CN1237337A - Avermectin and ivermectin micro emulsion - Google Patents
Avermectin and ivermectin micro emulsion Download PDFInfo
- Publication number
- CN1237337A CN1237337A CN 99107712 CN99107712A CN1237337A CN 1237337 A CN1237337 A CN 1237337A CN 99107712 CN99107712 CN 99107712 CN 99107712 A CN99107712 A CN 99107712A CN 1237337 A CN1237337 A CN 1237337A
- Authority
- CN
- China
- Prior art keywords
- avermectin
- cosolvent
- ivermectin
- wei
- deionized water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000005660 Abamectin Substances 0.000 title claims abstract description 15
- RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 title claims abstract description 14
- AZSNMRSAGSSBNP-UHFFFAOYSA-N 22,23-dihydroavermectin B1a Natural products C1CC(C)C(C(C)CC)OC21OC(CC=C(C)C(OC1OC(C)C(OC3OC(C)C(O)C(OC)C3)C(OC)C1)C(C)C=CC=C1C3(C(C(=O)O4)C=C(C)C(O)C3OC1)O)CC4C2 AZSNMRSAGSSBNP-UHFFFAOYSA-N 0.000 title claims abstract description 12
- SPBDXSGPUHCETR-JFUDTMANSA-N 8883yp2r6d Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O[C@@H]([C@@H](C)CC4)C(C)C)O3)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1C[C@H](C)[C@@H]([C@@H](C)CC)O[C@@]21O[C@H](C\C=C(C)\[C@@H](O[C@@H]1O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C1)[C@@H](C)\C=C\C=C/1[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\1)O)C[C@H]4C2 SPBDXSGPUHCETR-JFUDTMANSA-N 0.000 title claims abstract description 12
- 229960002418 ivermectin Drugs 0.000 title claims abstract description 12
- 239000004530 micro-emulsion Substances 0.000 title claims abstract description 12
- 239000006184 cosolvent Substances 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000008367 deionised water Substances 0.000 claims abstract description 12
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 12
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 12
- 239000003381 stabilizer Substances 0.000 claims abstract description 11
- 239000002917 insecticide Substances 0.000 claims abstract description 4
- 231100000053 low toxicity Toxicity 0.000 claims abstract description 4
- 239000000839 emulsion Substances 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 239000006188 syrup Substances 0.000 claims description 6
- 235000020357 syrup Nutrition 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 5
- -1 synergist Substances 0.000 claims description 5
- 239000003093 cationic surfactant Substances 0.000 claims description 2
- 239000000470 constituent Substances 0.000 claims description 2
- 238000001816 cooling Methods 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- ARXJGSRGQADJSQ-UHFFFAOYSA-N 1-methoxypropan-2-ol Chemical compound COCC(C)O ARXJGSRGQADJSQ-UHFFFAOYSA-N 0.000 claims 1
- POAOYUHQDCAZBD-UHFFFAOYSA-N 2-butoxyethanol Chemical compound CCCCOCCO POAOYUHQDCAZBD-UHFFFAOYSA-N 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 239000005906 Imidacloprid Substances 0.000 claims 1
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims 1
- 125000000129 anionic group Chemical group 0.000 claims 1
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims 1
- 150000002170 ethers Chemical class 0.000 claims 1
- YWTYJOPNNQFBPC-UHFFFAOYSA-N imidacloprid Chemical compound [O-][N+](=O)\N=C1/NCCN1CC1=CC=C(Cl)N=C1 YWTYJOPNNQFBPC-UHFFFAOYSA-N 0.000 claims 1
- 229940056881 imidacloprid Drugs 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 238000012856 packing Methods 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 239000000642 acaricide Substances 0.000 abstract description 4
- 229920000742 Cotton Polymers 0.000 abstract description 2
- 235000013399 edible fruits Nutrition 0.000 abstract description 2
- 239000005645 nematicide Substances 0.000 abstract description 2
- 235000013311 vegetables Nutrition 0.000 abstract description 2
- 241000238876 Acari Species 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 208000005141 Otitis Diseases 0.000 abstract 1
- 244000045947 parasite Species 0.000 abstract 1
- 241000238631 Hexapoda Species 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 230000003449 preventive effect Effects 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 241000500437 Plutella xylostella Species 0.000 description 2
- 239000003905 agrochemical Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 239000000575 pesticide Substances 0.000 description 2
- IBSREHMXUMOFBB-JFUDTMANSA-N 5u8924t11h Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C(C)C)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 IBSREHMXUMOFBB-JFUDTMANSA-N 0.000 description 1
- 235000017060 Arachis glabrata Nutrition 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 235000010777 Arachis hypogaea Nutrition 0.000 description 1
- 235000018262 Arachis monticola Nutrition 0.000 description 1
- FIPWRIJSWJWJAI-UHFFFAOYSA-N Butyl carbitol 6-propylpiperonyl ether Chemical group C1=C(CCC)C(COCCOCCOCCCC)=CC2=C1OCO2 FIPWRIJSWJWJAI-UHFFFAOYSA-N 0.000 description 1
- 241001182720 Cacopsylla pyrisuga Species 0.000 description 1
- 241000219146 Gossypium Species 0.000 description 1
- 241000255967 Helicoverpa zea Species 0.000 description 1
- WLLGXSLBOPFWQV-UHFFFAOYSA-N MGK 264 Chemical compound C1=CC2CC1C1C2C(=O)N(CC(CC)CCCC)C1=O WLLGXSLBOPFWQV-UHFFFAOYSA-N 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 241000488583 Panonychus ulmi Species 0.000 description 1
- 241001655322 Streptomycetales Species 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 229950008167 abamectin Drugs 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000002528 anti-freeze Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000004495 emulsifiable concentrate Substances 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 230000000749 insecticidal effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000003120 macrolide antibiotic agent Substances 0.000 description 1
- 229940041033 macrolides Drugs 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 230000001069 nematicidal effect Effects 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 229960005235 piperonyl butoxide Drugs 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000006097 ultraviolet radiation absorber Substances 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invented microemulsion insecticide for preventing and curing various mites, aphides of crops of fruit, vegetable and cotton, etc., American otitid and internal parasite of domestic animals is made up by using (wt%) 0.1-5.0% of avermectin or ivermectin, 4-20% of emulsifying agent, 0.1-2.0% of synergist, 5-30% of cosolvent, 0.1-1.0% of stabilizing agent and a proper quantity of deionized water, and features high-efficiency, low-toxicity and less dosage. Said invention also can be made into miticide and nematicide.
Description
The present invention relates to a kind of A Wei, Yi Wei micro emulsion insecticide, miticide, nematocide of preventing and treating insects such as the various insects of crops, mite class, tame carcass interior lines worm, it is a kind of by A Wei or the former powder of Yi Wei (or its syrup), emulsifier, synergist, cosolvent, stabilizing agent, deionized water etc. to say so in more detail, the water base microemulsion as insecticide-miticide of efficient, the low toxicity that processes with the PIT emulsifying process.
At present, the insect such as various insects, mite class that is used for crops such as fruit tree, wheat, paddy rice, peanut, cotton, vegetables is Avermectin or ivermectin cream preparation more effectively, and control efficiency is good, but cost is too high, drift is big during use, permeability is relatively poor, and residual effect is shorter.
The objective of the invention is to overcome the deficiency of above-mentioned existing procucts, and provide that the former dose of a kind of usefulness is few, with low cost, drift is little, permeability is strong during dispenser microemulsion as insecticide-miticide.
Purpose of the present invention can realize by following measure:
In reactor, add successively:
(a) weight concentration is Avermectin or the ivermectin of 0.1-5.0%;
(b) weight concentration is the emulsifier of 4-20%;
(c) weight concentration is the synergist of 0.1-2.0%;
(d) weight concentration is the cosolvent of 5-30%;
(e) weight concentration is the stabilizing agent of 0.1-1.0%;
The rest is deionized water.
Purpose of the present invention can also realize by following measure:
Adding a certain amount of cosolvent in A Wei or former powder of Yi Wei or the syrup (active constituent content 3-7%), be heated to 80-95 ℃, in (the rotating speed 200-400 rev/min) process of stirring, add emulsifier, temperature remains on 90-96 ℃, add hot deionized water (temperature 95-100 ℃) then, stirred 30-60 minute, add surplus cosolvent, synergist and stabilizing agent again, emulsion is converted into clear solution automatically in cooling procedure then, be chilled to about 30 ℃, leave standstill then, filter, pack and promptly get agricultural chemicals of the present invention.
The molecular structure of the Avermectin of using among the present invention is:
R wherein
1=H, R
2=C
2H
5B
1a
R
1=H,R
2=CH
3??B
1b
Avermectin (Avermectin) is the macrolides farm antibiotics that is produced by streptomycete, and its main active is B
1Component; Ivermectin (Ivermectin) is two hydrogenation Avermectin, and stability is better, and insecticidal activity and Avermectin are suitable.
Used emulsifier is to be formed according to 75/5/20 ratio is composite by anion surfactant, cationic surfactant and deionized water among the present invention.
Used cosolvent is made up of one-components such as higher aliphatic, PVP, ether, polyalcohols among the present invention, has height and oozes, helps emulsification function and can antifreeze, froth breaking, increases the stability of system simultaneously.
Used synergist is Butacide, Octacide 264 etc. among the present invention.
Used stabilizing agent is ultra-violet absorber, DMF etc. among the present invention.
The present invention give further instruction in order to illustrate better below by embodiment:
Embodiment 1:
In 2000 milliliters of there-necked flasks that thermometer (or electric thermo-couple temperature instrument) and agitator are housed, add purity and be 90% A Wei or the former powder of the Yi Wei syrup of effective composition (or contain) 1.11 grams, add 9 gram cosolvents, be heated to 80-90 ℃, stirred 10 minutes, treat dissolving evenly after, begin to drip emulsifier, totally 15 grams added in 20-30 minute.Continue to stir (temperature 80-90 ℃) 10-20 minute, drip 90-98 ℃ of deionized water 650 grams then, 300 gram cosolvents and the 10 gram synergist of adding during to 30-40 ℃ to be cooled, the 15g stabilizing agent, this moment, emulsion was automatically changeb to transparent water microemulsion, leave standstill, filter, be weighed as 1000 grams, bottling.
Embodiment 2:
In 2000 milliliters of there-necked flasks that thermometer (or electric thermo-couple temperature instrument) and agitator are housed, add purity and be 4.5% contain A Wei syrup 25.35 grams, add 50 gram cosolvents, be heated to 80-90 ℃, stirred 10 minutes, treat dissolving evenly after, begin to drip emulsifier, totally 80 grams added in 20-30 minute.Continue to stir (temperature 80-90 ℃) 10-20 minute, drip 90-98 ℃ of deionized water 500 grams then, 300 gram cosolvents and the 20 gram synergist of adding during to 30-40 ℃ to be cooled, 25 gram stabilizing agents, this moment, emulsion was automatically changeb to transparent water microemulsion, leave standstill, filter, be weighed as 1000 grams, bottling.
Embodiment 3:
In 2000 milliliters of there-necked flasks that thermometer (or electric thermo-couple temperature instrument) and agitator are housed, add purity and be 90% A Wei or the former powder of the Yi Wei syrup of effective composition (or contain) 1.24 grams, add 10 gram cosolvents, be heated to 80-90 ℃, stirred 10 minutes, treat dissolving evenly after, begin to drip emulsifier, totally 15 grams added in 20-30 minute.Continue to stir (temperature 80-90 ℃) 10-20 minute, drip 90-98 ℃ of deionized water 650 grams then, 310 gram cosolvents and the 8 gram synergist of adding during to 30-40 ℃ to be cooled, 18 gram stabilizing agents, this moment, emulsion was automatically changeb to transparent water microemulsion, leave standstill, filter, be weighed as 1000 grams, bottling.
The effect of pesticide control diamond-back moth of the present invention is as shown in table 1:
Table 1
| Handle | Liquor strength (ppm) | The investigation borer population | Preventive effect (%) | Average preventive effect (%) |
| Embodiment 1 | ????500 | ????500 | ????91.6 | ????93.3 |
| ????667 | ????500 | ????93.0 | ||
| ????1000 | ????500 | ????95.2 | ||
| Embodiment 2 | ????500 | ????500 | ????93.2 | ????95.5 |
| ????667 | ????500 | ????95.4 | ||
| ????1000 | ????500 | ????97.9 | ||
| Embodiment 3 | ????500 | ????500 | ????94.0 | ????96.6 |
| ????667 | ????500 | ????97.8 | ||
| ????1000 | ????500 | ????98.0 | ||
| 5% high chloro milk oil | ????120 | ????500 | ????90.2 | ????93.0 |
| ????150 | ????500 | ????94.8 | ||
| ????200 | ????500 | ????96.0 | ||
| 0.9% abamectin emulsifiable concentrate | ????200 | ????500 | ????98.0 | ????98.7 |
| ????400 | ????500 | ????98.8 | ||
| ????1000 | ????500 | ????99.2 |
The effect of pesticide control European red mite of the present invention is as shown in table 2:
Table 2
| Handle | Liquor strength (ppm) | Average relative control effect (%) | ||
| After 1 day | After 10 days | After 20 days | ||
| Embodiment 1 | ????667 | ????95.2 | ????97.0 | ????98.0 |
| Embodiment 2 | ????667 | ????96.6 | ????97.4 | ????98.2 |
| Embodiment 3 | ????667 | ????96.0 | ????97.2 | ????97.6 |
| 0.9% A Wei missible oil | ????400 | ????98.8 | ????99.2 | ????100.0 |
| Remarks | In one month, quantum of rainfall adds up 174 millimeters after the medication | |||
AVM of the present invention, ivermectin micro emulsion are compared with existing similar agricultural chemicals and are had the following advantages:
1, efficient, low toxicity, easy to use, safe;
But 2 pest controls, mite class etc.;
3, the resistant insects such as diamondback moth, pear sucker, bollworm also there is good preventive and therapeutic effect;
4, cost is low, can alleviate peasant's burden;
5, formulation is advanced, take water as solvent, and storing safety;
6, can substitute the various formulations of the AVM that uses at present fully.
Claims (4)
1, a kind of Avermectin or ivermectin novel form of efficient, low toxicity wherein contain Avermectin or ivermectin, emulsifier, synergist, cosolvent, stabilizing agent and deionized water, it is characterized in that:
(a) weight concentration is Avermectin or the ivermectin of 0.1-5.0%;
(b) weight concentration is the emulsifier of 4-20%;
(c) weight concentration is the synergist of 0.1-2.0%;
(d) weight concentration is the cosolvent of 5-30%;
(e) weight concentration is the stabilizing agent of 0.1-1.0%;
Surplus is a deionized water.
2, require described Avermectin or ivermectin micro emulsion insecticide according to right 1, adopted the manufacturing technology of nano particle emulsion, it is characterized in that adding a certain amount of cosolvent in A Wei or former powder of Yi Wei or the syrup (active constituent content 3-7%), be heated to 80-95 ℃, in whipping process, add emulsifier, temperature remains on 90-96 ℃, add hot deionized water (temperature 95-100 ℃) then, stirred 30-60 minute, add the surplus cosolvent again, synergist and stabilizing agent, emulsion is converted into clear solution automatically in cooling procedure then, is chilled to about 30 ℃, leaves standstill then, filter, packing.
3, require described A Wei or Yi Wei micro emulsion insecticide according to right 1, used emulsifier is made up of according to 75/5/20 anionic species surfactant, cationic surfactant, deionized water when making the liquid nanometer particle.
4, require described imidacloprid emulsion according to right 1, used cosolvent is by C in the manufacture process
2-C
8Class alcohol, pure ethers are formed as one-components such as butyl glycol ether, propylene glycol monomethyl ether, diglycol etc., DMF, N-Methyl pyrrolidone.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 99107712 CN1237337A (en) | 1999-05-26 | 1999-05-26 | Avermectin and ivermectin micro emulsion |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 99107712 CN1237337A (en) | 1999-05-26 | 1999-05-26 | Avermectin and ivermectin micro emulsion |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1237337A true CN1237337A (en) | 1999-12-08 |
Family
ID=5272891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 99107712 Pending CN1237337A (en) | 1999-05-26 | 1999-05-26 | Avermectin and ivermectin micro emulsion |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1237337A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004026033A1 (en) * | 2002-09-20 | 2004-04-01 | Artpharm Pty Ltd | Plant pesticides and uses thereof |
| CN1933856B (en) * | 2004-03-18 | 2010-12-08 | 盖尔德玛公司 | Cream-Gel Containing Ivermectin |
| CN103478144A (en) * | 2013-09-26 | 2014-01-01 | 卞佳林 | Avermectin and griseofulvin composite pesticidal nanoemulsion |
| CN104202976A (en) * | 2012-04-04 | 2014-12-10 | 先正达参股股份有限公司 | Pesticide Composition |
| CN104430394A (en) * | 2014-10-20 | 2015-03-25 | 广西大学 | Preparation method of ivermectin/emamectin benzoate compound microcapsule suspension |
| CN109984995A (en) * | 2017-12-29 | 2019-07-09 | 瑞普（天津）生物药业有限公司 | A kind of ivermectin nanoemulsion injection and preparation method thereof |
| CN115227645A (en) * | 2022-08-03 | 2022-10-25 | 上虞颖泰精细化工有限公司 | Antiparasitic solution preparation containing ivermectin and neonicotinoid insecticides and preparation method thereof |
-
1999
- 1999-05-26 CN CN 99107712 patent/CN1237337A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004026033A1 (en) * | 2002-09-20 | 2004-04-01 | Artpharm Pty Ltd | Plant pesticides and uses thereof |
| CN1933856B (en) * | 2004-03-18 | 2010-12-08 | 盖尔德玛公司 | Cream-Gel Containing Ivermectin |
| CN104202976A (en) * | 2012-04-04 | 2014-12-10 | 先正达参股股份有限公司 | Pesticide Composition |
| CN103478144A (en) * | 2013-09-26 | 2014-01-01 | 卞佳林 | Avermectin and griseofulvin composite pesticidal nanoemulsion |
| CN103478144B (en) * | 2013-09-26 | 2015-09-09 | 卞佳林 | A kind of Avermectin and griseofulvin composite pesticidal nanoemulsion |
| CN104430394A (en) * | 2014-10-20 | 2015-03-25 | 广西大学 | Preparation method of ivermectin/emamectin benzoate compound microcapsule suspension |
| CN109984995A (en) * | 2017-12-29 | 2019-07-09 | 瑞普（天津）生物药业有限公司 | A kind of ivermectin nanoemulsion injection and preparation method thereof |
| CN109984995B (en) * | 2017-12-29 | 2021-09-07 | 瑞普（天津）生物药业有限公司 | A kind of ivermectin nanoemulsion injection and preparation method thereof |
| CN115227645A (en) * | 2022-08-03 | 2022-10-25 | 上虞颖泰精细化工有限公司 | Antiparasitic solution preparation containing ivermectin and neonicotinoid insecticides and preparation method thereof |
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