CN1324405A - 新型g蛋白偶联型受体蛋白、dna及其配体 - Google Patents

新型g蛋白偶联型受体蛋白、dna及其配体 Download PDF

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Publication number
CN1324405A
CN1324405A CN99812722A CN99812722A CN1324405A CN 1324405 A CN1324405 A CN 1324405A CN 99812722 A CN99812722 A CN 99812722A CN 99812722 A CN99812722 A CN 99812722A CN 1324405 A CN1324405 A CN 1324405A
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China
Prior art keywords
protein
present
salt
receptor protein
ligand
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Pending
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CN99812722A
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English (en)
Chinese (zh)
Inventor
渡边卓也
寺尾宁子
新谷靖
大泷彻也
金桥贵美子
北田千惠子
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Takeda Pharmaceutical Co Ltd
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Takeda Chemical Industries Ltd
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Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of CN1324405A publication Critical patent/CN1324405A/zh
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Pregnancy & Childbirth (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Peptides Or Proteins (AREA)
CN99812722A 1998-10-27 1999-10-26 新型g蛋白偶联型受体蛋白、dna及其配体 Pending CN1324405A (zh)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP305949/1998 1998-10-27
JP30594998 1998-10-27
JP2771099 1999-02-04
JP27710/1999 1999-02-04
JP57207/1999 1999-03-04
JP5720799 1999-03-04
JP27622599A JP4486187B2 (ja) 1998-10-27 1999-09-29 新規ｇ蛋白質共役型レセプター蛋白質、そのｄｎａおよびそのリガンド
JP276225/1999 1999-09-29

Publications (1)

Publication Number Publication Date
CN1324405A true CN1324405A (zh) 2001-11-28

Family

ID=27458743

Family Applications (1)

Application Number Title Priority Date Filing Date
CN99812722A Pending CN1324405A (zh) 1998-10-27 1999-10-26 新型g蛋白偶联型受体蛋白、dna及其配体

Country Status (19)

Country Link
US (3) US6699965B1 (2)
EP (1) EP1126028B1 (2)
JP (1) JP4486187B2 (2)
KR (1) KR20010085974A (2)
CN (1) CN1324405A (2)
AT (1) ATE394485T1 (2)
AU (1) AU6230699A (2)
BR (1) BR9914835A (2)
CA (1) CA2347294A1 (2)
CZ (1) CZ20011358A3 (2)
DE (1) DE69938666D1 (2)
HU (1) HUP0104937A2 (2)
ID (1) ID28288A (2)
IL (1) IL142428A0 (2)
NO (1) NO20012059L (2)
NZ (1) NZ510977A (2)
PL (1) PL347553A1 (2)
SK (1) SK5502001A3 (2)
WO (1) WO2000024890A1 (2)

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JP2002536989A (ja) * 1999-02-24 2002-11-05 メルク エンド カムパニー インコーポレーテッド ガラニン受容体と類似したｇタンパク質共役受容体
US20050240008A1 (en) * 2000-03-30 2005-10-27 Tetsuya Ohtaki Novel protein, dna thereof and process for producing the same
EP1168259A3 (en) 2000-06-28 2003-12-17 Hitachi, Ltd. Data management method and system for IC card
JP4762481B2 (ja) 2000-08-30 2011-08-31 株式会社セルフリーサイエンス 無細胞タンパク質合成用転写鋳型の設計および構築、並びにこれを用いる希釈バッチ方式コムギ胚芽無細胞タンパク質合成法
JP2002109169A (ja) 2000-09-29 2002-04-12 Hitachi Ltd 作業支援方法並びにシステム及び作業支援方法を記録した記録媒体
CA2430934C (en) 2000-12-01 2011-06-21 Takeda Chemical Industries, Ltd. A method of producing sustained-release preparations of a bioactive substance using high-pressure gas
CA2431522A1 (en) * 2000-12-18 2002-08-01 Merck & Co. Inc. Isolated nucleic acid molecules encoding a human and mouse g protein-coupled receptor - gpr54; encoded proteins, cells transformed therewith and uses thereof
WO2002057309A1 (fr) * 2001-01-18 2002-07-25 Takeda Chemical Industries, Ltd. Nouvelle proteine receptrice couplee a la proteine g et adn de cette proteine
WO2002072816A1 (fr) * 2001-02-26 2002-09-19 Takeda Chemical Industries, Ltd. Proteine de recepteur murin de type kiss-1 et adn correspondant
WO2002083735A1 (fr) * 2001-04-06 2002-10-24 Takeda Chemical Industries, Ltd. Nouvelle proteine receptrice et son adn
AU2008202004A1 (en) * 2001-09-18 2008-05-29 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
EP1487877B1 (en) * 2001-09-18 2010-10-27 Genentech, Inc. Compositions and methods for the diagnosis of tumors
DE60219645T2 (de) 2001-09-19 2007-08-09 Takeda Pharmaceutical Co. Ltd. Antikörper gegen metastin und dessen verwendung zur diagnose von schwangerschaft
US20050176091A1 (en) * 2002-01-11 2005-08-11 Takao Yamada Process for producing kiss-1 peptide
EP2116551A1 (en) * 2002-09-11 2009-11-11 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
US20060241051A1 (en) 2002-12-26 2006-10-26 Chieko Kitada Metastin derivatives and use thereof
US6800611B2 (en) * 2003-01-06 2004-10-05 Takeda Chemical Industries, Ltd. Metastin derivatives and their use
WO2004080479A1 (ja) * 2003-03-12 2004-09-23 Takeda Pharmaceutical Company Limited 性腺機能改善剤
JP4639052B2 (ja) * 2003-03-12 2011-02-23 武田薬品工業株式会社 性腺機能改善剤
EP1464652A1 (en) * 2003-04-02 2004-10-06 Institut National De La Sante Et De La Recherche Medicale (Inserm) GPR54 receptor agonist and antagonist useful for the treatment of gonadotropin related diseases
WO2004096855A2 (en) * 2003-04-28 2004-11-11 Wyeth Methods utilising g-protein coupled receptor 54
WO2004101747A2 (en) * 2003-05-07 2004-11-25 The General Hospital Corporation Identification and use of gpr54 and its ligands for reproductive disorders and contraception
WO2005040833A1 (en) * 2003-10-21 2005-05-06 Bayer Healthcare Ag Regulation of human metastin recognising receptors
AR049938A1 (es) 2004-06-25 2006-09-13 Takeda Pharmaceutical Derivados de metastina y utilizacion de los mismos
TWI386417B (zh) 2005-12-22 2013-02-21 Takeda Pharmaceutical 轉移抑素衍生物及其用途
US20090099334A1 (en) * 2005-12-22 2009-04-16 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
US8404643B2 (en) 2005-12-22 2013-03-26 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
ITMI20061607A1 (it) 2006-08-09 2008-02-10 Maria Vincenza Carriero Peptidi con attivita farmacologica
TWI404726B (zh) 2006-10-25 2013-08-11 Takeda Pharmaceutical 腫瘤轉移抑制素衍生物及其用途
WO2009131191A1 (ja) * 2008-04-24 2009-10-29 武田薬品工業株式会社 メタスチン誘導体およびその用途
PT2314609T (pt) 2008-07-30 2017-03-06 Takeda Pharmaceuticals Co Derivado de metastina e sua utilização
EP2341942A1 (en) 2008-09-19 2011-07-13 Nektar Therapeutics Polymer conjugates of therapeutic peptides
US20110171160A1 (en) * 2008-09-19 2011-07-14 Nektar Therapeutics Polymer conjugates of kiss1 peptides
WO2010137022A1 (en) 2009-05-27 2010-12-02 Yeda Research And Development Co. Ltd Gpr54 agonists or antagonists for treatment of diseases presenting behavioral abnormalities
EP2873422A4 (en) 2012-07-10 2015-12-30 Takeda Pharmaceutical PHARMACEUTICAL PREPARATION FOR INJECTION
TWI810193B (zh) 2017-07-05 2023-08-01 大陸商尚華醫藥科技（江西）有限公司 一種Kiss1肽類化合物、其應用及含其的組合物
CN109212217B (zh) * 2018-11-07 2021-09-10 李玉民 基于amy1a蛋白胃癌检测试剂盒及其使用方法

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US5436155A (en) * 1991-12-31 1995-07-25 Arch Development Corporation Isolated DNA encoding a somatostatin receptor
WO1996005302A1 (en) 1994-08-11 1996-02-22 Takeda Chemical Industries, Ltd. G protein coupled receptor protein, production, and use thereof
WO1997013778A1 (en) 1995-10-11 1997-04-17 The Penn State Research Foundation A metastasis suppressor gene
US6010877A (en) * 1997-01-10 2000-01-04 Smithkline Beecham Corporation cDNA clone HE8CS41 that encodes a novel 7-transmembrane receptor
US5851798A (en) * 1997-01-27 1998-12-22 Smithkline Beecham Corporation Nucleic acid encoding human GPR14 receptor
US6420526B1 (en) * 1997-03-07 2002-07-16 Human Genome Sciences, Inc. 186 human secreted proteins
WO1998039448A2 (en) 1997-03-07 1998-09-11 Human Genome Sciences, Inc. 186 human secreted proteins
JP2002536989A (ja) 1999-02-24 2002-11-05 メルク エンド カムパニー インコーポレーテッド ガラニン受容体と類似したｇタンパク質共役受容体
US20020077469A1 (en) * 1999-03-10 2002-06-20 Borowsky Beth E. DNA encoding orphan SNORF11 receptor
WO2004080479A1 (ja) * 2003-03-12 2004-09-23 Takeda Pharmaceutical Company Limited 性腺機能改善剤

Also Published As

Publication number Publication date
US20080131976A1 (en) 2008-06-05
JP2000312590A (ja) 2000-11-14
IL142428A0 (en) 2002-03-10
JP4486187B2 (ja) 2010-06-23
SK5502001A3 (en) 2002-01-07
BR9914835A (pt) 2002-06-18
DE69938666D1 (de) 2008-06-19
NZ510977A (en) 2002-10-25
WO2000024890A1 (en) 2000-05-04
NO20012059L (no) 2001-06-26
US20040180407A1 (en) 2004-09-16
EP1126028B1 (en) 2008-05-07
PL347553A1 (en) 2002-04-08
CA2347294A1 (en) 2000-05-04
ATE394485T1 (de) 2008-05-15
US6699965B1 (en) 2004-03-02
KR20010085974A (ko) 2001-09-07
AU6230699A (en) 2000-05-15
EP1126028A4 (en) 2002-11-27
US7608409B2 (en) 2009-10-27
ID28288A (id) 2001-05-10
US7314754B2 (en) 2008-01-01
CZ20011358A3 (cs) 2001-08-15
EP1126028A1 (en) 2001-08-22
HUP0104937A2 (hu) 2002-04-29
NO20012059D0 (no) 2001-04-26

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