CN120899461B - Traditional Chinese medicine sleep-aiding eye mask based on herbal nanometer slow-release technology - Google Patents

Traditional Chinese medicine sleep-aiding eye mask based on herbal nanometer slow-release technology

Info

Publication number
CN120899461B
CN120899461B CN202511446932.3A CN202511446932A CN120899461B CN 120899461 B CN120899461 B CN 120899461B CN 202511446932 A CN202511446932 A CN 202511446932A CN 120899461 B CN120899461 B CN 120899461B
Authority
CN
China
Prior art keywords
temperature
traditional chinese
chinese medicine
release layer
sleep
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202511446932.3A
Other languages
Chinese (zh)
Other versions
CN120899461A (en
Inventor
林永飞
林梅
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nantong Mesofun Furniture Technology Co ltd
Original Assignee
Nantong Mesofun Furniture Technology Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nantong Mesofun Furniture Technology Co ltd filed Critical Nantong Mesofun Furniture Technology Co ltd
Priority to CN202511446932.3A priority Critical patent/CN120899461B/en
Publication of CN120899461A publication Critical patent/CN120899461A/en
Application granted granted Critical
Publication of CN120899461B publication Critical patent/CN120899461B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/04—Eye-masks ; Devices to be worn on the face, not intended for looking through; Eye-pads for sunbathing
    • A61F9/045—Eye-shades or visors; Shields beside, between or below the eyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M21/02—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis for inducing sleep or relaxation, e.g. by direct nerve stimulation, hypnosis, analgesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M35/00—Devices for applying media, e.g. remedies, on the human body
    • A61M35/10—Wearable devices, e.g. garments, glasses or masks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/36—General characteristics of the apparatus related to heating or cooling
    • A61M2205/3613—General characteristics of the apparatus related to heating or cooling by body heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0612—Eyes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Psychology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Vascular Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention belongs to the technical field of sleep-aiding eyeshades, in particular to a traditional Chinese medicine sleep-aiding eyeshade based on a herbal nanometer slow-release technology, which comprises a backing layer, a medicine carrier and a binding belt; according to the invention, the traditional Chinese medicine active ingredient treated by the nanoscale wall breaking technology is mixed with the polyurethane soft foam to prepare the medicine carrier, and then the surface aperture of the medicine carrier obtained by foaming is between 200 and 500nm, so that the traditional Chinese medicine active ingredient treated by the nanoscale wall breaking technology easily passes through the aperture of the medicine carrier to be contacted with the skin around the eyes of a human body in a particle size smaller than 100nm, and then the traditional Chinese medicine active ingredient is diffused out of the aperture on the medicine carrier in a slow release mode, thereby ensuring the durability of the traditional Chinese medicine sleep-aiding eyeshade in use, and improving the absorption effect of the traditional Chinese medicine active ingredient by the human body.

Description

Traditional Chinese medicine sleep-aiding eye mask based on herbal nanometer slow-release technology
Technical Field
The invention belongs to the technical field of sleep-aiding eyeshades, and particularly relates to a traditional Chinese medicine sleep-aiding eyeshade based on a herbal nanometer slow-release technology.
Background
In modern fast-paced life, often can lead to sleep time greatly reduced because work and study task volume are big, and the long-time eye that uses and bear is too high and then lead to sleep quality to be worse and worse moreover, not only influence next day work, study state, can also influence physical and mental health for a long time. Although other medicines such as hypnotics can solve the insomnia problem, the medicine has large side effects and causes great harm to human bodies after long-term use. Therefore, the effect of helping sleep is a good way by wearing the eyeshade, and the eyeshade has the important function of eliminating fatigue in life and travel.
However, the current eyeshade has single function, most of the eyeshade only has a shading effect, the requirement of modern people on high-quality sleep cannot be met, the traditional Chinese medicine eyeshade is only added with large-particle traditional Chinese medicine components, in this case, the traditional Chinese medicine only guides sleep in a volatile smell mode, and the components contributing to sleep in the traditional Chinese medicine are not really absorbed by human bodies, so that the effect of helping sleep is poor, and therefore, the eyeshade cannot have the effect of helping sleep for people needing long-term sleep assistance, such as old people, insomnia patients, chronic disease patients and the like. ‌ A
Disclosure of Invention
In order to make up the defects of the prior art, the invention provides a traditional Chinese medicine sleep-aiding eye mask based on a herbal nanometer slow-release technology. The invention is mainly used for solving the problems that the traditional Chinese medicine eyeshade is only prepared by adding large-particle Chinese medicine components into the eyeshade, the traditional Chinese medicine only guides sleep in a form of volatile smell under the condition, and the components which are beneficial to sleep in the traditional Chinese medicine are not really absorbed by human bodies, so that the drug effect of the sleep-aiding is poor.
The invention provides a traditional Chinese medicine sleep-aiding eye mask based on a herbal nanometer slow-release technology, which is characterized in that the eye mask comprises a backing layer, a medicine carrier and a binding belt, wherein the backing layer is of a frame-shaped structure with one surface open, the medicine carrier is embedded in the backing layer, the medicine carrier is prepared by mixing and foaming traditional Chinese medicine active ingredients treated by a nanometer wall-breaking technology with polyurethane soft foam, and two ends of the backing layer are connected through the binding belt.
The traditional Chinese medicine active ingredients treated by the nanoscale wall breaking technology are mixed and foamed with the polyurethane soft foam, and the surface aperture of the medicine carrier obtained by foaming is 200-500nm, so that the traditional Chinese medicine active ingredients treated by the nanoscale wall breaking technology easily pass through the aperture of the medicine carrier to contact with the skin around the eyes of a human body in a particle size smaller than 100nm, and the traditional Chinese medicine active ingredients are diffused out of the aperture on the medicine carrier in a slow release mode, so that the use durability of the traditional Chinese medicine sleep-aiding eyeshade is ensured, and the absorption effect of the traditional Chinese medicine active ingredients by the human body is improved. The pore size of the surface of the drug carrier can be controlled by controlling the concentration of the foaming agent in the process. If azodicarbonamide is used as the blowing agent, the concentration of azodicarbonamide is between 1.2 and 1.8 wt%. The backing layer adopts a frame-type structure with one surface open, so as to prevent the problem of drug effect loss caused by the diffusion of the active ingredients of the traditional Chinese medicine in the drug carrier out of the side edge of the drug carrier.
Preferably, the preparation process of the drug carrier comprises the following steps:
S1, putting raw materials of active ingredients of traditional Chinese medicines into a high-pressure nanometer crusher, circularly treating for 3-5 times under the pressure of 200-300MPa, each time lasting for 2-3 minutes, and collecting active ingredient suspension with the particle size smaller than 100nm after crushing is finished, wherein the working parameters of the high-pressure nanometer crusher are that the flow rate is 15L/h, the temperature is controlled to be 4-8 ℃, and zirconia beads are adopted as crushing media;
S2, reacting polyether glycol ‌ with toluene diisocyanate for 3-4 hours at 80-85 ℃ according to a molar ratio of 1:2 to obtain a polyurethane prepolymer with NCO content of 8.0+/-0.3%, wherein the polyether glycol can be ‌ PPG-2000 type, and the toluene diisocyanate can be ‌ MDI-50;
S3, after the polyurethane prepolymer is cooled to 40 ℃, mixing the polyurethane prepolymer and the active ingredient suspension according to the mass ratio of 8:2, and dispersing at a high speed of 1800-2000rpm for 8-10 minutes;
s4, adding a foaming agent azodicarbonamide, wherein the concentration is 1.2-1.8wt%, and foaming for 30-35 minutes;
s5, curing for 24-30 hours at normal temperature, and then cutting into standard sizes to obtain the drug carrier.
Preferably, the medicine sleep-aiding eye mask further comprises a temperature-sensitive controlled release layer, wherein the temperature-sensitive controlled release layer is arranged on one side of an opening of the back lining layer, the edge of the temperature-sensitive controlled release layer is in sealing connection with the edge of the back lining layer, and the preparation process of the temperature-sensitive controlled release layer comprises the following steps:
n1, dehydrating N-isopropyl acrylamide in a vacuum drying oven at 50-60 ℃ for 3-4 hours, and drying hydroxypropyl acrylamide in a dryer for later use;
n2, weighing 82.5g of N-isopropyl acrylamide and 12g of hydroxypropyl acrylamide, adding into a 500mL three-neck flask, injecting 200mL of absolute ethyl alcohol preheated to 50-60 ℃, magnetically stirring until the absolute ethyl alcohol is completely transparent, and rotating at 300-350rpm for 25+/-3 minutes;
N3, adding 5g of nanocellulose, starting a probe ultrasonic instrument, and treating for 20-30 minutes at the amplitude of 70% to form a homogeneous opalescence suspension;
n4, adding 0.5g of photoinitiator after cooling to 25-30 ℃, mechanically stirring for 10-15 minutes under the dark condition, and rotating at 150-200rpm;
N5, transferring to a vacuum defoaming tank, circularly defoaming for 3-5 times at 40-50 ℃ under the pressure of-0.095 MPa for 5-8 minutes each time until no bubbles escape from the liquid surface, and further obtaining a prepolymer;
N6, adopting a customized quartz mold, spraying PTFE release agent on the surface of the mold, preheating the mold to 30-35 ℃, injecting the prepolymer liquid, and controlling the thickness of the liquid layer to be 380+/-10 mu m by a scraper;
n7, irradiating the central area with ultraviolet light of 10mW/cm2 for 30-40 seconds to form a low cross-linking structure, irradiating the transition area with ultraviolet light of 18mW/cm2 for 75-85 seconds, irradiating the edge area with ultraviolet light of 25mW/cm2 for 120-130 seconds, dehydrating by 30-100% ethanol gradient after solidification, and drying at 40 ℃ to obtain a 120 mu m gel film;
And N8, spin-coating a silane coupling agent on the PET film subjected to plasma treatment, and then bonding the PET film and the gel film for 30-40 seconds under the conditions of 60 ℃ and 0.5MPa, wherein the cooling rate is controlled to be 5-6 ℃ per minute so as to avoid interfacial delamination, thereby preparing the temperature-sensitive controlled release layer. The plasma treatment parameters are specifically that the treatment is carried out for 180 seconds in an argon environment with the power of 100W;
In the phase of just contacting the temperature-sensitive controlled release layer with the skin around eyes, the temperature around eyes is between 34 and 35 ℃, the temperature-sensitive controlled release layer maintains a contracted state, the microporous structure of 50 to 100nm ensures that the active ingredients of the traditional Chinese medicine complete the permeation of basic medicines, the transdermal rate is stabilized at 0.8mg/h at the moment, the stable sleeping state of a user is ensured, and further the sleepiness side effect caused by the initial burst release of the traditional sleep-aiding eyeshade is effectively avoided.
When a user enters a deep sleep stage, the body temperature rises to 36.8-37.2 ℃, and the temperature-sensitive controlled-release layer is still in an expansion period dominated by hydroxypropyl acrylamide at the temperature, so that the phase change expansion of the temperature-sensitive controlled-release layer is triggered, the pore diameter of the temperature-sensitive controlled-release layer is expanded to 300-500nm, a high-speed channel for releasing the medicine is formed, the burst release rate reaches 2.3mg/h at the moment, and the blood concentration required by enhancing the brain electricity delta wave is exactly matched.
And the physical characteristics of the gel of the temperature-sensitive controlled release layer are further that the gel is easier to dissipate heat at normal temperature, so that the temperature of the gel is relatively low, the gel is in a highly contracted state, the pore diameter of micropores on the gel is small, and the diffusion of the active ingredients of the traditional Chinese medicine in the medicine carrier can be well limited, so that the diffusion loss of the active ingredients of the traditional Chinese medicine in the medicine carrier is prevented when the gel is not used, and the protection effect is further achieved. ‌ A
Preferably, a protective cover is arranged on the outer side of the temperature-sensitive controlled release layer, the inner wall of the protective cover is abutted against the outer side surface of the temperature-sensitive controlled release layer, a first circular arc flange is arranged on the outer side of the opening edge of the protective cover, and the first circular arc flange is buckled with a second circular arc flange protruding inwards on the outer side edge of the backing layer.
Through set up the protective cover rather than supporting mutually tightly laminating in the outside of temperature-sensitive controlled release layer, and then prevent that traditional chinese medicine active ingredient in the medicine carrier from diffusing out through temperature-sensitive controlled release layer, and then prevent that the sleep-aiding eye-shade from losing its traditional chinese medicine active ingredient in when idle, and then improved the life of sleep-aiding eye-shade. The anti-diffusion can be carried out by abutting and bonding the protective cover and the temperature-sensitive controlled release layer, so that the traditional Chinese medicine active ingredients can be completely reserved in the apertures of the medicine carrier and the temperature-sensitive controlled release layer, once the traditional Chinese medicine active ingredients are diffused outside the aperture of the temperature-sensitive controlled release layer, once the protective cover is opened in next use, the traditional Chinese medicine active ingredients outside the diffusion can not be utilized in the air, and further, the problem can be well solved by abutting and bonding. The back lining layer can be integrally formed by adopting a silica gel material, and the protective cover can be formed by adopting plastic or hard silica gel.
Preferably, a circumference protruding strip is arranged at the inner side of the protective cover and close to the edge of the temperature-sensitive controlled release layer.
When the inner wall of the protective cover is abutted against the outer side surface of the temperature-sensitive controlled release layer, the protruding strips on the protective cover also squeeze the edge of the temperature-sensitive controlled release layer, and the edge of the temperature-sensitive controlled release layer is squeezed and compressed so that the holes in the inner wall of the protective cover are squeezed and closed, so that the active ingredients of the traditional Chinese medicine entering the holes of the temperature-sensitive controlled release layer cannot diffuse out from the side edges of the temperature-sensitive controlled release layer, the diffusion prevention effect of the protective cover is further guaranteed, and the service life of the sleep-aiding eyeshade is further prolonged.
The traditional Chinese medicine sleep-aiding eye mask comprises a temperature-control module, wherein the temperature-control module comprises a first electric heating sheet, a storage battery, a wireless receiving unit and a control unit, the first electric heating sheet is uniformly distributed at intervals in the temperature-sensitive controlled release layer at a dual-purpose bonding position, the first electric heating sheet is electrically connected with the storage battery through the control unit, the control unit is electrically connected with the wireless receiving unit, and the wireless receiving unit is used for receiving control instructions of an external terminal.
The temperature-sensitive controlled release layer is uniformly distributed at intervals at two positions which are adhered to each other through the inner side of the temperature-sensitive controlled release layer, the current intensity of the first electric heating plate is controlled to be 0.1-0.5mA strictly through the control unit, the first electric heating plate can provide heat under the current intensity to enable the temperature-sensitive controlled release layer to be still in an expansion period which is mainly conducted by hydroxypropyl acrylamide, the expansion degree of the temperature-sensitive controlled release layer can be actively regulated and controlled through a micro-current mode, the expansion of the temperature-sensitive controlled release layer cannot be fully stimulated through the body temperature of the elderly mainly used for some cold people, the current received by the first electric heating plate is controlled through an external terminal, such as a mobile phone or a special remote controller through a Bluetooth wireless communication mode, the expansion of the temperature-sensitive controlled release layer can be controlled through Joule conversion heat, the diameter of pores on the temperature-sensitive controlled release layer is controlled, the diffusion quantity of traditional Chinese medicine active components in a medicine carrier is increased, the concentration of the traditional Chinese medicine active components in the medicine carrier can reach the sleep-assisting requirement, the micro-current control temperature-controlled release layer is used for assisting the diffusion of the traditional Chinese medicine active components, the traditional Chinese medicine active component concentration is controlled through the micro-current control module, the diffusion of the traditional Chinese medicine active component concentration is not only controlled, and the diffusion of the traditional Chinese medicine active component concentration is controlled, the concentration is not be controlled, and the eye mask is suitable for people can be used, and the eye mask is improved.
Preferably, the micro-current temperature control module further comprises a patch type temperature sensor, wherein the temperature sensor is arranged in the temperature-sensitive controlled release layer and positioned at a dual-purpose bonding position.
The temperature sensor is embedded in the temperature-sensitive controlled release layer during molding, the patch type temperature sensor is arranged at the position, which is positioned in the temperature-sensitive controlled release layer and is attached to the dual-purpose position, so that the size of the upper aperture of the temperature-sensitive controlled release layer at the temperature can be calculated through the temperature value measured by the temperature sensor, the diffusion speed of the traditional Chinese medicine active ingredient in the medicine carrier can be obtained, the data is fed back to the control unit, and the control unit controls the diffusion speed of the traditional Chinese medicine active ingredient in the high-quality sleep-aiding medicine concentration range through regulating and controlling the current intensity of the first electric heating plate, so that the sleep-aiding effect of the sleep-aiding eye mask is improved. And the temperature of the binocular position of real-time supervision laminating through temperature sensor can not be too high, if the high temperature appears, cuts off in time the power supply to first electric heat piece through control unit, reports to the police through giving the alarm with the signal of telecommunication simultaneously, and then reduces the injury to the user.
Preferably, the traditional Chinese medicine sleep-aiding eye mask further comprises an expansion module, wherein the expansion module is arranged between the medicine carrier and the back lining layer and positioned at a dual-purpose bonding position, the expansion module comprises an elastic membrane and an expansion body, the elastic membrane is of a closed bag-shaped structure, and the expansion body is filled in the elastic membrane.
The material of the expansion body is the same as that of the temperature-sensitive controlled release layer, and the expansion body which is the same as that of the temperature-sensitive controlled release layer is arranged at the position between the medicine carrier and the backing layer and positioned at the joint dual purposes, so that after a user enters deep sleep, the expansion body is expanded in volume due to the rise of body temperature, the medicine carrier is extruded to be outwards protruded, the medicine carrier at the position is extruded to be more closely contacted with the periphery of the eyes, the traditional Chinese medicine active ingredients diffused in the medicine carrier are more rapidly contacted with the skin around the eyes, the percutaneous absorption is further carried out more rapidly, the medicine action efficiency of the traditional Chinese medicine active ingredients is further improved, and the sleep-aiding effect of the sleep-aiding eyeshade is further improved.
Preferably, the expansion module further comprises a second electric heating plate, the second electric heating plate is arranged inside the expansion body, and the second electric heating plate is connected with the storage battery through the control unit in an electric signal mode.
The temperature-sensitive controlled release layer is further controlled to be attached to the periphery of the eyes more accurately, so that the traditional Chinese medicine active ingredients diffused in the medicine carrier are contacted with the skin around the eyes more quickly, transdermal absorption is further performed more quickly, the medicine action efficiency of the traditional Chinese medicine active ingredients is further improved, the sleep assisting effect of the sleep assisting eyeshade is further improved, the temperature-sensitive controlled release layer can be controlled not to be attached excessively or even extruded to the periphery of the eyes, and sleep of a user is further prevented.
Preferably, the expansion module further comprises a pressure sensor, wherein the pressure sensor is arranged between the elastic membrane and the drug carrier, and the pressure sensor is connected with the control unit through an electric signal.
Through set up pressure sensor between elastic membrane and medicine carrier, and then through pressure sensor can real-time supervision expansion module to medicine carrier's extrusion force, and then confirm the degree around the extrusion temperature-sensitive controlled release layer laminating eyes of medicine carrier, through giving control unit with this data transfer, and then the more accurate control expansion module's of control unit inflation degree, and then around the more accurate control temperature-sensitive controlled release layer laminating eyes, and then improved the medicine effect efficiency of traditional chinese medicine active ingredient, and then improved the effect of helping sleep of helping the eye-shade, and the control temperature-sensitive controlled release layer that can be more accurate can not excessively laminate even extrude around the eyes, and then prevent to influence user's sleep.
The beneficial effects of the invention are as follows:
1. According to the invention, the traditional Chinese medicine active ingredients treated by the nanoscale wall breaking technology are mixed and foamed with the polyurethane soft foam, and the surface aperture of the medicine carrier obtained by foaming is 200-500nm, so that the traditional Chinese medicine active ingredients treated by the nanoscale wall breaking technology easily pass through the aperture of the medicine carrier to be contacted with the skin around the eyes of a human body in a particle size smaller than 100nm, and the traditional Chinese medicine active ingredients are diffused out from the aperture on the medicine carrier in a slow release mode, so that the use durability of the traditional Chinese medicine sleep-aiding eyeshade is ensured, and the absorption effect of the traditional Chinese medicine active ingredients by the human body is improved. The pore size of the surface of the drug carrier can be controlled by controlling the concentration of the foaming agent in the process. If azodicarbonamide is used as the blowing agent, the concentration of azodicarbonamide is between 1.2 and 1.8 wt%. The backing layer adopts a frame-type structure with one surface open, so as to prevent the problem of drug effect loss caused by the diffusion of the active ingredients of the traditional Chinese medicine in the drug carrier out of the side edge of the drug carrier.
2. In the invention, when the temperature-sensitive controlled release layer is just in contact with the skin around eyes, the temperature around eyes is between 34 and 35 ℃, the temperature-sensitive controlled release layer maintains a contracted state, and the microporous structure of 50 to 100nm ensures that the active ingredients of the traditional Chinese medicine complete the permeation of basic medicines, and the transdermal rate is stabilized at 0.8mg/h, so that a user is ensured to stably enter a sleep state, and further, the sleepiness side effect caused by the initial burst release of the traditional sleep-aiding eyeshade is effectively avoided. When a user enters a deep sleep stage, the body temperature rises to 36.8-37.2 ℃, and the temperature-sensitive controlled-release layer is still in an expansion period dominated by hydroxypropyl acrylamide at the temperature, so that the phase change expansion of the temperature-sensitive controlled-release layer is triggered, the pore diameter of the temperature-sensitive controlled-release layer is expanded to 300-500nm, a high-speed channel for releasing the medicine is formed, the burst release rate reaches 2.3mg/h at the moment, and the blood concentration required by enhancing the brain electricity delta wave is exactly matched. And the physical characteristics of the gel of the temperature-sensitive controlled release layer are further that the gel is easier to dissipate heat at normal temperature, so that the temperature of the gel is relatively low, the gel is in a highly contracted state, the pore diameter of micropores on the gel is small, and the diffusion of the active ingredients of the traditional Chinese medicine in the medicine carrier can be well limited, so that the diffusion loss of the active ingredients of the traditional Chinese medicine in the medicine carrier is prevented when the gel is not used, and the protection effect is further achieved.
3. According to the invention, the protective cover which is mutually abutted and adhered is arranged on the outer side of the temperature-sensitive controlled release layer, so that the traditional Chinese medicine active ingredients in the medicine carrier are prevented from diffusing out through the temperature-sensitive controlled release layer, the loss of the traditional Chinese medicine active ingredients in the sleep-aiding eyeshade is prevented when the sleep-aiding eyeshade is in idle, and the service life of the sleep-aiding eyeshade is prolonged. The anti-diffusion can be carried out by abutting and bonding the protective cover and the temperature-sensitive controlled release layer, so that the traditional Chinese medicine active ingredients can be completely reserved in the apertures of the medicine carrier and the temperature-sensitive controlled release layer, once the traditional Chinese medicine active ingredients are diffused outside the aperture of the temperature-sensitive controlled release layer, once the protective cover is opened in next use, the traditional Chinese medicine active ingredients outside the diffusion can not be utilized in the air, and further, the problem can be well solved by abutting and bonding. The back lining layer can be integrally formed by adopting a silica gel material, and the protective cover can be formed by adopting plastic or hard silica gel.
4. According to the invention, the first electric heating plates are uniformly distributed at intervals at the positions of the two purposes of bonding in the temperature-sensitive controlled release layer, the current intensity of the first electric heating plates is controlled to be 0.1-0.5mA strictly through the control unit, the first electric heating plates can provide heat under the current intensity to ensure that the temperature-sensitive controlled release layer is still in the expansion period led by hydroxypropyl acrylamide, the expansion degree of the temperature-sensitive controlled release layer can be actively regulated and controlled in a micro-current mode, the active regulation and control is mainly used for controlling the expansion of the temperature-sensitive controlled release layer by the fact that some cold aged cannot completely stimulate the temperature of the temperature-sensitive controlled release layer through the body temperature, the current received by the first electric heating plates is controlled through an external terminal, such as a mobile phone or a special remote controller through a wireless communication mode such as Bluetooth, the expansion of the temperature-sensitive controlled release layer can be controlled through Joule conversion heat, the diffusion quantity of the active components of traditional Chinese medicine active components in the temperature-sensitive controlled release layer can be controlled, the diffusion quantity of the traditional Chinese medicine active components in the medicine carrier can be increased, the concentration of the traditional Chinese medicine active components in the medicine carrier can be ensured to reach the sleep-aid requirements, the diffusion of the traditional Chinese medicine active components can be controlled by setting the micro-electric temperature-controlled release module, the diffusion concentration of the traditional Chinese medicine active components can not be controlled, and the sleep-aid can be controlled, the eye mask can be applied to the eye mask, and the eye mask can be controlled.
Drawings
The invention is further described below with reference to the accompanying drawings.
FIG. 1 is a schematic view of the whole structure of a traditional Chinese medicine sleep-aiding eyeshade under a first view angle;
FIG. 2 is a schematic view of the overall structure of the traditional Chinese medicine sleep-aiding eyeshade under a second view angle;
FIG. 3 is a schematic view showing the internal structure of the traditional Chinese medicine sleep-aiding eyeshade;
FIG. 4 is a half cross-sectional view of a traditional Chinese medicine sleep-aiding eye mask of the present invention;
FIG. 5 is an enlarged view of a portion of FIG. 4 at A;
FIG. 6 is a schematic illustration of the expansion module of the present invention in an expanded state;
FIG. 7 is a schematic diagram of a second electric heat plate according to the present invention;
FIG. 8 is a schematic representation of a drug carrier of the present invention after being deformed by compression;
FIG. 9 is a schematic view of a first electric heat plate according to the present invention;
In the figure, a backing layer 1, a second circular arc flange 11, a drug carrier 2, a binding belt 3, a temperature-sensitive controlled release layer 4, a protective cover 5, a first circular arc flange 51, a convex strip 52, a first electric heating plate 6 and a second electric heating plate 7.
Detailed Description
The invention is further described in connection with the following detailed description in order to make the technical means, the creation characteristics, the achievement of the purpose and the effect of the invention easy to understand.
The traditional Chinese medicine sleep-aiding eye mask based on the herbal nanometer slow release technology is shown in fig. 1 to 5, and comprises a back lining layer 1, a medicine carrier 2 and a binding belt 3, wherein the back lining layer 1 is of a frame-shaped structure with one surface open, the medicine carrier 2 is embedded in the back lining layer 1, the medicine carrier 2 is prepared by mixing and foaming traditional Chinese medicine active ingredients treated by the nanometer wall breaking technology with polyurethane soft foam, and two ends of the back lining layer 1 are connected through the binding belt 3.
The traditional Chinese medicine active ingredient treated by the nanoscale wall breaking technology is mixed with the polyurethane soft foam for foaming, and then the surface aperture of the medicine carrier 2 obtained by foaming is between 200 and 500nm, so that the traditional Chinese medicine active ingredient treated by the nanoscale wall breaking technology easily passes through the aperture of the medicine carrier 2 to be contacted with the skin around the eyes of a human body in the particle size smaller than 100nm, and then the traditional Chinese medicine active ingredient is diffused out from the aperture on the medicine carrier 2 in a slow release mode, thereby ensuring the durability of the traditional Chinese medicine sleep-aiding eyeshade in use on one hand and improving the absorption effect of the traditional Chinese medicine active ingredient on the other hand. The pore size of the surface of the drug carrier 2 can be controlled by controlling the concentration of the foaming agent in the process. If azodicarbonamide is used as the blowing agent, the concentration of azodicarbonamide is between 1.2 and 1.8 wt%. The backing layer 1 adopts a frame-type structure with one surface open, so as to prevent the problem of drug effect loss caused by the diffusion of the active ingredients of the traditional Chinese medicine in the drug carrier 2 out of the side edge of the drug carrier 2.
The preparation process of the drug carrier 2 comprises the following steps:
S1, putting raw materials of active ingredients of traditional Chinese medicines into a high-pressure nanometer crusher, circularly treating for 3-5 times under the pressure of 200-300MPa, each time lasting for 2-3 minutes, and collecting active ingredient suspension with the particle size smaller than 100nm after crushing is finished, wherein the working parameters of the high-pressure nanometer crusher are that the flow rate is 15L/h, the temperature is controlled to be 4-8 ℃, and zirconia beads are adopted as crushing media;
S2, reacting polyether glycol ‌ with toluene diisocyanate for 3-4 hours at 80-85 ℃ according to a molar ratio of 1:2 to obtain a polyurethane prepolymer with NCO content of 8.0+/-0.3%, wherein the polyether glycol can be ‌ PPG-2000 type, and the toluene diisocyanate can be ‌ MDI-50;
S3, after the polyurethane prepolymer is cooled to 40 ℃, mixing the polyurethane prepolymer and the active ingredient suspension according to the mass ratio of 8:2, and dispersing at a high speed of 1800-2000rpm for 8-10 minutes;
s4, adding a foaming agent azodicarbonamide, wherein the concentration is 1.2-1.8wt%, and foaming for 30-35 minutes;
s5, curing for 24-30 hours at normal temperature, and then cutting into standard sizes to obtain the drug carrier 2.
As shown in fig. 3 to 5, the drug sleep-aiding eye patch further comprises a temperature-sensitive controlled release layer 4, wherein the temperature-sensitive controlled release layer 4 is arranged on one side of an opening of the backing layer 1, the edge of the temperature-sensitive controlled release layer 4 is in sealing connection with the edge of the backing layer 1, and the preparation process of the temperature-sensitive controlled release layer 4 comprises the following steps:
n1, dehydrating N-isopropyl acrylamide in a vacuum drying oven at 50-60 ℃ for 3-4 hours, and drying hydroxypropyl acrylamide in a dryer for later use;
n2, weighing 82.5g of N-isopropyl acrylamide and 12g of hydroxypropyl acrylamide, adding into a 500mL three-neck flask, injecting 200mL of absolute ethyl alcohol preheated to 50-60 ℃, magnetically stirring until the absolute ethyl alcohol is completely transparent, and rotating at 300-350rpm for 25+/-3 minutes;
N3, adding 5g of nanocellulose, starting a probe ultrasonic instrument, and treating for 20-30 minutes at the amplitude of 70% to form a homogeneous opalescence suspension;
n4, adding 0.5g of photoinitiator after cooling to 25-30 ℃, mechanically stirring for 10-15 minutes under the dark condition, and rotating at 150-200rpm;
N5, transferring to a vacuum defoaming tank, circularly defoaming for 3-5 times at 40-50 ℃ under the pressure of-0.095 MPa for 5-8 minutes each time until no bubbles escape from the liquid surface, and further obtaining a prepolymer;
N6, adopting a customized quartz mold, spraying PTFE release agent on the surface of the mold, preheating the mold to 30-35 ℃, injecting the prepolymer liquid, and controlling the thickness of the liquid layer to be 380+/-10 mu m by a scraper;
n7, irradiating the central area with ultraviolet light of 10mW/cm2 for 30-40 seconds to form a low cross-linking structure, irradiating the transition area with ultraviolet light of 18mW/cm2 for 75-85 seconds, irradiating the edge area with ultraviolet light of 25mW/cm2 for 120-130 seconds, dehydrating by 30-100% ethanol gradient after solidification, and drying at 40 ℃ to obtain a 120 mu m gel film;
and N8, spin-coating a silane coupling agent on the PET film subjected to plasma treatment, then bonding the silane coupling agent with the gel film under the conditions of 60 ℃ and 0.5MPa for 30-40 seconds, and controlling the cooling rate to be 5-6 ℃ per minute to avoid interfacial delamination, thereby preparing the temperature-sensitive controlled release layer 4. The plasma treatment parameters are specifically that the treatment is carried out for 180 seconds in an argon environment with the power of 100W;
in the contact stage of the temperature-sensitive controlled release layer 4 and the skin around eyes, the temperature around eyes is between 34 and 35 ℃, the temperature-sensitive controlled release layer 4 maintains a contracted state, the microporous structure of 50 to 100nm ensures that the active ingredients of the traditional Chinese medicine complete the permeation of basic medicines, the transdermal rate is stabilized at 0.8mg/h, the stable sleeping state of a user is ensured, and further the sleepiness side effect caused by the initial burst release of the traditional sleep-aiding eyeshade is effectively avoided.
When the user enters a deep sleep stage, the body temperature rises to 36.8-37.2 ℃, and the temperature-sensitive controlled-release layer 4 is still in an expansion period dominated by hydroxypropyl acrylamide at the temperature, so that the temperature-sensitive controlled-release layer 4 is triggered to perform phase change expansion, the pore diameter of the temperature-sensitive controlled-release layer 4 is expanded to 300-500nm, a high-speed channel for releasing the medicine is formed, the burst release rate reaches 2.3mg/h at the moment, and the blood concentration required by enhancing the brain electricity delta wave is exactly matched.
And the physical property of the gel of the temperature-sensitive controlled release layer 4 is further that the gel is easier to dissipate heat at normal temperature, so that the temperature of the gel is relatively low, the gel is in a highly contracted state, the pore diameter of micropores on the gel is small, and the diffusion of the active ingredients of the traditional Chinese medicine in the medicine carrier 2 can be well limited, so that the diffusion loss of the active ingredients of the traditional Chinese medicine in the medicine carrier 2 is prevented when the gel is not used, and the protection effect is further realized. ‌ A
As shown in fig. 4 to 5, a protective cover 5 is arranged on the outer side of the temperature-sensitive controlled release layer 4, the inner wall of the protective cover 5 is abutted against the outer side surface of the temperature-sensitive controlled release layer 4, a first arc flange 51 is arranged on the outer side of the opening edge of the protective cover 5, and the first arc flange 51 is buckled with a second arc flange 11 protruding inwards on the outer side edge of the backing layer 1.
Through set up rather than mutual tight protective cover 5 that supports laminating in the outside of temperature-sensitive controlled release layer 4, and then prevent that the traditional chinese medicine active ingredient in the medicine carrier 2 from diffusing out through temperature-sensitive controlled release layer 4, and then prevent that the traditional chinese medicine active ingredient in the sleep-aiding eye-shade from losing when idle, and then improved the life of sleep-aiding eye-shade. The diffusion prevention can be performed by the tight fit mode between the protective cover 5 and the temperature-sensitive controlled release layer 4, so that the traditional Chinese medicine active ingredients can be completely reserved in the apertures of the drug carrier 2 and the temperature-sensitive controlled release layer 4, once the traditional Chinese medicine active ingredients are diffused outside the aperture of the temperature-sensitive controlled release layer 4, once the protective cover 5 is opened in next use, the traditional Chinese medicine active ingredients outside the diffusion can not be utilized in the air, and then the problem can be well solved by the tight fit mode. The backing layer 1 can be integrally formed by adopting a silica gel material, and the protective cover 5 can be formed by adopting plastic or hard silica gel.
As shown in fig. 5, a circumferential protruding strip 52 is disposed on the inner side of the protective cover 5 near the edge of the temperature-sensitive controlled release layer 4.
When the inner wall of the protective cover 5 is abutted against the outer side surface of the temperature-sensitive controlled release layer 4, the raised strips 52 on the protective cover 5 also squeeze the edge of the temperature-sensitive controlled release layer 4, and because the edge of the temperature-sensitive controlled release layer 4 is squeezed and compressed, the pores of the inner wall of the temperature-sensitive controlled release layer are squeezed and closed, so that the active ingredients of the traditional Chinese medicine entering the pores of the temperature-sensitive controlled release layer 4 cannot diffuse out from the side edge of the temperature-sensitive controlled release layer 4, the diffusion prevention effect of the protective cover 5 is further ensured, and the service life of the sleep-aiding eyeshade is further prolonged.
The traditional Chinese medicine sleep-aiding eye mask further comprises a micro-current temperature control module, wherein the micro-current temperature control module comprises a first electric heating sheet 6, a storage battery, a wireless receiving unit and a control unit, the first electric heating sheets 6 are uniformly distributed at intervals on the inner side of the temperature-sensitive controlled release layer 4 at the positions of the two purposes of lamination, the first electric heating sheets 6 are electrically connected with the storage battery through the control unit, the control unit is electrically connected with the wireless receiving unit, and the wireless receiving unit is used for receiving control instructions of an external terminal.
The first electric heating plates 6 are uniformly distributed at intervals at the positions which are positioned at the inner side of the temperature-sensitive controlled release layer 4 and are adhered with two purposes, the current intensity of the first electric heating plates 6 is controlled to be 0.1-0.5mA strictly through the control unit, the first electric heating plates 6 can provide heat to enable the temperature-sensitive controlled release layer 4 to be still in the expansion period dominated by hydroxypropyl acrylamide under the current intensity, the expansion degree of the temperature-sensitive controlled release layer 4 can be actively regulated and controlled through a micro-current mode, the active regulation and control is mainly used for the elderly with cold body temperature, the expansion of the temperature-sensitive controlled release layer 4 cannot be completely stimulated through the body temperature of the elderly, the current received by the first electric heating plates 6 is controlled through an external terminal, such as a mobile phone or a special remote controller through a Bluetooth wireless communication mode, the expansion of the temperature-sensitive controlled release layer 4 can be controlled through Joule conversion heat, the diffusion of the active components of the traditional Chinese medicine can be controlled, the diffusion quantity of active components of traditional Chinese medicine in the eye-mask can be controlled, the diffusion quantity of the traditional Chinese medicine active components in the eye mask can be further controlled, the diffusion quantity of the traditional Chinese medicine active components in the medicine carrier 2 can be further controlled, the concentration of the traditional Chinese medicine active components can be further guaranteed, the concentration of the traditional Chinese medicine active components can be controlled, and the concentration of the eye mask can be controlled, the eye mask, and the eye mask can not be controlled, the concentration, be used, and the eye mask, only, can be controlled, and the precision, and can be controlled.
The micro-current temperature control module further comprises a patch type temperature sensor, wherein the temperature sensor is arranged in the temperature-sensitive controlled release layer 4 and located at a dual-purpose bonding position.
The temperature sensor is embedded in the temperature-sensitive controlled release layer 4 when the temperature-sensitive controlled release layer 4 is formed, and the patch type temperature sensor is arranged at a position, which is located at a joint dual purpose, inside the temperature-sensitive controlled release layer 4, so that the size of the upper aperture of the temperature-sensitive controlled release layer 4 at the temperature can be calculated through the temperature value measured by the temperature sensor, the diffusion speed of the traditional Chinese medicine active ingredient in the medicine carrier 2 can be obtained, the data is fed back to the control unit, and the control unit controls the diffusion speed of the traditional Chinese medicine active ingredient in a high-quality sleep-aiding medicine concentration range by regulating and controlling the current intensity of the first electric heating plate 6, so that the sleep-aiding effect of the sleep-aiding eyeshade is improved. And the temperature of the binocular position of real-time supervision laminating through temperature sensor can not be too high, if the high temperature appears, cuts off in time through control unit and supplies power to first electric heat piece 6, reports to the police through giving the alarm with the signal of telecommunication simultaneously, and then reduces the injury to the user.
As shown in fig. 6 and 8, the traditional Chinese medicine sleep-aiding eye mask further comprises an expansion module, wherein the expansion module is arranged between the medicine carrier 2 and the back lining layer 1 and positioned at a dual-purpose bonding position, the expansion module comprises an elastic membrane and an expansion body, the elastic membrane is of a closed bag-shaped structure, and the expansion body is filled in the elastic membrane.
The material of the expansion body is the same as that of the temperature-sensitive controlled release layer 4, and the expansion body which is the same as that of the temperature-sensitive controlled release layer 4 is arranged at the position between the medicine carrier 2 and the backing layer 1 and is positioned at the joint dual-purpose position, so that after a user enters deep sleep, the expansion body is expanded in volume due to the increase of body temperature, the medicine carrier 2 is extruded to be outwards protruded, the medicine carrier 2 at the position is extruded to be more closely contacted with the periphery of eyes, the traditional Chinese medicine active ingredients diffused in the medicine carrier 2 are enabled to be more rapidly contacted with the skin around the eyes, and further, the percutaneous absorption is carried out more rapidly, further, the medicine effect efficiency of the traditional Chinese medicine active ingredients is improved, and the sleep-aiding effect of the sleep-aiding eyeshade is further improved.
As shown in fig. 6 to 8, the expansion module further comprises a second electric heating plate 7, the second electric heating plate 7 is arranged inside the expansion body, and the second electric heating plate 7 is electrically connected with the storage battery through the control unit.
The second electric heating sheet 7 is arranged in the expansion body, the current intensity of 0.1-0.5mA which is fed into the second electric heating sheet 7 is strictly controlled through the control unit, the second electric heating sheet 7 can provide heat under the current intensity to ensure that the expansion body is still in the expansion period of hydroxypropyl acrylamide, the expansion degree of the expansion body can be actively regulated and controlled through a microcurrent mode, the temperature-sensitive controlled release layer 4 can be more accurately controlled to be attached to the periphery of eyes, the traditional Chinese medicine active ingredients diffused in the medicine carrier 2 can be more rapidly contacted with the skin around the eyes, the skin can be more rapidly absorbed through transdermal, the medicine action efficiency of the traditional Chinese medicine active ingredients can be further improved, the sleep-aiding effect of the sleep-aiding eyeshade can be further improved, the temperature-sensitive controlled release layer 4 can be controlled not be excessively attached to or even extruded around the eyes, and the sleep of a user can be prevented from being influenced.
The expansion module further comprises a pressure sensor arranged between the elastic membrane and the drug carrier 2, which is connected with the control unit by means of electrical signals.
The pressure sensor is arranged between the elastic membrane and the medicine carrier 2, the extrusion force of the expansion module to the medicine carrier 2 can be monitored in real time through the pressure sensor, the degree that the medicine carrier 2 extrudes the temperature-sensitive controlled release layer 4 to be attached to the periphery of the eyes is determined, the data are transmitted to the control unit, the expansion degree of the expansion module is controlled by the control unit, the temperature-sensitive controlled release layer 4 is controlled to be attached to the periphery of the eyes more accurately, the medicine action efficiency of traditional Chinese medicine active ingredients is improved, the sleep-assisting effect of the sleep-assisting eyeshade is improved, and the temperature-sensitive controlled release layer 4 is controlled to be prevented from being excessively attached to or even extruded to the periphery of the eyes, so that the sleep of a user is prevented from being influenced.
The embodiments of the present invention have been described above with reference to the accompanying drawings, but the present invention is not limited to the above-described embodiments, which are merely illustrative and not restrictive, and many forms may be made by those having ordinary skill in the art without departing from the spirit of the present invention and the scope of the claims, which are to be protected by the present invention.

Claims (8)

1.一种基于草本纳米缓释技术的中药助眠眼罩，其特征在于：包括背衬层(1)、药物载体(2)和束缚带(3)；所述背衬层(1)为一面开口的框型结构，所述背衬层(1)内嵌入所述药物载体(2)；所述药物载体(2)通过将纳米级破壁技术处理的中药活性成分与聚氨酯软质泡沫混合发泡制得；所述背衬层(1)两端通过束缚带(3)连接；1. A sleep-aid eye mask based on herbal nano-sustaining technology, characterized in that: it includes a backing layer (1), a drug carrier (2), and a binding strap (3); the backing layer (1) is a frame structure with one open side, and the drug carrier (2) is embedded in the backing layer (1); the drug carrier (2) is prepared by mixing and foaming the active ingredients of traditional Chinese medicine treated with nano-level cell wall breaking technology with polyurethane soft foam; the two ends of the backing layer (1) are connected by the binding strap (3); 所述药物载体(2)的制备过程包括如下步骤：The preparation process of the drug carrier (2) includes the following steps: S1：将中药活性成分的原料置于高压纳米破碎仪中，在200-300MPa压力下循环处理3-5次，每次持续2-3分钟，破碎完成后收集粒径小于100nm的活性成分悬浮液；S1: Place the raw materials of active ingredients of traditional Chinese medicine in a high-pressure nano-crusher and circulate them for 3-5 times under a pressure of 200-300MPa, each time for 2-3 minutes. After crushing, collect the active ingredient suspension with a particle size of less than 100nm. S2：将聚醚二醇‌与甲苯二异氰酸酯按摩尔比1：2在80-85℃反应3-4小时，制得NCO含量8.0±0.3%的聚氨酯预聚体；S2: Polyether diol and toluene diisocyanate are reacted at 80-85℃ for 3-4 hours in a molar ratio of 1:2 to obtain a polyurethane prepolymer with an NCO content of 8.0±0.3%; S3：将聚氨酯预聚体降温至40℃后，将所述聚氨酯预聚体与所述活性成分悬浮液按质量比8:2混合，并以1800-2000rpm高速分散8-10分钟；S3: After cooling the polyurethane prepolymer to 40°C, mix the polyurethane prepolymer with the active ingredient suspension at a mass ratio of 8:2, and disperse at a high speed of 1800-2000 rpm for 8-10 minutes. S4：加入发泡剂偶氮二甲酰胺，浓度在1.2-1.8wt%之间，发泡30-35分钟；S4: Add azodicarbonamide as a foaming agent at a concentration of 1.2-1.8 wt%, and foam for 30-35 minutes; S5：常温熟化24-30小时后切割成标准尺寸，进而得到所述药物载体(2)；S5: After aging at room temperature for 24-30 hours, cut into standard sizes to obtain the drug carrier (2); 基于草本纳米缓释技术的中药助眠眼罩还包括温敏控释层(4)；所述温敏控释层(4)设置在所述背衬层(1)的开口一侧，所述温敏控释层(4)的边沿与所述背衬层(1)的边沿密封连接；所述温敏控释层(4)的制备过程包括如下步骤：The herbal nano-sustaining technology-based sleep aid eye mask also includes a temperature-sensitive controlled-release layer (4); the temperature-sensitive controlled-release layer (4) is disposed on the opening side of the backing layer (1), and the edge of the temperature-sensitive controlled-release layer (4) is sealed to the edge of the backing layer (1); the preparation process of the temperature-sensitive controlled-release layer (4) includes the following steps: N1：将N-异丙基丙烯酰胺在50-60℃真空干燥箱中脱水3-4小时，同时将羟丙基丙烯酰胺置于干燥器中干燥后备用；N1: Dehydrate N-isopropylacrylamide in a vacuum drying oven at 50-60℃ for 3-4 hours, while simultaneously drying hydroxypropylacrylamide in a desiccator for later use. N2：称取82.5gN-异丙基丙烯酰胺和12g羟丙基丙烯酰胺加入500mL三口烧瓶，注入200mL预热至50-60℃的无水乙醇，通过磁力搅拌直至完全透明，转速300-350rpm，时长25±3分钟；N2: Weigh 82.5g of N-isopropylacrylamide and 12g of hydroxypropylacrylamide into a 500mL three-necked flask, add 200mL of anhydrous ethanol preheated to 50-60℃, and stir magnetically until completely transparent at 300-350rpm for 25±3 minutes. N3：加入5g纳米纤维素，开启探头超声仪，振幅70%处理20-30分钟，形成均质乳光悬浮液；N3: Add 5g of nanocellulose, turn on the probe ultrasonic instrument, treat with 70% amplitude for 20-30 minutes to form a homogeneous emulsified suspension; N4：降温至25-30℃后加入0.5g光引发剂，避光条件下机械搅拌10-15分钟，转速150-200rpm；N4: After cooling to 25-30℃, add 0.5g of photoinitiator and mechanically stir for 10-15 minutes at 150-200rpm under light-protected conditions; N5：转移至真空脱泡罐，在-0.095MPa、40-50℃条件下循环脱泡3-5次、每次5-8分钟，直至液面无气泡逸出，进而得到预聚液；N5: Transfer to a vacuum degassing tank and degas 3-5 times at -0.095MPa and 40-50℃ for 5-8 minutes each time until no bubbles escape from the liquid surface, thus obtaining the prepolymer liquid; N6：采用定制石英模具，表面喷涂PTFE脱模剂；模具预热至30-35℃后注入所述预聚液，刮刀控制液层厚度为380±10μm；N6: A custom quartz mold is used, and the surface is sprayed with PTFE release agent; after the mold is preheated to 30-35℃, the prepolymer liquid is injected, and the thickness of the liquid layer is controlled by a scraper to be 380±10μm. N7：中心区以10mW/cm²紫外光照射30-40秒形成低交联结构，过渡区18mW/cm²照射75-85秒，边缘区25mW/cm²照射120-130秒，固化后经30%-100%乙醇梯度脱水，40℃干燥得到120μm凝胶膜；N7: The central region is irradiated with 10mW/cm² UV light for 30-40 seconds to form a low cross-linked structure, the transition region is irradiated with 18mW/cm² light for 75-85 seconds, and the edge region is irradiated with 25mW/cm² light for 120-130 seconds. After curing, it is dehydrated by a gradient of 30%-100% ethanol and dried at 40℃ to obtain a 120μm gel film. N8：将等离子处理的PET薄膜旋涂硅烷偶联剂，之后与所述凝胶膜在60℃、0.5MPa条件下热压30-40秒键合，进而制得温敏控释层(4)。N8: A plasma-treated PET film is spin-coated with a silane coupling agent, and then bonded to the gel film under hot pressing at 60°C and 0.5MPa for 30-40 seconds to obtain a temperature-sensitive controlled-release layer (4). 2.根据权利要求1所述的一种基于草本纳米缓释技术的中药助眠眼罩，其特征在于：所述温敏控释层(4)的外侧设置防护盖(5)；所述防护盖(5)内壁与所述温敏控释层(4)的外侧表面抵紧贴合；所述防护盖(5)的开口边沿外侧设置第一圆弧凸缘(51)，所述第一圆弧凸缘(51)与所述背衬层(1)外侧边沿向内突出的第二圆弧凸缘(11)相互扣合。2. A traditional Chinese medicine sleep aid eye mask based on herbal nano-sustaining technology according to claim 1, characterized in that: a protective cover (5) is provided on the outer side of the temperature-sensitive controlled-release layer (4); the inner wall of the protective cover (5) is tightly fitted to the outer surface of the temperature-sensitive controlled-release layer (4); a first arcuate flange (51) is provided on the outer side of the opening edge of the protective cover (5), and the first arcuate flange (51) is engaged with a second arcuate flange (11) protruding inward from the outer edge of the backing layer (1). 3.根据权利要求2所述的一种基于草本纳米缓释技术的中药助眠眼罩，其特征在于：所述防护盖(5)内侧靠近所述温敏控释层(4)边沿处设置一周凸起条(52)。3. The herbal sleep aid eye mask based on herbal nano-sustaining technology according to claim 2, characterized in that: a raised strip (52) is provided around the inner side of the protective cover (5) near the edge of the temperature-sensitive controlled release layer (4). 4.根据权利要求1所述的一种基于草本纳米缓释技术的中药助眠眼罩，其特征在于：还包括微电流控温模块；所述微电流控温模块包括第一电热片(6)、蓄电池、无线接收单元和控制单元；所述温敏控释层(4)内侧位于贴合双目的位置均匀间隔排布所述第一电热片(6)；所述第一电热片(6)通过所述控制单元与所述蓄电池电信号连接；所述控制单元上通过电信号连接所述无线接收单元；所述无线接收单元用于接收外部终端的控制指令。4. A traditional Chinese medicine sleep aid eye mask based on herbal nano-slow-release technology according to claim 1, characterized in that: it further includes a micro-current temperature control module; the micro-current temperature control module includes a first heating element (6), a storage battery, a wireless receiving unit, and a control unit; the first heating element (6) is evenly spaced on the inner side of the temperature-sensitive controlled-release layer (4) at the position where it fits the eyes; the first heating element (6) is electrically connected to the storage battery through the control unit; the wireless receiving unit is electrically connected to the control unit; the wireless receiving unit is used to receive control commands from an external terminal. 5.根据权利要求4所述的一种基于草本纳米缓释技术的中药助眠眼罩，其特征在于：所述微电流控温模块还包括贴片式的温度传感器；所述温度传感器设置在所述温敏控释层(4)内部位于贴合双目的位置。5. The herbal nano-slow-release eye mask based on claim 4, characterized in that: the microcurrent temperature control module further includes a patch-type temperature sensor; the temperature sensor is disposed inside the temperature-sensitive controlled-release layer (4) at the position where it fits the eyes. 6.根据权利要求4所述的一种基于草本纳米缓释技术的中药助眠眼罩，其特征在于：还包括膨胀模块；所述膨胀模块设置在所述药物载体(2)与所述背衬层(1)之间位于贴合双目的位置；所述膨胀模块包括弹性膜和膨胀体；所述弹性膜为封闭的袋状结构；所述弹性膜内填充所述膨胀体。6. A sleep-aid eye mask based on herbal nano-sustaining technology according to claim 4, characterized in that: it further includes an expansion module; the expansion module is disposed between the drug carrier (2) and the backing layer (1) at a position that fits the eyes; the expansion module includes an elastic membrane and an expansion body; the elastic membrane is a closed bag-shaped structure; the expansion body is filled inside the elastic membrane. 7.根据权利要求6所述的一种基于草本纳米缓释技术的中药助眠眼罩，其特征在于：所述膨胀模块还包括第二电热片(7)；所述第二电热片(7)设置在所述膨胀体内部；所述第二电热片(7)通过所述控制单元与所述蓄电池电信号连接。7. A sleep-aid eye mask based on herbal nano-slow-release technology according to claim 6, characterized in that: the expansion module further includes a second heating element (7); the second heating element (7) is disposed inside the expansion body; the second heating element (7) is electrically connected to the battery through the control unit. 8.根据权利要求7所述的一种基于草本纳米缓释技术的中药助眠眼罩，其特征在于：所述膨胀模块还包括压力传感器；所述压力传感器设置在所述弹性膜与所述药物载体(2)之间；所述压力传感器与所述控制单元通过电信号连接。8. A sleep aid eye mask based on herbal nano-sustaining technology according to claim 7, characterized in that: the expansion module further includes a pressure sensor; the pressure sensor is disposed between the elastic membrane and the drug carrier (2); the pressure sensor is connected to the control unit via an electrical signal.
CN202511446932.3A 2025-10-11 2025-10-11 Traditional Chinese medicine sleep-aiding eye mask based on herbal nanometer slow-release technology Active CN120899461B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202511446932.3A CN120899461B (en) 2025-10-11 2025-10-11 Traditional Chinese medicine sleep-aiding eye mask based on herbal nanometer slow-release technology

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202511446932.3A CN120899461B (en) 2025-10-11 2025-10-11 Traditional Chinese medicine sleep-aiding eye mask based on herbal nanometer slow-release technology

Publications (2)

Publication Number Publication Date
CN120899461A CN120899461A (en) 2025-11-07
CN120899461B true CN120899461B (en) 2026-01-02

Family

ID=97557357

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202511446932.3A Active CN120899461B (en) 2025-10-11 2025-10-11 Traditional Chinese medicine sleep-aiding eye mask based on herbal nanometer slow-release technology

Country Status (1)

Country Link
CN (1) CN120899461B (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4990545A (en) * 1988-09-05 1991-02-05 Sanyo Chemical Industries, Ltd. Articles with polyurethane resin having memory shape characteristics and method of utilizing same
CN211610333U (en) * 2020-01-19 2020-10-02 疏博（上海）纳米科技有限公司 Aerogel heating eye-shade

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN192012B (en) * 1999-03-19 2004-02-07 Vinod Chintamani Malshe
CN101185779B (en) * 2007-12-19 2010-06-02 上海赢生医疗科技有限公司 A kind of preparation method of drug sustained-release stent
CN110123955A (en) * 2019-06-04 2019-08-16 丁萱 The spontaneous heating of a kind of eyeshield health composition and its preparation is sustained steam eyeshield articles
CN117924788A (en) * 2024-01-15 2024-04-26 万华化学集团股份有限公司 Thermal expansion microsphere and preparation method thereof
CN120501726A (en) * 2025-05-20 2025-08-19 河南利可医疗科技有限公司 Intelligent temperature control health care patch and preparation method thereof
CN120514688A (en) * 2025-05-22 2025-08-22 内蒙古自治区国际蒙医医院 Intelligent temperature-controlled drug sustained-release patch based on Mongolian medicine wrapping therapy and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4990545A (en) * 1988-09-05 1991-02-05 Sanyo Chemical Industries, Ltd. Articles with polyurethane resin having memory shape characteristics and method of utilizing same
CN211610333U (en) * 2020-01-19 2020-10-02 疏博（上海）纳米科技有限公司 Aerogel heating eye-shade

Also Published As

Publication number Publication date
CN120899461A (en) 2025-11-07

Similar Documents

Publication Publication Date Title
DE69423427T2 (en) TRANSDERMAL PLASTER MADE OF FOAM LAYER
EP1339435B1 (en) Layered materials for use as wound dressings
CN109771820A (en) A kind of conductive hydrogel electro photoluminescence patch and the preparation method and application thereof
CN1202785C (en) Hydrophilic trauma dressing made from polyurethane and its preparation method
CN120899461B (en) Traditional Chinese medicine sleep-aiding eye mask based on herbal nanometer slow-release technology
US20230270913A1 (en) Medical polyurethane foam dressing and preparation method thereof
CN217593430U (en) Anti-adhesion micro-negative pressure self-suction wound protection system
CN114712697B (en) Microneedle patch and preparation method and application thereof
CN120501726A (en) Intelligent temperature control health care patch and preparation method thereof
CN216022316U (en) Medical polyurethane foam dressing
CN201631490U (en) Analgesic paster for thermal therapy
CN201768070U (en) Medical hot patch
CN205494136U (en) Subsides of spontaneous heating aquogel
CN104382417A (en) Ice-cold breathable type gel double-layer mattress and production process
CN115804685B (en) A method for preparing spontaneous hot water gel
CN114796586A (en) Anti-adhesion micro-negative pressure self-suction wound protection system
CN217622648U (en) Compound curtain coating membrane
CN219423335U (en) Hot compress facial mask
CN109125784B (en) Hydrophilic polyurethane foam dressing and manufacturing method thereof
CN219878714U (en) Traditional Chinese medicine acupoint plaster
JP2850249B2 (en) Manufacturing method of integrated skin
CN221752015U (en) A temperature-control acupuncture point sticker
US20200030250A1 (en) Transdermal patch for oil delivery
CN214910451U (en) Self-heating moxibustion plaster
CN116687765B (en) Functional patch

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant