CN118286154B - Plant hyaluronic acid care solution for male private parts and preparation method thereof - Google Patents

Plant hyaluronic acid care solution for male private parts and preparation method thereof Download PDF

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CN118286154B
CN118286154B CN202410313355.XA CN202410313355A CN118286154B CN 118286154 B CN118286154 B CN 118286154B CN 202410313355 A CN202410313355 A CN 202410313355A CN 118286154 B CN118286154 B CN 118286154B
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hyaluronic acid
parts
plant
deionized water
titanium dioxide
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CN118286154A (en
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夏斌
李取泉
贾丙沂
廉少杰
康传利
刘磊
郑德强
王春喜
李庆
杜帅
汤丽伟
张美霞
徐贵祎
刘蔷
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Shandong Focus Furida Biological Co ltd
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Shandong Focus Furida Biological Co ltd
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    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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Abstract

本发明公开了一种针对男性私处的植物透明质酸护理液及其制备方法，属于外科用药护理技术领域，所述植物透明质酸护理液按重量份计，由以下成分组成：水解透明质酸8‑10份、阳离子透明质酸1‑2份、乙酰化透明质酸钠0.5‑1.5份、聚赖氨酸‑透明质酸钠复合粒子2‑3份、维生素E聚乙二醇琥珀酸酯0.5‑1.5份、纳米植物提取成分17‑20份、芦荟汁8‑10份、柠檬酸0.2‑0.3份、十二烷基二甲基甜菜碱18‑22份、去离子水100‑120份；本发明制备的护理液具有抑菌护理的作用，稳定性好，且无任何毒副作用，能够真正预防和有效治疗前列腺炎、男性阳痿、早泄。The invention discloses a plant hyaluronic acid care solution for male private parts and a preparation method thereof, belonging to the technical field of surgical drug care. The plant hyaluronic acid care solution consists of the following components by weight: 8-10 parts of hydrolyzed hyaluronic acid, 1-2 parts of cationic hyaluronic acid, 0.5-1.5 parts of acetylated sodium hyaluronate, 2-3 parts of polylysine-sodium hyaluronate composite particles, 0.5-1.5 parts of vitamin E polyethylene glycol succinate, 17-20 parts of nano plant extract components, 8-10 parts of aloe juice, 0.2-0.3 parts of citric acid, 18-22 parts of dodecyl dimethyl betaine, and 100-120 parts of deionized water. The care solution prepared by the invention has the function of antibacterial care, good stability, and no toxic side effects, and can truly prevent and effectively treat prostatitis, male impotence, and premature ejaculation.

Description

Plant hyaluronic acid care solution for private parts of men and preparation method thereof
Technical Field
The invention relates to the technical field of surgical medicine nursing, in particular to a plant hyaluronic acid nursing solution for male private parts and a preparation method thereof.
Background
Prostatitis is a major problem in urology and in men, the number of patients with prostatitis is 33% of the total number of patients out of urology. It is counted that about 30-40% of men aged 25-40 suffer from different degrees of chronic prostatitis. According to the statistics of the international health center, approximately half of men are affected by prostatitis at some time during their lifetime. With the progress and development of society, prostatitis has shown a trend of low age, is overtime in stay up and lack of exercise, has improper sexual life method and has a large number of irregular smoking and drinking, and the prostate is in a pressed state for a long time. The most common clinical symptoms of prostatitis are frequent urination, urgent urination and difficult urination, even complications caused by urinary system infection have great influence on the work and life of patients, in addition, the prostatitis is the first ti of sexual dysfunction such as male impotence, premature ejaculation, frigidity and the like, and the traditional medicines for treating the prostatitis have poor effects because the medicines cannot penetrate through glandular membranes due to special physiological structures and parts of the prostates.
For men, due to genital features such as scrotum and penis skin folds, gland multiple, and the like, when the private part wears tight clothes, the private part is easy to breathe poorly, and a plurality of factors such as a large amount of sweat, residual urine, unbeared fecal residues, semen left after the couple is in the same room, female secretion, and the like, cause easy occurrence of pollution and pathogen infection. Phimosis and foreskin growers often cause infection of mold (e.g., candida albicans), bacteria, viruses (e.g., human papilloma virus, genital herpes virus) and the like due to local dirty storage, resulting in glans penis inflammation; meanwhile, infection of bacteria, fungi and the like can also cause scrotum dampness, scrotum eczema and perianal eczema, the scrotum and perianal skin are dry and hypertrophic after a long time, the lasting period is difficult to heal, and prostatitis can be caused. In addition, infection and inflammation of the glans penis and the foreskin of a man can repeatedly occur, so that the foreskin is scarred, and the external orifice of the urethra is narrow, the urine retention and the penis cancer occur.
At present, most of nursing products used for private parts of men on the market are used for removing smell and scale, refreshing and refreshing the skin and promoting the appearance of the skin, and related chemical synthetic objects are added, so that the skin care product has poor antibacterial effect and can generate side effects, such as skin allergy, exacerbation of inflammation and the like.
In order to solve the problems, more and more enterprises turn to the research and development of plant care products, but the plant care products researched and developed at present have the problems of poor antibacterial and anti-inflammatory effects and slow absorption, and the prepared plant care products have poor storage property and are easy to lose efficacy due to poor stability of plant components.
Disclosure of Invention
Aiming at the defects existing in the prior art, the invention provides the plant hyaluronic acid nursing solution for the private parts of men and the preparation method thereof, and the prepared nursing solution has the functions of bacteriostasis and nursing, has good stability and no toxic or side effect, and can truly and effectively treat prostatitis, male impotence and premature ejaculation.
In order to solve the technical problems, the technical scheme adopted by the invention is as follows:
A plant hyaluronic acid care solution for private parts of men consists of the following components in parts by weight: 8-10 parts of hydrolyzed hyaluronic acid, 1-2 parts of cationic hyaluronic acid, 0.5-1.5 parts of acetylated sodium hyaluronate, 2-3 parts of polylysine-sodium hyaluronate composite particles, 0.5-1.5 parts of vitamin E polyethylene glycol succinate, 17-20 parts of nano plant extract components, 8-10 parts of aloe juice, 0.2-0.3 part of citric acid, 18-22 parts of dodecyl dimethyl betaine and 100-120 parts of deionized water;
The molecular weight of the hydrolyzed hyaluronic acid is 10-12kDa;
The molecular weight of the cationic hyaluronic acid is 200-400kDa, and the cationicity is 0.4-0.6;
the molecular weight of the sodium hyaluronate is 10-20kDa, and the substitution degree of acetyl is 2.6-3.6;
The preparation method of the polylysine-sodium hyaluronate composite particles comprises the following steps: coating and mixing;
The coating is carried out by mixing nano titanium dioxide, deionized water and absolute ethyl alcohol, ultrasonic oscillating, controlling ultrasonic oscillating frequency to 20-30kHz, time to 10-15min, adding into reactor after ultrasonic oscillating, controlling reactor temperature to 40-60 ℃, agitating speed to 100-300rpm, adding dopamine hydrochloride solution and ammonia water, agitating for 10-11h, centrifuging, controlling centrifuging rotating speed to 9000-10000rpm, time to 20-25min, cleaning precipitate with deionized water for 3-4 times, drying at 70-80 ℃ to obtain coated titanium dioxide;
In the coating, the mass ratio of the nano titanium dioxide to the deionized water to the absolute ethyl alcohol to the dopamine hydrochloride solution to the ammonia water is 2-2.2:500-600:200-250:500-550:70-80;
The concentration of the ammonia water is 25wt%;
the particle size of the nano titanium dioxide is 40-60nm;
the preparation method of the dopamine hydrochloride solution comprises the steps of dissolving dopamine hydrochloride in Tris-HCl buffer solution, and uniformly mixing to obtain the dopamine hydrochloride solution;
in the preparation of the dopamine hydrochloride solution, the mass ratio of the dopamine hydrochloride to the Tris-HCl buffer solution is 0.8-0.9:180-200;
The pH of the Tris-HCl buffer solution is 7.5-8.5;
adding coated titanium dioxide and deionized water into a reaction kettle, controlling the temperature of the reaction kettle to 35-50 ℃, controlling the stirring speed to 50-200rpm, stirring for 20-30min, adding sodium hydroxide aqueous solution to adjust the pH to 8.5-9.5, then adding sodium periodate, stirring for 1-1.5h, adding epsilon-polylysine, stirring for 1-2h, centrifuging, controlling the rotating speed during centrifuging to 9000-10000rpm for 15-20min, washing precipitate 3-4 times by using deionized water after centrifuging, and drying at 70-80 ℃ to obtain polylysine-sodium hyaluronate composite particles;
In the mixing, the mass ratio of the coated titanium dioxide to the deionized water to the sodium periodate to the epsilon-polylysine is 25-30:500-600:16-20:4-5;
The concentration of the sodium hydroxide aqueous solution is 0.4wt%;
the preparation method of the nano plant extract component comprises the following steps: surface modification and extraction;
Adding nano titanium dioxide, silane coupling agent KH-550, first deionized water and first absolute ethyl alcohol into a reaction kettle, controlling the temperature of the reaction kettle to 40-50 ℃, controlling the stirring speed to 200-300rpm, stirring for 5-6h, centrifuging, controlling the rotating speed in centrifuging to 9000-10000rpm for 20-25min, cleaning the precipitate 3-4 times by using deionized water after centrifuging, drying at 70-80 ℃, adding the precipitate, zein, 1-ethyl- (3-dimethylaminopropyl) carbodiimide, N-hydroxysuccinimide, second deionized water and second absolute ethyl alcohol into the reaction kettle, controlling the temperature of the reaction kettle to 40-50 ℃, controlling the stirring speed to 200-300rpm, stirring for 1-1.5h, centrifuging, controlling the rotating speed in centrifuging to 10000-11000rpm for 20-25min, cleaning the precipitate 3-4 times by using deionized water after centrifuging, and drying at 50-60 ℃ to obtain surface modified titanium dioxide;
In the surface modification, the mass ratio of nano titanium dioxide to silane coupling agent KH-550 to first deionized water to first absolute ethyl alcohol to zein to 1-ethyl- (3-dimethylaminopropyl) carbodiimide to N-hydroxysuccinimide to second deionized water to second absolute ethyl alcohol is 20-25:1.8-2:100-150:800-900:15-20:1.2-1.5:1.2-1.5:200-250:1000-1200;
the particle size of the nano titanium dioxide is 40-60nm;
Adding clove, leek seed, rhizoma polygonati, cynomorium songaricum, fructus cnidii, wolfberry fruit, semen cuscutae, raspberry, schisandra chinensis, semen plantaginis, absolute ethyl alcohol and deionized water into a reaction kettle with a reflux device, controlling the temperature of the reaction kettle to 60-70 ℃, controlling the stirring speed to 50-100rpm, refluxing and stirring for 8-10h, filtering, adding surface modified titanium dioxide into filtrate, carrying out ultrasonic oscillation, controlling the temperature of ultrasonic oscillation to 35-50 ℃, the frequency to 30-40kHz, the time to 1-1.5h, carrying out reduced pressure concentration after the ultrasonic oscillation is finished, controlling the temperature of reduced pressure concentration to 45-60 ℃, the vacuum degree to 0.06-0.08MPa, carrying out freeze drying after the reduced pressure concentration is finished, controlling the temperature of freeze drying to-40 ℃ to-35 ℃ for 12-15h, and grinding to the grain size to 200-250nm, thereby obtaining nano plant extract components;
In the extraction, the mass ratio of the clove to the leek seed to the sealwort to the cynomorium songaricum to the cnidium fruit to the medlar to the dodder seed to the raspberry to the schisandra chinensis to the plantain seed to the absolute ethanol to the deionized water to the surface modified titanium dioxide is 25-35:15-25:15-20:10-20:10-20:10-20:10-20:10-20:5-15:5-15:5-10:1000-2000:500-1000:10-15;
The preparation method of aloe juice comprises cleaning aloe, peeling to obtain aloe flesh, placing aloe flesh in a juicer, adding deionized water, squeezing, and filtering with 200-300 mesh sieve to obtain filtrate;
In the preparation of the aloe juice, the mass ratio of aloe flesh to deionized water is 500-520:800-1000.
According to the preparation method of the plant hyaluronic acid nursing liquid for the male private part, the hydrolyzed hyaluronic acid, the cationic hyaluronic acid, the acetylated sodium hyaluronate, the polylysine-sodium hyaluronate composite particles, the vitamin E polyethylene glycol succinate, the nano plant extract components, the aloe juice, the citric acid, the dodecyl dimethyl betaine and the deionized water are weighed according to the specified weight parts and added into a high-pressure homogenizer for high-pressure homogenization, the pressure of the high-pressure homogenization is controlled to be 50-60MPa, the time is 30-40min, and the plant hyaluronic acid nursing liquid for the male private part is obtained after the high-pressure homogenization is finished.
Compared with the prior art, the invention has the beneficial effects that:
(1) The plant hyaluronic acid care solution for the private parts of men, which is prepared by the invention, has good stability, and after 3 times of freeze thawing treatment, no precipitation and delamination appear in the plant hyaluronic acid care solution, and the plant hyaluronic acid care solution is still easy to flow;
(2) The plant hyaluronic acid care solution for private parts of men, which is prepared by the invention, has an antibacterial care function, deeply cleans dirt and bacteria hidden in a hairline, and has a sterilization rate of 98.8-99.3% for escherichia coli, 99.1-99.4% for candida albicans and 98.0-98.3% for staphylococcus aureus;
(3) The plant hyaluronic acid care solution for private parts of men, which is prepared by the invention, has no toxic or side effect, can truly prevent and effectively treat prostatitis, male impotence, premature ejaculation, sexual dysfunction, short duration of sexual life, physical weakness, weak heart and other common male sexual dysfunction, and in clinical effect test, lecithin small bodies are increased relatively before treatment after the plant hyaluronic acid care solution is continuously used for 6 weeks, premature ejaculation is improved, and the life of couples is normal;
(4) The plant hyaluronic acid care solution for private parts of men prepared by the invention has health care effects, can diminish inflammation, clear heat, remove dampness and relieve itching, effectively promote the absorption of effective components of the medicine effect by skin, accelerate cell metabolism and improve skin quality.
Detailed Description
Specific embodiments of the present invention will now be described in order to provide a clearer understanding of the technical features, objects and effects of the present invention.
Example 1
A plant hyaluronic acid care solution for private parts of men consists of the following components in parts by weight: 8 parts of hydrolyzed hyaluronic acid, 1 part of cationic hyaluronic acid, 0.5 part of acetylated sodium hyaluronate, 2 parts of polylysine-sodium hyaluronate composite particles, 0.5 part of vitamin E polyethylene glycol succinate, 17 parts of nano plant extract components, 8 parts of aloe juice, 0.2 part of citric acid, 18 parts of dodecyl dimethyl betaine and 100 parts of deionized water;
the molecular weight of the hydrolyzed hyaluronic acid is 10kDa;
The molecular weight of the cationic hyaluronic acid is 200kDa, and the cationicity is 0.4;
the molecular weight of the sodium hyaluronate is 10kDa, and the substitution degree of acetyl is 2.6;
the preparation method of the polylysine-sodium hyaluronate composite particles comprises the following steps:
(1) Coating: mixing 2g of nano titanium dioxide, 500g of deionized water and 200g of absolute ethyl alcohol, performing ultrasonic oscillation, controlling the frequency of ultrasonic oscillation to be 20kHz, the time to be 10min, adding the mixture into a reaction kettle after the ultrasonic oscillation is finished, controlling the temperature of the reaction kettle to be 40 ℃, controlling the stirring speed to be 100rpm, adding 500g of dopamine hydrochloride solution and 70g of ammonia water, stirring for 10h, centrifuging, controlling the rotating speed during centrifuging to be 9000rpm, controlling the time to be 25min, cleaning a precipitate by using deionized water after the centrifuging is finished, and drying at 70 ℃ to obtain coated titanium dioxide;
The concentration of the ammonia water is 25wt%;
the particle size of the nano titanium dioxide is 40nm;
the preparation method of the dopamine hydrochloride solution comprises the following steps: dissolving 0.8g of dopamine hydrochloride in 180g of Tris-HCl buffer solution with pH of 7.5, and uniformly mixing to obtain a dopamine hydrochloride solution;
(2) Mixing: adding 25g of coated titanium dioxide and 500g of deionized water into a reaction kettle, controlling the temperature of the reaction kettle to 35 ℃, controlling the stirring speed to 50rpm, stirring for 20min, adding a sodium hydroxide aqueous solution to adjust the pH to 8.5, then adding 16g of sodium periodate, stirring for 1h, adding 4g of epsilon-polylysine, stirring for 1h, centrifuging, controlling the rotating speed during centrifuging to 9000rpm, and controlling the time to 20min, washing the precipitate 3 times by using deionized water after centrifuging, and drying at 70 ℃ to obtain polylysine-sodium hyaluronate composite particles;
The concentration of the sodium hydroxide aqueous solution is 0.4wt%;
The preparation method of the nano plant extract comprises the following steps:
(1) Surface modification: adding 20g of nano titanium dioxide, 1.8g of silane coupling agent KH-550, 100g of deionized water and 800g of absolute ethyl alcohol into a reaction kettle, controlling the temperature of the reaction kettle to 40 ℃, controlling the stirring speed to 200rpm, stirring for 5h, centrifuging, controlling the rotating speed at 9000rpm for 25min, cleaning the precipitate with deionized water for 3 times after centrifuging is finished, drying at 70 ℃, adding the precipitate, 15g of zein, 1.2g of 1-ethyl- (3-dimethylaminopropyl) carbodiimide, 1.2g N-hydroxysuccinimide, 200g of deionized water and 1000g of absolute ethyl alcohol into the reaction kettle, controlling the temperature of the reaction kettle to 40 ℃, controlling the stirring speed to 200rpm, stirring for 1h, controlling the rotating speed at 10000rpm during centrifuging, controlling the rotating speed at 25min, cleaning the precipitate with deionized water for 3 times after centrifuging is finished, and drying at 50 ℃ to obtain surface modified titanium dioxide;
the particle size of the nano titanium dioxide is 40nm;
(2) Extracting: adding 25g of clove, 15g of leek seeds, 15g of rhizoma polygonati, 10g of cynomorium songaricum, 10g of fructus cnidii, 10g of medlar, 10g of semen cuscutae, 5g of raspberry, 5g of schisandra chinensis, 5g of plantain seeds, 1000g of absolute ethyl alcohol and 500g of deionized water into a reaction kettle with a reflux device, controlling the temperature of the reaction kettle to 60 ℃, controlling the stirring speed to 50rpm, refluxing and stirring for 8 hours, filtering, adding 10g of surface modified titanium dioxide into the filtrate, carrying out ultrasonic vibration, controlling the temperature of ultrasonic vibration to 35 ℃, the frequency to 30kHz, the time to 1 hour, carrying out reduced pressure concentration after the ultrasonic vibration is finished, controlling the temperature of the reduced pressure concentration to 45 ℃, the vacuum degree to 0.06MPa, the time of the reduced pressure concentration to 60 minutes, carrying out freeze drying after the reduced pressure concentration is finished, controlling the temperature of the freeze drying to-40 ℃ for 12 hours, finishing the freeze drying, and grinding to the particle size to 200nm to obtain nano plant extraction components;
The preparation method of the aloe juice comprises the following steps: cleaning aloe, peeling to obtain aloe flesh, placing 500g aloe flesh in a juicer, adding 800g deionized water, squeezing, and filtering with 200 mesh sieve to obtain aloe juice.
The embodiment also provides a preparation method of the plant hyaluronic acid care solution for the private parts of men, which specifically comprises the following steps: and (3) weighing the hydrolyzed hyaluronic acid, the cationic hyaluronic acid, the acetylated sodium hyaluronate, the polylysine-sodium hyaluronate composite particles, the vitamin E polyethylene glycol succinate, the nano plant extract components, the aloe juice, the citric acid, the dodecyl dimethyl betaine and the deionized water according to the specified weight parts, adding the materials into a high-pressure homogenizer for high-pressure homogenization, controlling the pressure of the high-pressure homogenization to be 50MPa, and controlling the time to be 30min, thus obtaining the plant hyaluronic acid care solution aiming at the private part of the male.
Example 2
A plant hyaluronic acid care solution for private parts of men consists of the following components in parts by weight: 9 parts of hydrolyzed hyaluronic acid, 1.5 parts of cationic hyaluronic acid, 1 part of acetylated sodium hyaluronate, 2.5 parts of polylysine-sodium hyaluronate composite particles, 1 part of vitamin E polyethylene glycol succinate, 18 parts of nano plant extract components, 9 parts of aloe juice, 0.2 part of citric acid, 20 parts of dodecyl dimethyl betaine and 110 parts of deionized water;
the molecular weight of the hydrolyzed hyaluronic acid is 10kDa;
the molecular weight of the cationic hyaluronic acid is 300kDa, and the cationicity is 0.5;
the molecular weight of the sodium hyaluronate is 15kDa, and the substitution degree of acetyl is 3;
the preparation method of the polylysine-sodium hyaluronate composite particles comprises the following steps:
(1) Coating: mixing 2.1g of nano titanium dioxide, 550g of deionized water and 220g of absolute ethyl alcohol, performing ultrasonic oscillation, controlling the frequency of ultrasonic oscillation to be 25kHz, controlling the time to be 12min, adding the mixture into a reaction kettle after the ultrasonic oscillation is finished, controlling the temperature of the reaction kettle to 50 ℃, controlling the stirring speed to 200rpm, adding 520g of dopamine hydrochloride solution and 75g of ammonia water, stirring for 10.5h, centrifuging, controlling the rotating speed during centrifuging to be 9500rpm, controlling the time to be 22min, cleaning a precipitate by using deionized water after the centrifuging is finished, and drying at 75 ℃ to obtain coated titanium dioxide;
The concentration of the ammonia water is 25wt%;
the particle size of the nano titanium dioxide is 50nm;
the preparation method of the dopamine hydrochloride solution comprises the following steps: dissolving 0.8g of dopamine hydrochloride in 190g of Tris-HCl buffer solution with pH of 8, and uniformly mixing to obtain a dopamine hydrochloride solution;
(2) Mixing: adding 28g of coated titanium dioxide and 550g of deionized water into a reaction kettle, controlling the temperature of the reaction kettle to 45 ℃, controlling the stirring speed to 100rpm, stirring for 25min, adding a sodium hydroxide aqueous solution to adjust the pH value to 9, then adding 18g of sodium periodate, stirring for 1.2h, adding 4.5g of epsilon-polylysine, stirring for 1.5h, centrifuging, controlling the rotating speed during centrifuging to 9500rpm for 18min, cleaning a precipitate 3 times by using deionized water after centrifuging, and drying at 75 ℃ to obtain polylysine-sodium hyaluronate composite particles;
The concentration of the sodium hydroxide aqueous solution is 0.4wt%;
The preparation method of the nano plant extract comprises the following steps:
(1) Surface modification: adding 22g of nano titanium dioxide, 1.9g of silane coupling agent KH-550, 120g of deionized water and 850g of absolute ethyl alcohol into a reaction kettle, controlling the temperature of the reaction kettle to 45 ℃, controlling the stirring speed to 250rpm, stirring for 5.5h, centrifuging, controlling the rotating speed during centrifuging to 9500rpm, controlling the time to 22min, cleaning the precipitate with deionized water for 3 times after centrifuging, drying at 75 ℃, adding the precipitate, 18g of zein, 1.3g of 1-ethyl- (3-dimethylaminopropyl) carbodiimide, 1.4g N-hydroxysuccinimide, 220g of deionized water and 1100g of absolute ethyl alcohol into the reaction kettle, controlling the temperature of the reaction kettle to 45 ℃, controlling the stirring speed to 250rpm, stirring for 1.2h, centrifuging, controlling the rotating speed during centrifuging to 11000rpm, controlling the time to 22min, cleaning the precipitate with deionized water for 3 times after centrifuging, and drying at 55 ℃ to obtain surface modified titanium dioxide;
the particle size of the nano titanium dioxide is 50nm;
(2) Extracting: adding 30g of clove, 20g of leek seeds, 18g of rhizoma polygonati, 15g of cynomorium songaricum, 15g of fructus cnidii, 15g of medlar, 15g of semen cuscutae, 10g of raspberry, 10g of schisandra chinensis, 8g of semen plantaginis, 1500g of absolute ethyl alcohol and 800g of deionized water into a reaction kettle with a reflux device, controlling the temperature of the reaction kettle to 65 ℃, controlling the stirring speed to 80rpm, refluxing and stirring for 9h, filtering, adding 12g of surface modified titanium dioxide into the filtrate, carrying out ultrasonic vibration, controlling the temperature of ultrasonic vibration to 45 ℃, the frequency to 35kHz, the time to 1.2h, carrying out reduced pressure concentration after the ultrasonic vibration is finished, controlling the temperature of the reduced pressure concentration to 55 ℃, the vacuum degree to 0.07MPa, carrying out freeze-drying after the reduced pressure concentration is finished, controlling the temperature of the freeze-drying to-38 ℃, and the time to 14h, finishing the freeze-drying, and grinding to the particle size to 220nm to obtain nano plant extract components;
The preparation method of the aloe juice comprises the following steps: cleaning aloe, peeling to obtain aloe flesh, placing 510g of aloe flesh in a juicer, adding 900g of deionized water, squeezing, and filtering with 250 mesh filter screen to obtain aloe juice.
The embodiment also provides a preparation method of the plant hyaluronic acid care solution for the private parts of men, which specifically comprises the following steps: and (3) weighing the hydrolyzed hyaluronic acid, the cationic hyaluronic acid, the acetylated sodium hyaluronate, the polylysine-sodium hyaluronate composite particles, the vitamin E polyethylene glycol succinate, the nano plant extract components, the aloe juice, the citric acid, the dodecyl dimethyl betaine and the deionized water according to the specified weight parts, adding the materials into a high-pressure homogenizer for high-pressure homogenization, controlling the pressure of the high-pressure homogenization to be 55MPa, and controlling the time to be 35min, wherein the high-pressure homogenization is finished to obtain the plant hyaluronic acid care solution aiming at the private part of the male.
Example 3
A plant hyaluronic acid care solution for private parts of men consists of the following components in parts by weight: 10 parts of hydrolyzed hyaluronic acid, 2 parts of cationic hyaluronic acid, 1.5 parts of acetylated sodium hyaluronate, 3 parts of polylysine-sodium hyaluronate composite particles, 1.5 parts of vitamin E polyethylene glycol succinate, 20 parts of nano plant extract components, 10 parts of aloe juice, 0.3 part of citric acid, 22 parts of dodecyl dimethyl betaine and 120 parts of deionized water;
The molecular weight of the hydrolyzed hyaluronic acid is 12kDa;
the molecular weight of the cationic hyaluronic acid is 400kDa, and the cationicity is 0.6;
the molecular weight of the sodium hyaluronate is 20kDa, and the substitution degree of acetyl is 3.6;
the preparation method of the polylysine-sodium hyaluronate composite particles comprises the following steps:
(1) Coating: mixing 2.2g of nano titanium dioxide, 600g of deionized water and 250g of absolute ethyl alcohol, performing ultrasonic oscillation, controlling the frequency of ultrasonic oscillation to be 30kHz, controlling the time to be 15min, adding the mixture into a reaction kettle after the ultrasonic oscillation is finished, controlling the temperature of the reaction kettle to be 60 ℃, controlling the stirring speed to be 300rpm, adding 550g of dopamine hydrochloride solution and 80g of ammonia water, stirring for 11h, centrifuging, controlling the rotating speed during centrifuging to be 10000rpm, controlling the time to be 20min, cleaning a precipitate by using deionized water after the centrifuging is finished, and drying at 80 ℃ to obtain coated titanium dioxide;
The concentration of the ammonia water is 25wt%;
The particle size of the nano titanium dioxide is 60nm;
The preparation method of the dopamine hydrochloride solution comprises the following steps: dissolving 0.9g of dopamine hydrochloride in 200g of Tris-HCl buffer solution with pH of 8.5, and uniformly mixing to obtain a dopamine hydrochloride solution;
(2) Mixing: adding 30g of coated titanium dioxide and 600g of deionized water into a reaction kettle, controlling the temperature of the reaction kettle to 50 ℃, controlling the stirring speed to 200rpm, stirring for 30min, adding sodium hydroxide aqueous solution to adjust the pH to 9.5, then adding 20g of sodium periodate, stirring for 1.5h, adding 5g of epsilon-polylysine, stirring for 2h, centrifuging, controlling the rotating speed during centrifuging to 10000rpm, controlling the time to 15min, cleaning the precipitate 4 times by using deionized water after centrifuging, and drying at 80 ℃ to obtain polylysine-sodium hyaluronate composite particles;
The concentration of the sodium hydroxide aqueous solution is 0.4wt%;
The preparation method of the nano plant extract comprises the following steps:
(1) Surface modification: adding 25g of nano titanium dioxide, 2g of silane coupling agent KH-550, 150g of deionized water and 900g of absolute ethyl alcohol into a reaction kettle, controlling the temperature of the reaction kettle to 50 ℃, controlling the stirring speed to 300rpm, stirring for 6 hours, centrifuging, controlling the rotating speed during centrifuging to 10000rpm, controlling the time to 20min, cleaning the precipitate by using deionized water for 4 times after centrifuging, drying at 80 ℃, adding the precipitate, 20g of zein, 1.5g of 1-ethyl- (3-dimethylaminopropyl) carbodiimide, 1.5g N-hydroxysuccinimide, 250g of deionized water and 1200g of absolute ethyl alcohol into the reaction kettle, controlling the temperature of the reaction kettle to 50 ℃, controlling the stirring speed to 300rpm, stirring for 1.5 hours, controlling the rotating speed during centrifuging to 11000rpm, controlling the time to 20min, cleaning the precipitate by using deionized water for 4 times after centrifuging, and drying at 60 ℃ to obtain surface modified titanium dioxide;
The particle size of the nano titanium dioxide is 60nm;
(2) Extracting: adding 35g of clove, 25g of leek seeds, 20g of rhizoma polygonati, 20g of cynomorium songaricum, 20g of fructus cnidii, 20g of medlar, 20g of semen cuscutae, 15g of raspberry, 15g of schisandra chinensis, 10g of semen plantaginis, 2000g of absolute ethyl alcohol and 1000g of deionized water into a reaction kettle with a reflux device, controlling the temperature of the reaction kettle to 70 ℃, controlling the stirring speed to 100rpm, refluxing and stirring for 10h, filtering, adding 15g of surface modified titanium dioxide into the filtrate, carrying out ultrasonic vibration, controlling the temperature of ultrasonic vibration to 50 ℃, the frequency to 40kHz, the time to 1.5h, carrying out reduced pressure concentration after the ultrasonic vibration is finished, controlling the temperature of reduced pressure concentration to 60 ℃, the vacuum degree to 0.08MPa, carrying out freeze-drying after the reduced pressure concentration is finished, controlling the temperature of freeze-drying to-35 ℃ for 15h, finishing the freeze-drying, and grinding to the particle size to 250nm to obtain nano plant extract components;
The preparation method of the aloe juice comprises the following steps: cleaning aloe, peeling to obtain aloe flesh, placing 520g of aloe flesh in a juicer, adding 1000g of deionized water, squeezing, and filtering with 300 mesh filter screen to obtain aloe juice.
The embodiment also provides a preparation method of the plant hyaluronic acid care solution for the private parts of men, which specifically comprises the following steps: and (3) weighing the hydrolyzed hyaluronic acid, the cationic hyaluronic acid, the acetylated sodium hyaluronate, the polylysine-sodium hyaluronate composite particles, the vitamin E polyethylene glycol succinate, the nano plant extract components, the aloe juice, the citric acid, the dodecyl dimethyl betaine and the deionized water according to the specified weight parts, adding the materials into a high-pressure homogenizer for high-pressure homogenization, controlling the pressure of the high-pressure homogenization to be 60MPa, and controlling the time to be 40min, wherein the high-pressure homogenization is finished to obtain the plant hyaluronic acid care solution aiming at the private part of the male.
Comparative example 1
The composition and preparation method of the plant hyaluronic acid care solution for male private parts of example 1 were changed, specifically in that: the addition of polylysine-sodium hyaluronate composite particles is omitted in the composition and preparation method of the plant hyaluronic acid care solution.
Comparative example 2
The composition and preparation method of the plant hyaluronic acid care solution for male private parts of example 1 were changed, specifically in that: in the composition of the plant hyaluronic acid care solution, in the preparation method of the nano plant extract component, the surface modification in the step (1) is omitted, and in the step (2) of extraction, the addition of the surface modified titanium dioxide is omitted.
Test example 1
The low temperature stability of the plant hyaluronic acid care solutions for male private parts prepared in examples 1 to 3 and comparative examples 1 to 2 was tested, and the test methods and test results are as follows:
The initial appearance of the plant hyaluronic acid solutions for male private parts prepared in examples 1 to 3 and comparative examples 1 to 2 was observed, respectively, and then subjected to freeze thawing treatment, the plant hyaluronic acid solutions were left at-4 ℃ for 24 hours, then at 25 ℃ for 12 hours, and after the above freeze thawing treatment was circulated 2 times, the treated appearance was observed, and the observation results were as follows:
From the above results, it can be seen that fluidity of the plant hyaluronic acid care solution can be improved by adding polylysine-sodium hyaluronate composite particles to the plant hyaluronic acid care solution; the fluidity of the plant hyaluronic acid care solution can be improved and the low-temperature stability of the plant hyaluronic acid care solution can be improved by adding the surface modified titanium dioxide into the preparation of the nano plant extract component;
The polylysine-sodium hyaluronate composite particles are coated on the surface of the nano titanium dioxide by using polymers of dopamine and epsilon-polylysine, and the compatibility of the nano titanium dioxide with other components in the plant hyaluronic acid care solution and the fluidity of the nano titanium dioxide in the plant hyaluronic acid care solution can be improved through coating, so that the fluidity of the plant hyaluronic acid care solution is improved;
The surface modified titanium dioxide is added into the preparation of the nano plant extract component, so that the dispersibility of the plant active component in the plant hyaluronic acid care solution can be improved, the fluidity of the plant hyaluronic acid care solution is improved, and meanwhile, the surface modified titanium dioxide can protect the plant active component, so that the failure of the plant active component caused by repeated freeze thawing treatment is avoided, and the problems of precipitation and layering are avoided.
Test example 2
The sterilization rates of the plant hyaluronic acid care solutions prepared in examples 1-3 and comparative examples 1-2 for male private parts on escherichia coli, candida albicans and staphylococcus aureus were tested according to QB/T2738-2012 test standard, and the test results are as follows:
From the above results, it can be seen that the bactericidal properties of the plant hyaluronic acid care solution can be improved by adding polylysine-sodium hyaluronate composite particles to the plant hyaluronic acid care solution;
The surface of the polylysine-sodium hyaluronate composite particle is the polymer of dopamine and epsilon-polylysine used on the surface of nano titanium dioxide, and the polymer has bactericidal property, and can avoid the defect of low bactericidal property of plant active ingredients, thereby improving the bactericidal property of the plant hyaluronic acid care solution.
Test example 3
The clinical effects of the plant hyaluronic acid care solutions for male private parts prepared in examples 1 to 3 and comparative examples 1 to 2 were tested, and the test methods and test results are as follows:
100 male patients with moderate premature ejaculation and lecithin corpuscles lower than normal values, which are aged between 30 and 35 years, are selected from the hospitals in the triax city, are randomly divided into 5 groups, 20 people in each group are marked as 1-5 groups, the treatment is carried out by using the plant hyaluronic acid care solutions for male private parts prepared in the examples 1-3 and the comparative examples 1-2, specifically, the private parts are washed by using the plant hyaluronic acid care solution for 1 time a day, the washing time period is 5 minutes, the continuous use is carried out for 6 weeks, whether side effects exist is recorded, and the treatment effect of the male patients in the groups 1-5 is respectively checked after the use is finished, and the check results are as follows:
from the above results, it can be seen that both premature ejaculation problem and lecithin small body are improved after using the plant hyaluronic acid care solutions for male private parts prepared in examples 1-3 and comparative example 1, indicating that premature ejaculation problem is improved by hydrolysis of hyaluronic acid, cationic hyaluronic acid, sodium hyaluronate, vitamin E polyethylene glycol succinate, nano plant extract components in cooperation with each other;
The hydrolyzed hyaluronic acid is combined with the cationic hyaluronic acid, so that the water-retention agent has the effects of resisting oxidization and aging, is rich in polar groups such as hydroxyl, carboxyl and the like, can realize the high affinity effect on water molecules through intermolecular force, and realizes the powerful water-retention effect. The expression of an antibacterial peptide component LCN2 and a pro-inflammatory factor Interleukin-8 (IL-8) of epithelial cells can be promoted by regulating a key NF-KK B signal path in an inherent immune response, so that the adhesion and infection of pathogenic bacteria can be reduced, skin injury can be prevented, and the components of skin injury can be repaired;
The function main treatment of the leek seeds is as follows: warm and nourish liver and kidney, strengthen yang and arrest spontaneous emission. Can be used for treating sexual impotence, spermatorrhea, soreness of waist and knees, enuresis, frequent urination, leukorrhagia. Is a traditional Chinese medicine capable of warming and invigorating kidney yang, can improve kidney function of human beings, can relieve kidney deficiency, can prevent impotence and premature ejaculation of men, has great benefit for maintaining male health, and can improve symptoms by timely using some leek seeds when the human beings feel soreness and weakness of waist and knees and pain of waist and legs due to kidney deficiency;
The function of the clove is mainly as follows: warming middle energizer to reduce adverse qi, warming kidney to promote yang, tonifying kidney, relieving impotence, and soreness and coldness of waist and knees. The clove has the effects of bacteriostasis and sterilization, and clove oil and eugenol in the clove have broad-spectrum antibacterial effect, and can effectively inhibit staphylococcus, escherichia coli, helicobacter pylori, streptococcus and the like;
The function of the rhizoma polygonati is mainly as follows: invigorating spleen, replenishing qi, nourishing kidney and replenishing essence. Cough due to yin deficiency; cough due to lung dryness; deficiency of spleen and debilitation; soreness and weakness of waist and knees due to kidney deficiency; impotence and spermatorrhea;
Herba Cynomorii can tonify kidney and strengthen yang. The kidney is considered to be the congenital origin by traditional Chinese medicine, and is one of the most important viscera in human body, and the essence qi stored in the kidney can influence the aspects of the growth, the life and the like of the human body. The cynomorium songaricum has the effects of warming and tonifying kidney yang and nourishing kidney essence, can promote secretion of sex hormones, strengthen physical strength and energy, relieve symptoms of sexual dysfunction such as male impotence, premature ejaculation, spermatorrhea and the like, and promote male reproductive capacity and vitality;
Fructus Cnidii contains various natural medicinal components, has super antibacterial capability, can eliminate sensitive bacteria and fungi in human body, can prevent diseases of human body caused by bacterial infection, and has great benefit for maintaining human skin health; the function main treatment of the fructus cnidii is as follows: warming kidney and strengthening yang; drying dampness and killing insects; dispelling wind and relieving itching. Impotence of main men; scrotum itching due to dampness;
the medlar and the semen cuscutae can produce sperm and tonify kidney;
the raspberry can improve the kidney function of a male, tonify kidney and strengthen yang to prevent sexual hypofunction, can accelerate erection of the male penis, can prolong the erection time of the penis, and has obvious relieving effects on symptoms such as impotence, premature ejaculation, sexual hypofunction, soreness of waist and knees and the like of the male. Efficacy indications of raspberry: kidney-tonifying, essence-securing and urination-reducing, nourishing liver and improving eyesight. Is mainly used for treating spermatorrhea, enuresis, frequent urination, impotence, premature ejaculation, liver and kidney deficiency and dim eyesight;
Fructus Schisandrae chinensis has effects in nourishing essence and promoting blood production, and can be added into semen Strychni to induce diuresis and strengthen kidney;
The nano titanium dioxide with the surface modified is added in the preparation of the nano plant extract component, specifically the nano titanium dioxide with the surface modified by using the zein crosslinked by the 1-ethyl- (3-dimethylaminopropyl) carbodiimide and the N-hydroxysuccinimide, so that the plant active component can be adsorbed and protected, and the penetrability of the plant active component can be improved after the nano titanium dioxide is used, thereby better playing the role of the plant active component.
The percentages used in the present invention are mass percentages unless otherwise indicated.
Finally, it should be noted that: the foregoing description is only a preferred embodiment of the present invention, and the present invention is not limited thereto, but it is to be understood that modifications and equivalents of some of the technical features described in the foregoing embodiments may be made by those skilled in the art, although the present invention has been described in detail with reference to the foregoing embodiments. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (8)

1.一种针对男性私处的植物透明质酸护理液，其特征在于，按重量份计，由以下成分组成：水解透明质酸8-10份、阳离子透明质酸1-2份、乙酰化透明质酸钠0.5-1.5份、聚赖氨酸-透明质酸钠复合粒子2-3份、维生素E聚乙二醇琥珀酸酯0.5-1.5份、纳米植物提取成分17-20份、芦荟汁8-10份、柠檬酸0.2-0.3份、十二烷基二甲基甜菜碱18-22份、去离子水100-120份；1. A plant hyaluronic acid care solution for male private parts, characterized in that it is composed of the following ingredients by weight: 8-10 parts of hydrolyzed hyaluronic acid, 1-2 parts of cationic hyaluronic acid, 0.5-1.5 parts of acetylated sodium hyaluronate, 2-3 parts of polylysine-sodium hyaluronate composite particles, 0.5-1.5 parts of vitamin E polyethylene glycol succinate, 17-20 parts of nano plant extract ingredients, 8-10 parts of aloe juice, 0.2-0.3 parts of citric acid, 18-22 parts of dodecyl dimethyl betaine, and 100-120 parts of deionized water; 所述聚赖氨酸-透明质酸钠复合粒子的制备方法，由以下步骤组成：包覆，混合；The preparation method of the polylysine-sodium hyaluronate composite particles comprises the following steps: coating and mixing; 所述包覆，将纳米二氧化钛、去离子水、无水乙醇混合后，超声振荡，超声振荡结束后加入反应釜中，将反应釜的温度控制至40-60℃，开启搅拌，然后加入盐酸多巴胺溶液、氨水，搅拌，离心，清洗、烘干沉淀物，得到包覆二氧化钛；The coating comprises mixing nano titanium dioxide, deionized water and anhydrous ethanol, and then ultrasonically oscillating the mixture. After the ultrasonic oscillation, the mixture is added to a reactor, the temperature of the reactor is controlled to 40-60° C., stirring is started, and then dopamine hydrochloride solution and ammonia water are added. The mixture is stirred, centrifuged, and the precipitate is washed and dried to obtain coated titanium dioxide. 所述盐酸多巴胺溶液的制备方法，将盐酸多巴胺溶于Tris-HCl缓冲液中，混合均匀，得到盐酸多巴胺溶液；The method for preparing the dopamine hydrochloride solution comprises dissolving dopamine hydrochloride in a Tris-HCl buffer solution and mixing the mixture evenly to obtain the dopamine hydrochloride solution; 所述混合，将包覆二氧化钛、去离子水加入反应釜中，将反应釜的温度控制至35-50℃，搅拌，加入氢氧化钠水溶液调节pH至8.5-9.5，然后加入高碘酸钠，搅拌，加入ε-聚赖氨酸，搅拌，离心，清洗、烘干沉淀物，得到聚赖氨酸-透明质酸钠复合粒子；The mixture is added into a reactor, the temperature of the reactor is controlled to 35-50° C., the mixture is stirred, an aqueous sodium hydroxide solution is added to adjust the pH to 8.5-9.5, sodium periodate is added, the mixture is stirred, ε-polylysine is added, the mixture is stirred, centrifuged, and the precipitate is washed and dried to obtain polylysine-sodium hyaluronate composite particles; 所述纳米植物提取成分的制备方法，由以下步骤组成：表面改性，提取；The method for preparing the nano-plant extract component comprises the following steps: surface modification, extraction; 所述表面改性，将纳米二氧化钛、硅烷偶联剂KH-550、第一份去离子水、第一份无水乙醇加入反应釜中，将反应釜的温度控制至40-50℃，搅拌，离心，清洗、烘干沉淀物，然后将沉淀物与玉米醇溶蛋白、1-乙基-(3-二甲基氨基丙基)碳酰二亚胺、N-羟基琥珀酰亚胺、第二份去离子水、第二份无水乙醇加入反应釜中，将反应釜的温度控制至40-50℃，搅拌，离心，清洗、烘干沉淀物，得到表面改性二氧化钛；The surface modification comprises adding nano titanium dioxide, silane coupling agent KH-550, a first portion of deionized water, and a first portion of anhydrous ethanol into a reactor, controlling the temperature of the reactor to 40-50° C., stirring, centrifuging, washing, and drying a precipitate, and then adding the precipitate, zein, 1-ethyl-(3-dimethylaminopropyl)carbodiimide, N-hydroxysuccinimide, a second portion of deionized water, and a second portion of anhydrous ethanol into a reactor, controlling the temperature of the reactor to 40-50° C., stirring, centrifuging, washing, and drying the precipitate to obtain surface-modified titanium dioxide; 所述提取，将丁香、韭菜籽、黄精、锁阳、蛇床子、枸杞子、菟丝子、覆盆子、五味子、车前子、无水乙醇、去离子水加入带有回流装置的反应釜中，将反应釜的温度控制至60-70℃，回流搅拌，过滤，向滤液中加入表面改性二氧化钛，超声振荡，超声振荡结束后进行减压浓缩，冷冻干燥，研磨，得到纳米植物提取成分。The extraction comprises the following steps: adding cloves, leek seeds, polygonatum, cynomorium songaricum, cnidium monnieri, wolfberry, dodder seed, raspberry, schisandra chinensis, plantago seed, anhydrous ethanol and deionized water into a reaction kettle with a reflux device, controlling the temperature of the reaction kettle to 60-70° C., reflux stirring, filtering, adding surface-modified titanium dioxide to the filtrate, ultrasonic oscillation, and after the ultrasonic oscillation is completed, vacuum concentration, freeze drying and grinding are performed to obtain nano-plant extract components. 2.根据权利要求1所述的针对男性私处的植物透明质酸护理液，其特征在于，所述水解透明质酸的分子量为10-12kDa；2. The plant hyaluronic acid care solution for male private parts according to claim 1, characterized in that the molecular weight of the hydrolyzed hyaluronic acid is 10-12 kDa; 所述阳离子透明质酸的分子量为200-400kDa，阳离子度为0.4-0.6；The cationic hyaluronic acid has a molecular weight of 200-400 kDa and a cationicity of 0.4-0.6; 所述乙酰化透明质酸钠的分子量为10-20kDa，乙酰基取代度为2.6-3.6。The molecular weight of the acetylated sodium hyaluronate is 10-20 kDa, and the degree of acetyl substitution is 2.6-3.6. 3.根据权利要求1所述的针对男性私处的植物透明质酸护理液，其特征在于，所述包覆中，纳米二氧化钛、去离子水、无水乙醇、盐酸多巴胺溶液、氨水的质量比为2-2.2:500-600:200-250:500-550:70-80；3. The plant hyaluronic acid care solution for male private parts according to claim 1, characterized in that in the coating, the mass ratio of nano titanium dioxide, deionized water, anhydrous ethanol, dopamine hydrochloride solution, and ammonia water is 2-2.2:500-600:200-250:500-550:70-80; 所述氨水的浓度为25wt%；The concentration of the ammonia water is 25wt%; 所述纳米二氧化钛的粒径为40-60nm；The particle size of the nano titanium dioxide is 40-60nm; 所述盐酸多巴胺溶液的制备中，盐酸多巴胺与Tris-HCl缓冲液的质量比为0.8-0.9:180-200；In the preparation of the dopamine hydrochloride solution, the mass ratio of dopamine hydrochloride to Tris-HCl buffer is 0.8-0.9:180-200; 所述Tris-HCl缓冲液的pH为7.5-8.5。The pH of the Tris-HCl buffer is 7.5-8.5. 4.根据权利要求1所述的针对男性私处的植物透明质酸护理液，其特征在于，所述混合中，包覆二氧化钛、去离子水、高碘酸钠、ε-聚赖氨酸的质量比为25-30:500-600:16-20:4-5；4. The plant hyaluronic acid care solution for male private parts according to claim 1, characterized in that, in the mixing, the mass ratio of coated titanium dioxide, deionized water, sodium periodate, and ε-polylysine is 25-30:500-600:16-20:4-5; 所述氢氧化钠水溶液的浓度为0.4wt%。The concentration of the sodium hydroxide aqueous solution is 0.4 wt %. 5.根据权利要求1所述的针对男性私处的植物透明质酸护理液，其特征在于，所述表面改性中，纳米二氧化钛、硅烷偶联剂KH-550、第一份去离子水、第一份无水乙醇、玉米醇溶蛋白、1-乙基-(3-二甲基氨基丙基)碳酰二亚胺、N-羟基琥珀酰亚胺、第二份去离子水、第二份无水乙醇的质量比为20-25:1.8-2:100-150:800-900:15-20:1.2-1.5:1.2-1.5:200-250:1000-1200；5. The plant hyaluronic acid care solution for male private parts according to claim 1, characterized in that, in the surface modification, the mass ratio of nano titanium dioxide, silane coupling agent KH-550, the first portion of deionized water, the first portion of anhydrous ethanol, zein, 1-ethyl-(3-dimethylaminopropyl) carbodiimide, N-hydroxysuccinimide, the second portion of deionized water, and the second portion of anhydrous ethanol is 20-25:1.8-2:100-150:800-900:15-20:1.2-1.5:1.2-1.5:200-250:1000-1200; 所述纳米二氧化钛的粒径为40-60nm。The particle size of the nano titanium dioxide is 40-60nm. 6.根据权利要求1所述的针对男性私处的植物透明质酸护理液，其特征在于，所述提取中，丁香、韭菜籽、黄精、锁阳、蛇床子、枸杞子、菟丝子、覆盆子、五味子、车前子、无水乙醇、去离子水、表面改性二氧化钛的质量比为25-35:15-25:15-20:10-20:10-20:10-20:10-20:5-15:5-15:5-10:1000-2000:500-1000:10-15。6. the plant hyaluronic acid care solution for male private parts according to claim 1, is characterized in that, in the described extraction, the mass ratio of cloves, leek seeds, polygonatum, cynomorium songaricum, cnidium monnieri, wolfberry fruit, dodder seed, raspberry, schisandra chinensis, plantago seed, absolute ethanol, deionized water, and surface modified titanium dioxide is 25-35:15-25:15-20:10-20:10-20:10-20:10-20:5-15:5-15:5-10:1000-2000:500-1000:10-15. 7.根据权利要求1所述的针对男性私处的植物透明质酸护理液，其特征在于，所述芦荟汁的制备方法，将芦荟洗净、削皮后，得到芦荟肉，取芦荟肉置于榨汁机中，然后加入去离子水，进行榨汁，然后使用滤网进行过滤，得到的滤液为芦荟汁；7. The plant hyaluronic acid care solution for male private parts according to claim 1, characterized in that the preparation method of the aloe juice comprises washing and peeling the aloe vera to obtain aloe vera pulp, placing the aloe vera pulp in a juicer, then adding deionized water to squeeze the juice, and then filtering with a filter screen to obtain the filtrate as the aloe vera juice; 所述芦荟汁的制备中，芦荟肉与去离子水的质量比为500-520:800-1000。In the preparation of the aloe vera juice, the mass ratio of aloe vera pulp to deionized water is 500-520:800-1000. 8.一种由权利要求1-7任一项所述的针对男性私处的植物透明质酸护理液的制备方法，其特征在于，按规定的重量份数称取水解透明质酸、阳离子透明质酸、乙酰化透明质酸钠、聚赖氨酸-透明质酸钠复合粒子、维生素E聚乙二醇琥珀酸酯、纳米植物提取成分、芦荟汁、柠檬酸、十二烷基二甲基甜菜碱、去离子水加入高压均质机中进行高压均质，得到针对男性私处的植物透明质酸护理液。8. A method for preparing a plant hyaluronic acid care solution for male private parts according to any one of claims 1 to 7, characterized in that hydrolyzed hyaluronic acid, cationic hyaluronic acid, acetylated sodium hyaluronate, polylysine-sodium hyaluronate composite particles, vitamin E polyethylene glycol succinate, nano-plant extract components, aloe juice, citric acid, dodecyl dimethyl betaine, and deionized water are weighed according to prescribed parts by weight and added into a high-pressure homogenizer for high-pressure homogenization to obtain a plant hyaluronic acid care solution for male private parts.
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