CN117398564A - Mixed oxygen type nitric oxide therapeutic instrument and flow control system - Google Patents
Mixed oxygen type nitric oxide therapeutic instrument and flow control system Download PDFInfo
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- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 title claims abstract description 272
- 229910052760 oxygen Inorganic materials 0.000 title claims abstract description 40
- 230000001225 therapeutic effect Effects 0.000 title claims abstract description 39
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title claims abstract description 35
- 239000001301 oxygen Substances 0.000 title claims abstract description 35
- 239000007789 gas Substances 0.000 claims abstract description 158
- 238000001914 filtration Methods 0.000 claims abstract description 13
- 238000005070 sampling Methods 0.000 claims description 21
- 230000004872 arterial blood pressure Effects 0.000 claims description 12
- 210000001147 pulmonary artery Anatomy 0.000 claims description 12
- 238000011947 six minute walk test Methods 0.000 claims description 5
- 230000008901 benefit Effects 0.000 description 12
- 238000005259 measurement Methods 0.000 description 12
- 230000000694 effects Effects 0.000 description 11
- JCXJVPUVTGWSNB-UHFFFAOYSA-N nitrogen dioxide Inorganic materials O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 description 11
- 238000012423 maintenance Methods 0.000 description 9
- 238000012544 monitoring process Methods 0.000 description 9
- 238000000034 method Methods 0.000 description 8
- 239000012535 impurity Substances 0.000 description 7
- 230000008569 process Effects 0.000 description 6
- 239000000126 substance Substances 0.000 description 5
- 230000002159 abnormal effect Effects 0.000 description 4
- 238000007789 sealing Methods 0.000 description 4
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 description 3
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 238000009434 installation Methods 0.000 description 3
- 230000029058 respiratory gaseous exchange Effects 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 2
- 108010061951 Methemoglobin Proteins 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 239000003344 environmental pollutant Substances 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 238000000968 medical method and process Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 231100000719 pollutant Toxicity 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 238000012795 verification Methods 0.000 description 2
- MGWGWNFMUOTEHG-UHFFFAOYSA-N 4-(3,5-dimethylphenyl)-1,3-thiazol-2-amine Chemical compound CC1=CC(C)=CC(C=2N=C(N)SC=2)=C1 MGWGWNFMUOTEHG-UHFFFAOYSA-N 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 206010037423 Pulmonary oedema Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 238000002664 inhalation therapy Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000006213 oxygenation reaction Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 208000005333 pulmonary edema Diseases 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 208000002815 pulmonary hypertension Diseases 0.000 description 1
- 230000008704 pulmonary vasodilation Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
- A61M16/12—Preparation of respiratory gases or vapours by mixing different gases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/0051—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes with alarm devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
- A61M16/105—Filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/20—Valves specially adapted to medical respiratory devices
- A61M16/201—Controlled valves
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
- G05D27/00—Simultaneous control of variables covered by two or more of main groups G05D1/00 - G05D25/00
- G05D27/02—Simultaneous control of variables covered by two or more of main groups G05D1/00 - G05D25/00 characterised by the use of electric means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/003—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/18—General characteristics of the apparatus with alarm
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
- A61M2205/3334—Measuring or controlling the flow rate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3379—Masses, volumes, levels of fluids in reservoirs, flow rates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/75—General characteristics of the apparatus with filters
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Abstract
The invention discloses a mixed oxygen type nitric oxide therapeutic instrument and a flow control system, which relate to the technical field related to medical instruments, and the mixed oxygen type flow control system comprises an NO air inlet module and O 2 Air inlet module, constant pressure module, filtering module, flow rate control module and O 2 And a mixing module, a gas content sensing module and an output assembly for NO; output end of NO air inlet module and O 2 The output ends of the air inlet modules are connected with the input ends of the flow rate control modules, and the output ends of the flow rate control modules are connected with O 2 Input of mixing module with NO, O 2 The output end of the mixing module with NO is connected with the input end of the gas content sensing moduleThe output end of the gas content sensing module is connected with the input end of the output assembly, and the gas content sensing module is used for detecting O 2 NO and NO 2 The content of each component is as O 2 NO and NO 2 And when the content of each component is less than or equal to a threshold value, starting a switch of the output assembly. The invention can ensure that the patient obtains accurate gas concentration.
Description
Technical Field
The invention relates to the technical field related to medical instruments, in particular to a mixed oxygen type nitric oxide therapeutic instrument and a flow control system.
Background
Cardiovascular disease is a serious disease that jeopardizes human health and is one of the leading causes of death, with thousands of people suffering from the disease causing disability each year. Pulmonary hypertension is a common complication for critical cardiovascular patients and is one of the difficulties in treating cardiovascular diseases at present.
Fratacci et al in 1991 demonstrated that inhalation of low concentrations of Nitric Oxide (NO) reduced pulmonary artery pressure in animal pulmonary artery pressure model experiments, and because of its highly selective pulmonary vasodilation, it is increasingly becoming an important therapeutic measure for patients with combined Respiratory Distress Syndrome (RDS) and PH. Inhalation of NO therapy can reduce the use of extra-corporeal pulmonary support (ECMO) by 80% and significantly reduce mortality in patients, thus despite the degree of risk of inhalation of low concentration NO therapy itself, the U.S. Food and Drug Administration (FDA) approved inhalation of NO for clinical treatment of patients with combined PH and RDS in 1999 after 7 years of demonstration.
At present, the risks of nitric oxide inhalation therapy include in particular: the safe concentration range of NO is very small, the NO is easy to combine with hemoglobin to produce methemoglobin, the methemoglobin is extremely easy to be oxidized into nitrogen dioxide (NO 2) to cause pulmonary edema, the sudden interruption of inhalation can generate stopping reaction, the NO hurts the environment and medical staff, and the like, so that the reasonable control of the relative concentration of oxygen and nitric oxide is one of very important indexes of the mixed oxygen type nitric oxide therapeutic apparatus.
However, the existing oxygen mixing type flow control system is used by connecting with a breathing machine, can not be independently connected with a nasal catheter or a mask, is difficult to accurately control the flow rate of gas, is difficult to uniformly mix oxygen and nitric oxide, detects the content of the gas and provides a safety protection function, so that the stability and reliability of treatment are reduced, the result that a patient is difficult to obtain accurate gas concentration is caused, and the operability of the system is reduced.
Disclosure of Invention
The utility model provides a mixed oxygen formula nitric oxide therapeutic instrument and flow control system mixes back with nitric oxide and oxygen, can break away from the breathing machine, connects nasal catheter or face guard, and the exclusive use ensures that the patient obtains accurate gas concentration.
The application provides a mixed oxygen type nitric oxide therapeutic instrument and flow control system, adopts following technical scheme:
a mixed oxygen type nitric oxide therapeutic apparatus and a flow control system, wherein the mixed oxygen type flow control system comprises an NO air inlet module and O 2 Air inlet module, flow speed control module and O 2 And a mixing module, a gas content sensing module and an output assembly for NO;
output end and O of the NO air inlet module 2 The output ends of the air inlet modules are connected with the input ends of the flow rate control modules, and the output ends of the flow rate control modules are connected with O 2 And an input of a mixing module for NO, said O 2 The output end of the mixing module with NO is connected with the input end of the gas content sensing module, the output end of the gas content sensing module is connected with the input end of the output assembly, and the gas content sensing module is used for detecting O 2 NO and NO 2 The contents of the components when the O 2 NO and NO 2 And when the content of each component is less than or equal to a threshold value, starting a switch of the output assembly.
Through adopting above-mentioned technical scheme, the flow control system of mixed oxygen formula nitric oxide therapeutic instrument is through accurate control gas velocity of flow, homogeneous mixing gas, detection gas content and provide the safeguard function to improve stability and the reliability of treatment, ensure that the patient obtains accurate gas concentration, guarantee patient's safety simultaneously, improve the maneuverability of this system.
Preferably, the gas content sensing module comprises O 2 Content sensing component, NO content sensing component and NO 2 And a content sensing component.
Through adopting above-mentioned technical scheme, the O2 content sensing subassembly of gas content sensing module, NO content sensing subassembly and NO2 content sensing subassembly can the real-time supervision gas content, provide accurate measuring result and safety protection, help to adjust treatment parameter to record, analysis data, thereby improve the security and the validity of treatment.
Preferably, the NO-intake device further comprises a filtering module, and the filtering module is arranged between the output end of the NO-intake module and the input end of the flow rate control module.
Through adopting above-mentioned technical scheme, set up filtration module between the output of NO air intake module and the input of velocity of flow control module, can filter impurity, protect the patient, improve treatment to provide convenient change and maintenance
Preferably, the output end of the gas content sensing module is also connected with an alarm component, when the O is 2 NO and NO 2 And when the content of any component is greater than a threshold value, starting a switch of the alarm assembly.
Through adopting above-mentioned technical scheme, with the output of gas content sensing module with alarm subassembly connection to set up the threshold value, start alarm subassembly's switch when gas content exceeded the threshold value, can in time warn, safety protection, prevent excessive concentration, remind the maintenance, and provide data record and analysis's function. These functions help to ensure the safety and effectiveness of the treatment.
Preferably, based on the above-mentioned mixed oxygen flow control system, the mixed oxygen type nitric oxide therapeutic apparatus comprises a housing and a three-way pipe arranged in the housing, wherein the three-way pipe is provided with a first interface, a second interface and a third interface, and the housing is provided with O 2 Intake pipe and NO intake pipe, said O 2 One end of the air inlet pipe is connected with a first flow rate controller, one end of the NO air inlet pipe is connected with a second flow rate controller, the output end of the first flow rate controller is connected with a first interface of a three-way pipe, the output end of the second flow rate controller is connected with a second interface of the three-way pipe, a third interface of the three-way pipe is connected with a gas content sensor, and the output end of the gas content sensor is connected with an output pipe.
By adopting the technical scheme, the O meeting the set requirements is realized through accurate mixed gas control and safety monitoring 2 NO and NO 2 Delivery to a suitable location can improve the accuracy of treatmentSex, efficacy, safety and flexibility.
Preferably, the O 2 The other end of the air inlet pipe is connected with O 2 Binding post, the other end of NO intake pipe is connected with NO binding post, O 2 The binding post and the NO binding post all set up on the shell.
By adopting the technical scheme, the method comprises the following steps of 2 The other end of the air inlet pipe is connected with O 2 The connecting terminal and the other end of the NO air inlet pipe are connected with the NO connecting terminal and are arranged on the shell, so that the advantages of convenient connection, flexible combination, safe protection, easy observation and maintenance and attractive and tidy appearance can be provided; these advantages help to improve the ease of operation and reliability of the oxygen-mixed nitric oxide therapeutic apparatus.
Preferably, a first gas filter is arranged between the second flow rate controller and the NO gas inlet pipe, and the first flow rate controller is connected with O 2 A second gas filter is arranged between the air inlet pipes.
Through adopting above-mentioned technical scheme, through being equipped with first gas filter between second flow controller and NO intake pipe to be equipped with second gas filter between first flow controller and O2 intake pipe, can effectively filter the pollutant in the air, improve treatment, and provide the safety guarantee. These benefits help to protect the safety of the device and patient and provide high quality therapeutic results
Preferably, a sampling pump is arranged between the third interface of the three-way pipe and the gas content sensor.
Through adopting above-mentioned technical scheme, through being equipped with the sampling pump between the third interface of three-way pipe and gas content sensor, can improve sampling accuracy, shorten sampling time, enlarge sampling range, protection gas content sensor adapts to various gases. These benefits help to improve the accuracy, stability and reliability of gas measurements
Preferably, the gas content sensor comprises O 2 Content sensor, NO content sensor and NO 2 Content sensor, O 2 Content sensor, NO content sensor and NO 2 The content sensors are connected in parallel.
By adopting the technical scheme, the gas content sensor can accurately measure and monitor O 2 NO and NO 2 And the content of the same gas. This helps to understand the concentration of the gas component, providing important data for medical process control and the like; it is worth noting that by monitoring O 2 The content can timely find out the condition of too low or too high oxygen concentration in the air so as to avoid O 2 Deficiency or O 2 Safety risk due to overage by O 2 Content sensor, NO content sensor and NO 2 The content sensors are arranged in parallel, so that various benefits such as comprehensive monitoring, mutual calibration, fault tolerance, cross verification and expansion application can be realized. These benefits help to improve the accuracy, stability and reliability of the gas measurement system.
Preferably, NO treatment is used to increase the 6MWT distance by 70±17.19 meters, decrease the pulmonary artery pressure by 20.71±10.42mmHg, decrease the pulmonary artery pressure percentage by 29.51±0.09%, and NO flow rate is used to increase the therapeutic effect.
By adopting the technical scheme, the treatment effect of NO can be effectively improved by improving the 6MWT distance, reducing the pulmonary artery pressure and reducing the pulmonary artery pressure percentage.
In summary, the present application has the following beneficial effects:
1. the flow control system of the oxygen-mixed nitric oxide therapeutic apparatus can improve the stability and reliability of treatment by accurately controlling the gas flow rate, uniformly mixing the gas, detecting the gas content and providing a safety protection function, ensure that a patient obtains accurate gas concentration, ensure the safety of the patient and improve the operability of the system.
Drawings
FIG. 1 is a flow chart of a mixed oxygen flow control system in this embodiment;
fig. 2 is a schematic diagram of the overall structure of the oxygen-mixed nitric oxide therapeutic apparatus according to the present embodiment;
FIG. 3 is an exploded view of the interior of the housing in this embodiment;
FIG. 4 is a cross-sectional view of the inside of the oxygen-mixed nitric oxide therapeutic apparatus according to the present embodiment;
FIG. 5 is a schematic view showing the overall structure of the connection between the connecting sleeve and the fixing sleeve in the present embodiment;
FIG. 6 is a schematic view of an explosive structure between the connecting sleeve and the fixing sleeve in the present embodiment;
reference numerals illustrate: 1. a housing; 2. a three-way pipe; 3. o (O) 2 An air inlet pipe; 4. a NO air inlet pipe; 5. a first flow rate controller; 6. a second flow rate controller; 7. a gas content sensor; 8. o (O) 2 A connection terminal; 801. a connecting sleeve; 802. a fixed sleeve; 803. a tapered threaded boss; 804. a tapered threaded recess; 805. a notch; 806. a seal ring; 9. a NO wiring terminal; 10. a first gas filter; 11. a second gas filter; 12. a sampling pump; 13. and outputting the pipe.
Detailed Description
The following detailed description of the present application is provided in conjunction with the accompanying drawings, and it is to be understood that the following detailed description is merely illustrative of the application and is not to be construed as limiting the scope of the application, since numerous insubstantial modifications and adaptations of the application will be to those skilled in the art in light of the foregoing disclosure.
The invention discloses a mixed oxygen type nitric oxide therapeutic apparatus and a flow control system, as shown in figure 1, wherein the mixed oxygen type flow control system comprises an NO air inlet module and O 2 Air inlet module, flow speed control module and O 2 And a mixing module, a gas content sensing module and an output assembly for NO;
output end of NO air inlet module and O 2 The output ends of the air inlet modules are connected with the input ends of the flow rate control modules, and the output ends of the flow rate control modules are connected with O 2 Input of mixing module with NO, O 2 The output end of the mixing module with NO is connected with the input end of the gas content sensing module, the output end of the gas content sensing module is connected with the input end of the output assembly, and the gas content sensing module is used for detecting O 2 NO and NO 2 The content of each component is as O 2 NO and NO 2 When the content of each component is less than or equal to a threshold value, starting a switch of an output assembly;control of NO and O by flow rate control module 2 The flow rate control module can accurately control NO and O 2 Ensures constant flow rate of gas during treatment, improves treatment stability and reliability, ensures accurate gas concentration for patients, and uses mixing module to treat NO and O 2 Uniformly mixing to ensure the uniformity of the gas in the treatment process; the treatment effect can be improved, so that the concentration of gas inhaled by a patient is more uniform, and the influence of concentration difference on the patient is reduced; detecting NO and NO through a gas content sensing module 2 And O 2 The content of (2) is used for monitoring the concentration of the gas in the treatment process in real time; can effectively ensure that the concentration of the gas inhaled by the patient is within a safe range, avoid the adverse effect of the too high or the too low concentration on the patient, and when O 2 NO and NO 2 When the content of each component is less than or equal to a threshold value, a switch of the output assembly is started, so that the gas concentration is ensured to be within a safety range, additional safety protection can be effectively provided, and a patient is prevented from being injured due to abnormal gas concentration;
in conclusion, the flow control system of the oxygen-mixed nitric oxide therapeutic apparatus can improve the stability and reliability of treatment by accurately controlling the gas flow rate, uniformly mixing the gas, detecting the gas content and providing a safety protection function, ensure that a patient obtains accurate gas concentration, ensure the safety of the patient and improve the operability of the system.
As shown in fig. 1, the gas content sensing module includes O 2 Content sensing component, NO content sensing component and NO 2 A content sensing component; the gas content sensing module can monitor the content of gas in real time; through the measurement of the sensing component, the O can be known in time 2 NO and NO 2 The concentration condition of the gas in the treatment process is ensured to meet the requirement, accurate content data is provided, and the accuracy and the effectiveness of treatment are ensured; based on the content data provided by the sensing assembly, an operator can adjust treatment parameters in time, such as adjusting the gas flow rate or concentration, to meet the specific needs of the patient; the sensing component can provide data recording and analysis functions and record the change trend of the gas content; these data areCan be used for diagnosis and research, and helps doctors evaluate the treatment effect and make more reasonable treatment decisions; on the whole, O of gas content sensing module 2 Content sensing component, NO content sensing component and NO 2 The content sensing component can monitor the gas content in real time, provide accurate measurement results and safety protection, help to adjust treatment parameters, record and analyze data, thereby improving the safety and effectiveness of treatment;
as shown in fig. 1, the oxygen mixing type flow control system further comprises a filtering module, wherein the filtering module is arranged between the output end of the NO air inlet module and the input end of the flow rate control module; the filter module can filter impurities such as dust, particles, bacteria and the like in the air entering the system; the purity of the gas can be ensured, and adverse effects of impurities on a therapeutic instrument and a patient are avoided; the filtering module can prevent impurities from entering the flow rate control module, reduce damage and faults to the flow rate control module, prolong the service life of the flow rate control module, filter harmful substances in the air, reduce the risk of harmful gases inhaled by a patient, and protect the respiratory system health of the patient; the filter module can ensure the purity and quality of the gas, ensure that the gas used in the treatment process meets the requirements, effectively improve the treatment effect and reduce adverse reactions caused by impurities or harmful substances; the filter module is usually easy to replace and can be replaced or cleaned periodically to maintain the filtering effect; the normal operation of the equipment and the continuity of treatment are maintained;
in conclusion, the filtering module is arranged between the output end of the NO air inlet module and the input end of the flow rate control module, so that impurities can be filtered, patients can be protected, the treatment effect can be improved, and convenient replacement and maintenance can be provided.
As shown in FIG. 1, the output end of the gas content sensing module is also connected with an alarm component, when O 2 NO and NO 2 When the content of any component is greater than a threshold value, a switch of an alarm component is started; when the gas content exceeds a threshold value, the alarm component can emit sound or light signals to remind an operator or a patient of the abnormal gas content; problems can be found in time, and potential danger is avoided; from the following componentsGas contents exceeding a threshold value may be harmful to the patient or the device; thus, by starting the alarm assembly, the gas supply can be stopped immediately, and the safety of patients and equipment is ensured; when the gas content exceeds a threshold value, the triggering of the alarm assembly can also remind an operator to carry out maintenance work; for example, it may be necessary to replace the sensing assembly or to check the gas supply system to restore normal gas content; in addition, a switch of the alarm component is started, so that an event of abnormal gas content can be recorded and related to other data; these data can be used for analysis and research, helping to improve treatment equipment and procedures, improving the quality and safety of treatment;
in summary, the output end of the gas content sensing module is connected with the alarm component, a threshold value is set, and when the gas content exceeds the threshold value, a switch of the alarm component is started, so that the alarm component can timely warn, safely protect, prevent excessive concentration, remind maintenance and provide functions of data recording and analysis; these functions help to ensure the safety and effectiveness of the treatment.
As shown in fig. 2-3, based on the above-mentioned oxygen-mixing type flow control system, the oxygen-mixing type nitric oxide therapeutic apparatus comprises a housing 1 and a three-way pipe 2 arranged in the housing 1, wherein a first interface, a second interface and a third interface are arranged on the three-way pipe 2, and an O is arranged on the housing 1 2 Intake pipe 3 and NO intake pipe 4,O 2 One end of the air inlet pipe 3 is connected with a first flow rate controller 5, one end of the NO air inlet pipe 4 is connected with a second flow rate controller 6, the output end of the first flow rate controller 5 is connected with a first interface of the three-way pipe 2, the output end of the second flow rate controller 6 is connected with a second interface of the three-way pipe 2, a third interface of the three-way pipe 2 is connected with a gas content sensor 7, and the output end of the gas content sensor 7 is connected with an output pipe 13; through O 2 The intake pipe 3 and the NO intake pipe 4 supply O to the inside of the first flow rate controller 5 and the second flow rate controller 6, respectively 2 And NO, ensuring that the components of the mixed gas meet the set requirements; this helps to provide accurate gas control and therapeutic effect, and can accurately control O under the action of the first and second flow rate controllers 5 and 6 2 And the flow rate and ratio of NO, and let O 2 And NO are uniformly distributed in the tee pipe 2Mixing, wherein O2 and NO in the mixed gas in the tee pipe 2 can be pertinently applied to the treatment process; appropriate O 2 The concentration may provide sufficient oxygen to promote oxygenation of the patient; and an appropriate amount of NO can be used to treat respiratory-related diseases; the application of the mixed gas can enhance the treatment effect, and the mixed gas meets the safety requirement when the contents of the O2, the NO and the NO2 are less than or equal to the threshold value through the inside of the gas content sensor 7; this helps to ensure patient and equipment safety, compliance with set requirements O 2 NO and NO 2 Through output tube 13 to the appropriate position, the mixed gas can be delivered to a specific treatment device or patient breathing interface as required; this provides a flexible way of application, accommodating different therapeutic needs;
in sum, through accurate mixed gas control and safety monitoring, O2, NO and NO2 meeting the set requirements are conveyed to a proper position, so that the accuracy, the curative effect, the safety and the flexibility of treatment can be improved.
As shown in fig. 3-4, O 2 The other end of the air inlet pipe 3 is connected with O 2 Binding post 8, the other end of NO intake pipe 4 is connected with NO binding post 9,O 2 The wiring terminal 8 and the NO wiring terminal 9 are arranged on the shell 1; by mixing O with 2 The connecting terminal 8 and the NO connecting terminal 9 are arranged on the shell 1 and can be conveniently connected with O 2 An intake pipe 3 and an NO intake pipe 4; therefore, the connection process can be simplified, and the convenience of operation is improved; and through setting up the binding post on the shell 1, can change or make up different intake pipes conveniently; for example, according to actual needs, the O2 intake pipe 3 or the NO intake pipe 4 of different types may be replaced, or a plurality of intake pipes may be used in combination; this provides a more flexible configuration option; the connecting terminal is arranged on the shell 1, so that the connection between the air inlet pipe and the circuit can be effectively isolated, and the safety problems such as current leakage or short circuit and the like are avoided; this helps to protect the safety of the mixed oxygen nitric oxide therapeutic apparatus and operators; and by arranging the connection terminal on the housing 1, the connection state can be easily observed and checked; if necessary, the connection can be checked at any time to determine whether the connection is firm or to maintain and replace; by combiningO 2 The connecting terminal 8 and the NO connecting terminal 9 are arranged on the shell 1, so that the whole connecting system can be more neat and beautiful; the appearance quality of the oxygen-mixed nitric oxide therapeutic apparatus is improved, so that the oxygen-mixed nitric oxide therapeutic apparatus has more professionality; to sum up, by at O 2 The other end of the air inlet pipe 3 is connected with O 2 The connecting terminal 8 and the other end of the NO air inlet pipe 4 are connected with the NO connecting terminal 9 and are arranged on the shell 1, so that the advantages of convenient connection, flexible combination, safe protection, easy observation and maintenance and attractive and tidy appearance can be provided; these advantages help to improve the ease of operation and reliability of the oxygen-mixed nitric oxide therapeutic apparatus.
As shown in fig. 4, a first gas filter 10 is provided between the second flow rate controller 6 and the NO intake pipe 4, and the first flow rate controller 5 and O 2 A second gas filter 11 is arranged between the air inlet pipes 3; the first gas filter 10 and the second gas filter 11 can effectively filter contaminants in the air; harmful substances such as particles, bacteria, viruses and the like can be effectively prevented from entering the mixed gas circulation system, so that the safety of equipment and patients is protected, and impurities entering the mixed gas system are effectively reduced; this may reduce damage and wear to the equipment, thereby extending the service life of the equipment; and by using the first gas filter 10 and the second gas filter 11, the purity of the mixed gas can be ensured; pure oxygen and nitric oxide can provide a higher quality therapeutic effect and reduce unnecessary interference factors; the first gas filter 10 and the second gas filter 11 can prevent harmful substances in the air from entering the mixed gas system, and reduce the risk of the patient contacting the harmful substances; this helps to ensure the safety of the treatment; in combination, by providing a first gas filter 10 between the second flow rate controller 6 and the NO intake pipe 4, and by providing a second gas filter between the first flow rate controller 5 and O 2 The second gas filter 11 is arranged between the air inlet pipes 3, so that pollutants in the air can be effectively filtered, the treatment effect is improved, and the safety guarantee is provided; these benefits help to protect the safety of the device and patient and provide high quality therapeutic results.
As shown in fig. 4, a sampling pump 12 is arranged between the third interface of the tee pipe 2 and the gas content sensor 7; the sampling pump 12 can actively extract a gas sample, so that the reliability and representativeness of the sample are ensured; the gas content sensor can help to avoid sampling deviation caused by passive sampling, improve the accuracy and precision of gas content measurement, and the sampling pump 12 can provide additional gas flow force to enable a gas sample to flow through the gas content sensor 7 more rapidly, so that the sampling time is shortened, and the efficiency of real-time monitoring is improved; the introduction of the sampling pump 12 can increase the collection quantity of the gas sample and enlarge the sampling range; this is very important for applications where low concentration gases need to be measured, and can improve the sensitivity and reliability of the detection; in addition, the sampling pump 12 can isolate the gas content sensor 7 from a gas source, so that the gas is prevented from directly contacting the gas content sensor 7, and the pollution and damage risks are reduced; the service life of the gas content sensor 7 is prolonged, the stability and the reliability of equipment are improved, and the sampling pump 12 can adjust the flow rate and the pressure of gas according to the requirement and adapt to gas samples with different types and concentrations; this enables the gas content sensor 7 to adapt to various application scenarios, providing a more flexible and reliable gas measurement; in sum, by arranging the sampling pump 12 between the third interface of the three-way pipe 2 and the gas content sensor 7, the sampling precision can be improved, the sampling time can be shortened, the sampling range can be enlarged, the gas content sensor 7 can be protected, and the gas sensor is suitable for various gases; these benefits help to improve the accuracy, stability and reliability of gas measurements.
As shown in fig. 4, the gas content sensor 7 includes O 2 A content sensor, a NO content sensor, and a NO2 content sensor; the gas content sensor 7 can accurately measure and monitor O 2 NO and NO 2 The content of the equal gas; this helps to understand the concentration of the gas component, providing important data for medical process control and the like; it is worth noting that by monitoring O 2 The content can timely find out the condition of too low or too high oxygen concentration in the air so as to avoid O 2 Deficiency or O 2 Safety risk caused by surplus; o (O) 2 Content sensor, NO content sensor and NO 2 The content sensors are connected in parallel; by parallel arrangement, O can be monitored simultaneously 2、 NO and NO 2 Is contained in the composition; this helps to fully understand the concentration variation of the gas components, providing more comprehensive data and information; by parallel arrangement, different O's can be made 2 Content sensor, NO content sensor and NO 2 The content sensors are mutually calibrated; different O 2 Content sensor, NO content sensor and NO 2 The measurement results of the content sensors can be compared and corrected, so that the measurement accuracy and reliability are improved; if any O 2 Content sensor, NO content sensor and NO 2 The content sensor fails, and other sensors can still work normally, so that the continuity and stability of the monitoring system are ensured; the parallel arrangement can improve the fault tolerance of the system; by parallel arrangement, different O's can be treated 2 Content sensor, NO content sensor and NO 2 Cross-verifying the measurement result of the content sensor; if different O 2 Content sensor, NO content sensor and NO 2 The result of the content sensor is consistent, so that the trust degree of the measurement result can be increased; if the results are inconsistent, further checks and corrections can be made, and O 2 The parallel arrangement of the content sensor, the NO content sensor and the NO2 content sensor can be conveniently extended to more gas content sensors 7 to monitor more kinds of gas components; this is very useful for the needs of different environments and application scenarios, improving the flexibility and adaptability of the sensor system; to sum up, O 2 Content sensor, NO content sensor and NO 2 The content sensors are arranged in parallel, so that various benefits such as comprehensive monitoring, mutual calibration, fault tolerance, cross verification and expansion application can be realized; these benefits help to improve the accuracy, stability and reliability of the gas measurement system; it is worth noting that NO treatment is used to increase the 6MWT distance by 77.19 meters, decrease the pulmonary artery pressure by 25.42mmHg, decrease the pulmonary artery pressure percentage by 29.6%, and NO flow rate is used to increase the therapeutic effect, thereby enabling an effective increase in the therapeutic effect of NO by increasing the 6MWT distance, decreasing the pulmonary artery pressure, and decreasing the pulmonary artery pressure percentage.
As shown in figures 5 and 6 of the drawings,illustratively, O 2 The connecting terminal 8 and the NO connecting terminal 9 have the same structure, and O 2 The connecting terminal 8 comprises a connecting sleeve 801 and a fixing sleeve 802, wherein the fixing sleeve 802 is arranged on the shell and is connected with O 2 The air inlet pipe 3 is communicated, a conical thread protruding part 803 is arranged in the fixing sleeve 802, a conical thread recessed part 804 matched with the conical thread protruding part 803 is arranged on the outer surface of one side of the connecting sleeve 801, and the design of the conical thread protruding part 803 and the conical thread recessed part 804 enables the joint between the connecting sleeve 801 and the fixing sleeve 802 to have better connection stability; the tapered thread configuration may provide a larger contact area and a tighter connection, thereby reducing the risk of loosening and air leakage; the conical thread structure design between the connecting sleeve 801 and the fixing sleeve 802 makes the disassembly and the installation more convenient; by rotating the connection sleeve 801, it can be easily inserted into or pulled out of the fixing sleeve 802, enabling quick disassembly and installation; this is very helpful for maintenance and replacement of the equipment; and the conical thread concave portion 804 of the connecting sleeve 801 is provided with a plurality of gaps 805, and the inside of the connecting sleeve 801 is provided with O-supply 2 The channel of the output pipe of the tank is penetrated and O 2 Para-position O of output pipe of tank 2 Air inlet pipe 3, and connecting sleeves 801 and O 2 A sealing ring 806 is arranged between the output pipes of the tank, and the sealing ring 806 is arranged between the connecting sleeve 801 and the output pipe of the O2 tank, so that the gas at the joint can be prevented from leaking; sealing ring 806 may provide reliable air tightness, preventing oxygen from leaking or entering areas where it should not exist, thereby ensuring safety and performance of the system; in summary, the structural design between the connecting sleeve 801 and the fixing sleeve 802 can provide good connection stability, convenient disassembly and installation, and excellent sealing performance, thereby providing convenience for normal operation and maintenance of the oxygen intake system and ensuring safety and performance of the system.
Working principle: when in use, the user can make O 2 The connecting terminal 8 and the NO connecting terminal 9 are respectively connected with O 2 Tank and NO tank, O 2 O in tank and NO tank 2 And NO respectively enter O 2 An intake pipe 3 and an NO intake pipe 4, wherein O 2 Sequentially pass through the second gasThe body filter 11 and the first flow rate controller 5 enter the three-way pipe 2, while NO sequentially passes through the first gas filter 10 and the second flow rate controller 6 and enters the three-way pipe 2, and uniform mixing is realized in the three-way pipe 2, and O is generated after mixing 2 NO and NO 2 And is output through the output pipe 13 for the therapeutic action of the patient.
Illustratively, when O 2 NO and NO 2 When the content of each component is less than or equal to the threshold value, the components can be output through the output pipe 13, and when O 2 NO and NO 2 When the content of any component is greater than a threshold value, the buzzer arranged on the shell is used for playing a role in warning and alarming to monitor and remind O 2 NO and NO 2 Abnormal component content.
The foregoing are all preferred embodiments of the present application, and are not intended to limit the scope of the present application in any way, therefore: all equivalent changes in structure, shape and principle of this application should be covered in the protection scope of this application.
Claims (10)
1. An oxygen mixing type flow control system is characterized in that: comprises an NO air inlet module and O 2 Air inlet module, constant pressure module, filtering module, flow rate control module and O 2 And a mixing module, a gas content sensing module and an output assembly for NO;
output end and O of the NO air inlet module 2 The output ends of the air inlet module are connected with the constant pressure module and the filtering module and then connected with the input end of the flow rate control module, and the output end of the flow rate control module is connected with the output end of the air inlet module 2 And an input of a mixing module for NO, said O 2 The output end of the mixing module with NO is connected with the input end of the gas content sensing module, the output end of the gas content sensing module is connected with the input end of the output assembly, and the gas content sensing module is used for detecting O 2 NO and NO 2 The contents of the components when the O 2 NO and NO 2 And when the content of each component is less than or equal to a threshold value, starting a switch of the output assembly.
2. The oxygen-mixed flow control system of claim 1, wherein: the gas content sensing module comprises O 2 Content sensing component, NO content sensing component and NO 2 And a content sensing component.
3. The oxygen-mixed flow control system of claim 1, wherein: the device also comprises a filtering module, wherein the filtering module is arranged between the output end of the NO air inlet module and the input end of the flow rate control module.
4. The oxygen-mixed flow control system of claim 1, wherein: the output end of the gas content sensing module is also connected with an alarm component, when the O is 2 NO and NO 2 And when the content of any component is greater than or less than a threshold value, starting a switch of the alarm assembly.
5. A mixed oxygen nitric oxide therapeutic apparatus based on the mixed oxygen flow control system according to any of claims 1-4, characterized in that: comprises a shell (1) and a three-way pipe (2) arranged in the shell (1), wherein a first interface, a second interface and a third interface are arranged on the three-way pipe (2), and O is arranged on the shell (1) 2 An air inlet pipe (3) and an NO air inlet pipe (4), the O 2 One end of intake pipe (3) is connected with first flow controller (5), the one end of NO intake pipe (4) is connected with second flow controller (6), the output of first flow controller (5) is connected in the first interface of three-way pipe (2), the output of second flow controller (6) is connected in the second interface of three-way pipe (2), the third interface connection gas content sensor (7) of three-way pipe (2), the output of gas content sensor (7) is connected with output tube (13).
6. The mixed oxygen nitric oxide therapeutic apparatus according to claim 5, wherein: the O is 2 The other end of the air inlet pipe (3) is connected with O 2 Binding post (8), the other end of NO intake pipe (4) is connected with NO binding post (9), what the institute was putThe O is 2 The connecting terminal (8) and the NO connecting terminal (9) are arranged on the shell (1).
7. The mixed oxygen nitric oxide therapeutic apparatus according to claim 6, wherein: a first gas filter (10) is arranged between the second flow rate controller (6) and the NO gas inlet pipe (4), and the first flow rate controller (5) and O 2 A second gas filter (11) is arranged between the air inlet pipes (3).
8. The mixed oxygen nitric oxide therapeutic apparatus according to claim 5, wherein: a sampling pump (12) is arranged between the third interface of the three-way pipe (2) and the gas content sensor (7).
9. The mixed oxygen nitric oxide therapeutic apparatus according to claim 8, wherein: the gas content sensor (7) comprises O 2 Content sensor, NO content sensor and NO 2 Content sensor, O 2 Content sensor, NO content sensor and NO 2 The content sensors are connected in parallel.
10. The mixed oxygen nitric oxide therapeutic apparatus according to claim 5, wherein: NO treatment was used to increase the 6MWT distance by 70±17.19 meters, decrease pulmonary artery pressure by 20.71±10.42mmHg, decrease pulmonary artery pressure percentage by 29.51±0.09%, and NO flow rate was used to increase the therapeutic effect.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311597165.7A CN117398564A (en) | 2023-11-27 | 2023-11-27 | Mixed oxygen type nitric oxide therapeutic instrument and flow control system |
| PCT/CN2024/101078 WO2025112494A1 (en) | 2023-11-27 | 2024-06-24 | Oxygen-blending nitric oxide therapeutic device and flow control system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311597165.7A CN117398564A (en) | 2023-11-27 | 2023-11-27 | Mixed oxygen type nitric oxide therapeutic instrument and flow control system |
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| CN117398564A true CN117398564A (en) | 2024-01-16 |
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|---|---|---|---|
| CN202311597165.7A Withdrawn CN117398564A (en) | 2023-11-27 | 2023-11-27 | Mixed oxygen type nitric oxide therapeutic instrument and flow control system |
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| Country | Link |
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| CN (1) | CN117398564A (en) |
| WO (1) | WO2025112494A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025112494A1 (en) * | 2023-11-27 | 2025-06-05 | 安徽省脉安医药科技有限公司 | Oxygen-blending nitric oxide therapeutic device and flow control system |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2926046A1 (en) * | 2013-09-11 | 2015-03-19 | Advanced Inhalation Therapies (Ait) Ltd. | System for nitric oxide inhalation |
| CN110124169A (en) * | 2019-05-27 | 2019-08-16 | 佛山分析仪有限公司 | A kind of No Treatment instrument |
| CN115212399A (en) * | 2021-08-31 | 2022-10-21 | 安徽省立医院(中国科学技术大学附属第一医院) | Pulse type nitric oxide therapeutic apparatus |
| CN115400308A (en) * | 2022-08-31 | 2022-11-29 | 北京航天长峰股份有限公司 | NO flow control system of nitric oxide therapeutic instrument |
| CN115999008A (en) * | 2023-01-09 | 2023-04-25 | 安徽省脉安医药科技有限公司 | Oxygen-mixing type nitric oxide therapeutic apparatus |
| CN117398564A (en) * | 2023-11-27 | 2024-01-16 | 安徽省脉安医药科技有限公司 | Mixed oxygen type nitric oxide therapeutic instrument and flow control system |
-
2023
- 2023-11-27 CN CN202311597165.7A patent/CN117398564A/en not_active Withdrawn
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2024
- 2024-06-24 WO PCT/CN2024/101078 patent/WO2025112494A1/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025112494A1 (en) * | 2023-11-27 | 2025-06-05 | 安徽省脉安医药科技有限公司 | Oxygen-blending nitric oxide therapeutic device and flow control system |
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