CN116269727A - Magnetic resonance-assisted ablation therapy method and device - Google Patents

Abstract

The application discloses an ablation treatment method and device based on magnetic resonance assistance, wherein the method comprises the following steps: detecting the current operation progress of a tumor ablation operation; when the preoperative simulation is detected, a scanning image is obtained based on three-dimensional magnetic resonance scanning, and an organ area and a tumor area are segmented to assist in generating an optimal probe strategy; when detecting that the navigation is in operation, carrying out real-time magnetic resonance scanning in the process of probe insertion to obtain a current magnetic resonance image, and marking a probe tip, a probe angle and tumor coordinates to assist the probe to reach a tumor; when the temperature measurement in the operation is detected, performing magnetic resonance sequence scanning in the probe ablation process to obtain a multi-echo magnetic resonance image, and displaying the current temperature distribution and the thermal ablation range in real time until the tumor is completely inactivated. Therefore, the problems of lower heating temperature interval, reduced tumor inactivation rate, increased postoperative recurrence rate, reduced success rate of operation, and application range in the related art are solved.

Description

Magnetic resonance-assisted ablation therapy method and device

technical field

The present application relates to the technical field of tumor hyperthermia, in particular to a magnetic resonance-assisted ablation treatment method and device.

Background technique

In related technologies, the tumor area is heated to 43°C to 50°C mainly through the characteristics of tumor sensitivity to temperature changes. In this temperature range, normal human cells and tissues will not be damaged, but tumor cells are sensitive to drugs and radiation. increase, or be induced to undergo autonomous apoptosis, and finally achieve the purpose of killing tumor cells and protecting normal tissues.

However, in the related art, the tumor area can only be heated to 43°C to 50°C, resulting in a lower heating temperature range, thereby reducing the tumor inactivation rate and inactivation efficiency, while increasing the postoperative recurrence rate of patients, thereby reducing The success rate of the operation and the scope of application have been compromised, which needs to be solved urgently.

Contents of the invention

This application is based on the inventor's understanding of the following issues:

According to the different temperature ranges during the treatment process, tumor hyperthermia surgery is divided into low temperature hyperthermia and tumor ablation. Among them, low temperature hyperthermia mainly utilizes the characteristics of tumor sensitivity to temperature changes, heating the tumor area to 43°C to 50°C, In this temperature range, the normal cells and tissues of the human body will not be damaged, but the sensitivity of tumor cells to drugs and radiation increases, or they are induced to self-apoptosis, and finally achieve the purpose of killing tumor cells and protecting normal tissues. The temperature range of the tumor ablation method reaches 50°C to 60°C, or even higher temperature, the tumor cells are directly necrotic, inactivated and coagulated, and finally the tumor cells are more completely eliminated. Compared with low temperature hyperthermia, tumor ablation has a higher temperature range, Therefore, it has a higher tumor inactivation rate and inactivation efficiency, a higher surgical success rate, and a lower patient recurrence rate. It has a good development prospect and is favored by doctors.

The biggest reason why tumor ablation surgery has not been widely used at present is that there is no integrated platform for intuitive and real-time monitoring of the operation process and heat consumption during the operation, and there is no precise positioning method, preoperative evaluation steps, etc., and there are relatively mature images Tracking algorithm, organ segmentation algorithm, biological heat transfer model, magnetic resonance temperature measurement algorithm, etc., as well as fast and harmless medical image acquisition methods, but most of them only stay in the scientific research stage and exist independently. Tumor ablation surgery has been popularized. A complete surgical platform needs to provide safety guarantees in terms of preoperative evaluation, intraoperative navigation, and intraoperative temperature measurement. The current situation of high recurrence rate and small application range after operation.

Compared with other medical imaging technologies, magnetic resonance technology has become an ideal method for preoperative evaluation and intraoperative monitoring of thermal ablation surgery due to its advantages of safety and non-invasiveness, high spatial resolution, high sensitivity, and multi-angle imaging. If the surgical assistance methods based on the magnetic resonance system (including fast scanning, temperature imaging and other magnetic resonance technologies and image segmentation, target tracking and other image post-processing methods) can be unified on one platform, it will bring great convenience and convenience to ablation surgery. Help to improve the success rate of minimally invasive surgery.

The present application provides a magnetic resonance-assisted ablation treatment method and device to solve the problem that in the related art, the tumor area can only be heated to 43°C to 50°C, resulting in a relatively low heating temperature range, thereby reducing tumor destruction. While improving the survival rate and inactivation efficiency, it increases the postoperative recurrence rate of patients, thereby reducing the success rate of surgery and the scope of application.

The embodiment of the first aspect of the present application provides a magnetic resonance-assisted ablation therapy method, including the following steps: detecting the current surgical progress of the tumor ablation operation; The scan image is obtained by scanning, and the organ region and the tumor region are segmented according to the scan image to assist in generating the optimal probe strategy; when it is detected that the current operation process is intraoperative navigation, a real-time magnetic Resonance scanning to obtain the current magnetic resonance image, and mark the probe tip, probe angle and tumor coordinates in the current magnetic resonance image to assist the probe to reach the tumor; when the current operation process is detected as During intraoperative temperature measurement, a magnetic resonance sequence scan is performed during the probe ablation process to obtain a multi-echo magnetic resonance image, and based on the multi-echo magnetic resonance image, the current temperature distribution and thermal ablation range are displayed in real time until the tumor Completely inactivated.

Optionally, in an embodiment of the present application, the obtaining a scan image based on the three-dimensional magnetic resonance scan, and segmenting the organ region and the tumor region according to the scan image include: receiving an operation input by the user in the function guidance area of the interface instruction; display the scan image according to the display instruction in the operation instruction, and perform automatic segmentation based on U-net according to the segmentation instruction in the operation instruction, identify the organ region and the tumor region, and The setup command in the above operation command sets the tumor position and the probe position and orientation to perform temperature simulation according to the a priori probe model and to display the cell inactivation area.

Optionally, in one embodiment of the present application, after performing the temperature simulation according to the a priori probe model, it further includes: checking whether the probe and power are currently set according to the check instruction in the operation instruction. parameter and/or whether to perform organ segmentation, and record the relationship between the current tumor and the probe.

Optionally, in one embodiment of the present application, the real-time magnetic resonance scanning is performed during the probe insertion process to obtain the current magnetic resonance image, and the probe tip and probe angle are marked in the current magnetic resonance image and tumor coordinates, including: loading the current magnetic resonance image according to the loading instruction in the operation instruction; setting the tumor coordinates, probe tip coordinates and probe direction according to the setting instruction in the operation instruction; After the confirmation instruction in the above operation instructions starts to insert the needle, the probe tip, probe angle and tumor coordinates are displayed in real time.

Optionally, in an embodiment of the present application, the magnetic resonance sequence scanning is performed during the probe ablation process to obtain a multi-echo magnetic resonance image, and the current temperature distribution is displayed in real time based on the multi-echo magnetic resonance image The thermal ablation range includes: determining the time resolution of the magnetic resonance scan according to the interval command in the operation command; acquiring the current magnetic resonance image in real time based on the time resolution of the magnetic resonance scan, calculating the temperature distribution, and displaying the thermal ablation at the same time In the ablation range, turn on the probe power to start heating at the same time, and turn off the probe power after the heating is completed.

The embodiment of the second aspect of the present application provides a magnetic resonance-assisted ablation therapy device, including: a detection module, used to detect the current operation progress of the tumor ablation operation; a scanning module, used to detect that the current operation progress is an operation During the pre-simulation, scan images are obtained based on 3D magnetic resonance scanning, and organ regions and tumor regions are segmented according to the scan images to assist in generating an optimal probe strategy; an identification module is used to detect that the current operation process is an operation During mid-navigation, real-time magnetic resonance scanning is performed during the probe insertion process to obtain the current magnetic resonance image, and the probe tip, probe angle and tumor coordinates are marked in the current magnetic resonance image to assist the probe to reach The tumor; an ablation module, configured to perform a magnetic resonance sequence scan during the probe ablation process to obtain a multi-echo magnetic resonance image when it is detected that the current surgical process is intraoperative temperature measurement, and based on the multiple echo The wave magnetic resonance image displays the current temperature distribution and thermal ablation range in real time until the tumor is completely inactivated.

Optionally, in an embodiment of the present application, the scanning module includes: a receiving unit, configured to receive an operation instruction input by the user in the interface function guidance area; a first processing unit, configured to The display instruction displays the scan image, and performs automatic segmentation based on U-net according to the segmentation instruction in the operation instruction, identifies the organ area and the tumor area, and sets Tumor location and probe position and orientation for temperature simulation based on a priori probe model and to visualize areas of cell inactivation.

Optionally, in one embodiment of the present application, the device in the embodiment of the present application further includes: a check module, configured to perform temperature simulation according to the a priori probe model, according to the check in the operation instruction The instruction checks whether the probe and power parameters are currently set and/or whether organ segmentation is performed, and records the current relationship between the tumor and the probe.

Optionally, in an embodiment of the present application, the identification module includes: a loading unit, configured to load the current magnetic resonance image according to a loading instruction in the operation instruction; a setting unit, configured to load the current magnetic resonance image according to the The coordinates of the tumor, the coordinates of the probe tip, and the direction of the probe set by the setting instruction in the operation instruction; the display unit is used to display the needle tip and probe in real time after the needle is inserted according to the determination instruction in the operation instruction. Needle angle and tumor coordinates.

Optionally, in an embodiment of the present application, the ablation module includes: a determining unit, configured to determine the magnetic resonance scanning time resolution according to the interval instruction in the operation instruction; a second processing unit, configured to The time resolution of the magnetic resonance scan is to acquire the current magnetic resonance image in real time, calculate the temperature distribution, and display the thermal ablation range at the same time. At the same time, turn on the probe power to start heating. After the heating is completed, turn off the probe power.

The embodiment of the third aspect of the present application provides an electronic device, including: a memory, a processor, and a computer program stored on the memory and operable on the processor, and the processor executes the program to realize The magnetic resonance-assisted ablation treatment method as described in the above-mentioned embodiments.

The embodiment of the fourth aspect of the present application provides a computer-readable storage medium, where the computer-readable storage medium stores a computer program, and when the program is executed by a processor, the above magnetic resonance-assisted ablation treatment method is implemented.

The embodiment of the present application can detect the current operation process of the tumor ablation operation. When it is detected as a preoperative simulation, the scanned image is obtained based on the three-dimensional magnetic resonance scanning, and the organ area and the tumor area are segmented to assist in generating the optimal probe strategy. When intraoperative navigation is detected, a real-time magnetic resonance scan is performed during the probe insertion process to obtain the current magnetic resonance image and mark the probe tip, probe angle and tumor coordinates to assist the probe to reach the tumor. For intraoperative temperature measurement, magnetic resonance sequence scanning is performed during probe ablation to obtain multi-echo magnetic resonance images, and the current temperature distribution and thermal ablation range are displayed in real time until the tumor is completely inactivated. Thus, it solves the problem that in the related art, the tumor area can only be heated to 43°C to 50°C, resulting in a lower heating temperature range, thereby reducing the tumor inactivation rate and inactivation efficiency, and increasing the postoperative recurrence rate of patients. , thereby reducing the success rate of surgery and the scope of application and other issues.

Additional aspects and advantages of the application will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the application.

Description of drawings

The above and/or additional aspects and advantages of the present application will become apparent and easy to understand from the following description of the embodiments in conjunction with the accompanying drawings, wherein:

FIG. 1 is a flow chart of a magnetic resonance-assisted ablation treatment method provided according to an embodiment of the present application;

Fig. 2 is a schematic diagram of a 3DSlicer preoperative simulation function image display interface of a specific embodiment of the present application;

Fig. 3 is a schematic diagram of the image segmentation interface of the 3DSlicer preoperative simulation function in a specific embodiment of the present application;

Fig. 4 is a schematic diagram of the display interface of the intraoperative navigation function of 3DSlicer in a specific embodiment of the present application;

Fig. 5 is a real-time navigation schematic diagram of a specific embodiment of the present application;

Fig. 6 is a schematic diagram of a display interface of an intraoperative temperature measurement function in a specific embodiment of the present application;

Fig. 7 is a schematic structural diagram of a magnetic resonance-assisted ablation therapy device according to an embodiment of the present application;

FIG. 8 is a schematic structural diagram of an electronic device provided according to an embodiment of the present application.

Detailed ways

Embodiments of the present application are described in detail below, examples of which are shown in the drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below by referring to the figures are exemplary, and are intended to explain the present application, and should not be construed as limiting the present application.

The following describes the magnetic resonance-assisted ablation treatment method and device according to the embodiments of the present application with reference to the accompanying drawings. In the related technology mentioned in the above-mentioned background technology center, the tumor area can only be heated to 43°C to 50°C, resulting in a lower heating temperature range, thereby reducing the tumor inactivation rate and inactivation efficiency, and increasing the patient's surgical time. recurrence rate, thereby reducing the success rate of surgery and the scope of application, this application provides a magnetic resonance-assisted ablation treatment method, in this method, the current surgical progress of tumor ablation surgery can be detected, when detected For preoperative simulation, scan images are obtained based on 3D magnetic resonance scanning, and organ regions and tumor regions are segmented to assist in generating the optimal probe strategy. Magnetic resonance scanning, to obtain the current magnetic resonance image, and mark the probe tip, probe angle and tumor coordinates to assist the probe to reach the tumor. When it is detected that it is intraoperative temperature measurement, the magnetic resonance sequence is performed during the probe ablation process Scan to obtain multi-echo magnetic resonance images, and display the current temperature distribution and thermal ablation range in real time until the tumor is completely inactivated. Thus, it solves the problem that in the related art, the tumor area can only be heated to 43°C to 50°C, resulting in a lower heating temperature range, thereby reducing the tumor inactivation rate and inactivation efficiency, and increasing the postoperative recurrence rate of patients. , thereby reducing the success rate of surgery and the scope of application and other issues.

Specifically, FIG. 1 is a schematic flowchart of a magnetic resonance-assisted ablation treatment method provided by an embodiment of the present application.

As shown in Figure 1, the magnetic resonance-assisted ablation treatment method includes the following steps:

In step S101, the current operation progress of the tumor ablation operation is detected.

It can be understood that the embodiment of the present application can detect the current surgical process of tumor ablation surgery, which can be divided into three processes of preoperative simulation, intraoperative navigation, and intraoperative temperature measurement in the following steps, so as to ensure that minimally invasive ablation surgery can be designed The visualization platform interacts with the magnetic resonance machine, so as to quickly provide more intuitive real-time data and improve the success rate of surgery.

In step S102, when it is detected that the current surgical process is a preoperative simulation, a scanned image is obtained based on a 3D magnetic resonance scan, and organ regions and tumor regions are segmented according to the scanned image to assist in generating an optimal probe strategy.

In the actual implementation process, when the embodiment of the present application detects that the current surgical process is a preoperative simulation, the scanned image can be obtained based on the three-dimensional magnetic resonance scan. For example, a three-dimensional T2 weighted magnetic resonance scan can be performed before the operation starts The image can be segmented based on the U-net in the following steps, and the doctor can plan the probe insertion point and insertion angle according to the segmentation results, and perform multiple simulations until a suitable probe plan is determined.

In addition, the embodiment of the present application can predict the global temperature field distribution based on parameters such as probe position, tumor shape and size, heat source power, and heating duration, and provide the range of thermal ablation, and change the heat source power and heating duration multiple times to determine Appropriate ablation and heating schemes can improve the resolution of soft tissue images, and can perform temperature simulation, providing doctors with a full range of preoperative simulations, effectively improving the success rate of surgery.

Optionally, in one embodiment of the present application, the scan image is obtained based on the three-dimensional magnetic resonance scan, and the organ region and the tumor region are segmented according to the scan image, including: receiving an operation instruction input by the user in the function guidance area of the interface; The display instruction in the instruction displays the scanned image, and performs automatic segmentation based on U-net according to the segmentation instruction in the operation instruction, identifies the organ area and tumor area, and sets the tumor position and probe position and direction according to the setting instruction in the operation instruction , to perform temperature simulations based on an a priori probe model and display regions of cell inactivation.

As a possible implementation, as shown in Figure 2, the embodiment of the present application can receive the operation instruction input by the user in the function guidance area of the interface, for example, in the preoperative simulation function, you can click "ImportDicom "Folder" button to import and display the 3D MRI image in dicom format. At this time, click the "Volumerendering" button to display the 3D image, which is convenient for the doctor to see the relationship between the probe and the patient more intuitively and clearly when placing the simulation probe.

Next, as shown in Figure 3, click the "Auto Segment" button to perform automatic segmentation based on U-net, and mark the tumor area and organ area. At this time, click the "Volume rendering" button to display the three-dimensional model of the organ and tumor. It can be adjusted to display the organ model or not (because the tumor is a solid tumor, the organ model will usually cover the tumor model, resulting in observation obstacles). At this time, the doctor can set the tumor location and probe respectively by clicking the "Tumor Label" button and the "Needle Label" button. Needle position and direction, after the setting is complete, click the "Ablation Simulate" button, the system will perform temperature simulation based on the prior probe model, and display the cell inactivation area, the doctor can compare the tumor area and the thermal ablation range, and reset the simulation The position and orientation of the probe is recalculated until the physician is satisfied with the heating of the probe at that position and orientation.

Optionally, in one embodiment of the present application, after performing the temperature simulation according to the priori probe model, it also includes: checking whether the probe and power parameters are currently set and/or whether to perform The organ is segmented and the current relationship between the tumor and the probe is recorded.

In some embodiments, the embodiment of the present application can check whether the probe and power parameters are currently set and/or whether organ segmentation is performed according to the check instruction in the operation instruction. For example, after the doctor completes the image segmentation and probe heating simulation, he can click "Check&Next" button, the system will automatically check whether the current probe and power parameters are set, whether organ segmentation is performed, and record the current relationship between the tumor and the probe, so as to enter the surgical navigation process in the subordinate steps, effectively improving the Tumor inactivation rate and inactivation efficiency.

In step S103, when it is detected that the current operation process is intraoperative navigation, real-time magnetic resonance scanning is performed during the probe insertion process to obtain the current magnetic resonance image, and the probe needle tip and probe angle are marked in the current magnetic resonance image coordinates with the tumor to assist the probe in reaching the tumor.

It can be understood that the embodiment of the present application can perform real-time magnetic resonance scanning during the probe insertion process and obtain the current magnetic resonance image, and can use the deep learning network framework to automatically identify the probe tip and probe angle in the current magnetic resonance image And the tumor coordinates are marked until the probe reaches the tumor, which effectively improves the accuracy of tumor location and improves the tumor inactivation rate and inactivation efficiency.

Optionally, in one embodiment of the present application, real-time magnetic resonance scanning is performed during the probe insertion process to obtain the current magnetic resonance image, and the probe tip, probe angle and tumor coordinates are identified in the current magnetic resonance image, Including: loading the current magnetic resonance image according to the loading instruction in the operation instruction; setting the tumor coordinates, probe tip coordinates and probe direction according to the setting instruction in the operation instruction; starting the needle insertion according to the confirmation instruction in the operation instruction Real-time display of probe tip, probe angle and tumor coordinates.

In the actual execution process, as shown in Figure 4, the embodiment of the present application can load the current magnetic resonance image according to the loading instruction in the operation instruction. For example, in the intraoperative navigation function, you can click "Load Real- timeImage" button to load the current scan image of the patient, click the three buttons "Tumor Location", "Needle Location" and "Needle Orientation" respectively, set the tumor coordinates, probe tip coordinates and probe orientation, and click " "Check&Start" button, start needle insertion according to the determined instruction in the operation instruction, and at the same time, the system will quickly read the magnetic resonance image and display the probe tip, probe angle and tumor coordinates in real time, and automatically identify the position of the probe and tumor in the image, It can help doctors observe the probe insertion process at any time, effectively improving the convenience and accuracy of the operation.

In some embodiments, as shown in Figure 5, it is a real-time image display during the probe insertion process in the embodiment of the present application, which shows the tumor and the probe during the rapid golden-angle radial GRE sequence reconstruction image probe introduction process Tracking results, "Tumor" in the figure is the tumor tracking mark, and the straight line is the probe tracking mark, so that the doctor can observe the image of the probe insertion in real time during the operation while fully grasping the patient's information before the operation, avoiding If the heat source deviates, the success rate of the operation is improved.

Those skilled in the art should understand that since there is no real-time image data of patients, images of normal volunteers are used for tracking, where "Tumor" is marked as speckles in normal liver images, and it is supposed to be tumors for tracking algorithm verification. After the needle is inserted and the probe reaches the tumor, you can click the "Finish&Next" button, and the system will automatically record the current relationship between the tumor and the probe, and read the preoperative simulation plan, so as to enter the intraoperative procedure in the following steps The temperature measurement process effectively improves the safety of the operation.

In step S104, when it is detected that the current operation process is intraoperative temperature measurement, a magnetic resonance sequence scan is performed during the probe ablation process to obtain a multi-echo magnetic resonance image, and the current temperature is displayed in real time based on the multi-echo magnetic resonance image Distribution and thermal ablation range until the tumor is completely inactivated.

It can be understood that in this embodiment of the present application, when it is detected that the current operation process is intraoperative temperature measurement, a magnetic resonance sequence scan is performed during the probe ablation process, and a multi-echo magnetic resonance image is obtained, so that based on the multi-echo Magnetic resonance images are used for magnetic resonance temperature measurement, and the current temperature distribution and thermal ablation range are displayed in real time until the tumor is completely inactivated and the ablation operation is completed, so that it can provide doctors with effective ablation range and surgical process information in real time, improving surgical safety.

Optionally, in an embodiment of the present application, a magnetic resonance sequence scan is performed during the probe ablation process to obtain a multi-echo magnetic resonance image, and the current temperature distribution and thermal ablation range are displayed in real time based on the multi-echo magnetic resonance image , including: determining the time resolution of the magnetic resonance scan according to the interval command in the operation instruction; acquiring the current magnetic resonance image in real time based on the time resolution of the magnetic resonance scan, calculating the temperature distribution, displaying the thermal ablation range at the same time, and turning on the probe power to start heating , after the heating is completed, turn off the probe power.

As a possible implementation, as shown in Figure 6, the embodiment of the present application can determine the time resolution of the MRI scan according to the interval instruction in the operation instruction, for example, in the intraoperative temperature measurement function, the Enter the time resolution of the magnetic resonance scan in "Timeresolution", that is, the time interval between frames, then click "Check&Start", the system will start to acquire image data in real time and calculate the temperature distribution, and display the thermal ablation range at the same time, and turn on the probe power to start heating After the heating is completed, turn off the power of the probe, and click the "Finish&stop" button to complete the ablation operation and close the software system.

Among them, as shown in Figure 6, it is the result of the simulated heat source under the real magnetic resonance image. In the image display area, the upper left corner is the original image of the magnetic resonance image, the lower left corner is the temperature distribution, and the lower right corner is the result according to the temperature distribution and time resolution. The thermal ablation range calculated by the rate calculation, in which area I is the inactivated area, which effectively provides doctors with a view of the ablation operation, assists in operation planning and process monitoring, and eliminates the natural disadvantage of minimally invasive surgery that is difficult to intuitively control the operation process, making ablation Surgery can be adapted to more and more complex application scenarios.

For example, 3DSlicer is an open source medical image processing software, which has toolkits such as ITK (InsightSegmentation and Registration Toolkit), VTK (visualization toolkit, visualization toolkit), and supports C++, python, etc. For secondary development of language, the embodiment of this application can carry out secondary development of 3DSlicer based on python language, and design a visualization platform for minimally invasive ablation surgery based on three steps of preoperative simulation, intraoperative navigation, and intraoperative temperature measurement. The MRI machine interacts to quickly provide more intuitive real-time data.

Furthermore, in order to assist clinical tumor ablation experiments, the embodiment of the present application carried out secondary development on the 3DSlicer open source platform, and integrated the three steps of preoperative simulation, intraoperative navigation, and intraoperative temperature measurement to build a minimally invasive surgery visualization platform, and combined with Interaction with magnetic resonance instruments, performing organ and tumor segmentation and probe heating simulation based on high-precision T2-weighted 3D magnetic resonance images before surgery, helping to draw up surgical plans, and identifying probes in real time based on fast-acquired magnetic resonance images during intraoperative navigation With the tumor location, and to assist in locating the lesion, the magnetic resonance thermometry method described in this study is used in the intraoperative temperature measurement to measure the temperature in real time and evaluate the range of cell inactivation, effectively achieving the role of surgical supervision.

In conclusion, the addition of magnetic resonance imaging technology breaks the natural drawback of minimally invasive surgery, which is difficult to intuitively control the surgical process, and aims to improve the success rate and scope of ablation surgery and reduce the possibility of postoperative recurrence.

According to the magnetic resonance-assisted ablation treatment method proposed in the embodiment of the present application, the current surgical process of the tumor ablation surgery can be detected. When it is detected as a preoperative simulation, the scanned image is obtained based on the three-dimensional magnetic resonance scan, and the organ area and Tumor area to assist in generating the optimal probe strategy. When it is detected for intraoperative navigation, real-time MRI scanning is performed during probe insertion to obtain the current MRI image and identify the probe tip, probe angle and tumor Coordinates to assist the probe to reach the tumor. When it is detected that it is intraoperative temperature measurement, a magnetic resonance sequence scan is performed during the probe ablation process to obtain a multi-echo magnetic resonance image, and the current temperature distribution and thermal ablation range are displayed in real time. until the tumor is completely inactivated.

Next, the magnetic resonance-assisted ablation therapy device proposed according to the embodiments of the present application will be described with reference to the accompanying drawings.

Fig. 7 is a schematic block diagram of a magnetic resonance-assisted ablation therapy device according to an embodiment of the present application.

As shown in FIG. 7 , the magnetic resonance-assisted ablation therapy device 10 includes: a detection module 100 , a scanning module 200 , an identification module 300 and an ablation module 400 .

Specifically, the detection module 100 is configured to detect the current operation progress of the tumor ablation operation.

The scanning module 200 is configured to obtain a scanned image based on a three-dimensional magnetic resonance scan when it is detected that the current operation process is a preoperative simulation, and segment the organ region and the tumor region according to the scanned image to assist in generating an optimal probe strategy.

The identification module 300 is configured to perform real-time magnetic resonance scanning during the probe insertion process to obtain the current magnetic resonance image when it is detected that the current operation process is intraoperative navigation, and to identify the needle tip of the probe and the probe in the current magnetic resonance image. Angle and tumor coordinates to assist the probe in reaching the tumor.

The ablation module 400 is configured to perform a magnetic resonance sequence scan during the probe ablation process to obtain a multi-echo magnetic resonance image when it is detected that the current operation process is intraoperative temperature measurement, and to display the current state in real time based on the multi-echo magnetic resonance image. Temperature distribution and thermal ablation range until the tumor is completely inactivated.

Optionally, in an embodiment of the present application, the scanning module 200 includes: a receiving unit and a first processing unit.

Wherein, the receiving unit is used for receiving the operation instruction input by the user in the interface function guidance area.

The first processing unit is used to display the scan image according to the display instruction in the operation instruction, and perform U-net-based automatic segmentation according to the segmentation instruction in the operation instruction, identify the organ area and the tumor area, and according to the setting instruction in the operation instruction Set the tumor location and probe position and orientation for temperature simulation based on the probe model a priori and display areas of cell inactivation.

Optionally, in an embodiment of the present application, the device 10 in the embodiment of the present application further includes: an inspection module.

Wherein, the check module is used to check whether the probe and power parameters are currently set and/or whether to perform organ segmentation according to the check instruction in the operation instruction after performing temperature simulation according to the prior probe model, and record the current tumor and relationship between probes.

Optionally, in an embodiment of the present application, the identification module 300 includes: a loading unit, a setting unit, and a display unit.

Wherein, the loading unit is configured to load the current magnetic resonance image according to the loading instruction in the operation instruction.

The setting unit is used to set the coordinates of the tumor, the coordinates of the needle tip of the probe and the direction of the probe according to the setting command in the operation command.

The display unit is used to display the probe tip, probe angle and tumor coordinates in real time after the needle is inserted according to the determined command in the operation command.

Optionally, in an embodiment of the present application, the ablation module 400 includes: a determination unit and a second processing unit.

Wherein, the determining unit is configured to determine the temporal resolution of the magnetic resonance scan according to the interval instruction in the operation instruction.

The second processing unit is used to obtain the current magnetic resonance image in real time based on the time resolution of the magnetic resonance scan, calculate the temperature distribution, display the thermal ablation range at the same time, turn on the probe power to start heating, and turn off the probe power after the heating is completed.

It should be noted that the foregoing explanations of the embodiment of the magnetic resonance-assisted ablation therapy method are also applicable to the magnetic resonance-assisted ablation therapy device of this embodiment, and details are not repeated here.

The magnetic resonance-assisted ablation therapy device proposed according to the embodiment of the present application can detect the current surgical progress of the tumor ablation surgery. When it is detected as a preoperative simulation, the scanned image is obtained based on the three-dimensional magnetic resonance scan, and the organ area and Tumor area to assist in generating the optimal probe strategy. When it is detected for intraoperative navigation, real-time MRI scanning is performed during probe insertion to obtain the current MRI image and identify the probe tip, probe angle and tumor Coordinates to assist the probe to reach the tumor. When it is detected that it is intraoperative temperature measurement, a magnetic resonance sequence scan is performed during the probe ablation process to obtain a multi-echo magnetic resonance image, and the current temperature distribution and thermal ablation range are displayed in real time. until the tumor is completely inactivated.

FIG. 8 is a schematic structural diagram of an electronic device provided by an embodiment of the present application. This electronic equipment can include:

A memory 801 , a processor 802 , and a computer program stored in the memory 801 and executable on the processor 802 .

The processor 802 implements the magnetic resonance-assisted ablation treatment method provided in the above-mentioned embodiments when executing the program.

Further, the electronic equipment also includes:

The communication interface 803 is used for communication between the memory 801 and the processor 802 .

The memory 801 is used to store computer programs that can run on the processor 802 .

The memory 801 may include a high-speed RAM memory, and may also include a non-volatile memory (non-volatile memory), such as at least one disk memory.

If the memory 801, the processor 802, and the communication interface 803 are independently implemented, the communication interface 803, the memory 801, and the processor 802 may be connected to each other through a bus to complete mutual communication. The bus may be an Industry Standard Architecture (Industry Standard Architecture, ISA for short) bus, a Peripheral Component Interconnect (PCI for short) bus, or an Extended Industry Standard Architecture (EISA for short) bus. The bus can be divided into address bus, data bus, control bus and so on. For ease of representation, only one thick line is used in FIG. 8 , but it does not mean that there is only one bus or one type of bus.

Optionally, in specific implementation, if the memory 801, the processor 802, and the communication interface 803 are integrated on one chip, then the memory 801, the processor 802, and the communication interface 803 can communicate with each other through the internal interface.

The processor 802 may be a central processing unit (Central Processing Unit, referred to as CPU), or a specific integrated circuit (Application Specific Integrated Circuit, referred to as ASIC), or configured to implement one or more of the embodiments of the present application integrated circuit.

This embodiment also provides a computer-readable storage medium, on which a computer program is stored, and when the program is executed by a processor, the above magnetic resonance-assisted ablation treatment method is realized.

In the description of this specification, descriptions referring to the terms "one embodiment", "some embodiments", "example", "specific examples", or "some examples" mean that specific features described in connection with the embodiment or example , structure, material or characteristic is included in at least one embodiment or example of the present application. In this specification, the schematic representations of the above terms are not necessarily directed to the same embodiment or example. Moreover, the described specific features, structures, materials or characteristics may be combined in any one or N embodiments or examples in an appropriate manner. In addition, those skilled in the art can combine and combine different embodiments or examples and features of different embodiments or examples described in this specification without conflicting with each other.

In addition, the terms "first" and "second" are used for descriptive purposes only, and cannot be interpreted as indicating or implying relative importance or implicitly specifying the quantity of indicated technical features. Thus, the features defined as "first" and "second" may explicitly or implicitly include at least one of these features. In the description of the present application, "N" means at least two, such as two, three, etc., unless otherwise specifically defined.

Any process or method description in a flowchart or otherwise described herein may be understood to represent a module, segment or portion of code comprising one or N steps of executable instructions for implementing a custom logical function or process, Also, the scope of preferred embodiments of the present application includes additional implementations in which functions may be performed out of the order shown or discussed, including substantially concurrently or in reverse order depending on the functions involved, which should be considered Those skilled in the art to which the embodiments of the present application belong can understand.

The logic and/or steps represented in the flowcharts or otherwise described herein, for example, can be considered as a sequenced listing of executable instructions for implementing logical functions, can be embodied in any computer-readable medium, For use with instruction execution systems, devices, or devices (such as computer-based systems, systems including processors, or other systems that can fetch instructions from instruction execution systems, devices, or devices and execute instructions), or in conjunction with these instruction execution systems, devices or equipment for use. For the purposes of this specification, a "computer-readable medium" may be any device that can contain, store, communicate, propagate or transmit a program for use in or in conjunction with an instruction execution system, device or device. More specific examples (non-exhaustive list) of computer readable media include the following: electrical connection with one or N wires (electronic device), portable computer disk case (magnetic device), random access memory (RAM), Read Only Memory (ROM), Erasable and Editable Read Only Memory (EPROM or Flash Memory), Fiber Optic Devices, and Portable Compact Disc Read Only Memory (CDROM). In addition, the computer-readable medium may even be paper or other suitable medium on which the program can be printed, since the paper or other medium can be optically scanned and subsequently edited, interpreted, or in other suitable manner as necessary Processing is performed to obtain the program electronically and then to store it in a computer memory.

It should be understood that each part of the present application may be realized by hardware, software, firmware or a combination thereof. In the above embodiments, the N steps or methods may be implemented by software or firmware stored in memory and executed by a suitable instruction execution system. For example, if implemented in hardware as in another embodiment, it can be implemented by any one or a combination of the following techniques known in the art: a discrete Logic circuits, ASICs with suitable combinational logic gates, Programmable Gate Arrays (PGA), Field Programmable Gate Arrays (FPGA), etc.

Those of ordinary skill in the art can understand that all or part of the steps carried by the methods of the above embodiments can be completed by instructing related hardware through a program, and the program can be stored in a computer-readable storage medium. During execution, one or a combination of the steps of the method embodiments is included.

In addition, each functional unit in each embodiment of the present application may be integrated into one processing module, each unit may exist separately physically, or two or more units may be integrated into one module. The above-mentioned integrated modules can be implemented in the form of hardware or in the form of software function modules. If the integrated modules are implemented in the form of software function modules and sold or used as independent products, they can also be stored in a computer-readable storage medium.

The storage medium mentioned above may be a read-only memory, a magnetic disk or an optical disk, and the like. Although the embodiments of the present application have been shown and described above, it can be understood that the above embodiments are exemplary and should not be construed as limitations on the present application, and those skilled in the art can make the above-mentioned The embodiments are subject to changes, modifications, substitutions and variations.

Claims (12)

1. A method of ablation therapy based on magnetic resonance assistance, comprising the steps of:

detecting the current operation progress of a tumor ablation operation;

when the current operation progress is detected to be preoperative simulation, a scanning image is obtained based on three-dimensional magnetic resonance scanning, and an organ area and a tumor area are segmented according to the scanning image so as to assist in generating an optimal probe strategy;

when detecting that the current operation progress is intra-operative navigation, performing real-time magnetic resonance scanning in a probe insertion process to obtain a current magnetic resonance image, and identifying a probe tip, a probe angle and tumor coordinates in the current magnetic resonance image to assist the probe to reach the tumor; and

and when detecting that the current operation progress is temperature measurement in operation, performing magnetic resonance sequence scanning in a probe ablation process to obtain a multi-echo magnetic resonance image, and displaying the current temperature distribution and the thermal ablation range in real time based on the multi-echo magnetic resonance image until the tumor is completely inactivated.

2. The method of claim 1, wherein the obtaining a scan image based on the three-dimensional magnetic resonance scan and segmenting the organ region and the tumor region from the scan image comprises:

receiving an operation instruction input by a user in an interface function guide area;

displaying the scanning image according to a display instruction in the operation instruction, automatically dividing the scanning image based on U-net according to a dividing instruction in the operation instruction, marking the organ area and the tumor area, setting the tumor position and the probe direction according to a setting instruction in the operation instruction, performing temperature simulation according to a priori probe model, and displaying a cell inactivation area.

3. The method of claim 2, further comprising, after performing a temperature simulation based on the a priori probe model:

and checking whether the probe and the power parameter are set currently and/or whether organ segmentation is performed or not according to checking instructions in the operation instructions, and recording the relation between the current tumor and the probe.

4. A method according to claim 2 or 3, wherein the performing of the real-time magnetic resonance scan during probe insertion to obtain a current magnetic resonance image and identifying the probe tip, probe angle and tumor coordinates in the current magnetic resonance image comprises:

Loading the current magnetic resonance image according to a loading instruction in the operation instructions;

tumor coordinates, probe tip coordinates and probe directions set according to the setting instructions in the operation instructions;

and displaying the probe tip, the probe angle and the tumor coordinates in real time after the needle starts to be inserted according to the determined instruction in the operation instructions.

5. The method according to any one of claims 2-4, wherein performing a magnetic resonance sequence scan during probe ablation to obtain a multi-echo magnetic resonance image, and displaying a current temperature distribution and a thermal ablation range in real time based on the multi-echo magnetic resonance image, comprises:

determining magnetic resonance scanning time resolution according to interval instructions in the operation instructions;

and acquiring the current magnetic resonance image in real time based on the magnetic resonance scanning time resolution, calculating temperature distribution, displaying a thermal ablation range, simultaneously starting heating by turning on probe power, and turning off the probe power after the heating is completed.

6. An ablation therapy device based on magnetic resonance assistance, comprising:

the detection module is used for detecting the current operation progress of the tumor ablation operation;

the scanning module is used for obtaining a scanning image based on three-dimensional magnetic resonance scanning when the current operation progress is detected to be preoperative simulation, and dividing an organ area and a tumor area according to the scanning image so as to assist in generating an optimal probe strategy;

The identification module is used for carrying out real-time magnetic resonance scanning in the probe insertion process when detecting that the current operation process is intra-operative navigation, obtaining a current magnetic resonance image, and identifying a probe tip, a probe angle and tumor coordinates in the current magnetic resonance image so as to assist the probe to reach the tumor; and

and the ablation module is used for scanning a magnetic resonance sequence in the probe ablation process when detecting that the current operation process is temperature measurement in operation, obtaining a multi-echo magnetic resonance image, and displaying the current temperature distribution and the thermal ablation range in real time based on the multi-echo magnetic resonance image until the tumor is completely inactivated.

7. The apparatus of claim 6, wherein the scanning module comprises:

the receiving unit is used for receiving an operation instruction input by a user in the interface function guide area;

the first processing unit is used for displaying the scanning image according to the display instruction in the operation instruction, automatically dividing the scanning image based on U-net according to the dividing instruction in the operation instruction, marking the organ area and the tumor area, setting the tumor position and the probe direction according to the setting instruction in the operation instruction, carrying out temperature simulation according to the prior probe model, and displaying the cell inactivation area.

8. The apparatus as recited in claim 7, further comprising:

and the checking module is used for checking whether the probe and the power parameter are currently set and/or whether organ segmentation is performed or not according to checking instructions in the operation instructions after the temperature simulation is performed according to the prior probe model, and recording the relation between the current tumor and the probe.

9. The apparatus of claim 7 or 8, wherein the identification module comprises:

the loading unit is used for loading the current magnetic resonance image according to a loading instruction in the operation instructions;

the setting unit is used for setting tumor coordinates, probe tip coordinates and probe directions according to the setting instructions in the operation instructions;

and the display unit is used for displaying the probe tip, the probe angle and the tumor coordinates in real time after the needle starts to be inserted according to the determined instruction in the operation instructions.

10. The apparatus of any one of claims 7-9, wherein the ablation module comprises:

a determining unit for determining a magnetic resonance scanning time resolution according to an interval instruction in the operation instructions;

and the second processing unit is used for acquiring the current magnetic resonance image in real time based on the magnetic resonance scanning time resolution, calculating the temperature distribution, displaying the thermal ablation range, simultaneously starting the probe power to heat, and closing the probe power after the heating is finished.

11. An electronic device, comprising: a memory, a processor and a computer program stored on the memory and executable on the processor, the processor executing the program to implement the magnetic resonance assisted ablation therapy method of any of claims 1-5.

12. A computer readable storage medium having stored thereon a computer program, characterized in that the program is executed by a processor for implementing a magnetic resonance-based ablation therapy method as claimed in any of claims 1-5.

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