CN121843967A - 抗-ror1/抗-4-1bb抗体及其用途 - Google Patents

抗-ror1/抗-4-1bb抗体及其用途

Info

Publication number
CN121843967A
CN121843967A CN202480056848.8A CN202480056848A CN121843967A CN 121843967 A CN121843967 A CN 121843967A CN 202480056848 A CN202480056848 A CN 202480056848A CN 121843967 A CN121843967 A CN 121843967A
Authority
CN
China
Prior art keywords
seq
amino acid
acid sequence
peptide
sequence identity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202480056848.8A
Other languages
English (en)
Chinese (zh)
Inventor
刘婵娟
陈曦
王正毅
邢晓军
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tianjing Biotechnology Shanghai Co ltd
Original Assignee
Tianjing Biotechnology Shanghai Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tianjing Biotechnology Shanghai Co ltd filed Critical Tianjing Biotechnology Shanghai Co ltd
Publication of CN121843967A publication Critical patent/CN121843967A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
CN202480056848.8A 2023-09-06 2024-09-06 抗-ror1/抗-4-1bb抗体及其用途 Pending CN121843967A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2023117286 2023-09-06
CNPCT/CN2023/117286 2023-09-06
PCT/CN2024/117323 WO2025051220A1 (fr) 2023-09-06 2024-09-06 Anticorps anti-ror1/anti-4-1bb et leurs utilisations

Publications (1)

Publication Number Publication Date
CN121843967A true CN121843967A (zh) 2026-04-10

Family

ID=94922931

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202480056848.8A Pending CN121843967A (zh) 2023-09-06 2024-09-06 抗-ror1/抗-4-1bb抗体及其用途

Country Status (2)

Country Link
CN (1) CN121843967A (fr)
WO (1) WO2025051220A1 (fr)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201803098VA (en) * 2015-10-30 2018-05-30 Nbe Therapeutics Ag Anti-ror1 antibodies
CN112646031B (zh) * 2019-10-10 2021-12-07 天境生物科技(上海)有限公司 抗4-1bb纳米抗体及其用途
WO2021101346A1 (fr) * 2019-11-21 2021-05-27 Dong-A St Co., Ltd. Anticorps bispécifiques anti-ror1/anti-4-1bb et leurs utilisations
WO2022174103A2 (fr) * 2021-02-11 2022-08-18 The Regents Of The University Of California Anticorps monoclonaux spécifiques de ror1 humain
CN114014938B (zh) * 2021-11-19 2022-09-13 陈天睿 一种嵌合抗原受体(car)及其应用

Also Published As

Publication number Publication date
WO2025051220A9 (fr) 2025-10-30
WO2025051220A1 (fr) 2025-03-13

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