CN1299411A - 用于基因治疗的高温诱导表达载体及其使用方法 - Google Patents

用于基因治疗的高温诱导表达载体及其使用方法 Download PDF

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CN1299411A
CN1299411A CN98812752A CN98812752A CN1299411A CN 1299411 A CN1299411 A CN 1299411A CN 98812752 A CN98812752 A CN 98812752A CN 98812752 A CN98812752 A CN 98812752A CN 1299411 A CN1299411 A CN 1299411A
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expression
feature
cell
expression construct
gene
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CN98812752A
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Chinese (zh)
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汤姆·昌
尤金·W·格尔纳
大卫·T·哈里斯
伊万·赫什
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University of Arizona
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University of Arizona
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
CN98812752A 1997-11-03 1998-11-03 用于基因治疗的高温诱导表达载体及其使用方法 Pending CN1299411A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6408897P 1997-11-03 1997-11-03
US60/064,088 1997-11-03

Publications (1)

Publication Number Publication Date
CN1299411A true CN1299411A (zh) 2001-06-13

Family

ID=22053477

Family Applications (1)

Application Number Title Priority Date Filing Date
CN98812752A Pending CN1299411A (zh) 1997-11-03 1998-11-03 用于基因治疗的高温诱导表达载体及其使用方法

Country Status (9)

Country Link
EP (1) EP1029041A2 (fr)
JP (1) JP2001521740A (fr)
KR (1) KR20010031762A (fr)
CN (1) CN1299411A (fr)
AU (1) AU1377299A (fr)
BR (1) BR9813917A (fr)
CA (1) CA2308575A1 (fr)
IL (1) IL135943A0 (fr)
WO (1) WO1999023216A2 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103667345A (zh) * 2013-12-02 2014-03-26 东南大学 一种抗肿瘤基因磁性复合纳米颗粒及制备方法
WO2017133633A1 (fr) * 2016-02-04 2017-08-10 Nanjing Legend Biotech Co., Ltd. Cellules mammifères génétiquement modifiées pour thérapie anticancéreuse
CN108913661A (zh) * 2018-06-22 2018-11-30 安徽 一种人体研究用造血干细胞的制备和提取方法
WO2022067875A1 (fr) * 2020-09-29 2022-04-07 中国农业科学院生物技术研究所 Boucle de régulation de la méthylation précise du génome de type réponse aux hautes températures de culture
CN116536349A (zh) * 2023-05-22 2023-08-04 安徽农业大学 一种大豆GmMLP34基因在调控植物耐高温性上的应用
CN119327020A (zh) * 2024-12-18 2025-01-21 吉林大学 一种便携式双压电微泵作用的无痛注射装置

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19951765A1 (de) * 1999-10-27 2001-05-03 Thomas Schweder Wirts-Vektor-Systeme zur Überproduktion von thermolabilen Enzymen psychrophiler Organismen
US6579522B1 (en) 2000-06-27 2003-06-17 Genvec, Inc. Replication deficient adenoviral TNF vector
US7285414B2 (en) 2000-09-26 2007-10-23 Emory University Viruses targeted to hypoxic cells and tissues
DE60137137D1 (de) * 2000-09-26 2009-02-05 Univ Emory Viren gegen hypoxische zellen und gewebe
US20030086903A1 (en) 2001-11-02 2003-05-08 Genvec, Inc. Therapeutic regimen for treating cancer
PT2213730E (pt) 2002-06-18 2016-02-26 Eisai R&D Man Co Ltd Adipócitos de cultura primária para terapia génica
WO2004035082A2 (fr) * 2002-10-14 2004-04-29 DeveloGen Aktiengesellschaft für entwicklungsbiologische Forschung Proteines impliquees dans la regulation de l'homeostasie energetique
JP2008048601A (ja) * 2004-06-15 2008-03-06 Nippon Kosei Kagaku Kenkyusho:Kk 治療に有用な産物の生産法およびシステム
WO2006116789A2 (fr) * 2005-05-03 2006-11-09 Veterinärmedizinische Universität Wien Capsules permeables
NZ584848A (en) * 2007-09-28 2012-09-28 Intrexon Corp Therapeutic gene-switch constructs and bioreactors for the expression of biotherapeutic molecules, and uses thereof
IT202200000788A1 (it) * 2022-01-19 2023-07-19 Bruno Cell S R L Induzione sensibile alla temperatura del programma miogenico e/o adipogenico in cellule per la produzione di tessuto muscolare e/o adiposo

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3991770A (en) * 1974-01-24 1976-11-16 Leveen Harry H Method for treating benign and malignant tumors utilizing radio frequency, electromagnetic radiation
EP0299127A1 (fr) * 1987-07-16 1989-01-18 IntraCel Corporation Procédé pour exprimer des gènes recombinants, stimulés par une protéine activatrice, exprimée par induction
EP0455424A3 (en) * 1990-05-02 1992-04-29 Merck & Co. Inc. Mammalian inducible promoter cascade system
FR2717187B1 (fr) * 1994-03-10 1996-05-31 Transgene Sa Usage combiné de deux cassettes d'expression pour la production d'une protéine d'intérêt.

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103667345A (zh) * 2013-12-02 2014-03-26 东南大学 一种抗肿瘤基因磁性复合纳米颗粒及制备方法
WO2017133633A1 (fr) * 2016-02-04 2017-08-10 Nanjing Legend Biotech Co., Ltd. Cellules mammifères génétiquement modifiées pour thérapie anticancéreuse
CN108883202A (zh) * 2016-02-04 2018-11-23 南京传奇生物科技有限公司 用于癌症治疗的工程化的哺乳动物细胞
CN108913661A (zh) * 2018-06-22 2018-11-30 安徽 一种人体研究用造血干细胞的制备和提取方法
WO2022067875A1 (fr) * 2020-09-29 2022-04-07 中国农业科学院生物技术研究所 Boucle de régulation de la méthylation précise du génome de type réponse aux hautes températures de culture
CN116536349A (zh) * 2023-05-22 2023-08-04 安徽农业大学 一种大豆GmMLP34基因在调控植物耐高温性上的应用
CN116536349B (zh) * 2023-05-22 2024-02-20 安徽农业大学 一种大豆GmMLP34基因在调控植物耐高温性上的应用
CN119327020A (zh) * 2024-12-18 2025-01-21 吉林大学 一种便携式双压电微泵作用的无痛注射装置

Also Published As

Publication number Publication date
JP2001521740A (ja) 2001-11-13
WO1999023216A2 (fr) 1999-05-14
CA2308575A1 (fr) 1999-05-14
KR20010031762A (ko) 2001-04-16
BR9813917A (pt) 2001-10-30
WO1999023216A3 (fr) 1999-08-05
AU1377299A (en) 1999-05-24
IL135943A0 (en) 2001-05-20
EP1029041A2 (fr) 2000-08-23

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