CN116507620B - Cdk4抑制剂的固体形式 - Google Patents
Cdk4抑制剂的固体形式Info
- Publication number
- CN116507620B CN116507620B CN202180071477.7A CN202180071477A CN116507620B CN 116507620 B CN116507620 B CN 116507620B CN 202180071477 A CN202180071477 A CN 202180071477A CN 116507620 B CN116507620 B CN 116507620B
- Authority
- CN
- China
- Prior art keywords
- cancer
- ppm
- crystalline form
- values
- solid state
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Fats And Perfumes (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063078636P | 2020-09-15 | 2020-09-15 | |
| US63/078,636 | 2020-09-15 | ||
| US202163240268P | 2021-09-02 | 2021-09-02 | |
| US63/240,268 | 2021-09-02 | ||
| PCT/IB2021/058320 WO2022058871A1 (en) | 2020-09-15 | 2021-09-13 | Solid forms of a cdk4 inhibitor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN116507620A CN116507620A (zh) | 2023-07-28 |
| CN116507620B true CN116507620B (zh) | 2025-11-18 |
Family
ID=78000744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180071477.7A Active CN116507620B (zh) | 2020-09-15 | 2021-09-13 | Cdk4抑制剂的固体形式 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US12570641B2 (2) |
| EP (2) | EP4214202B1 (2) |
| JP (2) | JP7260606B2 (2) |
| KR (1) | KR20230069983A (2) |
| CN (1) | CN116507620B (2) |
| AU (1) | AU2021345531B2 (2) |
| DK (1) | DK4214202T3 (2) |
| ES (1) | ES3022913T3 (2) |
| FI (1) | FI4214202T3 (2) |
| HU (1) | HUE070846T2 (2) |
| MX (1) | MX2023003054A (2) |
| PL (1) | PL4214202T3 (2) |
| PT (1) | PT4214202T (2) |
| SI (1) | SI4214202T1 (2) |
| TW (2) | TWI809503B (2) |
| WO (1) | WO2022058871A1 (2) |
| ZA (1) | ZA202303655B (2) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20220054347A (ko) | 2019-08-26 | 2022-05-02 | 아비나스 오퍼레이션스, 인코포레이티드 | 에스트로겐 수용체 분해제로서의 테트라히드로나프탈렌 유도체로 유방암을 치료하는 방법 |
| AU2021345531B2 (en) | 2020-09-15 | 2024-02-29 | Pfizer Inc. | Solid forms of a CDK4 inhibitor |
| US20250041298A1 (en) * | 2021-12-02 | 2025-02-06 | Pfizer Inc. | Cdk4 inhibitor for the treatment of cancer |
| JP2025533719A (ja) | 2022-07-29 | 2025-10-09 | ファイザー・インク | がんの治療のためのｋａｔ６阻害剤を含む投与レジメン |
| WO2024051702A1 (zh) * | 2022-09-05 | 2024-03-14 | 浙江同源康医药股份有限公司 | 用作cdk4激酶抑制剂的化合物及其应用 |
| CN120981721A (zh) | 2023-03-30 | 2025-11-18 | 辉瑞大药厂 | Kat6a作为用kat6a抑制剂治疗的预测性生物标志物和相关治疗方法 |
| WO2024201340A1 (en) | 2023-03-30 | 2024-10-03 | Pfizer Inc. | Kat6a as a predictive biomarker for treatment of breast cancer with a cdk4 inhibitor and an antiestrogen and methods of treatment thereof |
| CN121368483A (zh) | 2023-06-02 | 2026-01-20 | 辉瑞公司 | 雌激素受体降解剂与cdk4抑制剂的组合 |
| EP4719405A1 (en) | 2023-06-02 | 2026-04-08 | Pfizer Inc. | Methods and modified dosing regimens comprising a cdk4 inhibitor for the treatment of cancer |
| WO2025024388A1 (en) | 2023-07-21 | 2025-01-30 | Accutar Biotechnology Inc. | Aminopyrimidine derivatives as cyclin-dependent kinase inhibitors |
| WO2025104624A1 (en) | 2023-11-14 | 2025-05-22 | Pfizer Inc. | Synthesis of 1,5-anhydro-3-({5-chloro-4-[4-fluoro-2-(2-hydroxypropan-2-yl)-1-(propan-2-yl)-1h-benzimidazol-6-yl]pyrimidin-2-yl}amino)-2,3-dideoxy-d-threo-pentitol |
| WO2025202871A1 (en) | 2024-03-27 | 2025-10-02 | Pfizer Inc. | Methods for identifying biomarkers of treatment response and use thereof with a cdk4 inhibitor |
| WO2025202900A1 (en) | 2024-03-27 | 2025-10-02 | Pfizer Inc. | Cdk4 inhibitors for use in the treatment of mantle cell lymphoma |
| WO2025202854A1 (en) | 2024-03-27 | 2025-10-02 | Pfizer Inc. | Cdk4 inhibitors and combinations with cdk2 inhibitors or further agents for use in the treatment of cancer |
| WO2026025013A2 (en) | 2024-07-26 | 2026-01-29 | Pfizer Inc. | Combination therapy using cdk4 inhibitors for cancer treatments |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018013867A1 (en) * | 2016-07-13 | 2018-01-18 | Marineau Jason J | Inhibitors of cyclin dependnt kinase 7 (cdk7) |
| WO2019207463A1 (en) * | 2018-04-26 | 2019-10-31 | Pfizer Inc. | 2-amino-pyridine or 2-amino-pyrimidine derivatives as cyclin dependent kinase inhibitors |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9518953D0 (en) | 1995-09-15 | 1995-11-15 | Pfizer Ltd | Pharmaceutical formulations |
| WO2000035296A1 (en) | 1996-11-27 | 2000-06-22 | Wm. Wrigley Jr. Company | Improved release of medicament active agents from a chewing gum coating |
| TW201105669A (en) | 2009-07-30 | 2011-02-16 | Irm Llc | Compounds and compositions as Syk kinase inhibitors |
| EP2970200A1 (en) | 2013-03-13 | 2016-01-20 | Abbvie Inc. | Pyridine cdk9 kinase inhibitors |
| CN105111191B (zh) | 2015-07-21 | 2018-06-08 | 上海皓元生物医药科技有限公司 | 一种用于合成cdk9抑制剂的关键中间体及其制备方法和用途 |
| PT3497103T (pt) | 2016-08-15 | 2021-06-17 | Pfizer | Inibidores de piridopirimidinona cdk2/4/6 |
| AU2021345531B2 (en) | 2020-09-15 | 2024-02-29 | Pfizer Inc. | Solid forms of a CDK4 inhibitor |
-
2021
- 2021-09-13 AU AU2021345531A patent/AU2021345531B2/en active Active
- 2021-09-13 HU HUE21783049A patent/HUE070846T2/hu unknown
- 2021-09-13 US US18/245,039 patent/US12570641B2/en active Active
- 2021-09-13 FI FIEP21783049.6T patent/FI4214202T3/fi active
- 2021-09-13 SI SI202130288T patent/SI4214202T1/sl unknown
- 2021-09-13 PL PL21783049.6T patent/PL4214202T3/pl unknown
- 2021-09-13 EP EP21783049.6A patent/EP4214202B1/en active Active
- 2021-09-13 MX MX2023003054A patent/MX2023003054A/es unknown
- 2021-09-13 EP EP25153633.0A patent/EP4578450A3/en active Pending
- 2021-09-13 PT PT217830496T patent/PT4214202T/pt unknown
- 2021-09-13 JP JP2021148619A patent/JP7260606B2/ja active Active
- 2021-09-13 ES ES21783049T patent/ES3022913T3/es active Active
- 2021-09-13 KR KR1020237012766A patent/KR20230069983A/ko not_active Ceased
- 2021-09-13 DK DK21783049.6T patent/DK4214202T3/da active
- 2021-09-13 CN CN202180071477.7A patent/CN116507620B/zh active Active
- 2021-09-13 WO PCT/IB2021/058320 patent/WO2022058871A1/en not_active Ceased
- 2021-09-14 TW TW110134168A patent/TWI809503B/zh active
- 2021-09-14 TW TW112102545A patent/TW202334125A/zh unknown
-
2022
- 2022-10-27 JP JP2022172594A patent/JP7291839B2/ja active Active
-
2023
- 2023-03-16 ZA ZA2023/03655A patent/ZA202303655B/en unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018013867A1 (en) * | 2016-07-13 | 2018-01-18 | Marineau Jason J | Inhibitors of cyclin dependnt kinase 7 (cdk7) |
| WO2019207463A1 (en) * | 2018-04-26 | 2019-10-31 | Pfizer Inc. | 2-amino-pyridine or 2-amino-pyrimidine derivatives as cyclin dependent kinase inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| ES3022913T3 (en) | 2025-05-29 |
| AU2021345531B2 (en) | 2024-02-29 |
| MX2023003054A (es) | 2023-04-05 |
| ZA202303655B (en) | 2024-09-25 |
| TW202216698A (zh) | 2022-05-01 |
| WO2022058871A1 (en) | 2022-03-24 |
| TWI809503B (zh) | 2023-07-21 |
| JP2022186995A (ja) | 2022-12-15 |
| PT4214202T (pt) | 2025-04-11 |
| CN116507620A (zh) | 2023-07-28 |
| EP4578450A2 (en) | 2025-07-02 |
| EP4214202A1 (en) | 2023-07-26 |
| SI4214202T1 (sl) | 2025-05-30 |
| TW202334125A (zh) | 2023-09-01 |
| KR20230069983A (ko) | 2023-05-19 |
| DK4214202T3 (da) | 2025-03-31 |
| US12570641B2 (en) | 2026-03-10 |
| JP2022049005A (ja) | 2022-03-28 |
| FI4214202T3 (fi) | 2025-04-25 |
| US20230357211A1 (en) | 2023-11-09 |
| HUE070846T2 (hu) | 2025-07-28 |
| AU2021345531A1 (en) | 2023-04-20 |
| EP4578450A3 (en) | 2025-07-16 |
| BR112023004713A2 (pt) | 2023-04-18 |
| PL4214202T3 (pl) | 2025-05-19 |
| JP7260606B2 (ja) | 2023-04-18 |
| JP7291839B2 (ja) | 2023-06-15 |
| CA3195063A1 (en) | 2022-03-24 |
| EP4214202B1 (en) | 2025-02-26 |
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