CN1187098C - Coremia-resisting wound protecting film and its prepn - Google Patents
Coremia-resisting wound protecting film and its prepn Download PDFInfo
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- CN1187098C CN1187098C CNB011341653A CN01134165A CN1187098C CN 1187098 C CN1187098 C CN 1187098C CN B011341653 A CNB011341653 A CN B011341653A CN 01134165 A CN01134165 A CN 01134165A CN 1187098 C CN1187098 C CN 1187098C
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- 108010022355 Fibroins Proteins 0.000 claims abstract description 45
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 33
- 239000000654 additive Substances 0.000 claims abstract description 20
- 238000000034 method Methods 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 239000000243 solution Substances 0.000 claims description 28
- 230000000996 additive effect Effects 0.000 claims description 19
- 239000011248 coating agent Substances 0.000 claims description 17
- 238000000576 coating method Methods 0.000 claims description 17
- 241000255789 Bombyx mori Species 0.000 claims description 13
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
- 238000001035 drying Methods 0.000 claims description 11
- 239000012460 protein solution Substances 0.000 claims description 11
- 230000000845 anti-microbial effect Effects 0.000 claims description 8
- 206010039424 Salivary hypersecretion Diseases 0.000 claims description 7
- 208000008630 Sialorrhea Diseases 0.000 claims description 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 7
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- 239000003431 cross linking reagent Substances 0.000 claims description 6
- 239000003230 hygroscopic agent Substances 0.000 claims description 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 6
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 5
- 229940124530 sulfonamide Drugs 0.000 claims description 4
- 150000003456 sulfonamides Chemical class 0.000 claims description 4
- 239000004310 lactic acid Substances 0.000 claims description 3
- 235000014655 lactic acid Nutrition 0.000 claims description 3
- 125000001477 organic nitrogen group Chemical group 0.000 claims description 3
- 238000000746 purification Methods 0.000 claims description 3
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 238000000502 dialysis Methods 0.000 claims description 2
- 150000002118 epoxides Chemical class 0.000 claims description 2
- 239000004744 fabric Substances 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- 235000011194 food seasoning agent Nutrition 0.000 claims description 2
- 229940075507 glyceryl monostearate Drugs 0.000 claims description 2
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 claims description 2
- 150000002989 phenols Chemical class 0.000 claims description 2
- 239000002798 polar solvent Substances 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 238000012545 processing Methods 0.000 claims description 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 2
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- 230000001954 sterilising effect Effects 0.000 abstract description 5
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 5
- 230000002349 favourable effect Effects 0.000 abstract description 4
- 206010070834 Sensitisation Diseases 0.000 abstract description 3
- 230000008313 sensitization Effects 0.000 abstract description 3
- 230000006870 function Effects 0.000 abstract description 2
- 239000012567 medical material Substances 0.000 abstract description 2
- 239000000203 mixture Substances 0.000 abstract description 2
- 239000003242 anti bacterial agent Substances 0.000 abstract 3
- 230000001681 protective effect Effects 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 239000003053 toxin Substances 0.000 abstract 1
- 231100000765 toxin Toxicity 0.000 abstract 1
- 108700012359 toxins Proteins 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 description 35
- 208000027418 Wounds and injury Diseases 0.000 description 35
- 238000003756 stirring Methods 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 4
- 239000001110 calcium chloride Substances 0.000 description 4
- 229910001628 calcium chloride Inorganic materials 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
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- 230000035699 permeability Effects 0.000 description 4
- 108010013296 Sericins Proteins 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 230000001524 infective effect Effects 0.000 description 3
- 239000011259 mixed solution Substances 0.000 description 3
- 239000002250 absorbent Substances 0.000 description 2
- 230000002745 absorbent Effects 0.000 description 2
- 230000001476 alcoholic effect Effects 0.000 description 2
- 235000015165 citric acid Nutrition 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000005251 gamma ray Effects 0.000 description 2
- 238000011034 membrane dialysis Methods 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
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- 239000004033 plastic Substances 0.000 description 2
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- 238000012958 reprocessing Methods 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 229910000029 sodium carbonate Inorganic materials 0.000 description 2
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- 229920000298 Cellophane Polymers 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 206010053692 Wound complication Diseases 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 230000002924 anti-infective effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
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- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
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- 239000012528 membrane Substances 0.000 description 1
- 230000001937 non-anti-biotic effect Effects 0.000 description 1
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- 235000018102 proteins Nutrition 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
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- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- 238000010129 solution processing Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
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- 230000029663 wound healing Effects 0.000 description 1
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- Materials For Medical Uses (AREA)
Abstract
The present invention relates to a medical material for covering wound surfaces, which is characterized in that silk is used as the main film forming raw material, and antibacterial agents and additives are added into the raw material. The mixture is coated in layers and dried by a hydrostomia method to be prepared into an antibacterial fibroin wound surface protective film. Clinical application indicates that the protective film has no bacteria, or toxins or irradiation or sensitization, and has favorable histocompatibility with human bodies and favorable binding power with wound surfaces. The present invention is mixed with a right amount of antibacterial agents and can control the release of the antibacterial agents, so that the present invention has favorable functions of sterilization and infection prevention, and can accelerate wound surfaces to heal.
Description
Technical field
The present invention relates to the medical material that a kind of wound surface covers, particularly a kind ofly be main material of preparing, contain Wound surface protection film of antibacterial and preparation method thereof with fibroin albumen.
Background technology
Before the present invention makes, publication number is the Chinese invention patent " a kind of Wound surface protection film and preparation method thereof " of CN1121836, disclosing a kind of is main film forming raw material with silkworm silk, the Wound surface protection film that adjuvants such as adding additive are prepared from, the process for preparing this Wound surface protection film is: earlier silkworm silk is heated in degumming liquid, slough the sericin of silkworm silk periphery, obtain fibroin albumen; Then, with the fibroin albumen heating for dissolving in solvent after the oven dry, make silk fibroin protein solution; Again silk fibroin protein solution is dialysed, filtered, carry out purification processing, obtain pure silk fibroin protein solution; At last, in pure silk fibroin protein solution, add additive, mix homogeneously; be injected in the film die, with promptly getting fibroin protein film behind 40～60 ℃ of hot blast dryings, fibroin protein film is processed into certain specification on demand after; packing, sterilization promptly get the Wound surface protection film finished product.The Wound surface protection film that makes with said method; good permeable, steam permeability reach and the performances such as bonding force of wound surface though have; but can't treat infective wound surface because of no bactericidal action, limit the use of clinically in early stage nothing and infect wound surface and aseptic operation wound surface, as skin donor site.
Summary of the invention
The objective of the invention is to overcome the deficiency that Wound surface protection film in the prior art exists no bactericidal action, provide a kind of both good, have Wound surface protection film of bactericidal action and preparation method thereof again with human compatibility.
The technology implementation scheme that realizes the object of the invention is: a kind of Coremia-resisting wound protecting film, by being that the fibroin albumen that raw material is made is that filmogen, antibacterial and additive are formed with silkworm silk, the content of fibroin albumen is 80～90%, described antibacterial is one or more in phenols, quaternary ammonium salt, sulfonamides and the organic nitrogen, and content is 1～5%; Described additive is by hygroscopic agent, and cross-linking agent is formed, and additive level is 10～15%, and wherein, hygroscopic agent is one or more in propanol, propylene glycol, glycerol, ethylene glycol, Polyethylene Glycol, the glyceryl monostearate; Cross-linking agent is one or more in citric acid, lactic acid, ethylenediaminetetraacetic acid, the epoxide; The total amount of above-mentioned substance is 100%.
The method for preparing described Coremia-resisting wound protecting film, be earlier silkworm silk is come unstuck, dissolving, dialysis, filtration, purification process, obtain carrying out again behind the pure silk fibroin protein solution processing of following steps:
A. antibacterial is dissolved in the polar solvent in 1: 10～30 ratio, makes antimicrobial;
B. the additive that hygroscopic agent and cross-linking agent are formed is dissolved in the normal saline in 1: 5～20 ratio, makes additive solution;
C. with pure silk fibroin protein solution and antimicrobial, additive solution uniform mixing, make and be mixed into coating solution;
D. with pure silk fibroin protein solution or the coating solution system of being mixed into film, make the counterdie that thickness is 0.002～0.006mm after the drying;
E. on counterdie, adopt the sialorrhea method will be mixed into coating solution and drip, be coated with fabric film; repeat this step 10～60 times behind the drying and forming-film; be prepared into the Coremia-resisting wound protecting film that thickness is 0.02～0.06mm, wherein the content of antibacterial is 0.1～1.0 milligram in every square centimeter of fibroin protein film.
Above-described one-tenth membrane drying process is a hot-air seasoning, and baking temperature is 30～40 ℃.
Coremia-resisting wound protecting film provided by the present invention owing to be primary raw material with silkworm silk, therefore, with human body have the favorable tissue compatibility, permeable steam permeability and with the bonding force of wound surface; Especially in film, contain a certain amount of antibacterial, therefore, wound surface is had good sterilization and anti-infectious function; Also because adopted the processing method of layering sialorrhea, coating film forming, smooth smooth, the thickness homogeneous of finished film makes antibacterial being evenly distributed in Wound surface protection film, and can effectively control the release of antibacterial.
Because fibroin albumen is quite pure native protein, the aminoacid of fibroin albumen is formed with the collagen protein that constitutes human body skin bigger similarity, and thus, Wound surface protection film and the human body made with it have the good tissue compatibility, aseptic, nontoxic, and to skin non-stimulated and sensitization; It also have good permeable steam permeability and with the bonding force of wound surface.In Coremia-resisting wound protecting film, contain antibacterial and additive, used antibacterial is the non-antibiotic class, its has a broad antifungal spectrum, the common staphylococcus aureus of infective wound surface, escherichia coli and bacillus pyocyaneus are had good killing action, and little to the human body side effect, toxicity is low, skin is had no stimulation, have good light, heat stability, good with the filmogen compatibility, separately performance is independent of each other after the mixing; Adopt the film build method of substep sialorrhea coating, antibacterial is evenly distributed in protecting film, and can control the release of antibacterial, initial release concentration is bigger, so that release concentration surpasses its minimum bactericidal concentration and has good bactericidal action, subsequently, the antibacterial in the protecting film discharges sustainably, keeps the effect of long period; Simultaneously, because the sialorrhea coating film forming is thin, therefore, drying and forming-film has at a lower temperature guaranteed the bactericidal effect of antibacterial.The outward appearance of this Coremia-resisting wound protecting film is translucent, and thickness is even, and is pliable and tough, smooth, smooth, meet water do not dissolve, not damaged, use very convenient.
The specific embodiment
Coremia-resisting wound protecting film of the present invention and preparation method thereof can be further specified by following examples:
Embodiment one:
1,1 kilogram of silkworm silk being put into 30 liters of concentration is 0.05% aqueous sodium carbonate, boils 0.5 hour, and the sericin of most silkworm silk periphery is taken off in reprocessing three times, obtains fibroin;
2, with exsiccant fibroin, be 1: 8: 2 calcium chloride, water, alcoholic solution with 6 liters of mol ratios, become silk fibroin protein solution 78 ± 2 ℃ of following heating for dissolving;
3, with the cellophane membrane dialysis, the fibroin albumen mixed solution of gained is dialysed to deionized water, to remove calcium chloride, ethanol, reuse multilamellar absorbent carbasus filters, and makes pure silk fibroin protein solution;
4,25 gram sulfonamides antibacterial are dissolved in 500 ml physiological salines, make antimicrobial;
5, the ratio of 70 gram glycerol in 1: 5 is dissolved in the normal saline, the ratio of 15 gram citric acids in 1: 10 is dissolved in the normal saline, and then, makes additive solution above-mentioned two kinds of solution mixing and stirring;
6, will be added in the container by step 1～3 prepared pure silk fibroin solution, and add the antimicrobial that step 4 makes, and stir after one hour, the additive solution that again step 5 is made adds, and at room temperature stirs half an hour, makes and is mixed into coating solution;
7, with pure silk fibroin solution film forming on the one-tenth film container,, be processed into the counterdie that thickness is 0.003mm with 50 ℃ hot blast drying;
8, adopt the sialorrhea method to drip on counterdie and be mixed into coating solution, coating evenly behind the drying and forming-film, repeats this step 20 times in 35 ℃ hot blast, make the fibroin protein film that contains antibacterial;
9, the fibroin protein film that will contain antibacterial after moisture equilibrium at dry side is cut into 10 * 20 centimetre of 2 specification, and about 0.04 millimeter of thickness is packed and sealed on the high frequency sealing machine with the double-layer plastic bag, with the gamma-ray irradiation sterilization, is finished product then.
With the principle of layering coating film forming, can adjust the thickness of film as required.
Embodiment two:
1,0.5 kilogram of leftover bits and pieces silkworm silk being put into 15 liters of concentration is 0.05% aqueous sodium carbonate, boils 0.5 hour, and the sericin of most silkworm silk periphery is taken off in reprocessing three times, obtains fibroin;
2, be 1: 8: 2 calcium chloride, water, alcoholic solution with exsiccant fibroin with 3 liters of mol ratios, become the fibroin albumen mixed solution 78 ± 2 ℃ of following heating for dissolving;
3, with the cellulose membrane dialysis, the fibroin albumen mixed solution of gained is dialysed to deionized water, to remove calcium chloride, ethanol, reuse multilamellar absorbent carbasus filters, and makes pure silk fibroin protein solution;
4,10 gram organic nitrogens and 5 gram sulfonamides antibacterial being dissolved in 300 ml concns is in 5% the glycerol solvent, to make antimicrobial;
5,20 gram glyceryl monostearates and 10 gram lactic acid all are dissolved in the normal saline respectively in 1: 10 ratio, and then, make additive solution above-mentioned two kinds of solution mixing and stirring;
6, will be added in the container by step 1～3 prepared pure silk fibroin solution, and add the antimicrobial that step 4 makes then, and stir after one hour, the additive solution that again step 5 is made adds, and at room temperature stirs half an hour, makes and is mixed into coating solution;
7, the prepared coating solution film forming in becoming film container that is mixed into,, be processed into the counterdie that thickness is 0.002mm with 40 ℃ hot blast drying;
8, adopting the sialorrhea method to drip on counterdie and be mixed into coating solution, after coating is even, is drying and forming-film in 35 ℃ the hot blast in temperature, and the duplicate step 40 of laying equal stress on time makes the fibroin protein film that contains antibacterial;
9, the fibroin protein film that will contain antibacterial after moisture equilibrium at dry side is cut into 10 * 20cm
2Specification, the about 0.05mm of thickness packs and seals on the high frequency sealing machine with the double-layer plastic bag, with the gamma-ray irradiation sterilization, is finished product then.
All can to obtain with silkworm silk be primary raw material, contain the fibroin Wound surface protection film of antibacterial by above embodiment one, two described process operations, and wherein fibroin albumen content is 80～90%, contains 0.1～1.0 milligram of antibacterial on every square centimeter of fibroin protein film.
The Wound surface protection film of made of the present invention has been used over one hundred routine patient's wound surface clinically at burn, clinical practice shows, aseptic nontoxic, no skin irritation of this protecting film and sensitization, have good pliability, permeable steam permeability and with the bonding force of wound surface, can alleviate wound pain; This protecting film has antibiotic and quickens the effect of wound healing, therefore can be used for the treatment of infective wound surface and deep ii degree burn wound surface, and curative effect is good.Table 1 is the contrast of Coremia-resisting wound protecting film of the present invention and prior art fibroin Wound surface protection film technical specification, and result of use can be done concrete statement by table 1.
Table 1
Annotate: in the table "+" number expression effectively, "-" number expression is invalid.
Claims (3)
1. Coremia-resisting wound protecting film, by being that the fibroin albumen that raw material is made is that filmogen, antibacterial and additive are formed with silkworm silk, the content of fibroin albumen is 80～90%, it is characterized in that: described antibacterial is one or more in phenols, quaternary ammonium salt, sulfonamides and the organic nitrogen, and content is 1～5%; Described additive is by hygroscopic agent, and cross-linking agent is formed, and hygroscopic agent is one or more in propanol, propylene glycol, glycerol, ethylene glycol, Polyethylene Glycol, the glyceryl monostearate; Cross-linking agent is one or more in citric acid, lactic acid, ethylenediaminetetraacetic acid, the epoxide, and additive level is 10～15%; The total amount of above-mentioned substance is 100%.
2. method for preparing Coremia-resisting wound protecting film as claimed in claim 1, earlier with silkworm silk through come unstuck, dissolving, dialysis, filtration, purification process, obtain pure silk fibroin protein solution after, it is characterized in that carrying out again the processing of following steps:
A. antibacterial is dissolved in the polar solvent in 1: 10～30 ratio, makes antimicrobial;
B. the additive that hygroscopic agent and cross-linking agent are formed is dissolved in the normal saline in 1: 5～20 ratio, makes additive solution;
C. pure silk fibroin solution and antimicrobial, additive solution are uniformly mixed to form and are mixed into coating solution;
D. with pure silk fibroin solution or the coating solution system of being mixed into film, make the counterdie that thickness is 0.002～0.006mm after the drying;
E. on counterdie, adopt the sialorrhea method will be mixed into coating solution and drip, be coated with fabric film; repeat this step 10～60 times behind the drying and forming-film; be prepared into the Coremia-resisting wound protecting film that thickness is 0.02～0.06mm, wherein the content of antibacterial is 0.1～1.0 milligram in every square centimeter of fibroin protein film.
3. the method for preparing Coremia-resisting wound protecting film according to claim 2 is characterized in that: the dry hot-air seasoning that adopts, baking temperature is 30～40 ℃.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB011341653A CN1187098C (en) | 2001-11-10 | 2001-11-10 | Coremia-resisting wound protecting film and its prepn |
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| Application Number | Priority Date | Filing Date | Title |
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| CNB011341653A CN1187098C (en) | 2001-11-10 | 2001-11-10 | Coremia-resisting wound protecting film and its prepn |
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| CN1187098C true CN1187098C (en) | 2005-02-02 |
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Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100342924C (en) * | 2004-10-13 | 2007-10-17 | 苏州苏豪生物材料科技有限公司 | Skin substitute and its preparation method |
| CN100371027C (en) * | 2004-12-02 | 2008-02-27 | 华子昂 | Biological sterilizeld sanitary napkins and functional biological material therefor |
| JP5096736B2 (en) * | 2006-12-13 | 2012-12-12 | ユニ・チャーム株式会社 | Absorbent articles |
| CN101053670B (en) * | 2007-04-03 | 2011-02-02 | 浙江理工大学 | Silk fibroin and polymeric lactic acid compound film and its preparation method |
| JP5896743B2 (en) * | 2008-10-09 | 2016-03-30 | タフツ ユニバーシティー／トラスティーズ オブ タフツ カレッジ | Modified silk film containing glycerol |
| CN101545199B (en) * | 2009-04-22 | 2011-12-21 | 苏州大学 | Antibiosis processing method of silk fiber or fabric thereof |
| CN102133425B (en) * | 2011-03-13 | 2014-05-14 | 苏州大学 | Tussah silk fibroin film and preparation method thereof |
| CN102319448A (en) * | 2011-09-16 | 2012-01-18 | 华中科技大学 | Antibacterial aquagel material for preparing medical wound dressing and preparation method thereof |
| CN107308490A (en) * | 2017-06-07 | 2017-11-03 | 常州市天宁区鑫发织造有限公司 | A kind of preparation method of liquid antibiotic wound-protecting film |
| CN108478850A (en) * | 2018-02-01 | 2018-09-04 | 束河医疗科技江苏有限公司 | A kind of regenerated silk fibroin hydrogel bandage and the preparation method and application thereof |
| CN108316018A (en) * | 2018-03-15 | 2018-07-24 | 南通纺织丝绸产业技术研究院 | A kind of preparation method of fibroin albumen/chitosan functional solution |
| CN110448715A (en) * | 2019-09-03 | 2019-11-15 | 西南大学 | A kind of preparation method of curcumin-containing medical dressing based on silk fibroin |
| CN115105634B (en) * | 2022-06-27 | 2023-09-19 | 西北有色金属研究院 | Process for preparing composite coating with timeliness for orthopedics |
| CN115233445B (en) * | 2022-08-25 | 2024-07-02 | 浙江理工大学 | Method for visible light catalytic real silk antibacterial durable finishing |
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