CN114687071A - Medical wet dressing and preparation method thereof - Google Patents
Medical wet dressing and preparation method thereof Download PDFInfo
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- CN114687071A CN114687071A CN202210284073.2A CN202210284073A CN114687071A CN 114687071 A CN114687071 A CN 114687071A CN 202210284073 A CN202210284073 A CN 202210284073A CN 114687071 A CN114687071 A CN 114687071A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- 238000009987 spinning Methods 0.000 claims abstract description 79
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims abstract description 64
- 239000012528 membrane Substances 0.000 claims abstract description 51
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract description 42
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims abstract description 34
- 239000011787 zinc oxide Substances 0.000 claims abstract description 32
- 229920001661 Chitosan Polymers 0.000 claims abstract description 31
- 239000000725 suspension Substances 0.000 claims abstract description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
- 238000000034 method Methods 0.000 claims abstract description 20
- 238000010041 electrostatic spinning Methods 0.000 claims abstract description 19
- 238000002791 soaking Methods 0.000 claims abstract description 16
- 238000001035 drying Methods 0.000 claims abstract description 14
- 238000003756 stirring Methods 0.000 claims abstract description 13
- -1 polyoxyethylene Polymers 0.000 claims abstract description 9
- 230000008569 process Effects 0.000 claims abstract description 5
- 238000004132 cross linking Methods 0.000 claims description 16
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims description 10
- 238000004108 freeze drying Methods 0.000 claims description 8
- 238000001291 vacuum drying Methods 0.000 claims description 8
- 238000001523 electrospinning Methods 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 238000009210 therapy by ultrasound Methods 0.000 claims description 2
- 208000027418 Wounds and injury Diseases 0.000 abstract description 30
- 206010052428 Wound Diseases 0.000 abstract description 29
- 230000029663 wound healing Effects 0.000 abstract description 14
- 230000035876 healing Effects 0.000 abstract description 8
- 230000000694 effects Effects 0.000 abstract description 7
- 206010011409 Cross infection Diseases 0.000 abstract description 3
- 206010029803 Nosocomial infection Diseases 0.000 abstract description 3
- 239000000835 fiber Substances 0.000 description 26
- 230000000844 anti-bacterial effect Effects 0.000 description 14
- 239000007788 liquid Substances 0.000 description 9
- 238000012360 testing method Methods 0.000 description 9
- 230000009286 beneficial effect Effects 0.000 description 7
- 239000002121 nanofiber Substances 0.000 description 7
- 206010028980 Neoplasm Diseases 0.000 description 6
- 230000006750 UV protection Effects 0.000 description 6
- 239000002253 acid Substances 0.000 description 6
- 239000003513 alkali Substances 0.000 description 6
- 230000003110 anti-inflammatory effect Effects 0.000 description 6
- 230000001580 bacterial effect Effects 0.000 description 6
- 201000011510 cancer Diseases 0.000 description 6
- 230000007797 corrosion Effects 0.000 description 6
- 238000005260 corrosion Methods 0.000 description 6
- 230000023597 hemostasis Effects 0.000 description 6
- 230000036039 immunity Effects 0.000 description 6
- 150000002632 lipids Chemical class 0.000 description 6
- 230000014759 maintenance of location Effects 0.000 description 6
- 231100000956 nontoxicity Toxicity 0.000 description 6
- 230000035790 physiological processes and functions Effects 0.000 description 6
- 239000002994 raw material Substances 0.000 description 6
- 230000009467 reduction Effects 0.000 description 6
- 230000004224 protection Effects 0.000 description 5
- 241000283973 Oryctolagus cuniculus Species 0.000 description 4
- 210000000056 organ Anatomy 0.000 description 4
- 229920002101 Chitin Polymers 0.000 description 3
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 3
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 description 3
- 230000008827 biological function Effects 0.000 description 3
- 230000001276 controlling effect Effects 0.000 description 3
- 210000002744 extracellular matrix Anatomy 0.000 description 3
- 150000004676 glycans Chemical class 0.000 description 3
- 239000002085 irritant Substances 0.000 description 3
- 231100000021 irritant Toxicity 0.000 description 3
- 231100000252 nontoxic Toxicity 0.000 description 3
- 230000003000 nontoxic effect Effects 0.000 description 3
- 230000009965 odorless effect Effects 0.000 description 3
- 230000035699 permeability Effects 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 229920001282 polysaccharide Polymers 0.000 description 3
- 239000005017 polysaccharide Substances 0.000 description 3
- 239000004576 sand Substances 0.000 description 3
- 230000009967 tasteless effect Effects 0.000 description 3
- 230000002411 adverse Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 238000000527 sonication Methods 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000011587 new zealand white rabbit Methods 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Classifications
-
- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/70—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres
- D04H1/72—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged
- D04H1/728—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by electro-spinning
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F8/00—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof
- D01F8/04—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof from synthetic polymers
- D01F8/16—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof from synthetic polymers with at least one other macromolecular compound obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds as constituent
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F8/00—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof
- D01F8/18—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof from other substances
-
- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/40—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties
- D04H1/42—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties characterised by the use of certain kinds of fibres insofar as this use has no preponderant influence on the consolidation of the fleece
- D04H1/4282—Addition polymers
- D04H1/4291—Olefin series
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M11/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereof; Such treatment combined with mechanical treatment, e.g. mercerising
- D06M11/32—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereof; Such treatment combined with mechanical treatment, e.g. mercerising with oxygen, ozone, ozonides, oxides, hydroxides or percompounds; Salts derived from anions with an amphoteric element-oxygen bond
- D06M11/36—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereof; Such treatment combined with mechanical treatment, e.g. mercerising with oxygen, ozone, ozonides, oxides, hydroxides or percompounds; Salts derived from anions with an amphoteric element-oxygen bond with oxides, hydroxides or mixed oxides; with salts derived from anions with an amphoteric element-oxygen bond
- D06M11/44—Oxides or hydroxides of elements of Groups 2 or 12 of the Periodic Table; Zincates; Cadmates
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M13/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
- D06M13/10—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing oxygen
- D06M13/12—Aldehydes; Ketones
- D06M13/123—Polyaldehydes; Polyketones
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- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M16/00—Biochemical treatment of fibres, threads, yarns, fabrics, or fibrous goods made from such materials, e.g. enzymatic
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M2101/00—Chemical constitution of the fibres, threads, yarns, fabrics or fibrous goods made from such materials, to be treated
- D06M2101/16—Synthetic fibres, other than mineral fibres
- D06M2101/30—Synthetic polymers consisting of macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M2200/00—Functionality of the treatment composition and/or properties imparted to the textile material
- D06M2200/25—Resistance to light or sun, i.e. protection of the textile itself as well as UV shielding materials or treatment compositions therefor; Anti-yellowing treatments
-
- D—TEXTILES; PAPER
- D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B2401/00—Physical properties
- D10B2401/12—Physical properties biodegradable
-
- D—TEXTILES; PAPER
- D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B2401/00—Physical properties
- D10B2401/13—Physical properties anti-allergenic or anti-bacterial
-
- D—TEXTILES; PAPER
- D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B2509/00—Medical; Hygiene
- D10B2509/02—Bandages, dressings or absorbent pads
- D10B2509/022—Wound dressings
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- Engineering & Computer Science (AREA)
- Textile Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention provides a medical wet dressing and a preparation method thereof, and relates to the technical field of medical dressings. A preparation method of medical wet dressing comprises the following steps: adding chitosan and polyoxyethylene into an acetic acid solution, stirring for dissolving, and standing to obtain a spinning solution; adding the spinning solution into an injector, and performing electrostatic spinning to obtain a spinning membrane; adding water into medical zinc oxide to prepare a suspension, putting the spinning membrane into the suspension, soaking and ultrasonically treating, and then drying to obtain a finished product; the method has simple process, and the prepared product has good application effect. The moist dressing is prepared by the preparation method, and can effectively protect wound surfaces, provide a healing environment for wounds, promote wound healing and prevent cross infection.
Description
Technical Field
The invention relates to the technical field of medical dressings, in particular to a medical wet dressing and a preparation method thereof.
Background
The skin is an organ which is wrapped on the surface of the body and directly contacts with the external environment, has the functions of protecting, excreting, regulating body temperature, sensing external stimulation and the like, is also the largest organ in human body organs, and is also the organ which is most easily injured by the external environment. The skin has strong capability of repairing and regenerating, when the skin is wounded and skin tissues are separated or damaged, the skin can heal automatically, and in the healing process, the wound is easily infected by the outside, so that the wound surface needs to be protected by using the medical dressing. The traditional medical dressings mainly comprise gauze, bandages and the like, are relatively simple in production and processing processes, have the effect of rapidly absorbing wound exudate, but are often too high in permeability, so that the wound surface is easy to dehydrate, and the chance of cross infection is high; the wound dressing is usually used in a large amount, needs to be replaced frequently, can adhere to the wound surface, can cause secondary mechanical injury during replacement, increases the pain of a patient, can only play a role in physically protecting the wound, is poor in protection effect, and cannot promote the healing of the wound.
Disclosure of Invention
The invention aims to provide a medical wet dressing which can effectively protect a wound surface, provide a healing environment for a wound, promote the healing of the wound and prevent cross infection.
The invention also aims to provide a preparation method of the medical wet dressing, which has simple process and good use effect of the prepared product dressing.
The technical problem to be solved by the invention is realized by adopting the following technical scheme.
In one aspect, the embodiment of the present invention provides a method for preparing a medical wet dressing, which includes the following steps: adding chitosan and polyoxyethylene into an acetic acid solution, stirring for dissolving, and standing to obtain a spinning solution; adding the spinning solution into an injector, and performing electrostatic spinning to obtain a spinning membrane; adding water into medical zinc oxide to prepare a suspension, putting the spinning membrane into the suspension, soaking and ultrasonically treating, and then drying to obtain a finished product.
Further, in some embodiments of the present invention, the weight ratio of the chitosan to the polyethylene oxide is 7 to 9: 1.
further, in some embodiments of the present invention, chitosan and polyethylene oxide are added to 70% -90% acetic acid solution, dissolved with stirring and then left to stand, to obtain 3-5 wt% of spinning solution.
Further, in some embodiments of the present invention, the dope advancing rate during the electrospinning is 0.5 to 1.2 ml/h.
Further, in some embodiments of the invention, electrospinning is carried out at a working distance of 15-30cm at 15-30 kV.
Further, in some embodiments of the present invention, the method further comprises the following steps: and after the spinning membrane is obtained, crosslinking the spinning membrane for 4-12h by glutaraldehyde steam, and then drying.
Further, in some embodiments of the present invention, after the crosslinking treatment, the resin is dried in a vacuum oven at 25 to 40 ℃.
Further, in some embodiments of the present invention, 0.01 to 0.03 parts by weight of medical zinc oxide is added to 25 to 50 parts by weight of water and ultrasonically treated to form a suspension.
Further, in some embodiments of the invention, soaking and sonication is performed for 60min, followed by lyophilization at-20 ℃.
In another aspect, embodiments of the present invention provide a medical wet dressing, which is prepared by the above method for preparing a medical wet dressing.
Compared with the prior art, the embodiment of the invention has at least the following advantages or beneficial effects:
in a first aspect, embodiments of the present invention provide a medical moist dressing comprising the steps of: adding chitosan and polyoxyethylene into an acetic acid solution, stirring for dissolving, and standing to obtain a spinning solution; adding the spinning solution into an injector, and performing electrostatic spinning to obtain a spinning membrane; adding water into medical zinc oxide to prepare a suspension, putting the spinning membrane into the suspension, soaking and ultrasonically treating, and then drying to obtain a finished product.
The preparation method of the medical wet dressing takes chitosan and polyethylene oxide as main raw materials, and a spinning film is prepared by electrostatic spinning. Wherein, the chitosan is a product of natural polysaccharide chitin with partial acetyl removed, has multiple physiological functions of biodegradability, biocompatibility, nontoxicity, bacteriostasis, cancer resistance, lipid reduction, hemostasis, immunity enhancement and the like, also has excellent moisture retention, film forming property and fiber forming property, and has wide application prospect in the medical field; polyethylene oxide is a high-molecular polymer with high water solubility, is non-toxic and non-irritant, has good biocompatibility and fiber forming property, and is stable in property, resistant to bacterial corrosion, acid and alkali; the nano-scale fibrous membrane prepared by adopting the electrostatic spinning technology can simulate the structure and biological functions of natural extracellular matrix, has excellent characteristics of large specific surface area, porosity and the like, has good antibacterial capacity and liquid absorption, and can better protect wound surface and promote wound healing. And then adding water into medical zinc oxide to prepare turbid liquid, putting the prepared spinning membrane into the turbid liquid, and performing ultrasonic soaking to obtain the nanofiber membrane dressing compounded with the zinc oxide. The zinc oxide is odorless, tasteless, free of sand and stable in property, can provide broad-spectrum ultraviolet protection, has antibacterial and anti-inflammatory effects, and contributes to further improving the antibacterial protection performance of the product dressing. The whole preparation method is simple in flow, and the prepared product dressing can better protect the wound, promote the wound healing and is more beneficial to treatment and use.
In view of the second aspect, the embodiment of the invention provides a preparation method of a medical wet dressing, which is prepared by the preparation method of the medical wet dressing.
The medical wet dressing is prepared into a nano-scale fiber film by taking chitosan and polyethylene oxide as main raw materials, wherein the chitosan has multiple physiological functions of biodegradability, biocompatibility, nontoxicity, bacteriostasis, cancer resistance, lipid reduction, hemostasis, immunity enhancement and the like, and also has excellent moisture retention, film forming property and fiber forming property; the polyethylene oxide has good biocompatibility and fiber forming property, and meanwhile, the polyethylene oxide is stable in property, resistant to bacterial corrosion, acid and alkali; and the zinc oxide is compounded to provide broad-spectrum ultraviolet protection, so that the antibacterial and anti-inflammatory performance of the product dressing is further improved. The medical wet dressing can better protect the wound surface, absorb the wound surface seepage, provide a good healing environment for the wound, promote the wound healing, and is convenient and quick to use.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.
The embodiment of the invention provides a preparation method of a medical wet dressing, which comprises the following steps: adding chitosan and polyoxyethylene into an acetic acid solution, stirring for dissolving, and standing to obtain a spinning solution; adding the spinning solution into an injector, and performing electrostatic spinning to obtain a spinning membrane; adding water into medical zinc oxide to prepare a suspension, putting the spinning membrane into the suspension, soaking and ultrasonically treating, and then drying to obtain a finished product.
In the above examples, a spinning film was prepared by electrospinning using chitosan and polyethylene oxide as main raw materials. Wherein, the chitosan is a product of natural polysaccharide chitin with partial acetyl removed, has multiple physiological functions of biodegradability, biocompatibility, nontoxicity, bacteriostasis, cancer resistance, lipid reduction, hemostasis, immunity enhancement and the like, also has excellent moisture retention, film forming property and fiber forming property, and has wide application prospect in the medical field; polyethylene oxide is a high-molecular polymer with high water solubility, is non-toxic and non-irritant, has good biocompatibility and fiber forming property, and is stable in property, resistant to bacterial corrosion, acid and alkali; the nano-scale fibrous membrane prepared by adopting the electrostatic spinning technology can simulate the structure and biological functions of natural extracellular matrix, has excellent characteristics of large specific surface area, porosity and the like, has good antibacterial capacity and liquid absorption, and can better protect wound surface and promote wound healing. And then adding water into medical zinc oxide to prepare turbid liquid, putting the prepared spinning membrane into the turbid liquid, and performing ultrasonic soaking to obtain the nanofiber membrane dressing compounded with the zinc oxide. The zinc oxide is odorless, tasteless, free of sand and stable in property, can provide broad-spectrum ultraviolet protection, has antibacterial and anti-inflammatory effects, and contributes to further improving the antibacterial protection performance of the product dressing. The whole preparation method is simple in flow, and the prepared product dressing can better protect the wound, promote the wound healing and is more beneficial to treatment and use.
Further, in some embodiments of the present invention, the weight ratio of the chitosan to the polyethylene oxide is 7 to 9: 1.
in the embodiment, the beneficial effects of the chitosan and the polyoxyethylene can be better exerted by further controlling the dosage ratio of the chitosan and the polyoxyethylene, so that the ratio is more reasonable; by matching the chitosan and the polyoxyethylene, the quality of the prepared fibrous membrane wet dressing can be further improved, and the biocompatibility of the fibrous membrane wet dressing is enhanced, so that the protective effect of the fibrous membrane wet dressing on wounds is further enhanced, and the fibrous membrane wet dressing is more beneficial to treatment and use.
Further, in some embodiments of the present invention, chitosan and polyethylene oxide are added to 70% -90% acetic acid solution, dissolved with stirring and then left to stand, to obtain 3-5 wt% of spinning solution.
In the above embodiment, through controlling the concentration of the acetic acid that uses and the concentration of the spinning solution that obtains of preparing, the performance of the spinning solution that obtains of preparation that can be better to make things convenient for going on of follow-up electrostatic spinning step, can obtain high-quality fibre through electrostatic spinning more smoothly, thereby further promote the quality of product dressing, further promote its result of use.
Further, in some embodiments of the present invention, the dope advancing rate during the electrospinning is 0.5 to 1.2 ml/h.
In the embodiment, the propulsion speed of the spinning solution is controlled, so that the quality of fibers obtained by electrostatic spinning can be effectively improved, the fiber texture is more uniform, the use performance of product dressing is further improved, the appearance and uniformity of the fibers are prevented from being adversely affected due to the fact that the propulsion speed is not appropriate, and the spinning efficiency is also improved.
Further, in some embodiments of the invention, electrospinning is carried out at a working distance of 15-30cm at 15-30 kV.
In the embodiment, electrostatic spinning is carried out at 15-30kV and 15-30cm working distance, so that fibers with better appearance state and more uniform texture can be obtained, beaded or beaded fibers can be avoided, the quality of the obtained nano fibers can be further improved, the treatment effect of product dressing can be further improved, and the production and use are facilitated.
Further, in some embodiments of the present invention, the method further comprises the following steps: and after the spinning membrane is obtained, crosslinking the spinning membrane for 4-12h by glutaraldehyde steam, and then drying.
In the above embodiment, the cross-linking treatment is performed on the spinning membrane by using glutaraldehyde steam, and the time of the cross-linking treatment is controlled, so that the mechanical strength of the spinning membrane can be better improved by the cross-linking treatment, the water resistance of the spinning membrane can be further improved, the property of the spinning membrane is more stable, the fiber texture is more uniform, the distribution of the fiber texture is more regular, adverse effects on the product performance due to improper cross-linking time can be avoided, and the quality of the product dressing can be further improved.
Further, in some embodiments of the present invention, after the crosslinking treatment, the resin is dried in a vacuum oven at 25 to 40 ℃.
In the embodiment, the vacuum drying is carried out in the vacuum drying oven at the temperature of 25-40 ℃, so that residual glutaraldehyde in the cross-linking process can be removed, and redundant moisture in the obtained spinning film can be removed, so that the structure and the appearance of the fiber are kept stable, and the use performance of the product dressing is better guaranteed.
Further, in some embodiments of the present invention, 0.01 to 0.03 parts by weight of medical zinc oxide is added to 25 to 50 parts by weight of water and ultrasonically treated to form a suspension.
By controlling the dosage ratio of the medical zinc oxide to the water, the spinning film and the zinc oxide can be better compounded in the subsequent steps, so that the zinc oxide can better exert the beneficial effects of the zinc oxide, the antibacterial performance of the product dressing is further improved on the basis of not influencing the original performance of the spinning film, the quality of the product dressing is further improved, the service performance of the product dressing is further enhanced, and the treatment and the use are more facilitated.
Further, in some embodiments of the invention, soaking and sonication is performed for 60min, followed by lyophilization at-20 ℃.
In the embodiment, the zinc oxide can be better combined with the spinning membrane by soaking and ultrasonic treatment for 60min, so that the zinc oxide is uniformly distributed on the spinning membrane, and the zinc oxide can fully exert the antibacterial effect; through carrying out freeze drying at-20 ℃, redundant moisture can be better removed on the premise of maintaining the stability of the fiber structure, so that the performance of the product dressing is further improved, and the quality of the product dressing is improved.
The embodiment of the invention also provides the medical wet dressing which is prepared by the preparation method of the medical wet dressing.
In the above embodiment, chitosan and polyethylene oxide are used as main raw materials to prepare the nano-scale fiber membrane, wherein chitosan has multiple physiological functions of biodegradability, biocompatibility, nontoxicity, bacteriostasis, cancer resistance, lipid reduction, hemostasis, immunity enhancement and the like, and also has excellent moisture retention, film forming property and fiber forming property; the polyethylene oxide has good biocompatibility and fiber forming property, and meanwhile, the polyethylene oxide is stable in property, resistant to bacterial corrosion, acid and alkali; and the zinc oxide is compounded to provide broad-spectrum ultraviolet protection, so that the antibacterial and anti-inflammatory performance of the product dressing is further improved. The medical wet dressing can better protect the wound surface, absorb the wound surface seepage, provide a good healing environment for the wound, promote the wound healing, and is convenient and quick to use.
The features and properties of the present invention are described in further detail below with reference to examples.
Example 1
This example provides a medical moist dressing, which is prepared by the following method:
according to the weight ratio of 7: 1, adding chitosan and polyethylene oxide into 80% acetic acid solution, stirring to dissolve, and standing to obtain 3 wt% of spinning solution; adding the spinning solution into an injector, performing electrostatic spinning at a working distance of 15cm and a spinning solution advancing rate of 0.5ml/h at 30kV to obtain a spinning membrane, performing crosslinking treatment on the spinning membrane for 12 hours by glutaraldehyde steam, and then drying at 40 ℃ in a vacuum drying oven; taking 0.03g of medical zinc oxide, adding 40g of water to prepare a suspension, putting the spinning membrane into the suspension, soaking and ultrasonically treating for 60min, and then carrying out freeze drying at-20 ℃ to obtain a finished product.
Example 2
This example provides a medical moist dressing, which is prepared by the following method:
according to the weight ratio of 8: 1, adding chitosan and polyethylene oxide into a 90% acetic acid solution, stirring to dissolve, and standing to obtain a 5 wt% spinning solution; adding the spinning solution into an injector, performing electrostatic spinning at a working distance of 20cm and a spinning solution advancing rate of 1.0ml/h at 20kV to obtain a spinning membrane, performing crosslinking treatment on the spinning membrane for 10 hours by glutaraldehyde steam, and then drying at 35 ℃ in a vacuum drying oven; taking 0.03g of medical zinc oxide, adding 25g of water to prepare a suspension, putting the spinning membrane into the suspension, soaking and ultrasonically treating for 60min, and then carrying out freeze drying at-20 ℃ to obtain a finished product.
Example 3
This example provides a medical moist dressing, which is prepared by the following method:
according to the weight ratio of 7: 1, adding chitosan and polyethylene oxide into a 90% acetic acid solution, stirring to dissolve, and standing to obtain a 4 wt% spinning solution; adding the spinning solution into an injector, performing electrostatic spinning at a working distance of 15cm and a spinning solution advancing rate of 0.8ml/h at 25kV to obtain a spinning membrane, performing crosslinking treatment on the spinning membrane for 6 hours by glutaraldehyde steam, and then drying at 40 ℃ in a vacuum drying oven; taking 0.01g of medical zinc oxide, adding 25g of water to prepare a suspension, putting the spinning membrane into the suspension, soaking and ultrasonically treating for 60min, and then carrying out freeze drying at-20 ℃ to obtain a finished product.
Example 4
The embodiment provides a medical moist dressing, which is prepared by the following method:
according to the weight ratio of 8: 1, adding chitosan and polyethylene oxide into a 90% acetic acid solution, stirring to dissolve, and standing to obtain a 5 wt% spinning solution; adding the spinning solution into an injector, performing electrostatic spinning at a working distance of 20cm and a spinning solution advancing speed of 0.8ml/h under 15kV to obtain a spinning membrane, performing crosslinking treatment on the spinning membrane for 10 hours by glutaraldehyde steam, and then drying at 40 ℃ in a vacuum drying oven; taking 0.03g of medical zinc oxide, adding 40g of water to prepare a suspension, putting the spinning membrane into the suspension, soaking and ultrasonically treating for 60min, and then carrying out freeze drying at-20 ℃ to obtain a finished product.
Example 5
This example provides a medical moist dressing, which is prepared by the following method:
according to the weight ratio of 8: 1, adding chitosan and polyethylene oxide into a 90% acetic acid solution, stirring to dissolve, and standing to obtain a 5 wt% spinning solution; adding the spinning solution into an injector, performing electrostatic spinning at a working distance of 22cm and a spinning solution advancing rate of 0.7ml/h under 15kV to obtain a spinning membrane, performing crosslinking treatment on the spinning membrane for 8 hours by glutaraldehyde steam, and then drying at 35 ℃ in a vacuum drying oven; 0.02g of medical zinc oxide is taken and added with 35g of water to prepare suspension, the spinning membrane is put into the suspension, soaked and ultrasonically treated for 60min, and then freeze-dried at the temperature of minus 20 ℃ to prepare the finished product.
Test examples
The medical wet dressing provided by the embodiments 1 to 5 of the present invention was subjected to a performance test, and a comparison test was performed using a commercially available medical fiber dressing as a control group, wherein the test items and the test method were as follows:
air permeability: the test specimens were tested for breathability according to GB/T5453-1997;
and (3) testing mechanical properties: testing the breaking strength and the breaking elongation of the sample by an electronic single fiber strength tester;
wound healing test: 90 New Zealand white rabbits (2-2.5 kg) are selected and divided into 6 groups, 15 rabbits in each group are depilated with the back, the back of the white rabbit is slightly burned by II degrees after anesthesia, and then the medical moist dressing and the commercially available medical fiber auxiliary materials provided by the embodiments 1-5 of the invention are respectively used for six groups of white rabbits, and the wound healing conditions of the white rabbits in each group are observed after 10 days.
The test results are shown in table 1:
TABLE 1
| Group of | Air permeability (mm/s) | Breaking Strength (MPa) | Elongation at Break (%) | Wound healing Rate (%) |
| Control group | 59.24±4.08 | 2.01±0.41 | 2.61±0.45 | 86.7 |
| Example 1 | 68.21±3.15 | 1.92±0.33 | 2.45±0.34 | 88.1 |
| Example 2 | 70.42±2.89 | 2.15±0.41 | 2.81±0.28 | 93.2 |
| Example 3 | 72.14±3.11 | 2.42±0.35 | 3.83±0.21 | 89.6 |
| Example 4 | 71.28±2.19 | 1.98±0.64 | 2.52±0.38 | 94.3 |
| Example 5 | 72.21±4.12 | 2.82±0.41 | 4.12±0.18 | 96.2 |
According to tests, the medical wet dressing provided by the embodiment of the invention is obviously superior to the medical fiber auxiliary materials sold in the market in performance, and has an obvious wound healing effect.
In summary, in the medical wet dressing and the preparation method thereof provided by the embodiments of the present invention, in the preparation method, chitosan and polyethylene oxide are used as main raw materials, and a spinning film is prepared through electrostatic spinning. Wherein, the chitosan is a product of natural polysaccharide chitin with partial acetyl removed, has multiple physiological functions of biodegradability, biocompatibility, nontoxicity, bacteriostasis, cancer resistance, lipid reduction, hemostasis, immunity enhancement and the like, also has excellent moisture retention, film forming property and fiber forming property, and has wide application prospect in the medical field; polyethylene oxide is a high-molecular polymer with high water solubility, is non-toxic and non-irritant, has good biocompatibility and fiber forming property, and is stable in property, resistant to bacterial corrosion, acid and alkali; the nano-scale fibrous membrane prepared by adopting the electrostatic spinning technology can simulate the structure and biological functions of natural extracellular matrix, has excellent characteristics of large specific surface area, porosity and the like, has good antibacterial capacity and liquid absorption, and can better protect wound surface and promote wound healing. And then adding water into medical zinc oxide to prepare turbid liquid, putting the prepared spinning membrane into the turbid liquid, and performing ultrasonic soaking to obtain the nanofiber membrane dressing compounded with the zinc oxide. The zinc oxide is odorless, tasteless, free of sand and stable in property, can provide broad-spectrum ultraviolet protection, has antibacterial and anti-inflammatory effects, and contributes to further improving the antibacterial protection performance of the product dressing. The whole preparation method is simple in flow, and the prepared product dressing can better protect the wound, promote the wound healing and is more beneficial to treatment and use. The medical wet dressing is prepared into a nano-scale fiber film by taking chitosan and polyoxyethylene as main raw materials, wherein the chitosan has multiple physiological functions of biodegradability, biocompatibility, nontoxicity, bacteriostasis, cancer resistance, lipid reduction, hemostasis, immunity enhancement and the like, and also has excellent moisture retention, film forming property and fiber forming property; the polyethylene oxide has good biocompatibility and fiber forming property, and meanwhile, the polyethylene oxide is stable in property, resistant to bacterial corrosion, acid and alkali; and the zinc oxide is compounded to provide broad-spectrum ultraviolet protection, so that the antibacterial and anti-inflammatory performance of the product dressing is further improved. The medical wet dressing can better protect the wound surface, absorb wound surface seepage, provide a good healing environment for the wound, promote the wound healing, and is convenient and quick to use.
The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Claims (10)
1. The preparation method of the medical wet dressing is characterized by comprising the following steps: adding chitosan and polyoxyethylene into an acetic acid solution, stirring for dissolving, and standing to obtain a spinning solution; adding the spinning solution into an injector, and performing electrostatic spinning to obtain a spinning membrane; adding water into medical zinc oxide to prepare suspension, putting the spinning membrane into the suspension, soaking and ultrasonically treating, and then drying to obtain a finished product.
2. The method of making a medical wet dressing according to claim 1 wherein the weight ratio of the chitosan to the polyethylene oxide is 7-9: 1.
3. the method for preparing a medical wet dressing according to claim 1, wherein chitosan and polyethylene oxide are added to a 70% -90% acetic acid solution, dissolved with stirring and then left to stand to obtain a 3-5 wt% spinning solution.
4. The method for preparing a medical wet dressing according to claim 1, wherein the advancing rate of the spinning dope is 0.5 to 1.2ml/h during the electrospinning.
5. The method of producing a medical wet dressing according to claim 1, wherein the electrospinning is performed at a working distance of 15-30cm at 15-30 kV.
6. The method of making a medical moist dressing according to claim 1, further comprising the steps of: and after the spinning membrane is obtained, crosslinking the spinning membrane for 4-12h by glutaraldehyde steam, and then drying.
7. The process for producing a medical wet dressing according to claim 6, wherein the crosslinking treatment is followed by drying at 25 to 40 ℃ in a vacuum drying oven.
8. The method for preparing a medical wet dressing according to claim 1, wherein 0.01 to 0.03 parts by weight of medical zinc oxide is added to 25 to 50 parts by weight of water and ultrasonically treated to form a suspension.
9. The method for preparing a medical wet dressing according to claim 1, wherein the soaking and ultrasonic treatment is performed for 60min, and then the freeze-drying is performed at-20 ℃.
10. A medical moist dressing produced by the production method of the medical moist dressing according to any one of claims 1 to 9.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103394114A (en) * | 2013-07-03 | 2013-11-20 | 东华大学 | Method for preparing chitosan-based superfine fiber carrier material for medical dressing |
| CN104822366A (en) * | 2012-07-13 | 2015-08-05 | 塔夫茨大学 | Encapsulation of fragrances and/or flavoring agents in silk fibroin biomaterials |
| CN108478845A (en) * | 2018-03-30 | 2018-09-04 | 王敏 | A kind of preparation method of modified polyurethane prepolymer medical bandage |
| CN111424425A (en) * | 2020-05-09 | 2020-07-17 | 刘成刚 | Nano hemostatic and antibacterial composite material for vascular surgery and preparation method thereof |
-
2022
- 2022-03-22 CN CN202210284073.2A patent/CN114687071A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104822366A (en) * | 2012-07-13 | 2015-08-05 | 塔夫茨大学 | Encapsulation of fragrances and/or flavoring agents in silk fibroin biomaterials |
| CN103394114A (en) * | 2013-07-03 | 2013-11-20 | 东华大学 | Method for preparing chitosan-based superfine fiber carrier material for medical dressing |
| CN108478845A (en) * | 2018-03-30 | 2018-09-04 | 王敏 | A kind of preparation method of modified polyurethane prepolymer medical bandage |
| CN111424425A (en) * | 2020-05-09 | 2020-07-17 | 刘成刚 | Nano hemostatic and antibacterial composite material for vascular surgery and preparation method thereof |
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