CN115043843A - 3-(咪唑并[1,2-b]哒嗪-3-基乙炔基)-4-甲基-n{4-[(4-甲基哌嗪-1-基)甲基]-3-(三氟甲基)苯基}苯甲酰胺和它的单盐酸盐的晶形 - Google Patents

3-(咪唑并[1,2-b]哒嗪-3-基乙炔基)-4-甲基-n{4-[(4-甲基哌嗪-1-基)甲基]-3-(三氟甲基)苯基}苯甲酰胺和它的单盐酸盐的晶形 Download PDF

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Publication number
CN115043843A
CN115043843A CN202210369530.8A CN202210369530A CN115043843A CN 115043843 A CN115043843 A CN 115043843A CN 202210369530 A CN202210369530 A CN 202210369530A CN 115043843 A CN115043843 A CN 115043843A
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CN
China
Prior art keywords
methyl
ponatinib
crystalline
xrpd
imidazo
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Pending
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CN202210369530.8A
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English (en)
Chinese (zh)
Inventor
C.K.默里
L.W.罗扎马斯
J.J.沙伯
P.夏尔马
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Takeda Pharmaceuticals USA Inc
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Ariad Pharmaceuticals Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50929140&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN115043843(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ariad Pharmaceuticals Inc filed Critical Ariad Pharmaceuticals Inc
Publication of CN115043843A publication Critical patent/CN115043843A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN202210369530.8A 2012-12-12 2013-12-12 3-(咪唑并[1,2-b]哒嗪-3-基乙炔基)-4-甲基-n{4-[(4-甲基哌嗪-1-基)甲基]-3-(三氟甲基)苯基}苯甲酰胺和它的单盐酸盐的晶形 Pending CN115043843A (zh)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201261736543P 2012-12-12 2012-12-12
US61/736,543 2012-12-12
US201261737007P 2012-12-13 2012-12-13
US61/737,007 2012-12-13
US201361788208P 2013-03-15 2013-03-15
US61/788,208 2013-03-15
PCT/US2013/074571 WO2014093579A2 (en) 2012-12-12 2013-12-12 Crystalline forms of 3-(imidazo[1,2-b] pyridazin-3-ylethynyl)-4-methyl-n-(4-[(4-methylpiperazin-1-yl) methyl]-3-(trifluoromethyl)phenyl)benzamide and its mono hydrochloride salt
CN201380072027.5A CN105188701A (zh) 2012-12-12 2013-12-12 3-(咪唑并[1，2-b]哒嗪-3-基乙炔基)-4-甲基-n{4-[(4-甲基哌嗪-1-基)甲基]-3-(三氟甲基)苯基}苯甲酰胺和它的单盐酸盐的晶形

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CN201380072027.5A Division CN105188701A (zh) 2012-12-12 2013-12-12 3-(咪唑并[1，2-b]哒嗪-3-基乙炔基)-4-甲基-n{4-[(4-甲基哌嗪-1-基)甲基]-3-(三氟甲基)苯基}苯甲酰胺和它的单盐酸盐的晶形

Publications (1)

Publication Number Publication Date
CN115043843A true CN115043843A (zh) 2022-09-13

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Family Applications (2)

Application Number Title Priority Date Filing Date
CN201380072027.5A Pending CN105188701A (zh) 2012-12-12 2013-12-12 3-(咪唑并[1，2-b]哒嗪-3-基乙炔基)-4-甲基-n{4-[(4-甲基哌嗪-1-基)甲基]-3-(三氟甲基)苯基}苯甲酰胺和它的单盐酸盐的晶形
CN202210369530.8A Pending CN115043843A (zh) 2012-12-12 2013-12-12 3-(咪唑并[1,2-b]哒嗪-3-基乙炔基)-4-甲基-n{4-[(4-甲基哌嗪-1-基)甲基]-3-(三氟甲基)苯基}苯甲酰胺和它的单盐酸盐的晶形

Family Applications Before (1)

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CN201380072027.5A Pending CN105188701A (zh) 2012-12-12 2013-12-12 3-(咪唑并[1，2-b]哒嗪-3-基乙炔基)-4-甲基-n{4-[(4-甲基哌嗪-1-基)甲基]-3-(三氟甲基)苯基}苯甲酰胺和它的单盐酸盐的晶形

Country Status (9)

Country Link
US (9) US9493470B2 (2)
JP (5) JP6447508B2 (2)
CN (2) CN105188701A (2)
CA (3) CA3022250A1 (2)
CL (1) CL2015001643A1 (2)
HK (1) HK1218878A1 (2)
MX (11) MX391445B (2)
NZ (1) NZ709648A (2)
WO (2) WO2014093583A2 (2)

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EA034598B1 (ru) 2005-12-23 2020-02-25 Ариад Фармасьютикалз, Инк. Применение бициклических гетероарильных соединений для лечения рака
TWI568722B (zh) 2012-06-15 2017-02-01 葛蘭馬克製藥公司 作爲ｍＰＧＥＳ－１抑制劑之三唑酮化合物
CA3022250A1 (en) * 2012-12-12 2014-06-12 Ariad Pharmaceuticals, Inc. Crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride
EP3016954B1 (en) * 2013-07-04 2018-10-31 Sandoz AG Crystalline forms of ponatinib hydrochloride
CN104496995A (zh) * 2014-01-06 2015-04-08 广东东阳光药业有限公司 制备3-乙炔基咪唑并[1,2-b]哒嗪的方法
EA201991197A1 (ru) * 2016-12-15 2020-01-13 Ариад Фармасьютикалз, Инк. БЕНЗИМИДАЗОЛЬНЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ c-Kit
US10221184B2 (en) 2017-01-20 2019-03-05 Apicore Us Llc Polymorphs of ponatinib hydrochloride
CA3067271A1 (en) 2017-06-20 2018-12-27 Apotex Inc. Crystalline forms of ponatinib hydrochloride
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WO2020223235A1 (en) 2019-04-29 2020-11-05 Incyte Corporation Mini-tablet dosage forms of ponatinib
CN111004240B (zh) * 2019-12-13 2020-12-01 山东铂源药业有限公司 一种泊那替尼中间体3-乙炔基咪唑并[1,2-b]哒嗪的合成方法

Citations (1)

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CN102770129A (zh) * 2009-10-30 2012-11-07 阿里亚德医药股份有限公司 治疗癌症的方法和组合物

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US20210024527A1 (en) 2021-01-28
US20210277011A1 (en) 2021-09-09
US9493470B2 (en) 2016-11-15
MX2021002258A (es) 2021-05-27
JP2016503010A (ja) 2016-02-01
MX2021002261A (es) 2021-05-27
JP7042175B2 (ja) 2022-03-25
MX359147B (es) 2018-09-17
US20210277012A1 (en) 2021-09-09
NZ709648A (en) 2020-05-29
JP2026010061A (ja) 2026-01-21
HK1218878A1 (zh) 2017-03-17
WO2014093579A2 (en) 2014-06-19
US11279705B2 (en) 2022-03-22
US20210277010A1 (en) 2021-09-09
WO2014093583A3 (en) 2014-08-07
US11192896B2 (en) 2021-12-07
MX2021002253A (es) 2021-05-27
CA3022250A1 (en) 2014-06-12
JP7352841B2 (ja) 2023-09-29
JP2018168191A (ja) 2018-11-01
MX2021002255A (es) 2021-05-27
CA2815506C (en) 2018-12-11
WO2014093579A3 (en) 2014-07-10
CA3167093A1 (en) 2014-06-12
WO2014093583A2 (en) 2014-06-19
MX2021002259A (es) 2021-05-27
JP2022037122A (ja) 2022-03-08
US20190169196A1 (en) 2019-06-06
MX2021002254A (es) 2021-05-27
MX2021002264A (es) 2021-05-27
US10662197B2 (en) 2020-05-26
US10125136B2 (en) 2018-11-13
US20210340149A1 (en) 2021-11-04
US11384086B2 (en) 2022-07-12
MX391445B (es) 2025-03-21
MX2021002257A (es) 2021-05-27
JP6447508B2 (ja) 2019-01-09
CL2015001643A1 (es) 2015-10-02
US11192895B2 (en) 2021-12-07
JP2023179498A (ja) 2023-12-19
MX2021002256A (es) 2021-05-27
US20240083902A1 (en) 2024-03-14
US20150315194A1 (en) 2015-11-05
CA2815506A1 (en) 2014-06-12
US20170190707A1 (en) 2017-07-06
US11192897B2 (en) 2021-12-07
MX2015007578A (es) 2016-03-21
CN105188701A (zh) 2015-12-23

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