CN114870066A

CN114870066A - Functional dressing for treating chronic wound surface, preparation and preparation method thereof

Info

Publication number: CN114870066A
Application number: CN202210420249.2A
Authority: CN
Inventors: 田耿家; 王晨鸣
Original assignee: Individual
Current assignee: Individual
Priority date: 2022-04-21
Filing date: 2022-04-21
Publication date: 2022-08-09

Abstract

The invention relates to a functional dressing for chronic wound treatment, a preparation and a preparation method thereof, wherein the functional dressing for chronic wound treatment comprises the following raw material components: antibacterial agent, water soluble chitosan, polyalcohol, poloxamer 188, tissue activating factor, and cell protection factor; the antibacterial agent is polyhexamethylene biguanide hydrochloride or cason CG; the tissue activating factor is any one or more of ceruloplasmin, hyaluronic acid and allantoin; the cytoprotective factor is gelacodine and/or trehalose. The invention has the beneficial effects that: the functional dressing for treating the chronic wound adopts scientific compatibility of multiple components and reasonable proportion, has synergistic effects in resisting infection, moisturizing, nourishing the wound, protecting and repairing the wound and promoting healing, can achieve excellent effect of promoting healing of the chronic wound, and can meet the requirement of clinical treatment of the chronic wound.

Description

Functional dressing for treating chronic wound surface, preparation and preparation method thereof

Technical Field

The invention belongs to the technical field of medical supplies, and particularly relates to a functional dressing for treating chronic wounds, a preparation and a preparation method thereof.

Background

At present, more functional dressings are clinically used for chronic wound surfaces, such as benzalkonium bromide and chlorhexidine, which are traditionally used, iodophors which are widely used at present, and latest bactericidal dressings such as hypochlorous acid liquid bactericidal dressings and the like. The repair of chronic wounds is a complex process requiring many conditions and a suitable environment. For example, the wound surface must be repaired under the conditions of relative cleanness, certain humidity and participation of various factors for promoting healing. The existing functional dressing has a single function, mainly resists infection, cannot meet objective conditions and requirements required by chronic wound repair, and becomes a problem to be solved urgently.

Disclosure of Invention

The first purpose of the invention is to provide a functional dressing for chronic wound treatment, which eliminates infection factors by utilizing complementation of various sterilization mechanisms of different raw materials, creates external conditions for wound repair by providing a moist wound environment, creates internal conditions for wound repair by promoting granulation tissue proliferation and protecting histiocytes under repair from adverse factors, and can achieve excellent chronic wound treatment effect by the synergistic effect of the aspects;

the invention further aims to provide the preparation of the dressing and the preparation method thereof, and the preparation has the advantages of scientific raw material compatibility, reasonable proportion, simple preparation method and easy industrial production and application.

In order to achieve the purpose, the invention adopts the following technical scheme:

the invention provides a functional dressing for treating chronic wounds, which comprises the following raw material components: antibacterial agent, water soluble chitosan, polyalcohol, poloxamer 188, tissue activating factor, and cell protection factor; the antibacterial agent is polyhexamethylene biguanide hydrochloride or cason CG; the tissue activating factor is any one or more of ceruloplasmin, hyaluronic acid and allantoin; the cell protective factor is gelicaine and/or trehalose.

(mono) polyhexamethylene biguanide hydrochloride (PHMB)

PHMB is a high molecular polymer, the guanidyl group of which has high activity and is electropositive in aqueous solution. Because the pathogenic microorganisms are mostly electronegative in appearance, after meeting, the pathogenic microorganisms are easily adsorbed by various electronegative bacteria and viruses, so that PHMB is gathered on the outer surface of the pathogenic microorganisms in a large amount, and further the pathogenic microorganisms play a role in two aspects: on one hand, the cross-linked film formed on the outer surface of the pathogenic microorganism by the polymer is bound to influence the propagation of the pathogenic microorganism, so that the pathogenic microorganism loses the reproductive capacity, and simultaneously, the metabolic channel of the pathogenic microorganism is blocked, so that the pathogenic microorganism rapidly dies. On the other hand, the polymer molecules have a large mass (of PHMB)The average molecular weight is 1100-1800, and the molecular formula is (C) ₈ H ₁₇ N ₅ ) _n xHCl, n is 12-16), a large amount of PHMB attached to the outer surface of pathogenic microorganisms can generate a heavy weight drop effect, so that the pathogenic microorganisms cannot move and bounce, and finally, the metabolism cannot be normally carried out due to the fact that the activity range of the PHMB is greatly limited, so that the PHMB is dead. The PHMB has wide bactericidal spectrum and strong bactericidal power, has strong killing effect on various pathogenic microorganisms including bacteria, viruses and fungi, has long-term bacteriostatic action and can effectively prevent secondary pollution of the bacteria. It is not only a high-efficiency disinfectant, but also an ideal broad-spectrum antibacterial agent.

(di) polyols

Including but not limited to 1, 2-pentanediol, glycerol, wherein:

(1)1, 2-pentanediol: the water-soluble chitosan water-soluble humectant is colorless transparent liquid, can be dissolved in organic solvents such as alcohol and ethyl acetate, is a humectant with excellent performance, is compatible with water-soluble chitosan, and has synergistic effect. Because the antibacterial agent has certain antibacterial property, the antibacterial agent has certain antibacterial synergistic effect when being used with polyhexamethylene biguanide hydrochloride. It has wide antibacterial spectrum, and can effectively inhibit gram-negative bacteria, positive bacteria, yeast and other fungi. In addition, the 1, 2-pentanediol is also a good solubilizer, has good compatibility and is mild and non-irritant, can dissolve insoluble active ingredients, is beneficial to the stability of the formula, and can reduce the sticky feeling of the formula caused by adding a polymer.

(2) Glycerol: is colorless, odorless, sweet liquid organic matter with clear and viscous appearance, has strong water absorption, and can provide a wet healing environment for wound repair. It is sticky and mild in nature, and can be mixed with water, alcohols, amines and phenols in any proportion, and its aqueous solution is neutral. Can be used for chronic wound surface, and has effects of moistening, protecting, isolating and relieving pain. The dressing can not be adhered to the wound surface, and the dressing is easy to remove when being replaced next time, so that the patient can not feel pain, thereby protecting the wound surface and promoting the healing of the wound surface. In addition, glycerol is a high-energy substance, and each gram of glycerol can be completely oxidized to generate 4 kcal of heat, and the blood sugar and the insulin level cannot be changed after the glycerol is absorbed by a human body. After entering the wound surface, the liquid is decomposed into carbon dioxide and water by tissue cells on the wound surface, and a large amount of energy is released, so that dynamic support is provided for the repair of the wound surface.

(II) Water-soluble Chitosan

Has all the common properties of chitosan, and is white or yellowish tasteless, nontoxic and amorphous powder. Soluble in water, the water solution is faintly acid, clear and transparent. Is a chitosan derivative with strong cationic property, can promote the absorption of nutrient components or medicaments by body cells, and has good hydrophilicity, film forming property and antibacterial property. The Chinese medicinal composition is used for chronic wounds, can resist bacteria and diminish inflammation, can protect and relieve pain, and can provide a wet healing environment and condition for the repair of the wounds, thereby promoting the healing of the wounds.

(III) Poloxamer 188

Is a comprehensive functional factor, is a polyoxyethylene polyoxypropylene ether block copolymer, and is a novel high molecular nonionic surfactant. Stable chemical property and mild physical property. It is easily soluble in water or ethanol, and is stable to acid, alkaline aqueous solution and metal ions. Has no toxic and side effect, no antigenicity, no irritation and no sensitization, and has various clinical efficacies.

(1) Self-dissolving debridement effect

The chronic wound infection has purulent secretion attached, which mainly contains albumin, potassium, sodium, chlorine, calcium and other electrolytes, various inflammation mediators (5-hydroxytryptamine, bradykinin and the like), bacteria and exotoxin produced by the bacteria, tumor necrosis factor, leucocytes, various growth factors, liquefied necrotic tissues (putrescine, oxime) and the like. These substances are often fat-soluble, and are adverse factors that hinder and inhibit wound healing, and are collectively referred to as toxic substances or harmful substances. Poloxamer 188 can effectively remove the harmful substances on the wound surface in time, and the specific action mechanism is as follows:

due to the fact that most of the large and small harmful substances on the wound surface are fat-soluble substances (fat-soluble structures are also formed on cell membranes of bacteria), the substances are wrapped by micelles of poloxamer 188 when encountering a surfactant poloxamer 188 in the formula, and the hydrophilic ends of poloxamer 188 are all exposed outside. At this time, poloxamer 188 which had entrapped these harmful substances was dissolved in the aqueous solution. It will be appreciated that water-soluble substances will diffuse from a high concentration to a low concentration. Therefore, poloxamer 188 or a small amount of water-soluble substances such as electrolyte ions, which are entrapped with harmful substances, gradually migrate from the wound surface into the dressing, and the harmful substances dissolved therein move from the deep side (the surface in contact with the wound surface) of the dressing to the shallow (outer) side. This is a result of two effects, the tension effect (siphoning effect) of water molecules and the dispersion effect of particles. In holidays, harmful substances attached to the chronic wound are thoroughly removed through the transfer effect of poloxamer, so that adverse factors inhibiting and hindering the healing of the wound are eliminated, the healing environment and conditions of the wound are improved, and the healing of the wound is promoted.

(2) Antibacterial and anti-inflammatory effects

Poloxamer 188, because of small molecules and no electric charge, can penetrate the cell wall of bacteria and combine with liposome on the cell membrane of the bacteria, thereby blocking the metabolic pathway of the bacteria and influencing the normal metabolism of the bacteria. In addition, poloxamer 188 entering the bacterial cell can also be combined with lipid structures on the envelope of organelles in the bacterial cell, so that the normal functions of the organelles of the bacteria are influenced, and the effects finally result in bacterial death.

(3) Repairing and healing effects

For damaged tissue cells, the lipophilic end of poloxamer 188 can be combined with lipid on cell membranes to block damaged channels on the cell membranes, so that cell fluid is not outflowing, time is won for self-repair of cells, opportunities are won, and conditions are created. Therefore, poloxamer 188 has the effect of repairing damaged tissue cells, which is also the cytological basis for the effect of poloxamer 188 on repairing and healing wounds.

(4) Improving microcirculation

A large number of clinical practices and basic researches prove that poloxamer 188 has the effects of expanding capillary vessels, influencing hemorheology and improving microcirculation. This effect may be related to the formation of hydrogen bonding structures between the lipophilic end of poloxamer 188 and the liposomal hydrocarbon chains at angiotensin ii receptors (AnA ii) on the capillary network. It blocks AnA II from contracting blood vessel, so that it can relax smooth muscle of capillary network, dilate blood vessel, accelerate blood flow and metabolism, and has another mechanism of improving blood circulation and healing of wound.

(5) Anti-inflammatory and analgesic effects

It is known that many tissues contain a large number of nociceptors, which are normally at rest and are found in skin, joints and muscle tissue. They are afferent terminal structures of the pain nerve (pain nerve terminal structures) that have receptors for receiving the various inflammatory mediators that cause pain. Tissue damage causes inflammatory mediators, such as prostaglandins, 5-hydroxytryptamine, bradykinin, and the like, released by mast cells, platelets, and the like, which can cause pain. The wound can activate nociceptors, which are stimulated by many inflammation-associated chemical mediators. The damaged tissue cells themselves may also release mediators such as potassium ions, leukotrienes, etc. These painful inflammatory mediators bind to specific receptors on the pain nerve endings, activate the pain nerve receptors, and thus produce a series of pain sensation responses.

The generation and transmission of pain nerve impulses depends on a series of changes in ion permeability of the cell membrane of pain nerve endings. In the resting state, calcium ions bind to phospholipoprotein on the membrane, preventing the influx of sodium ions. When the pain nerve is excited by external stimulation (mechanical and chemical), calcium ions leave the binding point, and sodium ions flow in a large amount to generate action potential, so that the pain nerve impulse and conduction are generated, and the pain nerve stem passes through the spinal pain nerve to the brain pain center to generate qualitative and localized pain.

Poloxamer 188 also has a good analgesic effect. The mechanism of action of analgesia is complex, but it is directly related to inhibition of the release of inflammatory mediators prostaglandins and bradykinin and the like, the activity of Na + -Ca2+ -ATPase and blocking of its binding to specific receptors by poloxamer 188. Specifically, it finally produces a good and long-lasting analgesic effect through the synergistic action of the following three mechanisms:

one is as follows: poloxamer 188, due to its fat-soluble carbon chain structure, small molecule and no electric charge, easily penetrates the skin, enters deep tissues, then combines with mast cells in the tissues, inhibits the mast cells from releasing nociceptive inflammatory mediators such as 5-hydroxytryptamine, and blocks and relieves the pain response mediated by inflammatory mediators from the initial stage of pain, which is one of the main mechanisms of poloxamer 188 with the analgesic effect and is the starting point of inhibiting the pain response.

The second step is as follows: the painful inflammatory mediators released by mast cells, platelets and damaged tissue cells bind to specific receptors on the membrane of the pain receptor, and activate the pain messenger (mRNA), which further activates Na + -Ca2+ -atpase, causing calcium ion efflux, sodium ion influx, and action potential, thus producing hyperalgesia and excitement, conduction through the pain nerve, and finally sensory sensation. Because the membrane on the receptor has a liposome structure, the lipophilic end of poloxamer 188 entering deep tissues can be combined with the carbon chain in the liposome structure on the receptor, thereby blocking the combination of the nociceptive inflammatory mediators and the receptor thereof. This site-occupying effect inhibits the production of pain signals mediated by the nociceptive inflammatory mediators, such that Na + -Ca2+ -atpase cannot be activated, action potentials cannot be produced, pain impulses and excitations cannot be formed, and the patient cannot produce pain sensations. This is the second mechanism by which poloxamer 188 has an analgesic effect.

And thirdly: poloxamer 188 entering deep tissues is hydrophilic and lipophilic because it is an amphoteric active group structure, so its lipophilic end can be directly combined with liposome structure in phospholipoprotein on pain nerve peripheral membrane, so that it can inhibit the activity of Na + -Ca2+ -ATP enzyme, prevent sodium ion from inward flowing, and can result in that action potential can not be produced, nerve conduction can be blocked, and the pain reaction of patient can not be produced. This is another important mechanism by which poloxamer 188 has an analgesic effect.

(6) Solubilization by dispersion

Poloxamer 188 is a good nonionic surfactant, can increase the solubility of fat-soluble drugs, and has a certain solubilizing effect on other compounds which are difficult to dissolve in water.

(IV) tissue activating factor

The healing mechanism of the chronic wound is complex, and various factors are needed to participate in the repair. Except the clean degree and the wet healing environment of the wound surface, the most fundamental tissue repair is the hyperplasia of granulation tissue, and the recovery of the skin can be supported only after the hyperplastic granulation tissue is filled with the wound surface bed or bare bone tissue, which is a key link of the chronic wound surface repair. The blue copper peptide, hyaluronic acid and allantoin all have the function of stimulating the proliferation of granulation tissues.

(1) Blue copper peptide

The ceruloplasmin is a natural healing promoting factor, is quickly absorbed and has strong permeability. It is mainly characterized by that it utilizes the carrier of amino acid compound to make the bivalent copper ion component with biochemical effect enter into cell to make physiological function be played. Copper-bonded amino acid (GHK-CU) can effectively promote the synthesis of collagen (Collaaen) and fibrin, promote the growth of blood vessels and the oxidation resistance, stimulate the production of glucose polyamine, help the skin to recover the self-repairing ability, increase the activity of fibroblasts, promote the production of collagen and accelerate the healing of wounds.

(2) Hyaluronic acid

Hyaluronic acid, also known as hyaluronic acid, is a high molecular polymer, a high-grade polysaccharide composed of units of D-glucuronic acid and N-acetylglucosamine, and is an acidic mucopolysaccharide.

Hyaluronic acid contains a large amount of carboxyl and hydroxyl in molecules, and hydrogen bonds in molecules and among molecules are formed in an aqueous solution, so that the hyaluronic acid has a strong water retention effect. The hyaluronic acid with 1 molecule can lock 1000 water molecules and can be combined with water more than 400 times of the hyaluronic acid, which is a chemical factor of good wettability and hydrophilicity. The characteristic provides essential wet healing environment and condition for the repair of the wound surface, and the wetting effect is better when the composition is combined with water-soluble chitosan.

Hyaluronic acid is a physiological substance inherent to the skin, is a main component of an intercellular matrix, directly participates in regulation of the communication of electrolytes inside and outside cells, and plays a role of a filter of physical and molecular information. Plays important physiological functions of water retention, extracellular space maintenance, osmotic pressure regulation and cell repair promotion in vivo.

The hyaluronic acid has effects of slightly dilating capillary, increasing blood circulation, improving metabolism, and promoting skin nutrition absorption.

The hyaluronic acid can promote the regeneration of the skin of the injured part and accelerate the healing of the skin of the injured part by promoting the proliferation and differentiation of epidermal cells and scavenging oxygen free radicals.

(3) Allantoin

Allantoin has the physiological functions of promoting cell growth, accelerating wound healing, softening keratin and the like, and is a good healing agent and an anti-ulcer agent for skin wounds.

The allantoin is an amphoteric compound, can combine with various substances to form double salt, has the effects of sterilizing, preventing corrosion, protecting, relieving pain, resisting oxidation, etc., can keep moisture of skin, moisten and soften, provide a moist healing environment, and enhance cell metabolism, thereby promoting wound healing.

(V) cytoprotective factor

On chronic wounds, there are often metaplasic tissues, which may transform in a good direction under the action of various beneficial factors, and finally become viable normal tissues. In addition, in the process of chronic wound repair, the wound is often affected by various physicochemical factors, and the healing of the wound is further affected. Therefore, protecting the tissue cells under repair from adverse effects or even damage is also a factor that must be considered for wound repair. The glaucone and trehalose have the effects of protecting cells and maintaining normal morphology and physiological functions of cells.

(1) Gelaike's cause

Glabridin (Glycoidin), which is an active ingredient of immortal grass, can protect cell membranes and cell structures from degeneration and damage, and has excellent water locking capacity. The chemical component of the compound is the glycerol glucoside which is proved by research. It is a glycoside compound formed by connecting sugar molecules through glycosidic bonds. Researches prove that the hyaluronic acid mainly has the effects of locking water, preserving moisture, stabilizing the integrity of a cell structure, enhancing the activity of cells, promoting the metabolism of cells and the like, and has better water-locking and moisture-preserving performance than the hyaluronic acid. Has no toxic and side effects such as irritation and sensitization.

(2) Trehalose

A non-reducing disaccharide consisting of two glucose molecules has no reducibility and very good stability to heat, acid and alkali. Under the severe environmental conditions of high temperature, high cold, high osmotic pressure, dry dehydration and the like, a unique protective film can be formed on the surface of the cell, the structure of a biological molecule is effectively protected from being damaged, and the stability and the integrity of a biological film, protein and active peptide in the cell are maintained, so that the life process and the biological characteristics of a living body are maintained.

The dressing provided by the invention can integrate multiple functions by combining the raw materials, and can play a better role in resisting bacteria and diminishing inflammation, removing the necrotic tissue and promoting granulation, promoting blood circulation and removing blood stasis, moisturizing and relieving pain, improving microcirculation and promoting wound healing when being used on acute and chronic wounds.

On the basis of the functional dressing for treating chronic wounds, the dressing can be prepared into any pharmaceutically acceptable and conveniently used medicinal preparation form by adding conventional auxiliary materials according to a general preparation method, wherein the medicinal preparation form comprises but is not limited to a solution, a cream and a gel, preferably the solution, and when the solution is selected, a certain amount of solubilizer such as polyethylene glycol 400 and polysorbate 80 is added.

As an alternative embodiment, the functional dressing solution for chronic wound treatment of the invention comprises the following raw material components in percentage by weight: 0.1-1% of polyhexamethylene biguanide hydrochloride, 0.05-0.5% of water-soluble chitosan, 0.3-4.0% of 1, 2-pentanediol, 1880.3-4.0% of poloxamer, 0.05-0.5% of bronze peptide, 0.05-0.1% of hyaluronic acid, 0.1-2% of allantoin, 0.5-5% of Glasin, 0.4-0.8% of trehalose, 0.2-5% of glycerol, 4000.5-5% of polyethylene glycol, 800.1-10% of polysorbate, and the balance of deionized water. Preferably, the material comprises the following raw material components in percentage by weight: 0.1% of polyhexamethylene biguanide hydrochloride, 0.1% of water-soluble chitosan, 1, 2-pentanediol, 1881% of poloxamer, 0.1% of ceruloplasmin, 0.05% of hyaluronic acid, 1% of allantoin, 0.5% of gleacrine, 0.5% of trehalose, 0.5% of glycerol, 4001% of polyethylene glycol, 800.5% of polysorbate, and the balance of deionized water.

The preparation method of the functional dressing solution for chronic wound treatment comprises the following steps:

(1) heating deionized water to 85-90 deg.C and maintaining for 30-45min to obtain phase A;

(2) sequentially adding poloxamer 188, allantoin, trehalose, and glycerol into phase A, stirring, and cooling to 50-60 deg.C, preferably 55 deg.C to obtain phase B;

(3) adding 1, 2-pentanediol, polyethylene glycol 400, polysorbate 80, polyhexamethylene biguanide hydrochloride and water-soluble chitosan into the phase B in sequence, uniformly stirring, and cooling to below 40 ℃, preferably 35 ℃, to obtain phase C;

(4) and sequentially adding the ceruloplasmin, the hyaluronic acid and the gelicaine into the phase C, uniformly stirring, and filtering to remove residues to obtain the functional dressing solution for treating the chronic wound.

The invention has the beneficial effects that:

the functional dressing for treating the chronic wound adopts scientific compatibility of multiple components and reasonable proportion, has synergistic effects in resisting infection, moisturizing, nourishing the wound, protecting and repairing the wound and promoting healing, can achieve excellent effect of promoting healing of the chronic wound, and can meet the requirement of clinical treatment of the chronic wound.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely a few embodiments of the invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention.

Example 1

The embodiment provides a functional dressing solution for chronic wound treatment, which comprises the following raw material components in percentage by weight:

0.1% of polyhexamethylene biguanide hydrochloride, 0.1% of chitosan hydrochloride, 1, 2-pentanediol, 1881% of poloxamer, 0.1% of ceruloplasmin, 0.05% of hyaluronic acid, 1% of allantoin, 0.5% of gleacrine, 0.5% of trehalose, 0.5% of glycerol, 4001% of polyethylene glycol, 800.5% of polysorbate, and the balance of deionized water;

(1) heating deionized water to 90 deg.C and maintaining for 40min to obtain phase A;

(2) sequentially adding poloxamer 188, allantoin, trehalose and glycerol into the phase A, uniformly stirring, and cooling to 55 ℃ to obtain a phase B;

(3) adding 1, 2-pentanediol, polyethylene glycol 400, polysorbate 80, polyhexamethylene biguanide hydrochloride and chitosan hydrochloride into the phase B in sequence, uniformly stirring, and cooling to 35 ℃ to obtain a phase C;

(4) and sequentially adding the ceruloplasmin, the hyaluronic acid and the glaucone into the phase C, stirring uniformly, naturally cooling to room temperature, filtering to remove residues, inspecting, subpackaging and packaging to obtain the functional dressing solution for treating the chronic wound.

Example 2

0.1% of polyhexamethylene biguanide hydrochloride, 0.5% of chitosan hydrochloride, 0.3% of 1, 2-pentanediol, 1884% of poloxamer, 0.05% of ceruloplasmin, 0.1% of hyaluronic acid, 0.1% of allantoin, 5% of glecaine, 0.4% of trehalose, 5% of glycerol, 4000.5% of polyethylene glycol, 8010% of polysorbate and the balance of deionized water;

(1) heating deionized water to 85 deg.C and maintaining for 45min to obtain phase A;

(2) sequentially adding poloxamer 188, allantoin, trehalose and glycerol into the phase A, uniformly stirring, and cooling to 60 ℃ to obtain a phase B;

(3) adding 1, 2-pentanediol, polyethylene glycol 400, polysorbate 80, polyhexamethylene biguanide hydrochloride and chitosan hydrochloride into the phase B in sequence, uniformly stirring, and cooling to 40 ℃ to obtain a phase C;

Example 3

1% of polyhexamethylene biguanide hydrochloride, 0.05% of chitosan hydrochloride, 4% of 1, 2-pentanediol, 1880.3% of poloxamer, 0.5% of ceruloplasmin, 0.05% of hyaluronic acid, 2% of allantoin, 0.5% of gleacrine, 0.8% of trehalose, 0.2% of glycerol, 4005% of polyethylene glycol, 800.1% of polysorbate, and the balance of deionized water;

(1) heating deionized water to 90 deg.C and maintaining for 30min to obtain phase A;

(2) sequentially adding poloxamer 188, allantoin, trehalose and glycerol into the phase A, uniformly stirring, and cooling to 50 ℃ to obtain a phase B;

The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.

Claims

1. A functional dressing for treating chronic wound surfaces is characterized by comprising the following raw material components: antibacterial agent, water soluble chitosan, polyalcohol, poloxamer 188, tissue activating factor, and cell protection factor;

the antibacterial agent is polyhexamethylene biguanide hydrochloride or cason CG; the tissue activating factor is any one or more of ceruloplasmin, hyaluronic acid and allantoin; the cell protective factor is gelicaine and/or trehalose.

2. The functional dressing for chronic wound treatment according to claim 1, wherein the dosage form of the functional dressing for chronic wound treatment is any one of solution, cream and gel.

3. The functional dressing for chronic wound treatment according to claim 2, characterized in that the dosage form of the functional dressing for chronic wound treatment is solution.

4. The functional dressing solution for chronic wound treatment according to claim 3, is characterized by comprising the following raw material components in percentage by weight:

0.1-1% of polyhexamethylene biguanide hydrochloride, 0.05-0.5% of water-soluble chitosan, 0.3-4.0% of 1, 2-pentanediol, 1880.3-4.0% of poloxamer, 0.05-0.5% of ceruloplasmin, 0.05-0.1% of hyaluronic acid, 0.1-2% of allantoin, 0.5-5% of Glaesene, 0.4-0.8% of trehalose, 0.2-5% of glycerol, 4000.5-5% of polyethylene glycol, 800.1-10% of polysorbate and the balance of deionized water.

5. The functional dressing solution for chronic wound treatment according to claim 4, is characterized by comprising the following raw material components in percentage by weight:

0.1% of polyhexamethylene biguanide hydrochloride, 0.1% of water-soluble chitosan, 1, 2-pentanediol, 1881% of poloxamer, 0.1% of ceruloplasmin, 0.05% of hyaluronic acid, 1% of allantoin, 0.5% of gleacrine, 0.5% of trehalose, 0.5% of glycerol, 4001% of polyethylene glycol, 800.5% of polysorbate, and the balance of deionized water.

6. The method for preparing a functional dressing solution for chronic wound treatment according to claim 4 or 5, characterized by comprising the following steps:

(2) sequentially adding poloxamer 188, allantoin, trehalose and glycerol into the phase A, stirring, and cooling to 50-60 deg.C to obtain phase B;

(3) adding 1, 2-pentanediol, polyethylene glycol 400, polysorbate 80, polyhexamethylene biguanide hydrochloride and water-soluble chitosan into the phase B in sequence, uniformly stirring, and cooling to below 40 ℃ to obtain a phase C;

7. The method for preparing a functional dressing solution for chronic wound treatment according to claim 6, characterized in that, in step (2), the cooling is performed to 55 ℃.

8. The method for preparing a functional dressing solution for chronic wound treatment according to claim 6, characterized in that, in step (3), the cooling is performed to 35 ℃.