilisations
AU2001249619B2 (en) * 2000-03-29 2006-08-17 Vertex Pharmaceuticals Incorporated Carbamate caspase inhibitors and uses thereof
KR20020025959A (ko) 2000-05-23 2002-04-04 버텍스 파마슈티칼스 인코포레이티드 카스파제 억제제 및 이의 용도
US20020052323A1 (en) * 2000-08-30 2002-05-02 Jinhai Wang Quinoline-(C=O)-(multiple amino acids)-leaving group compounds for pharmaceutical compositions and reagents
CA2418720A1 (fr) 2000-09-13 2002-03-21 Vertex Pharmaceuticals Incorporated Inhibiteurs de caspase et leurs utilisations
WO2002022605A1 (fr) 2000-09-15 2002-03-21 Vertex Pharmaceuticals Incorporated Composes de pyrazole utiles comme inhibiteurs de proteine kinase
US7473691B2 (en) 2000-09-15 2009-01-06 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
US6660731B2 (en) 2000-09-15 2003-12-09 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
US6989385B2 (en) 2000-12-21 2006-01-24 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
US20030096737A1 (en) 2001-04-19 2003-05-22 Anita Diu-Hercend Caspase inhibitors and uses thereof
MY141867A (en) 2002-06-20 2010-07-16 Vertex Pharma Substituted pyrimidines useful as protein kinase inhibitors
CN1319968C (zh) 2002-08-02 2007-06-06 沃泰克斯药物股份有限公司 用作gsk－3的抑制剂的吡唑组合物
EP1549224A1 (fr) * 2002-10-10 2005-07-06 Becton Dickinson and Company Systeme collecteur d'echantillons avec inhibiteur de caspase
WO2006036834A2 (fr) 2004-09-24 2006-04-06 Amgen Inc. Molecules fc modifiees
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
MX2008005814A (es) 2005-11-03 2008-10-15 Vertex Pharma Aminopirimidinas utiles como inhibidores de cinasa.
JP5389785B2 (ja) 2007-05-02 2014-01-15 バーテックス ファーマシューティカルズ インコーポレイテッド キナーゼ阻害剤として有用なチアゾールおよびピラゾール
NZ582879A (en) 2007-07-31 2012-03-30 Vertex Pharma Process for preparing 5-fluoro-1h-pyrazolo [3, 4-b] pyridin-3-amine and derivatives thereof
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CN117045634B (zh) * 2022-05-06 2025-10-10 北京康蒂尼药业股份有限公司 一种二肽衍生物组合物及其制备方法和用途

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106317161A (zh) * 2015-06-29 2017-01-11 深圳翰宇药业股份有限公司 一种氟甲基酮肽系列化合物的制备方法
CN106317161B (zh) * 2015-06-29 2020-05-15 深圳翰宇药业股份有限公司 一种氟甲基酮肽系列化合物的制备方法

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KR20010031053A (ko) 2001-04-16
CA2306692A1 (fr) 1999-04-22
KR100580333B1 (ko) 2006-05-16
CA2306692C (fr) 2010-09-21
NO20001323L (no) 2000-06-13
AU741203B2 (en) 2001-11-22
EP1033910A4 (fr) 2004-11-24
NO20001323D0 (no) 2000-03-14
BR9814817A (pt) 2002-01-08
WO1999018781A1 (fr) 1999-04-22
JP2001519358A (ja) 2001-10-23
CN1301131A (zh) 2001-06-27
AU9793098A (en) 1999-05-03
JP4439111B2 (ja) 2010-03-24
EP1033910A1 (fr) 2000-09-13
EA200000409A1 (ru) 2000-10-30

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