CN1429541A - Biomimetic cosmetic for courishing skin - Google Patents
Biomimetic cosmetic for courishing skin Download PDFInfo
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- CN1429541A CN1429541A CN 02100003 CN02100003A CN1429541A CN 1429541 A CN1429541 A CN 1429541A CN 02100003 CN02100003 CN 02100003 CN 02100003 A CN02100003 A CN 02100003A CN 1429541 A CN1429541 A CN 1429541A
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- 239000002537 cosmetic Substances 0.000 title claims description 34
- 230000003592 biomimetic effect Effects 0.000 title claims description 14
- 239000003814 drug Substances 0.000 claims abstract description 56
- 108010010803 Gelatin Proteins 0.000 claims abstract description 28
- 239000008273 gelatin Substances 0.000 claims abstract description 28
- 229920000159 gelatin Polymers 0.000 claims abstract description 28
- 235000019322 gelatine Nutrition 0.000 claims abstract description 28
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 28
- 229920001661 Chitosan Polymers 0.000 claims abstract description 24
- 239000000126 substance Substances 0.000 claims abstract description 7
- 102000008186 Collagen Human genes 0.000 claims abstract description 3
- 108010035532 Collagen Proteins 0.000 claims abstract description 3
- 241001465754 Metazoa Species 0.000 claims abstract 2
- 230000015556 catabolic process Effects 0.000 claims abstract 2
- 238000006731 degradation reaction Methods 0.000 claims abstract 2
- 239000011664 nicotinic acid Substances 0.000 claims abstract 2
- 230000028327 secretion Effects 0.000 claims abstract 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 54
- 235000001968 nicotinic acid Nutrition 0.000 claims description 49
- 239000000047 product Substances 0.000 claims description 41
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 40
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 33
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- 239000000463 material Substances 0.000 claims description 18
- 239000002994 raw material Substances 0.000 claims description 17
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 16
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 14
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 14
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- 239000003429 antifungal agent Substances 0.000 claims description 9
- 229960002233 benzalkonium bromide Drugs 0.000 claims description 9
- KHSLHYAUZSPBIU-UHFFFAOYSA-M benzododecinium bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 KHSLHYAUZSPBIU-UHFFFAOYSA-M 0.000 claims description 9
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- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 claims description 9
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- MUQNGPZZQDCDFT-JNQJZLCISA-N Halcinonide Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CCl)[C@@]1(C)C[C@@H]2O MUQNGPZZQDCDFT-JNQJZLCISA-N 0.000 claims description 4
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- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 3
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- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 claims description 2
- KPHWPUGNDIVLNH-UHFFFAOYSA-M diclofenac sodium Chemical compound [Na+].[O-]C(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl KPHWPUGNDIVLNH-UHFFFAOYSA-M 0.000 claims description 2
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- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 2
- 210000003491 skin Anatomy 0.000 claims 48
- 239000010408 film Substances 0.000 claims 12
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims 1
- 241000255789 Bombyx mori Species 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
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- 210000002615 epidermis Anatomy 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- 235000010981 methylcellulose Nutrition 0.000 claims 1
- 230000003169 placental effect Effects 0.000 claims 1
- 239000010409 thin film Substances 0.000 claims 1
- 229920001436 collagen Polymers 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 238000007670 refining Methods 0.000 abstract 1
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- 239000000428 dust Substances 0.000 description 4
- 241001597008 Nomeidae Species 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 244000025254 Cannabis sativa Species 0.000 description 2
- 201000004624 Dermatitis Diseases 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 244000052616 bacterial pathogen Species 0.000 description 2
- 230000036760 body temperature Effects 0.000 description 2
- 210000000981 epithelium Anatomy 0.000 description 2
- 230000009545 invasion Effects 0.000 description 2
- 239000002075 main ingredient Substances 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical class O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- 229920001817 Agar Chemical class 0.000 description 1
- 241001116389 Aloe Species 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 208000037259 Amyloid Plaque Diseases 0.000 description 1
- 208000010445 Chilblains Diseases 0.000 description 1
- 229920002101 Chitin Polymers 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 241000533849 Gleditsia Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 241000195474 Sargassum Species 0.000 description 1
- 208000033809 Suppuration Diseases 0.000 description 1
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- 241000130764 Tinea Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
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- 239000008272 agar Chemical class 0.000 description 1
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- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000000589 cicatrix Anatomy 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000008406 cosmetic ingredient Substances 0.000 description 1
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- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
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- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
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- 235000013336 milk Nutrition 0.000 description 1
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- 206010033675 panniculitis Diseases 0.000 description 1
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- 229940114930 potassium stearate Drugs 0.000 description 1
- ANBFRLKBEIFNQU-UHFFFAOYSA-M potassium;octadecanoate Chemical compound [K+].CCCCCCCCCCCCCCCCCC([O-])=O ANBFRLKBEIFNQU-UHFFFAOYSA-M 0.000 description 1
- 238000009418 renovation Methods 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
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- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
A bionic consmetic for nourishing skin and treating dermatopathy is prepared from the skin, shell, or secretion (silk) of animal through degradation, refining to obtain hydrolytic gelatin (collagen), chitosan and silk protein, and mixing with water-soluble high-molecular filming substance, skin protecting medicine and assistant.
Description
Someone was divided into for four generations to cosmetics according to the progress of cosmetic ingredient: first generation cosmetics main component is an oil substances, Oleum concha Mactrae for example, sheep wet goods.Second filial generation cosmetics main component is an aliphatic compound, sodium stearate for example, potassium stearate, hexadecanol, octadecanol etc.Be divided into two big classes of oil-in-water and Water-In-Oil.Third generation cosmetics main component is the extract of natural animal-plant, includes gelatin hydrolysate, chitin, chitosan, Fructus Gleditsia, Fructus Chaenomelis, fruit acid, Aloe, Sargassum, Chinese crude drug etc.The 4th generation cosmetics adopted similarly and have the biological elite example Placenta extract etc. of high-affinity with the human body self structure, thereby better effect is arranged.Because extractive technique and raw material sources or the like are different, it is different to obtain biological essence, thus just have a multitude of names the 4th generation cosmetics.Above-mentioned four generation cosmetics do not have absolute boundary, the composition that has intersects use in the several generations product.Four generation cosmetics a common characteristic is arranged is exactly that the material that uses in the product nearly all is difficult to independent film forming, perhaps be difficult on skin, evenly launch film forming.
Skin is the ingredient that body weight for humans is wanted.Undertake the important task of parcel and the whole organs of protection human body, the mission of also have regulate body temperature, draining refuse or the like, its surface area maximum is human body first barrier.All organs of human body are all worked under the constant temperature and humidity condition, and big and small blood vessel transporting supplies is arranged.The working condition of skin is the poorest, faces external environment directly.The epiderm skin blood capillary is not sensible.Stand the poorest " material treatment ", can only lean on the body fluid infiltration to carry out metabolism, keep it with continual renovation and exist.In general, 40 days people from left and right sides skin will upgrade once.Skin structure of today is the long-term result who optimizes over 10000000 year, but not talkative it be out of this world.For example skin just may be brought into play the function of draining refuse regulate body temperature and skin care because fine hair hole and sebum glandular orifice have been arranged, but these " holes " therefore become " passage " of external world's " invasion " human body, cause scytitis or the like easily.Investigating human body from microcosmic is riddled with gaping wounds aggregation." passage " suitably closing or turn down on the skin is favourable to health.
Whether the people shows " always " and skin and subcutaneous tissue, and whether aging has confidential relation.The people is seemed, and youth preferably makes skin keep spring green grass or young crops.Making skin keep the best approach of spring green grass or young crops is to alleviate the skin burden.We think that one of best approach that alleviates the skin burden covers one deck bionics skin exactly again outside human body skin.
Thus, we propose the 5th generation cosmetics-biomimetic cosmetic for courishing skin-new ideas.
So-called " biomimetic cosmetic for courishing skin " refers to a kind of like this composite, be coated in and produce a kind of material on the skin like Pi Feipi, be equivalent to the additional newer bionics skin of one deck on people's the skin, this layer bionics skin " externally " undertaken the skin part of functions, for example keep out the erosion of dust storm dust and pathogenic bacteria virus and harmful substance, " internally " maintenance skin is with the treatment skin disorder and remedy the inborn deficiency of skin, for example it can make " passages " such as fine hair holes suitably to diminish, or contain erosion-resistant material, just can significantly reduce the chance by skin " invasion " human body such as harmful substance and pathogenic bacteria, do not influence skin again and bring into play original function, or the like.
We think: " bionics skin " should have following several function at least: between (1) bionics skin and people's the skin the good compatibility must be arranged, can be close on the skin not can " peeling ", can not chap, and can not cause skin allergy, can mouldyly not become mildewed.(2) bionics skin must have suitable mechanical property, and is can be with skin flexible and do not chap.(3) " hole " of suitable size and quantity should be arranged on the bionics skin, make it stop the antibacterial dust, suitably dwindle or the pore of closing on the human body skin does not influence the performance original function again external enwergy.(4) should contain functional mass in this layer bionics skin, thus the function of performance maintenance and treatment skin.(5) bionics skin can be cleaned tear (membranous type) of (cream type) or slabbing with clear water.
We think: bionics skin should have such microstructure: the macromolecule filming material constitutes the framework of bionics skin, and functional mass is stored in the framework of film forming matter formation, slowly and enduringly outwards and inwardly discharges, and has slow releasing function.Reduce the shortcoming that functional mass concentration " peak valley " is brought, functional mass is not easy to come off or taken away by sweat under the protection of film forming matter, improves the utilization rate of functional mass.Bionics skin produces certain " tension force " to human body skin, impels the interior functional mass of bionics skin to carry to deep skin, strengthens maintenance and therapeutical effect.
Patent of the present invention " biomimetic cosmetic for courishing skin " is made up of five class materials: (1) filmogen: the cosmetics common feature that preceding four generations are applied to skin is that constituent nearly all is a lower-molecular substance, and the characteristics of patent of the present invention are that film forming matter is introduced cosmetic field as Main Ingredients and Appearance.The filmogen that is adopted in the cosmetics must have " compatibility " preferably with people's skin, constitutes the framework of bionics skin, gives suitable mechanical property of epithelium and suitable elasticity, can contain other all kinds of materials simultaneously again.Film forming matter divides natural and synthetic and semisynthetic three major types.The natural semisynthetic film forming matter that reaches that patent of the present invention adopts comprises cellulose and derivant, starch and modified starch series, the collagen protein class, gelatin and gelatin hydrolysate class, fibroin albumen, chitosan and derivant thereof, hyaluronic acid, alginate, agar class, xanthan gum, Chinese medicine filmogen example Pseudobulbus Bletillae (Rhizoma Bletillae) glue etc.Synthetic class film forming matter comprises polyacrylate, Polyethylene Glycol, and polyvinyl alcohol, polyvinylpyrrolidone, the acrylate starch graft copolymer, or the like.(2) functional material: comprise the already used effective functional mass of preceding four generations woman's persona product, for example various Western medicine, Chinese medicine and extract, various skin protection medicines, or the like.(3) adjuvant: comprise glycerol, Mel, ethylene glycol, surfactant or the like, this class material can improve or coordinate the part or the overall performance of cosmetics.(4) solvent: mainly be water, regulate the rare denseness of product and make epithelium produce the suitably hole of size, make skin can bring into play original function normally.(5) other: comprise filler (starch, Kaolin, bentonite, silicon dioxide, Pulvis Talci, oxide powder and zinc, etc.), pigment and spice etc.
Adopt filmogen as one of Main Ingredients and Appearance in the patent of the present invention, therefore must have and the different compatibility rule of preceding four generation cosmetics.Obviously, the suitable combination of above-mentioned five class materials just can develop out dissimilar biomimetic cosmetic for courishing skin.
Polyvinyl alcohol in patent of the present invention, cellulose family, polyacrylates etc. use as filmogen, make main composition with it and can make " film " better products.The composition that has is gelatin or gelatin hydrolysate for example, chitosan and derivant thereof, and fibroin albumen, hyaluronic acid, sodium alginate etc. are not only as filmogen but also use as functional material.
Patented product of the present invention is divided into " film " and " cream " two major types.They are differentiated on prescription, use the back sensuously also having than big difference.
" film " biomimetic cosmetic for courishing skin is spread upon skin after last tens minute, touch the existence that just can feel " film " with hands, skin feels that slightly " tension force " is arranged a bit." cream " biomimetic cosmetic for courishing skin is coated in the sensation that does not have to produce " tension force " on the skin.No matter be " film " or " cream " product, water washes you and can feel that skin is very lubricated during makeup removing, and this is the biomimetic cosmetic for courishing skin place different with other cosmetics.
The function of biomimetic cosmetic for courishing skin depends primarily on functional mass.Add different functional mass and just can produce the biomimetic cosmetic for courishing skin of difference in functionality, be the bionical cosmetics of three classes below: (1) is universal: nutrient substance is provided, makes skin more moist, shrinking pore, mottle shoal or come off.At the difference between morning and evening and the four seasons and everyone skin, product can be divided into a lot of models again.(2) therapeutic type:, add the medicine of difference in functionality at the inflammation of skin, tinea, acne, pus furuncle, comedo, acarid, chilblain, cicatrix, " senile plaque " etc.(3) special procure type: the product that designs production at severe cold (comprising freezer), wind and snow, ultraviolet, dust storm, hot dry wind, high light, stage cosmetic or the like specified conditions.
Embodiment one: with polyvinyl alcohol and water-soluble cellulose is that " film " bionics skin prescription (raw material weight than) of main filmogen is as follows:
Polyvinyl alcohol 2-10 part (is good with 5-7 part)
Water-soluble cellulose 1-5 part (is good with 2-4 part)
Gelatin hydrolysate 0.2-5 part (is good with 1-2 part)
Glycerol 2-18 part (is good with 8-12 part)
Sodium alginate (add or do not add) 0.2-5 part (is good with 1-3 part)
Water-soluble chitosan (add or do not add) 0.2-5 part (is good with 1-3 part)
Hyaluronic acid (add or do not add) 0.2-5 part (is good with 1-3 part)
Fibroin albumen (add or do not add) 0.2-4 part (is good with 1-2 part)
Regulation in antifungus agent, the antibacterial consumption by specification is carried out
The skin protection medicine is an amount of
Azone (add or do not add) 0.1-2 part (is good with 0.5-1 part)
Filler, spice is an amount of
Water 90-130 part (consumption of water changes with season and film forming matter consumption, with can be on skin uniform spreading and not tangible " nervous sense " degree of being).Embodiment two: have anti-inflammation and sterilization and kill " film " with polyvinyl alcohol and the main filmogen of sodium carboxymethyl cellulose general bionics skin prescription (raw material weight than) of acarid effect as follows:
6 parts of polyvinyl alcohol
3 parts of sodium carboxymethyl cellulose
Gelatin hydrolysate 1-1.5 part
Glycerol 6-15 part (is good with 8-12 part)
Water-soluble chitosan 0.2-5 part (is good with 1-2 part)
Sodium alginate (add or do not add) 0.2-5 part (is good with 1-2 part)
Hyaluronic acid (add or do not add) 0.2-5 part (is good with 1-2 part)
Fibroin albumen (add or do not add) 0.2-4 part (is good with 1-2 part)
Benzalkonium bromide 0.2
Metronidazole 0.2-0.5 part
Azone (add or do not add) 0.1-2 part
Filler, spice, pigment is an amount of
Water 90-130 part (consumption of water changes with season and film forming matter consumption, with can be on skin uniform spreading and not tangible " nervous sense " degree of being).Embodiment three: have " film " bionics skin product of anti-uv-ray, fill a prescription following (weight ratio):
6 parts of 1 polyvinyl alcohol
3 parts of 2 sodium carboxymethyl cellulose
1.5 parts of 3 gelatin hydrolysates
4 glycerol 4-15 parts (is good with 8-12 part)
5 water-soluble chitosan 0.2-5 parts (is good with 1-2 part)
6 sodium alginates (add or do not add) 0.2-5 part (is good with 1-2 part)
7 hyaluronic acids (add or do not add) 0.2-5 part (is good with 1-2 part)
8 fibroin albumens (add or do not add) 0.2-4 part (is good with 1-2 part)
0.2 part of 9 benzalkonium bromide
0.2 part of 10 metronidazole
11 UV absorbent 0.1-5 parts
12 titanium dioxide 5-15 parts
13 spice are an amount of
14 water 90-130 parts (consumption of water changes with season and film forming matter consumption, with can be on skin uniform spreading and not tangible " nervous sense " degree of being).
If in above-mentioned prescription the 11st and 12 binomials (UV absorbent and titanium dioxide) remove need not, add other skin protection medicine and just become bionics skin articles for use with other new function.Example changes into adds 5 parts of ethylene glycol, and 3 parts of Mel just become and are applied to " film " prescription that has antifreeze function on the baring skin under the environment in severe winter.Equally, 11 and 12 binomials are changed into the Chinese medicine of treatment dermatosis, acne, decubital ulcer or Western medicine and just become bionics skin medication with the corresponding dermatosis of treatment.Embodiment four: be " cream " bionics skin prescription (raw material weight ratio) of main filmogen with water-soluble cellulose:
Water-soluble cellulose 1-5 part (is good with 1-2 part)
Gelatin hydrolysate 1-4 part (is good with 1-2 part)
Sodium alginate 0.2-5 part (is good with 1-2 part)
Water-soluble chitosan (add or do not add) 0.2-5 part (is good with 1-2 part)
Hyaluronic acid (add or do not add) 0.2-5 part (is good with 1-2 part)
Fibroin albumen (add or do not add) 0.2-4 part (is good with 1-2 part)
Glycerol 4-15 part (is good with 8-12 part)
The antifungus agent antibacterial is an amount of
The skin protection medicine is an amount of
Water 90-130 part (consumption of water changes with season and film forming matter consumption, with can be on skin uniform spreading and not tangible " nervous sense " degree of being).
In above-mentioned prescription, add the bionics skin articles for use that different protecting held up medicine just to become to have different efficacies based on " cream ".If will make product have the ability of anti-ultraviolet, as long as the skin protection medicine is changed into titanium dioxide 5-15 part and UV absorbent in right amount.Have the ability of protection baring skin if product is had under cold environment, the skin protection medicine is ethylene glycol 5-10 part, Mel 4-8 part.The medicine that adds treatment dermatosis, acne, decubital ulcer in above-mentioned prescription has just become bionics skin medication with the corresponding dermatosis of treatment.Embodiment five: with sodium carboxymethyl cellulose, sodium alginate, gelatin hydrolysate is that the general bionics skin prescription based on " cream " (raw material weight than) of main filmogen is as follows:
1 sodium carboxymethyl cellulose 1-2 part
2 gelatin hydrolysate 1-2 parts
3 sodium alginate 1-2 parts
4 water-soluble chitosans (add or do not add) 1-2 part
5 hyaluronic acids (add or do not add) 1-3 part
6 fibroin albumens (add or do not add) 1-2 part
7 glycerol 8-15 parts
0.2 part of 8 benzalkonium bromide
9 metronidazole 0.2-5 parts (is good with 0.2-0.5 part)
10 azones (add or do not add) 0.5-1 part
5 parts of 11 starch (or bentonite)
12 spice and pigment are an amount of
100 parts in 13 water (consumption of water can become with prescription and season, can evenly launch on skin and too significantly not nervous sense degree of being with product).
If will make product have the ability of anti-ultraviolet, in above-mentioned prescription, add an amount of UV absorbent again and titanium dioxide 5-15 part gets final product.Product is had under cold environment, have the ability of protection baring skin, in above-mentioned prescription, add ethylene glycol 5-10 part, Mel 4-8 part.The medicine that adds treatment dermatosis, acne, decubital ulcer in above-mentioned prescription has just become bionics skin medication with the corresponding dermatosis of treatment.Embodiment six: with water-soluble polyacrylate and graft copolymer thereof is that the bionics skin prescription (raw material weight than) of main filmogen is as follows:
Water-soluble polyacrylate (graft copolymer that comprises acrylic acid and starch)
1-8 part (is good with 2-4 part)
Gelatin hydrolysate 0.2-5 part (is good with 1-2 part)
Sodium alginate (add or do not add) 0.2-5 part (is good with 1-2 part)
Water-soluble chitosan (add or do not add) 0.2-5 part (is good with 1-2 part)
Hyaluronic acid (add or do not add) 0.2-5 part (is good with 1-2 part)
Fibroin albumen (add or do not add) 0.2-4 part (is good with 1-2 part)
Glycerol 2-15 part (is good with 8-12 part)
Antifungus agent, antibacterial 0.01-4 part (is good with 0.2-2 part)
The skin protection medicine is an amount of
Azone (add or do not add) 0.1-2 part (is good with 0.5-1 part)
Filler, spice, pigment is an amount of
Water 90-130 part (consumption of water changes with season and film forming matter consumption, with can be on skin uniform spreading and not tangible " nervous sense " degree of being).
In above-mentioned prescription, add " film " bionics skin articles for use that different protecting held up medicine just to become to have different efficacies.If will make product have the ability of anti-ultraviolet, in above-mentioned prescription, add an amount of UV absorbent and titanium dioxide 5-15 part again.Have the ability of protection baring skin if product is had under cold environment, the skin protection medicine is ethylene glycol 5-10 part, 3 parts of Mel.The medicine that adds treatment dermatosis, acne, decubital ulcer in above-mentioned prescription has just become bionics skin product with corresponding function.Embodiment seven: with fibroin albumen is that the bionics skin prescription (raw material weight than) of main filmogen is as follows:
Water-soluble fibroin albumen 2-8 part (is good with 3-5 part)
Water-soluble cellulose (add or do not add) 1-4 part (is good with 2-3 part)
Gelatin hydrolysate (add or do not add) 1-4 part (is good with 1-2 part)
Sodium alginate (add or do not add) 0.5-4 part (is good with 1-2 part)
Water-soluble chitosan (add or do not add) 0.2-4 part (is good with 1-2 part)
Hyaluronic acid (add or do not add) 0.2-4 part (is good with 1-2 part)
Glycerol 2-15 part (is good with 8-12 part)
Antifungus agent, antibacterial are an amount of
The skin protection medicine is an amount of
Azone (add or do not add) 0.1-2 part (is good with 0.5-1 part)
Filler, spice, pigment is an amount of
Water 90-130 part (consumption of water changes with season and film forming matter consumption, with can be on skin uniform spreading and not tangible " nervous sense " degree of being).
In above-mentioned prescription, add " film " bionics skin articles for use that different protecting held up medicine just to become to have different efficacies.If will make product have the ability of anti-ultraviolet, in above-mentioned prescription, add UV absorbent and titanium dioxide 5-15 part again, the regulation that UV absorbent interpolation concentration is pressed in the product description is carried out.Have the ability of protection baring skin if product is had under cold environment, the skin protection medicine is ethylene glycol 5-10 part, 3 parts of Mel.The medicine that adds treatment dermatosis, acne, decubital ulcer in above-mentioned prescription has just become bionics skin product with corresponding function.Embodiment eight: have mercerising and anti-inflammation and sterilization and kill the bionics skin prescription based on " cream " (raw material weight compares) of acarid effect as follows:
Water-soluble cellulose (is good with sodium carboxymethyl cellulose) 1-4 part (is good with 1.5 parts)
Gelatin hydrolysate 1-4 part (is good with 1.5 parts)
Sodium alginate 1-4 part (is good with 1.5 parts)
Water-soluble chitosan (add or do not add) 0.2-4 part (is good with 1 part)
Hyaluronic acid (add or do not add) 0.2-4 part (is good with 1 part)
Fibroin albumen (add or do not add) 0.2-4 part (is good with 1 part)
Glycerol 2-15 part (is good with 10 parts)
Benzalkonium bromide 0.01-0.3 part (is good with 0.2 part)
Metronidazole 0.1-2 part (is good with 0.5 part)
Azone (add or do not add) 0.1-2 part (is good with 0.5-1 part)
Mel 2-10 part (is good with 5 parts)
Starch (or bentonite, or milk powder) 2-10 part (is good with 5 parts)
Pigment, spice is an amount of
Water 90-120 part (how many consumptions of water changes with content in season and the prescription, can evenly spread out on skin and significantly not nervous sense degree of being).
Embodiment nine: " cream " biomimetic cosmetic for courishing skin raw material weight with the various acute and chronic dermatosiss of treatment, contact dermatitis, neurodermatitis, lichen planus, psoriasis (psoriasis) is such as following:
1 sodium carboxymethyl cellulose 1-2 part
2 gelatin hydrolysate 1-2 parts
3 sodium alginates (add or do not add) 1-2 part
4 water-soluble chitosan 1-2 parts
5 hyaluronic acids (add or do not add) 1-3 part
6 fibroin albumens (add or do not add) 1-2 part
7 glycerol 8-15 parts
0.2 part of 8 benzalkonium bromide
9 metronidazole 0.2-5 parts (is good with 0.2-0.5 part)
10 azones (add or do not add) 0.5-1 part
0.2 part of 11 halcinonide
12 spice and pigment are an amount of
100 parts in 13 water (consumption of water can become with prescription and season, can evenly launch on skin and too significantly not nervous sense degree of being with product).
If in above-mentioned prescription, the 11st halcinonide changed into 6 parts of diclofenac diethylammonium salt, then become " diclofenac biomimetic cosmetic for courishing skin " with treatment muscular soreness or the like effect.
Claims (10)
- (1) manufacture method of a kind of bionics skin base material and Related product is as cosmetics for skin and treatment dermatosis.It is characterized in that carrying out degradation treatment for raw material with the epidermis of animal and shell or secretions (silkworm silk), be refined into gelatin hydrolysate (collagen protein) respectively, chitosan or fibroin albumen, carry out they and water miscible synthetic or semi-synthetic macromolecule filming material and skin protection medicine and auxiliary agent or the like composite again, reassemble into colloid substance, be coated in skin surface and produce the bionic thin film of one deck like Pi Feipi, be referred to as bionics skin, the externally erosion of blocking harmful material and environment, internally maintenance skin and treatment dermatosis.
- (2) as described in the claim (1), the synthetic macromolecule filming material of water solublity refers to polyvinyl alcohol, Polyethylene Glycol, polyvinylpyrrolidone, polyacrylate, the graft copolymer of acrylic acid and starch.Semi-synthetic macromolecular material refers to water-soluble cellulose class material (sodium carboxymethyl cellulose, methylcellulose, hydroxypropyl cellulose, hydroxypropyl emthylcellulose etc.), gelatin and gelatin hydrolysate, chitosan and water-soluble chitosan, hyaluronic acid, fibroin albumen, water-soluble modified starch.The medicine of using always when the skin protection medicine refers to cosmetics or dermatosis with certain effect comprises UV absorbent, has the Chinese medicine or Western medicine (the routine Aloe extract of maintenance and the effect of treatment dermatosis, Radix Glycyrrhizae extract, SOD, sheep placental extract etc.), the antifungus agent antibacterial that uses in the cosmetics etc.The working concentration of skin protection medicine in this product carried out by the regulation in this product description.Above-mentioned various material has only just can become the reasonable product of effect when specified ratio is composite in the following claim.
- (3), be that " film " bionics skin prescription (raw material weight than) of main filmogen is as follows with polyvinyl alcohol and water-soluble cellulose as described in claim (1) and (2):Polyvinyl alcohol 2-10 part (is good with 5-7 part)Water-soluble cellulose 1-5 part (is good with 2-4 part)Gelatin hydrolysate 0.2-5 part (is good with 1-2 part)Glycerol 2-18 part (is good with 8-12 part)Sodium alginate (add or do not add) 0.2-5 part (is good with 1-3 part)Water-soluble chitosan (add or do not add) 0.2-5 part (is good with 1-3 part)Hyaluronic acid (add or do not add) 0.2-5 part (is good with 1-3 part)Fibroin albumen (add or do not add) 0.2-4 part (is good with 1-2 part)Regulation in antifungus agent, the antibacterial consumption by specification is carried outThe skin protection medicine is an amount ofAzone (add or do not add) 0.1-2 part (is good with 0.5-1 part)Filler, spice is an amount ofWater 90-130 part (consumption of water changes with season and film forming matter consumption, with can be on skin uniform spreading and not tangible " nervous sense " degree of being).
- (4), have anti-inflammation and sterilization and kill " film " with polyvinyl alcohol and the main filmogen of sodium carboxymethyl cellulose general bionics skin prescription (raw material weight than) of acarid effect as follows as described in claim (1), (2) and (3):6 parts of polyvinyl alcohol3 parts of sodium carboxymethyl celluloseGelatin hydrolysate 1-1.5 partGlycerol 6-15 part (is good with 8-12 part)Water-soluble chitosan 0.2-5 part (is good with 1-2 part)Sodium alginate (add or do not add) 0.2-5 part (is good with 1-2 part)Hyaluronic acid (add or do not add) 0.2-5 part (is good with 1-2 part)Fibroin albumen (add or do not add) 0.2-4 part (is good with 1-2 part)Benzalkonium bromide 0.2Metronidazole 0.2-0.5 partAzone (add or do not add) 0.1-2 partFiller, spice, pigment is an amount ofWater 90-130 part (consumption of water changes with season and film forming matter consumption, with can be on skin uniform spreading and not tangible " nervous sense " degree of being).
- (5), add and can absorb ultraviolet medicine and become to having " film " bionics skin product of anti-uv-ray, fill a prescription following (weight ratio) as described in claim (1), (2), (3) and (4):6 parts of 1 polyvinyl alcohol3 parts of 2 sodium carboxymethyl cellulose1.5 parts of 3 gelatin hydrolysates4 glycerol 4-15 parts (is good with 8-12 part)5 water-soluble chitosan 0.2-5 parts (is good with 1-2 part)6 sodium alginates (add or do not add) 0.2-5 part (is good with 1-2 part)7 hyaluronic acids (add or do not add) 0.2-5 part (is good with 1-2 part)8 fibroin albumens (add or do not add) 0.2-4 part (is good with 1-2 part)0.2 part of 9 benzalkonium bromide0.2 part of 10 metronidazole11 UV absorbent 0.1-5 parts12 titanium dioxide 5-15 parts13 spice are an amount of14 water 90-130 parts (consumption of water changes with season and film forming matter consumption, with can be on skin uniform spreading and not tangible " nervous sense " degree of being).If in above-mentioned prescription the 11st and 12 binomials (UV absorbent and titanium dioxide) remove need not, add other skin protection medicine and just become bionics skin articles for use with other new function.Example changes into adds 5 parts of ethylene glycol, and 3 parts of Mel just become and are applied to " film " prescription that has antifreeze function on the baring skin under the environment in severe winter.Equally, 11 and 12 binomials are changed into the Chinese medicine of treatment dermatosis, acne, decubital ulcer or Western medicine and just become bionics skin medication with the corresponding dermatosis of treatment.
- (6) as described in claim (1) and (2), water-soluble cellulose is " cream " bionics skin prescription (raw material weight than) of main filmogen:Water-soluble cellulose 1-5 part (is good with 1-2 part)Gelatin hydrolysate 1-4 part (is good with 1-2 part)Sodium alginate 0.2-5 part (is good with 1-2 part)Water-soluble chitosan (add or do not add) 0.2-5 part (is good with 1-2 part)Hyaluronic acid (add or do not add) 0.2-5 part (is good with 1-2 part)Fibroin albumen (add or do not add) 0.2-4 part (is good with 1-2 part)Glycerol 4-15 part (is good with 8-12 part)The antifungus agent antibacterial is an amount ofThe skin protection medicine is an amount ofWater 90-130 part (consumption of water changes with season and film forming matter consumption, with can be on skin uniform spreading and not tangible " nervous sense " degree of being).In above-mentioned prescription, add the bionics skin articles for use that different protecting held up medicine just to become to have different efficacies based on " cream ".If will make product have the ability of anti-ultraviolet, as long as the skin protection medicine is changed into titanium dioxide 5-15 part and UV absorbent in right amount.Have the ability of protection baring skin if product is had under cold environment, the skin protection medicine is ethylene glycol 5-10 part, Mel 4-8 part.The medicine that adds treatment dermatosis, acne, decubital ulcer in above-mentioned prescription has just become bionics skin medication with the corresponding dermatosis of treatment.
- (7), be that the general bionics skin prescription based on " cream " (raw material weight than) of main filmogen is as follows with sodium carboxymethyl cellulose, sodium alginate, gelatin hydrolysate as described in claim (1), (2) and (6):1 sodium carboxymethyl cellulose 1-2 part2 gelatin hydrolysate 1-2 parts3 sodium alginate 1-2 parts4 water-soluble chitosans (add or do not add) 1-2 part5 hyaluronic acids (add or do not add) 1-3 part6 fibroin albumens (add or do not add) 1-2 part7 glycerol 8-15 parts0.2 part of 8 benzalkonium bromide9 metronidazole 0.2-5 parts (is good with 0.2-0.5 part)10 azones (add or do not add) 0.5-1 part5 parts of 11 starch (or bentonite)12 spice and pigment are an amount of100 parts in 13 water (consumption of water can become with prescription and season, can evenly launch on skin and too significantly not nervous sense degree of being with product).If will make product have the ability of anti-ultraviolet, in above-mentioned prescription, add an amount of UV absorbent again and titanium dioxide 5-15 part gets final product.Product is had under cold environment, have the ability of protection baring skin, in above-mentioned prescription, add ethylene glycol 5-10 part, Mel 4-8 part.The medicine that adds treatment dermatosis, acne, decubital ulcer in above-mentioned prescription has just become bionics skin medication with the corresponding dermatosis of treatment.
- (8), be that the bionics skin prescription (raw material weight than) of main filmogen is as follows with water-soluble polyacrylate and graft copolymer thereof as described in claim (1), (2):Water-soluble polyacrylate (graft copolymer that comprises acrylic acid and starch)1-8 part (is good with 2-4 part)Gelatin hydrolysate 0.2-5 part (is good with 1-2 part)Sodium alginate (add or do not add) 0.2-5 part (is good with 1-2 part)Water-soluble chitosan (add or do not add) 0.2-5 part (is good with 1-2 part)Hyaluronic acid (add or do not add) 0.2-5 part (is good with 1-2 part)Fibroin albumen (add or do not add) 0.2-4 part (is good with 1-2 part)Glycerol 2-15 part (is good with 8-12 part)Antifungus agent, antibacterial 0.01-4 part (is good with 0.2-2 part)The skin protection medicine is an amount ofAzone (add or do not add) 0.1-2 part (is good with 0.5-1 part)Filler, spice, pigment is an amount ofWater 90-130 part (consumption of water changes with season and film forming matter consumption, with can be on skin uniform spreading and not tangible " nervous sense " degree of being).In above-mentioned prescription, add " film " bionics skin articles for use that different protecting held up medicine just to become to have different efficacies.If will make product have the ability of anti-ultraviolet, in above-mentioned prescription, add an amount of UV absorbent and titanium dioxide 5-15 part again.Have the ability of protection baring skin if product is had under cold environment, the skin protection medicine is ethylene glycol 5-10 part, 3 parts of Mel.The medicine that adds treatment dermatosis, acne, decubital ulcer in above-mentioned prescription has just become bionics skin product with corresponding function.
- (9), be that the bionics skin prescription (raw material weight than) of main filmogen is as follows with fibroin albumen as described in claim (1) and (2):Water-soluble fibroin albumen 2-8 part (is good with 3-5 part)Water-soluble cellulose (add or do not add) 1-4 part (is good with 2-3 part)Gelatin hydrolysate (add or do not add) 1-4 part (is good with 1-2 part)Sodium alginate (add or do not add) 0.5-4 part (is good with 1-2 part)Water-soluble chitosan (add or do not add) 0.2-4 part (is good with 1-2 part)Hyaluronic acid (add or do not add) 0.2-4 part (is good with 1-2 part)Glycerol 2-15 part (is good with 8-12 part)Antifungus agent, antibacterial are an amount ofThe skin protection medicine is an amount ofAzone (add or do not add) 0.1-2 part (is good with 0.5-1 part)Filler, spice, pigment is an amount ofWater 90-130 part (consumption of water changes with season and film forming matter consumption, with can be on skin uniform spreading and not tangible " nervous sense " degree of being).In above-mentioned prescription, add " film " bionics skin articles for use that different protecting held up medicine just to become to have different efficacies.If will make product have the ability of anti-ultraviolet, in above-mentioned prescription, add UV absorbent and titanium dioxide 5-15 part again, the regulation that UV absorbent interpolation concentration is pressed in the product description is carried out.Have the ability of protection baring skin if product is had under cold environment, the skin protection medicine is ethylene glycol 5-10 part, 3 parts of Mel.The medicine that adds treatment dermatosis, acne, decubital ulcer in above-mentioned prescription has just become bionics skin product with corresponding function.
- (10) as described in the claim 1,2,6 and 7, have the various acute and chronic dermatosiss of treatment, contact dermatitis, neurodermatitis, lichen planus, psoriasis (psoriasis) based on the biomimetic cosmetic for courishing skin raw material weight of " cream " such as descending:1 sodium carboxymethyl cellulose 1-2 part2 gelatin hydrolysate 1-2 parts3 sodium alginates (add or do not add) 1-2 part4 water-soluble chitosan 1-2 parts5 hyaluronic acids (add or do not add) 1-3 part6 fibroin albumens (add or do not add) 1-2 part7 glycerol 8-15 parts0.2 part of 8 benzalkonium bromide9 metronidazole 0.2-5 parts (is good with 0.2-0.5 part)10 azones (add or do not add) 0.5-1 part0.2 part of 11 halcinonide12 spice and pigment are an amount of100 parts in 13 water (consumption of water can become with prescription and season, can evenly launch on skin and too significantly not nervous sense degree of being with product).If in above-mentioned prescription, the 11st halcinonide changed into 6 parts of diclofenac diethylammonium salt, then become " diclofenac biomimetic cosmetic for courishing skin " with treatment muscular soreness or the like effect.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021000034A CN1244319C (en) | 2002-01-04 | 2002-01-04 | Biomimetic cosmetic for courishing skin |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021000034A CN1244319C (en) | 2002-01-04 | 2002-01-04 | Biomimetic cosmetic for courishing skin |
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| Publication Number | Publication Date |
|---|---|
| CN1429541A true CN1429541A (en) | 2003-07-16 |
| CN1244319C CN1244319C (en) | 2006-03-08 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB021000034A Expired - Fee Related CN1244319C (en) | 2002-01-04 | 2002-01-04 | Biomimetic cosmetic for courishing skin |
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| CN102631305A (en) * | 2012-05-11 | 2012-08-15 | 苏州宜生生物技术有限公司 | Finishing liquid |
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| CN113041164A (en) * | 2021-03-12 | 2021-06-29 | 广州武州制药有限公司 | Application of succinimide stearate in preparation of anti-friction skin care masking liquid and anti-friction skin care masking liquid containing succinimide stearate |
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2002
- 2002-01-04 CN CNB021000034A patent/CN1244319C/en not_active Expired - Fee Related
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102631305A (en) * | 2012-05-11 | 2012-08-15 | 苏州宜生生物技术有限公司 | Finishing liquid |
| CN111671658A (en) * | 2014-01-27 | 2020-09-18 | 考司美德制药株式会社 | Concealer patch, manufacturing method thereof, skin whitening and protecting method and anti-acne and protecting method |
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| CN107374983A (en) * | 2017-07-05 | 2017-11-24 | 北京化工大学 | A kind of composite fibre facial mask rich in collagen and preparation method thereof |
| CN109512681A (en) * | 2018-10-30 | 2019-03-26 | 安徽新衡新材料科技有限公司 | A kind of novel facial-care film base material and its preparation method and application |
| CN113041164A (en) * | 2021-03-12 | 2021-06-29 | 广州武州制药有限公司 | Application of succinimide stearate in preparation of anti-friction skin care masking liquid and anti-friction skin care masking liquid containing succinimide stearate |
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