CN1307253C - Chitosan water-retaining gel adhesive substrate materials and method for preparing same - Google Patents
Chitosan water-retaining gel adhesive substrate materials and method for preparing same Download PDFInfo
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- CN1307253C CN1307253C CNB2005100490389A CN200510049038A CN1307253C CN 1307253 C CN1307253 C CN 1307253C CN B2005100490389 A CNB2005100490389 A CN B2005100490389A CN 200510049038 A CN200510049038 A CN 200510049038A CN 1307253 C CN1307253 C CN 1307253C
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- polyvinyl alcohol
- polyvinylpyrrolidone
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- 229920001661 Chitosan Polymers 0.000 title claims abstract description 69
- 239000000463 material Substances 0.000 title claims abstract description 25
- 239000000758 substrate Substances 0.000 title abstract description 7
- 239000000853 adhesive Substances 0.000 title abstract description 4
- 230000001070 adhesive effect Effects 0.000 title abstract description 4
- 238000000034 method Methods 0.000 title description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 52
- 239000004372 Polyvinyl alcohol Substances 0.000 claims abstract description 51
- 229920002451 polyvinyl alcohol Polymers 0.000 claims abstract description 51
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims abstract description 28
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims abstract description 28
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims abstract description 28
- 238000002360 preparation method Methods 0.000 claims abstract description 24
- 229920000136 polysorbate Polymers 0.000 claims abstract description 21
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 20
- 239000000243 solution Substances 0.000 claims description 108
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 38
- 239000010695 polyglycol Substances 0.000 claims description 30
- 229920000151 polyglycol Polymers 0.000 claims description 30
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 claims description 29
- DGLRDKLJZLEJCY-UHFFFAOYSA-L disodium hydrogenphosphate dodecahydrate Chemical compound O.O.O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].OP([O-])([O-])=O DGLRDKLJZLEJCY-UHFFFAOYSA-L 0.000 claims description 29
- 229960004873 levomenthol Drugs 0.000 claims description 29
- -1 Polyoxyethylene Polymers 0.000 claims description 27
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 24
- 235000011187 glycerol Nutrition 0.000 claims description 23
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 19
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 19
- 239000003795 chemical substances by application Substances 0.000 claims description 15
- 239000000017 hydrogel Substances 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- 150000001875 compounds Chemical class 0.000 claims description 12
- 239000007864 aqueous solution Substances 0.000 claims description 10
- 239000011248 coating agent Substances 0.000 claims description 6
- 238000000576 coating method Methods 0.000 claims description 6
- 230000006196 deacetylation Effects 0.000 claims description 6
- 238000003381 deacetylation reaction Methods 0.000 claims description 6
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 6
- 229960004756 ethanol Drugs 0.000 claims description 6
- 239000012467 final product Substances 0.000 claims description 6
- 238000012856 packing Methods 0.000 claims description 6
- IQXJCCZJOIKIAD-UHFFFAOYSA-N 1-(2-methoxyethoxy)hexadecane Chemical compound CCCCCCCCCCCCCCCCOCCOC IQXJCCZJOIKIAD-UHFFFAOYSA-N 0.000 claims description 3
- 229950009789 cetomacrogol 1000 Drugs 0.000 claims description 3
- 229940093429 polyethylene glycol 6000 Drugs 0.000 claims description 3
- 239000003814 drug Substances 0.000 abstract description 8
- 230000008901 benefit Effects 0.000 abstract description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 abstract 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 abstract 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 abstract 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 abstract 2
- 239000002202 Polyethylene glycol Substances 0.000 abstract 2
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 abstract 2
- 229910000397 disodium phosphate Inorganic materials 0.000 abstract 2
- 235000019800 disodium phosphate Nutrition 0.000 abstract 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 abstract 2
- 229940041616 menthol Drugs 0.000 abstract 2
- 229920001223 polyethylene glycol Polymers 0.000 abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract 1
- 206010002198 Anaphylactic reaction Diseases 0.000 abstract 1
- 208000003455 anaphylaxis Diseases 0.000 abstract 1
- 230000035515 penetration Effects 0.000 abstract 1
- 239000000499 gel Substances 0.000 description 5
- 229920006316 polyvinylpyrrolidine Polymers 0.000 description 5
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 4
- 229920000053 polysorbate 80 Polymers 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- 206010070834 Sensitisation Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 230000008313 sensitization Effects 0.000 description 2
- 239000004902 Softening Agent Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 239000000989 food dye Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
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Abstract
The present invention relates to a chitosan water-retaining gel adhesive substrate material and a preparation method thereof. The chitosan water-retaining gel adhesive substrate material comprises the components of the following weight percentage content: 2.4 to 16 wt% of chitosan, 1.9 to 18 wt% of Na2HPO4*12H2O, 1.9 to 18 wt% of hydroxyethyl cellulose, 15 to 80 wt% of polyvinyl alcohol, 0.79 to 21 wt% of polyethyleneglycol, 0.54 to 56 wt% of glycerol, 0.44 to 35 wt% of tweenm 0.25 to 24 wt% of polyvinylpyrrolidone and 0.20 to 8.9 wt% of menthol. The preparation method comprises: the solution of the chitosan, ethanol and acetate, a polyvinyl alcohol solution containing Na2HPO4*12H2O, the hydroxyethyl cellulose and the polyvinylpyrrolidone, and a polyethyleneglycol solution containing the glycerol, the tween and the solution of the menthol and ethanol are mixed, and are coated, cut and separately packed. The material has the advantages of simple technology, good water-retaining performance, good medicine penetration performance, no skin anaphylactic reaction, low price, convenient use, etc.
Description
Technical field
The present invention relates to chitosan hydrogel adhibit agent host material and preparation method thereof.
Background technology
Patch is the important component part of China's traditional medicine, and the history in existing more than 2000 year has the incomparable advantage of other formulations, and is easy to use, sustainable administration, also interruption of the administration at any time.But traditional patch mainly with the rubber plaster as substrate material, this substrate material approaches greatly in appearance, its shortcoming is that active drug containing amount is little, airtight, the drug transdermal weak effect, easily stimulate irritated, can't alleviate the efficacy of a drug, viscosity can not be regulated and control, and generally, limited the development of patch dramatically only with the load fat-soluble medicine.Traditional gel adhesive, the matrix content height, water-retaining capacity is little.
Summary of the invention
The objective of the invention is for overcoming the problems referred to above that patch and conventional gel exist, and a kind of chitosan hydrogel adhibit agent host material and preparation method thereof is provided.
Chitosan hydrogel adhibit agent host material of the present invention, its component and weight percent content are:
Chitosan 2.4-16
Disodium hydrogen phosphate dodecahydrate 1.9-18
Natvosol 1.9-18
Polyvinyl alcohol 15-80
Polyoxyethylene glycol 0.79-21
Glycerine 0.54-56
Tween 0.44-35
Polyvinylpyrrolidone 0.25-24
Mentha camphor 0.20-8.9
The summation of said components equals 100%.
The preparation method of chitosan hydrogel adhibit agent host material may further comprise the steps:
1) preparation 0.5-1.0% (v/v) ethanol 0.5% (v/v) acetic acid aqueous solution system, with this solution system dissolving chitosan, compound concentration is the chitosan solution of 1.5% (m/v);
2) polyvinyl alcohol is dissolved in compound concentration is the polyvinyl alcohol solution of 7-15% (m/v) in the hot pure water, it is standby to be cooled to room temperature;
3) polyoxyethylene glycol is dissolved in is mixed with the polyglycol solution that concentration is 10-25% (m/v) in the pure water;
4) be 20% (m/v) mentha camphor ethanolic soln with the dehydrated alcohol compound concentration;
5) according to chitosan solution and polyvinyl alcohol solution with volume ratio 1: (0.7-1.3), determine the use volume of polyvinyl alcohol solution, according to polyvinyl alcohol solution and polyglycol solution volume ratio is 40: (1-5) determining the use volume of polyglycol solution, is chitosan according to weight percent: disodium hydrogen phosphate dodecahydrate: Natvosol: polyvinylpyrrolidone=1: (0.8-1.2): (0.8-1.2): the weight of (0.1-2) determining disodium hydrogen phosphate dodecahydrate, Natvosol, polyvinylpyrrolidone;
6) above-mentioned disodium hydrogen phosphate dodecahydrate, Natvosol, polyvinylpyrrolidone are joined in the polyvinyl alcohol solution, mix;
7) press polyglycol solution, glycerine, tween, mentha camphor ethanolic soln with following volume ratio 2: (0.1-2): (0.1-1): (0.25-1), glycerine, tween, mentha camphor ethanolic soln are joined in the polyglycol solution and go, mix;
8) mixing solutions with step 7) joins in the mixing solutions of step 6), mixes;
9) mixing solutions with step 8) joins in the step 1) chitosan solution, mixes, and coating is cut, and packing gets final product.
Among the present invention, employed chitosan specification is: the range of viscosities that deacetylation 〉=85% chitosan is dissolved in 1% (v/v) acetic acid solution is: 400-600mPaS; Use the medium-viscosity Natvosol; The polyvinyl alcohol that uses there is not particular requirement, good with polyvinyl alcohol 124 results of use; Polyoxyethylene glycol can be a polyethylene glycol 6000, polyoxyethylene glycol 8000 or cetomacrogol 1000 0; Polyvinylpyrrolidone can adopt polyvinylpyrrolidone K30; Tween can be polysorbas20 or tween 80, and is good with the tween 80 result of use.
Chitosan hydrogel adhibit agent host material of the present invention, rely on electrostatic force, hydrophobic interaction and hydrogen bond action generation crosslinked with chitosan, disodium hydrogen phosphate dodecahydrate, Natvosol, with the polyvinyl alcohol is membrane-forming agent, glycerine, polyoxyethylene glycol are softening agent, tween is a thickening material, polyvinylpyrrolidone is tackifier, and the mentha camphor ethanolic soln is a Percutaneous absorption enhancer, works to improve the smell of gel simultaneously.Include a large amount of moisture in the gelling system, can make skin surface hydration, the effective ingredient in the matrix can successfully see through skin and enter in the body.Can add food dye and essence in the chitosan water-keeping gel simultaneously, to improve user's acceptability.
Preparation method of the present invention adopts the physical property crosslinking method to form gel, make whole gelling system form stable structure, can contain a large amount of moisture and medicine, comprise fat-soluble and water soluble drug, become not have in the glue process new material to generate simultaneously, make whole gelling system possess validity, security.Substrate material adopts the hydrophilic macromolecule material, with the skin good biocompatibility, possesses water retention property efficiently, not sensitization, have no side effect, can not draw pain skin yet.Therefore, this hydrogel can solve the deficiency of traditional patch, expands the range of application of patch.
Beneficial effect of the present invention is: 1. technology is simple, and is easy to operate; 2. the pharmaceutical pack capacity is big, and transdermal effect is good; 3. good water-retaining property, substrate material and skin good biocompatibility, sensitization does not have no side effect, and may command viscosity can not drawn pain skin.
Embodiment
The invention will be further described below in conjunction with embodiment.
Embodiment 1:
The component of chitosan hydrogel adhibit agent host material and weight percent content are: chitosan 6.49, disodium hydrogen phosphate dodecahydrate 6.49, Natvosol 6.49, polyvinyl alcohol 43.29, polyoxyethylene glycol 6.49, glycerine 13.64, tween 11.70, polyvinylpyrrolidone 4.33, mentha camphor 1.08.
The raw material that adopts in this example: chitosan: deacetylation 90.1%, viscosity 430mPaS; Natvosol: the about 1500mPaS of viscosity (5% concentration in the aqueous solution); Polyvinyl alcohol 124; Polyoxyethylene glycol 8000; Tween 80; Polyvinylpyrrolidone K30, biochemical reagents; Disodium hydrogen phosphate dodecahydrate, analytical pure; Glycerine, analytical pure; Mentha camphor, pharmaceutical grade.
Its preparation method is as follows:
1) preparation 1.0% (v/v) ethanol 0.5% (v/v) acetic acid aqueous solution system, with this solution system dissolving chitosan, compound concentration is the chitosan solution of 1.5% (m/v);
2) polyvinyl alcohol is dissolved in compound concentration is the polyvinyl alcohol solution of 10% (m/v) in the hot pure water, it is standby to be cooled to room temperature;
3) polyoxyethylene glycol is dissolved in is mixed with the polyglycol solution that concentration is 20% (m/v) in the pure water;
4) with dehydrated alcohol preparation 20% (m/v) mentha camphor ethanolic soln;
5) get the 40ml chitosan solution, according to chitosan solution and polyvinyl alcohol solution with volume ratio 1: 1, the volume that uses of determining polyvinyl alcohol solution is 40ml, according to polyvinyl alcohol solution and polyglycol solution volume ratio is 40: 3, the volume that uses of determining polyglycol solution is 3ml, according to weight percent is chitosan: disodium hydrogen phosphate dodecahydrate: Natvosol: polyvinylpyrrolidone=1: 1: 1: 0.67, determine that disodium hydrogen phosphate dodecahydrate is that 0.6 gram, Natvosol 0.6 restrain, polyvinylpyrrolidone is 0.4 gram;
6) above-mentioned disodium hydrogen phosphate dodecahydrate, Natvosol, polyvinylpyrrolidone are joined in the polyvinyl alcohol solution, mix;
7) press polyglycol solution, glycerine, tween, mentha camphor ethanolic soln with following volume ratio 2: 0.67: 0.67: 0.33,1ml glycerine, 1ml tween, 0.5ml mentha camphor ethanolic soln are joined in the 3ml polyglycol solution and go, mix;
8) mixing solutions with step 7) joins in the mixing solutions of step 6), mixes;
9) mixing solutions with step 8) joins in the step 1) chitosan solution, mixes, and coating is cut, and packing gets final product.
Embodiment 2:
The component of chitosan hydrogel adhibit agent host material and weight percent content are: chitosan 11.77, disodium hydrogen phosphate dodecahydrate 11.77, Natvosol 11.77, polyvinyl alcohol 43.93, polyoxyethylene glycol 1.37, glycerine 8.65, tween 7.41, polyvinylpyrrolidone 1.96, mentha camphor 1.37.
The raw material that adopts in this example: chitosan: deacetylation 89%, viscosity 500mPaS; Natvosol: the about 1500mPaS of viscosity (5% concentration in the aqueous solution); Polyvinyl alcohol 124; Polyethylene glycol 6000; Polysorbas20; Polyvinylpyrrolidone K30, biochemical reagents; Disodium hydrogen phosphate dodecahydrate, analytical pure; Glycerine, analytical pure; Mentha camphor, pharmaceutical grade.
Its preparation method is as follows:
1) preparation 1.0% (v/v) ethanol 0.5% (v/v) acetic acid aqueous solution system, with this solution system dissolving chitosan, compound concentration is the chitosan solution of 1.5% (m/v);
2) polyvinyl alcohol is dissolved in compound concentration is the polyvinyl alcohol solution of 8% (m/v) in the hot pure water, it is standby to be cooled to room temperature;
3) polyoxyethylene glycol is dissolved in is mixed with the polyglycol solution that concentration is 10% (m/v) in the pure water;
4) with dehydrated alcohol preparation 20% (m/v) mentha camphor ethanolic soln;
5) get the 40ml chitosan solution, according to chitosan solution and polyvinyl alcohol solution with volume ratio 1: 0.7, the volume that uses of determining polyvinyl alcohol solution is 28ml, according to polyvinyl alcohol solution and polyglycol solution volume ratio is 40: 1, the volume that uses of determining polyglycol solution is 0.7ml, according to weight percent is chitosan: disodium hydrogen phosphate dodecahydrate: Natvosol: polyvinylpyrrolidone=1: 1: 1: 0.17, determine that disodium hydrogen phosphate dodecahydrate is that 0.6 gram, Natvosol 0.6 restrain, polyvinylpyrrolidone is 0.1 gram;
6) above-mentioned disodium hydrogen phosphate dodecahydrate, Natvosol, polyvinylpyrrolidone are joined in the polyvinyl alcohol solution, mix;
7) press polyglycol solution, glycerine, tween, mentha camphor ethanolic soln with following volume ratio 2: 1: 1: 1,0.35ml glycerine, 0.35ml tween, 0.35ml mentha camphor ethanolic soln are joined in the 0.7ml polyglycol solution and go, mix;
8) mixing solutions with step 7) joins in the mixing solutions of step 6), mixes;
9) mixing solutions with step 8) joins in the step 1) chitosan solution, mixes, and coating is cut, and packing gets final product.
Embodiment 3:
The component of chitosan hydrogel adhibit agent host material and weight percent content are: chitosan 3.30, disodium hydrogen phosphate dodecahydrate 3.30, Natvosol 3.30, polyvinyl alcohol 34.34, polyoxyethylene glycol 7.15, glycerine 22.54, tween 19.32, polyvinylpyrrolidone 4.96, mentha camphor 1.79.
The raw material that adopts in this example: chitosan: deacetylation 91%, viscosity 560mPaS; Natvosol: the about 1500mPaS of viscosity (5% concentration in the aqueous solution); Polyvinyl alcohol 124; Cetomacrogol 1000 0; Tween 80; Polyvinylpyrrolidone K30, biochemical reagents; Disodium hydrogen phosphate dodecahydrate, analytical pure; Glycerine, analytical pure; Mentha camphor, pharmaceutical grade.
Its preparation method is as follows:
1) preparation 1.0% (v/v) ethanol 0.5% (v/v) acetic acid aqueous solution system, with this solution system dissolving chitosan, compound concentration is the chitosan solution of 1.5% (m/v);
2) polyvinyl alcohol is dissolved in compound concentration is the polyvinyl alcohol solution of 12% (m/v) in the hot pure water, it is standby to be cooled to room temperature;
3) polyoxyethylene glycol is dissolved in is mixed with the polyglycol solution that concentration is 20% (m/v) in the pure water;
4) with dehydrated alcohol preparation 20% (m/v) mentha camphor ethanolic soln;
5) get the 40ml chitosan solution, according to chitosan solution and polyvinyl alcohol solution with volume ratio 1: 1.3, the volume that uses of determining polyvinyl alcohol solution is 52ml, according to polyvinyl alcohol solution and polyglycol solution volume ratio is 40: 5, the volume that uses of determining polyglycol solution is 6.5ml, according to weight percent is chitosan: disodium hydrogen phosphate dodecahydrate: Natvosol: polyvinylpyrrolidone=1: 1: 1: 1.5, determine that disodium hydrogen phosphate dodecahydrate is that 0.6 gram, Natvosol 0.6 restrain, polyvinylpyrrolidone is 0.9 gram;
6) above-mentioned disodium hydrogen phosphate dodecahydrate, Natvosol, polyvinylpyrrolidone are joined in the polyvinyl alcohol solution, mix;
7) press polyglycol solution, glycerine, tween, mentha camphor ethanolic soln with following volume ratio 2: 1: 1: 0.5,3.25ml glycerine, 3.25ml tween, 1.63ml mentha camphor ethanolic soln are joined in the 6.5ml polyglycol solution and go, mix;
8) mixing solutions with step 7) joins in the mixing solutions of step 6), mixes;
9) mixing solutions with step 8) joins in the step 1) chitosan solution, mixes, and coating is cut, and packing gets final product.
Embodiment 4:
The component of chitosan hydrogel adhibit agent host material and weight percent content are: chitosan 6.19, disodium hydrogen phosphate dodecahydrate 6.19, Natvosol 6.19, polyvinyl alcohol 32.98, polyoxyethylene glycol 4.12, glycerine 25.98, tween 11.13, polyvinylpyrrolidone 6.19, mentha camphor 1.03.
The raw material that adopts in this example: chitosan: deacetylation 90.1%, viscosity 430mPaS; Natvosol: the about 1500mPaS of viscosity (5% concentration in the aqueous solution); Polyvinyl alcohol 124; Polyoxyethylene glycol 8000; Polysorbas20; Polyvinylpyrrolidone K30, biochemical reagents; Disodium hydrogen phosphate dodecahydrate, analytical pure; Glycerine, analytical pure; Mentha camphor, pharmaceutical grade.
Its preparation method is as follows:
1) preparation 1.0% (v/v) ethanol 0.5% (v/v) acetic acid aqueous solution system, with this solution system dissolving chitosan, compound concentration is the chitosan solution of 1.5% (m/v);
2) polyvinyl alcohol is dissolved in compound concentration is the polyvinyl alcohol solution of 8% (m/v) in the hot pure water, it is standby to be cooled to room temperature;
3) polyoxyethylene glycol is dissolved in is mixed with the polyglycol solution that concentration is 20% (m/v) in the pure water;
4) with dehydrated alcohol preparation 20% (m/v) mentha camphor ethanolic soln;
5) get the 40ml chitosan solution, according to chitosan solution and polyvinyl alcohol solution with volume ratio 1: 1, the volume that uses of determining polyvinyl alcohol solution is 40ml, according to polyvinyl alcohol solution and polyglycol solution volume ratio is 40: 2, the volume that uses of determining polyglycol solution is 2ml, according to weight percent is chitosan: disodium hydrogen phosphate dodecahydrate: Natvosol: polyvinylpyrrolidone=1: 1: 1: 1, determine that disodium hydrogen phosphate dodecahydrate is that 0.6 gram, Natvosol 0.6 restrain, polyvinylpyrrolidone is 0.6 gram;
6) above-mentioned disodium hydrogen phosphate dodecahydrate, Natvosol, polyvinylpyrrolidone are joined in the polyvinyl alcohol solution, mix;
7) press polyglycol solution, glycerine, tween, mentha camphor ethanolic soln with following volume ratio 2: 2: 1: 0.5,2ml glycerine, 1ml tween, 0.5ml mentha camphor ethanolic soln are joined in the 2ml polyglycol solution and go, mix;
8) mixing solutions with step 7) joins in the mixing solutions of step 6), mixes;
9) mixing solutions with step 8) joins in the step 1) chitosan solution, mixes, and coating is cut, and packing gets final product.
Claims (4)
1. chitosan hydrogel adhibit agent host material is characterized in that its component and weight percent content are:
Chitosan 2.4-16
Disodium hydrogen phosphate dodecahydrate 1.9-18
Natvosol 1.9-18
Polyvinyl alcohol 15-80
Polyoxyethylene glycol 0.79-21
Glycerine 0.54-56
Tween 0.44-35
Polyvinylpyrrolidone 0.25-24
Mentha camphor 0.20-8.9
The summation of said components equals 100%.
2. the preparation method of chitosan hydrogel adhibit agent host material according to claim 1 is characterized in that may further comprise the steps:
1) preparation 0.5-1.0% (v/v) ethanol 0.5% (v/v) acetic acid aqueous solution system, with this solution system dissolving chitosan, compound concentration is the chitosan solution of 1.5% (m/v);
2) polyvinyl alcohol is dissolved in compound concentration is the polyvinyl alcohol solution of 7-15% (m/v) in the hot pure water, it is standby to be cooled to room temperature;
3) polyoxyethylene glycol is dissolved in is mixed with the polyglycol solution that concentration is 10-25% (m/v) in the pure water;
4) be 20% (m/v) mentha camphor ethanolic soln with the dehydrated alcohol compound concentration;
5) according to chitosan solution and polyvinyl alcohol solution with volume ratio 1: (0.7-1.3), determine the use volume of polyvinyl alcohol solution, according to polyvinyl alcohol solution and polyglycol solution volume ratio is 40: (1-5) determining the use volume of polyglycol solution, is chitosan according to weight percent: disodium hydrogen phosphate dodecahydrate: Natvosol: polyvinylpyrrolidone=1: (0.8-1.2): (0.8-1.2): the weight of (0.1-2) determining disodium hydrogen phosphate dodecahydrate, Natvosol, polyvinylpyrrolidone;
6) above-mentioned disodium hydrogen phosphate dodecahydrate, Natvosol, polyvinylpyrrolidone are joined in the polyvinyl alcohol solution, mix;
7) press polyglycol solution, glycerine, tween, mentha camphor ethanolic soln with following volume ratio 2: (0.1-2): (0.1-1): (0.25-1), glycerine, tween, mentha camphor ethanolic soln are joined in the polyglycol solution and go, mix;
8) mixing solutions with step 7) joins in the mixing solutions of step 6), mixes;
9) mixing solutions with step 8) joins in the step 1) chitosan solution, mixes, and coating is cut, and packing gets final product.
3. the preparation method of chitosan hydrogel adhibit agent host material according to claim 2, it is characterized in that employed chitosan is: the range of viscosities that deacetylation 〉=85% chitosan is dissolved in 1% (v/v) acetic acid solution is: 400-600mPaS.
4. the preparation method of chitosan hydrogel adhibit agent host material according to claim 2 is characterized in that said polyoxyethylene glycol is a polyethylene glycol 6000, polyoxyethylene glycol 8000 or cetomacrogol 1000 0.
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|---|---|---|---|---|
| CN101525541B (en) * | 2008-03-04 | 2010-10-06 | 钟维安 | Soil stabilizing and curing agent |
| CN101926833B (en) * | 2010-08-06 | 2012-01-04 | 云南白药集团无锡药业有限公司 | Hydrogel patch and preparation method thereof |
| CN105030659A (en) * | 2015-06-16 | 2015-11-11 | 贵州大学 | Gel for body surface wound and preparation method of gel |
| CN106474529B (en) * | 2015-08-28 | 2019-05-28 | 贵州扬生医用器材有限公司 | A kind of hemostasis adhesive of the body containing amino acid lipids and preparation method thereof |
| CN108113963A (en) * | 2017-12-28 | 2018-06-05 | 仙居优亿医疗器械有限公司 | A kind of Dispoable medical hydrogel eye plaster and preparation method thereof |
| CN115851161A (en) * | 2022-12-01 | 2023-03-28 | 惠州市美孚涂节能材料有限公司 | Preparation method of medical water-soluble double-sided adhesive tape |
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| EP1098931B1 (en) * | 1998-07-17 | 2002-10-09 | Kemestrie Inc. | Polyionic hydrogels based on xanthan and chitosan for stabilising and controlled release of vitamins |
| CN1389503A (en) * | 2002-07-15 | 2003-01-08 | 浙江大学 | In-situ compounding process of synthesizing nano composite chitosan/hydroxyapatite material |
| CN1422668A (en) * | 2001-11-29 | 2003-06-11 | 浙江大学 | Medical micro porouse chitoglycan asymmetric film and preparation method thereof |
| JP2004217933A (en) * | 2003-01-09 | 2004-08-05 | Jakwang Co Ltd | Water-soluble natural film and its manufacturing method |
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| EP1098931B1 (en) * | 1998-07-17 | 2002-10-09 | Kemestrie Inc. | Polyionic hydrogels based on xanthan and chitosan for stabilising and controlled release of vitamins |
| CN1422668A (en) * | 2001-11-29 | 2003-06-11 | 浙江大学 | Medical micro porouse chitoglycan asymmetric film and preparation method thereof |
| CN1389503A (en) * | 2002-07-15 | 2003-01-08 | 浙江大学 | In-situ compounding process of synthesizing nano composite chitosan/hydroxyapatite material |
| JP2004217933A (en) * | 2003-01-09 | 2004-08-05 | Jakwang Co Ltd | Water-soluble natural film and its manufacturing method |
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