CN1246858A - 取代的嘧啶化合物和它们的应用 - Google Patents

取代的嘧啶化合物和它们的应用 Download PDF

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Publication number
CN1246858A
CN1246858A CN97181563A CN97181563A CN1246858A CN 1246858 A CN1246858 A CN 1246858A CN 97181563 A CN97181563 A CN 97181563A CN 97181563 A CN97181563 A CN 97181563A CN 1246858 A CN1246858 A CN 1246858A
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CN
China
Prior art keywords
amino
group
alkyl
pyridyl
hydroxyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN97181563A
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English (en)
Chinese (zh)
Inventor
U·D·斯波尔
M·J·马隆
N·B·曼特罗
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of CN1246858A publication Critical patent/CN1246858A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C07D213/643—2-Phenoxypyridines; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN97181563A 1996-12-05 1997-12-04 取代的嘧啶化合物和它们的应用 Pending CN1246858A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US3212896P 1996-12-05 1996-12-05
US60/032,128 1996-12-05
US5095097P 1997-06-13 1997-06-13
US60/050,950 1997-06-13
US97605497A 1997-11-21 1997-11-21
US08/976,054 1997-11-21

Publications (1)

Publication Number Publication Date
CN1246858A true CN1246858A (zh) 2000-03-08

Family

ID=27364030

Family Applications (1)

Application Number Title Priority Date Filing Date
CN97181563A Pending CN1246858A (zh) 1996-12-05 1997-12-04 取代的嘧啶化合物和它们的应用

Country Status (11)

Country Link
EP (1) EP0948497A2 (cs)
CN (1) CN1246858A (cs)
AR (1) AR048564A1 (cs)
AU (1) AU733877C (cs)
BG (1) BG65128B1 (cs)
BR (1) BR9713850A (cs)
CA (1) CA2274063C (cs)
CZ (1) CZ296911B6 (cs)
HU (1) HUP0001698A3 (cs)
IL (1) IL130180A0 (cs)
NZ (1) NZ335997A (cs)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100441581C (zh) * 2002-02-28 2008-12-10 赛诺菲-安万特 1-[烷基],1-[(杂芳基)烷基]及1-[(芳基)烷基]-7-(嘧啶-4-基)-咪唑并[1,2-a]嘧啶-5(1H)-酮衍生物
CN100506801C (zh) * 2000-09-06 2009-07-01 诺华疫苗和诊断公司 糖元合成酶激酶3的抑制剂
CN100519549C (zh) * 2001-10-22 2009-07-29 卫材R&D管理有限公司 嘧啶化合物以及含有该化合物的药物组合物
CN106167483A (zh) * 2010-10-18 2016-11-30 塞伦尼斯医疗控股有限公司 可用于胆固醇动员的化合物、组合物和方法
CN106232585A (zh) * 2014-02-20 2016-12-14 日本烟草产业株式会社 三嗪化合物和其药物用途
CN108137513A (zh) * 2015-10-29 2018-06-08 Aska 制药株式会社 嘧啶衍生物

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL160700A0 (en) 2001-09-21 2004-08-31 Mitsubishi Pharma Corp 3-substituted-4-pyrimidone derivatives
IL160701A0 (en) 2001-09-21 2004-08-31 Mitsubishi Pharma Corp 3-substituted-4-pyrimidone derivatives
CN1726209B (zh) 2002-12-16 2011-04-13 三菱制药株式会社 3-取代的-4-嘧啶酮衍生物
TWI357408B (en) 2003-03-26 2012-02-01 Mitsubishi Tanabe Pharma Corp 3-substituted-4-pyrimidone derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE759176A (fr) * 1969-11-20 1971-05-19 Sandoz Sa Derives de la pyrimidine, leur preparation et medicaments contenant cesderives
US4438117A (en) * 1980-09-03 1984-03-20 E. I. Du Pont De Nemours And Company 2-Substituted thio-4,5-diarylpyrimidines
DE3319843A1 (de) * 1983-06-01 1984-12-06 Ali-Akbar Dipl.-Chem. Dr. 4300 Mülheim Pourzal Verfahren zur herstellung von pyrimidinen aus nitrilen und alkinen
US4500533A (en) * 1983-06-22 1985-02-19 Eli Lilly And Company 2,4,5-Triaryl pyrimidines and a method of treating pain, fever, thrombosis, inflammation and arthritis
US5077142A (en) * 1989-04-20 1991-12-31 Ricoh Company, Ltd. Electroluminescent devices
US5620999A (en) * 1994-07-28 1997-04-15 Weier; Richard M. Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100506801C (zh) * 2000-09-06 2009-07-01 诺华疫苗和诊断公司 糖元合成酶激酶3的抑制剂
CN100519549C (zh) * 2001-10-22 2009-07-29 卫材R&D管理有限公司 嘧啶化合物以及含有该化合物的药物组合物
CN100441581C (zh) * 2002-02-28 2008-12-10 赛诺菲-安万特 1-[烷基],1-[(杂芳基)烷基]及1-[(芳基)烷基]-7-(嘧啶-4-基)-咪唑并[1,2-a]嘧啶-5(1H)-酮衍生物
CN106167483A (zh) * 2010-10-18 2016-11-30 塞伦尼斯医疗控股有限公司 可用于胆固醇动员的化合物、组合物和方法
CN106167483B (zh) * 2010-10-18 2019-02-15 塞伦尼斯医疗控股有限公司 可用于胆固醇动员的化合物、组合物和方法
CN106232585A (zh) * 2014-02-20 2016-12-14 日本烟草产业株式会社 三嗪化合物和其药物用途
CN106232585B (zh) * 2014-02-20 2019-04-02 日本烟草产业株式会社 三嗪化合物和其药物用途
CN108137513A (zh) * 2015-10-29 2018-06-08 Aska 制药株式会社 嘧啶衍生物
CN108137513B (zh) * 2015-10-29 2022-03-01 Aska 制药株式会社 嘧啶衍生物

Also Published As

Publication number Publication date
NZ335997A (en) 2001-08-31
HUP0001698A3 (en) 2002-07-29
IL130180A0 (en) 2000-06-01
CZ296911B6 (cs) 2006-07-12
CA2274063A1 (en) 1998-06-11
BR9713850A (pt) 2000-02-29
BG65128B1 (bg) 2007-03-30
CZ9902015A3 (cs) 1999-11-17
AU6012098A (en) 1998-06-29
AU733877C (en) 2003-05-08
BG103512A (en) 2000-07-31
AR048564A1 (es) 2006-05-10
EP0948497A2 (en) 1999-10-13
AU733877B2 (en) 2001-05-31
CA2274063C (en) 2007-09-04
HUP0001698A2 (hu) 2001-04-28

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