CN1245954C - Povidone iodine toothpaste and preparing method - Google Patents
Povidone iodine toothpaste and preparing method Download PDFInfo
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- CN1245954C CN1245954C CN 200410051033 CN200410051033A CN1245954C CN 1245954 C CN1245954 C CN 1245954C CN 200410051033 CN200410051033 CN 200410051033 CN 200410051033 A CN200410051033 A CN 200410051033A CN 1245954 C CN1245954 C CN 1245954C
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- sodium
- povidone iodine
- toothpaste
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- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 title claims abstract description 34
- 229920000153 Povidone-iodine Polymers 0.000 title claims abstract description 34
- 229960001621 povidone-iodine Drugs 0.000 title claims abstract description 34
- 229940034610 toothpaste Drugs 0.000 title claims abstract description 25
- 239000000606 toothpaste Substances 0.000 title claims abstract description 25
- 238000000034 method Methods 0.000 title abstract description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 20
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000008213 purified water Substances 0.000 claims abstract description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 9
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims abstract description 8
- JLKDVMWYMMLWTI-UHFFFAOYSA-M potassium iodate Chemical compound [K+].[O-]I(=O)=O JLKDVMWYMMLWTI-UHFFFAOYSA-M 0.000 claims abstract description 8
- 239000001230 potassium iodate Substances 0.000 claims abstract description 8
- 229940093930 potassium iodate Drugs 0.000 claims abstract description 8
- 235000006666 potassium iodate Nutrition 0.000 claims abstract description 8
- 239000000377 silicon dioxide Substances 0.000 claims abstract description 8
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims abstract description 8
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims abstract description 7
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims abstract description 7
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims abstract description 7
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 7
- 235000011187 glycerol Nutrition 0.000 claims abstract description 7
- 229940085605 saccharin sodium Drugs 0.000 claims abstract description 7
- 239000000661 sodium alginate Substances 0.000 claims abstract description 7
- 235000010413 sodium alginate Nutrition 0.000 claims abstract description 7
- 229940005550 sodium alginate Drugs 0.000 claims abstract description 7
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims abstract description 7
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims abstract description 7
- 239000000600 sorbitol Substances 0.000 claims abstract description 7
- 235000012239 silicon dioxide Nutrition 0.000 claims abstract description 6
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims abstract description 5
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims abstract description 4
- 235000019799 monosodium phosphate Nutrition 0.000 claims abstract description 4
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims abstract description 4
- 238000003756 stirring Methods 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 5
- 239000004141 Sodium laurylsulphate Substances 0.000 claims description 4
- 229910000397 disodium phosphate Inorganic materials 0.000 claims description 4
- 235000019800 disodium phosphate Nutrition 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000008363 phosphate buffer Substances 0.000 claims description 4
- 230000001105 regulatory effect Effects 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 2
- 230000001476 alcoholic effect Effects 0.000 claims description 2
- 208000002064 Dental Plaque Diseases 0.000 abstract description 10
- 230000000694 effects Effects 0.000 abstract description 7
- 230000015572 biosynthetic process Effects 0.000 abstract description 3
- 239000001525 mentha piperita l. herb oil Substances 0.000 abstract 2
- 235000019477 peppermint oil Nutrition 0.000 abstract 2
- 239000008055 phosphate buffer solution Substances 0.000 abstract 2
- 230000001680 brushing effect Effects 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 239000000243 solution Substances 0.000 description 4
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 239000011630 iodine Substances 0.000 description 3
- 229910052740 iodine Inorganic materials 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- 239000002390 adhesive tape Substances 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 208000002925 dental caries Diseases 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 210000000214 mouth Anatomy 0.000 description 2
- 229940088417 precipitated calcium carbonate Drugs 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 101100433727 Caenorhabditis elegans got-1.2 gene Proteins 0.000 description 1
- 208000025157 Oral disease Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 229920005601 base polymer Polymers 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 150000002085 enols Chemical class 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000010977 jade Substances 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 208000030194 mouth disease Diseases 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 208000028169 periodontal disease Diseases 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
The present invention discloses a preparing method of povidone iodine toothpaste. (1), sodium carboxymethyl cellulose is taken and added in glycerin; (2), sodium alginate is taken and dissolved by adding purified water; (3), (1) and (2) are mixed; sorbitol is added and stirred; (4), the purified water is added in sodium dodecyl sulfate and potassium iodate; after the sodium dodecyl sulfate and the potassium iodate are heated, povidone iodine and saccharin sodium are added and stirred; (5), (4) is added in (3) and is uniformly mixed; silicon dioxide is added and is uniformly mixed; (6), peppermint oil is taken, dissolved in alcohol and added in (5); the peppermint oil is uniformly stirred; sodium dihydrogen phosphate buffer solution or disodium hydrogen phosphate buffer solution is used for adjusting a pH into 5.5 to 6.5. When povidone iodine toothpaste is used, a great amount of bubbles are generated and are in sufficient contact with dental positions. The povidone iodine toothpaste adds detention time and has a good effect on suppressing the formation of dental plaques. Simultaneously, the povidone iodine toothpaste is adopted for brushing teeth and has the function of mechanically removing the dental plaques. The good effect and the function are combined for effectively suppressing the teeth to generate the dental plaques.
Description
Technical field
The present invention relates to a kind of preparation method of toothpaste, particularly a kind of toothpaste preparation method that contains povidone iodine.
Background technology
Dental plaque is the major reason that causes human two big oral disease dental caries, periodontitis.It is difficult for being eliminated, because it is water insoluble, certain viscosity is arranged, and adhesive force is good, and the formation of bacterial plaque is relevant with bacterial infection.The method that is used to control bacterial plaque at present is a lot, as mechanical means and pharmaceutical methods etc.Add antibacterial or sterilization composition such as hibitane etc. in the toothpaste, the most popular in the world antibacterial is pure as jade pure, all flora is had certain inhibitory action.But hibitane has bitterness, and is invalid to acid-fast bacilli, fungus, virogenetic infection; Pure as jadely purely be used the enol base polymer and thereby herbal component makes toothpaste have the potent biocidal efficacies of wide spectrum.Povidone iodine is a kind of broad-spectrum high efficacy disinfection preservative, and antibacterial, fungus and virus are all had killing action.Gargle with 1% betagen solution, to suppressing the formation of dental plaque, oral cavity infections such as prevention of periodontal disease and dental caries have certain curative effect, but owing to the solution short effect that influences performance dead time in the oral cavity.
Summary of the invention
Purpose of the present invention just provides a kind of tooth that can suppress and produces povidone iodine toothpaste of bacterial plaque and preparation method thereof.
The present invention is grouped into by following one-tenth, and its percentage by weight is: povidone iodine 1%, potassium iodate 0.01～0.03%, sodium carboxymethyl cellulose 0.5～1.5%, sodium lauryl sulphate 2～3%, sodium alginate 0.5～1%, sorbitol 13～18%, glycerol 25～30%, silica 1 5～20%, saccharin sodium 0.05～0.15%, Oleum menthae 0.5～1%, purified water 29～34%.Its preparation method: (1) is got sodium carboxymethyl cellulose and is added glycerol; (2) get sodium alginate and add the purified water dissolving; (3) (1), (2) are mixed, add sorbitol, stir; (4) get sodium lauryl sulphate and potassium iodate adds purified water, after the heating, add povidone iodine and saccharin sodium again, stir; (5) (4) are added in (3), mixing adds silicon dioxide, mixes thoroughly; (6) get Oleum menthae and be dissolved in the ethanol, Oleum menthae and alcoholic acid weight ratio are 1: 0.9～1.6, add in (5), mix thoroughly, and regulating pH with sodium dihydrogen phosphate or sodium hydrogen phosphate buffer is 5.5～6.5.
When povidone iodine toothpaste uses, can produce a large amount of foams, fully contact, increase the holdup time, be formed with effect preferably suppressing dental plaque with the tooth position; Simultaneously, adopt povidone iodine toothpaste to brush teeth, have mechanicalness to remove the effect of dental plaque, both combine can suppress tooth generation bacterial plaque effectively.
The applicant suppresses dental plaque to povidone iodine toothpaste and has been used as test.Select 18 experimenters to carry out successively that povidone iodine toothpaste is brushed teeth and 1% betagen solution is gargled to suppress the test of dental plaque, result such as following table:
Povidone iodine toothpaste suppresses the result of the test of bacterial plaque
| Group | The experimenter | The dental plaque index (x ± s) |
| Povidone iodine toothpaste group betagen solution group | 18 18 | 0.21±0.15 0.76±0.48 |
There were significant differences between test group and matched group P＜0.01
Povidone iodine is a kind of strong oxidizer.Fade gradually under alkali condition, available iodine content reduces and loses activity.The abrasivus of povidone iodine toothpaste can not adopt conventional used precipitated calcium carbonate, because precipitated calcium carbonate is alkalescence, can reacts with povidone iodine and its available iodine content is descended.Povidone iodine toothpaste of the present invention adopts silicon dioxide to do abrasivus, regulates pH in the scope that povidone iodine is fit to sodium dihydrogen phosphate or sodium hydrogen phosphate buffer simultaneously, can guarantee the stable of povidone iodine quality.The povidone iodine toothpaste of the present invention's preparation is made stable accelerated test, and it is stable that quality keeps.The results are shown in following table:
Povidone iodine toothpaste stability test result
Experimental condition: 30 ℃ ± 2 ℃ of temperature, relative humidity 60% ± 5%
| Time | Outward appearance | Available iodine content (%) |
| June in March February January | The reddish brown color brownish red of reddish brown color brownish red cream cream | 0.096 0.096 0.096 0.095 |
The specific embodiment
Below in conjunction with embodiment, the invention will be further described.
Embodiment one
Preparation method of the present invention: (1) is got 1 kilogram of sodium carboxymethyl cellulose and is added 28 kilograms of glycerol, and swelling is disperseed, and places 12 hours; (2) get 0.8 kilogram of sodium alginate and add 5 kilograms of purification water dissolutioies; (3) with after (1), (2) liquid mixing, add 15 kilograms of sorbitol, be stirred to agranular transparent adhesive tape; (4) get 2.5 kilograms of sodium lauryl sulphates and 0.02 kilogram of potassium iodate adds 28.08 kilograms of purified water, place the heating in water bath dissolving, put cold after, adds 1 kilogram of povidone iodine and 0.1 kilogram of saccharin sodium and stirs and make it to dissolve; (5) (4) liquid is added in (3), stir, add 18 kilograms of silicon dioxide, stir; (6) get 0.5 kilogram of Oleum menthae and be dissolved in the ethanol of 1000 ml concns 95%, add in (5), stir, regulating pH with phosphate sodium dihydrogen buffer solution is 5.0, gets povidone iodine toothpaste double centner.
Embodiment two
Preparation method of the present invention: (1) is got 1.5 kilograms of sodium carboxymethyl cellulose and is added 30 kilograms of glycerol, and swelling is disperseed, and places 16 hours; (2) get 1 kilogram of sodium alginate and add 5.32 kilograms of purification water dissolutioies; (3) with after (1), (2) liquid mixing, add 13 kilograms of sorbitol, be stirred to into agranular transparent adhesive tape; (4) get 3 kilograms of sodium lauryl sulphates and 0.03 kilogram of potassium iodate adds 24 kilograms of purified water, place the heating in water bath dissolving, put cold after, adds 1 kilogram of povidone iodine and 0.15 kilogram of saccharin sodium and stirs and make it to dissolve; (5) (4) liquid is added in (3), stir, add 20 kilograms of silicon dioxide, stir; (6) get 1 kilogram of Oleum menthae and be dissolved in the ethanol of 1200 ml concns 95%, add in (5), stir, regulating pH with the sodium hydrogen phosphate buffer is 6.5, gets povidone iodine toothpaste double centner.
Claims (2)
1, a kind of povidone iodine toothpaste is characterized in that being grouped into by following one-tenth, and its percentage by weight is:
Povidone iodine 1 potassium iodate 0.01～0.03 sorbitol 13～18
Sodium alginate 0.5～1 saccharin sodium 0.05～0.15 purified water 29～34
Silica 1 5～20 Oleum menthae 0.5～1 glycerol 25～30
Sodium lauryl sulphate 2～3 sodium carboxymethyl cellulose 0.5～1.5
2, according to the preparation method of the described povidone iodine toothpaste of claim 1, it is characterized in that:
(1) gets sodium carboxymethyl cellulose and add glycerol;
(2) get sodium alginate and add the purified water dissolving;
(3) (1), (2) are mixed, add sorbitol, stir;
(4) get sodium lauryl sulphate and potassium iodate adds purified water, after the heating, add povidone iodine and saccharin sodium again, stir;
(5) (4) liquid is added in (3), mixing adds silicon dioxide, mixes thoroughly;
(6) get Oleum menthae and be dissolved in the ethanol, Oleum menthae and alcoholic acid weight ratio are 1: 0.9～1.6, add in (5), mix thoroughly, and regulating PH with sodium dihydrogen phosphate or sodium hydrogen phosphate buffer is 5.5～6.5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410051033 CN1245954C (en) | 2004-08-08 | 2004-08-08 | Povidone iodine toothpaste and preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410051033 CN1245954C (en) | 2004-08-08 | 2004-08-08 | Povidone iodine toothpaste and preparing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1626066A CN1626066A (en) | 2005-06-15 |
| CN1245954C true CN1245954C (en) | 2006-03-22 |
Family
ID=34763981
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410051033 Expired - Fee Related CN1245954C (en) | 2004-08-08 | 2004-08-08 | Povidone iodine toothpaste and preparing method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1245954C (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102068704B (en) * | 2009-11-23 | 2013-01-09 | 日进齿科材料(昆山)有限公司 | Dental plaque detection liquid |
| CN105078877A (en) * | 2015-09-24 | 2015-11-25 | 福建绿宝食品集团有限公司 | Mushroom type anti-cavity toothpaste and preparing method thereof |
| CN109512683B (en) * | 2018-12-14 | 2021-06-15 | 上海融澈水性材料有限公司 | Povidone-iodine composition and preparation method and application thereof |
| CN110037940A (en) * | 2019-05-22 | 2019-07-23 | 浙江欧洁科技股份有限公司 | A kind of sterilizing oral disinfection mouthwash and preparation method thereof and application method |
-
2004
- 2004-08-08 CN CN 200410051033 patent/CN1245954C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1626066A (en) | 2005-06-15 |
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Owner name: GUANGDONG KELUN PHARMACEUTICAL CO., LTD. Free format text: FORMER NAME: GUANGDONG QINGFA PHARMACEUTICAL INDUSTRY CO., LTD. |
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Address after: 514031, on the west side of Ring Road, Meizhou, Guangdong Patentee after: GUANGDONG KELUN PHARMACEUTICAL Co.,Ltd. Address before: 514031, on the west side of Ring Road, Meizhou, Guangdong Patentee before: Guangdong Qingfa Pharmaceutical Co.,Ltd. |
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