CN1437581A - 胰高血糖素拮抗剂/反向激动剂 - Google Patents
胰高血糖素拮抗剂/反向激动剂 Download PDFInfo
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- CN1437581A CN1437581A CN01811591A CN01811591A CN1437581A CN 1437581 A CN1437581 A CN 1437581A CN 01811591 A CN01811591 A CN 01811591A CN 01811591 A CN01811591 A CN 01811591A CN 1437581 A CN1437581 A CN 1437581A
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- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
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- A61P3/04—Anorexiants; Antiobesity agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
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- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
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- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
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- C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
- C07C317/38—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atom of at least one amino group being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfones
- C07C317/42—Y being a hetero atom
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- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
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- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
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- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200000984 | 2000-06-23 | ||
| DKPA200000984 | 2000-06-23 | ||
| DKPA200001734 | 2000-11-17 | ||
| DKPA200001734 | 2000-11-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1437581A true CN1437581A (zh) | 2003-08-20 |
Family
ID=26068842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN01811591A Pending CN1437581A (zh) | 2000-06-23 | 2001-06-21 | 胰高血糖素拮抗剂/反向激动剂 |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1296942A1 (fr) |
| JP (1) | JP2004501897A (fr) |
| KR (1) | KR20030029061A (fr) |
| CN (1) | CN1437581A (fr) |
| AU (1) | AU2001265834A1 (fr) |
| BR (1) | BR0111908A (fr) |
| CA (1) | CA2411552A1 (fr) |
| CZ (1) | CZ20024105A3 (fr) |
| HU (1) | HUP0301501A2 (fr) |
| IL (1) | IL153181A0 (fr) |
| MX (1) | MXPA02012273A (fr) |
| NO (1) | NO20026149L (fr) |
| PL (1) | PL359619A1 (fr) |
| WO (1) | WO2002000612A1 (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101312963B (zh) * | 2005-11-23 | 2012-03-14 | 伊莱利利公司 | 胰高血糖素受体拮抗剂、制备和治疗用途 |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030203946A1 (en) * | 2000-11-17 | 2003-10-30 | Carsten Behrens | Glucagon antagonists/inverse agonists |
| US6881746B2 (en) | 2001-12-03 | 2005-04-19 | Novo Nordick A/S | Glucagon antagonists/inverse agonists |
| US6762318B2 (en) | 2001-12-03 | 2004-07-13 | Novo Nordisk A/S | Glucagon antagonists |
| JP2005511683A (ja) * | 2001-12-03 | 2005-04-28 | ノボ ノルディスク アクティーゼルスカブ | 新規なグルカゴンアンタゴニスト |
| JPWO2003097031A1 (ja) * | 2002-05-22 | 2005-09-15 | 株式会社三和化学研究所 | メチリデンヒドラジド化合物を有効成分とする、肥満の予防又は改善剤 |
| EP1519723A1 (fr) * | 2002-06-27 | 2005-04-06 | Novo Nordisk A/S | Nouveaux antagonistes/agonistes inverses du glucagon |
| WO2004056763A2 (fr) * | 2002-12-20 | 2004-07-08 | Novo Nordisk A/S | Nouveaux antagonistes du glucagon |
| WO2004063147A1 (fr) * | 2003-01-10 | 2004-07-29 | Novo Nordisk A/S | Sels et solvates d'antagonistes de glucagon |
| AU2004210127B2 (en) | 2003-01-27 | 2009-10-01 | Merck Sharp & Dohme Corp. | Substituted pyrazoles, compositions containing such compounds and methods of use |
| WO2004101505A1 (fr) * | 2003-05-14 | 2004-11-25 | Novo Nordisk A/S | Nouveaux composes pour le traitement de l'obesite |
| SI1656139T1 (sl) * | 2003-07-21 | 2011-12-30 | Merck Serono Sa | Aril dikarboksamidi |
| EP1689707A1 (fr) * | 2003-11-25 | 2006-08-16 | Novo Nordisk A/S | Nouveaux composes pour le traitement de l'obesite |
| WO2005058845A2 (fr) * | 2003-12-19 | 2005-06-30 | Novo Nordisk A/S | Nouveaux antagonistes/agonistes inverses du glucagon |
| CN1968921B (zh) * | 2004-06-14 | 2011-11-23 | 伊莱利利公司 | 胰高血糖素受体拮抗剂、制备和治疗用途 |
| US8318760B2 (en) | 2005-03-21 | 2012-11-27 | Merck Sharp & Dohme Corp. | Substituted aryl and heteroaryl derivatives, compositions containing such compounds and methods of use |
| JP2008534593A (ja) | 2005-03-30 | 2008-08-28 | メルク エンド カムパニー インコーポレーテッド | グルカゴン受容体アンタゴニスト化合物、そのような化合物を含む組成物、及びその使用方法 |
| CN101300232A (zh) | 2005-07-26 | 2008-11-05 | 默克公司 | 合成取代的吡唑的方法 |
| TW200745031A (en) | 2005-10-13 | 2007-12-16 | Merck & Co Inc | Acyl indoles, compositions containing such compounds and methods of use |
| US7989472B2 (en) | 2006-03-23 | 2011-08-02 | Merck Sharp & Dohme Corp. | Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use |
| US7935713B2 (en) | 2006-05-16 | 2011-05-03 | Merck Sharp & Dohme Corp. | Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use |
| TW200821284A (en) | 2006-10-03 | 2008-05-16 | Merck & Co Inc | Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use |
| KR20200123866A (ko) | 2007-02-09 | 2020-10-30 | 메타베이시스 테라퓨틱스, 인크. | 글루카곤 수용체의 길항제 |
| WO2009140342A1 (fr) * | 2008-05-16 | 2009-11-19 | Schering Corporation | Antagonistes du récepteur de glucagon, compostions et procédé d'utilisation de ces composés |
| PT2799428T (pt) | 2008-08-13 | 2017-02-17 | Metabasis Therapeutics Inc | Antagonistas de glicagina |
| NZ611529A (en) | 2010-12-23 | 2015-06-26 | Pfizer | Glucagon receptor modulators |
| WO2012107850A1 (fr) | 2011-02-08 | 2012-08-16 | Pfizer Inc. | Modulateur du récepteur de glucagon |
| US8927577B2 (en) | 2011-07-22 | 2015-01-06 | Pfizer Inc. | Quinolinyl glucagon receptor modulators |
| US9725427B2 (en) | 2012-03-16 | 2017-08-08 | Biohaven Pharmaceutical Holding Company Limited | Prodrugs of riluzole and their method of use |
| EP3065736B1 (fr) | 2013-11-04 | 2018-11-14 | Merck Sharp & Dohme Corp. | Composés antagonistes du récepteur du glucagon, compositions correspodantes et méthodes d'utilisation |
| WO2015191900A1 (fr) | 2014-06-12 | 2015-12-17 | Ligand Pharmaceuticals, Inc. | Antagonistes du glucagon |
| WO2019160940A1 (fr) | 2018-02-13 | 2019-08-22 | Ligand Pharmaceuticals Incorporated | Antagonistes de récepteur de glucagon |
| CN113784713A (zh) | 2019-01-11 | 2021-12-10 | 纳吉斯制药股份有限公司 | 白三烯合成抑制剂 |
| CA3226162A1 (fr) | 2021-07-09 | 2023-01-12 | Plexium, Inc. | Composes aryle et compositions pharmaceutiques modulant l'ikzf2 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6174905B1 (en) * | 1996-09-30 | 2001-01-16 | Mitsui Chemicals, Inc. | Cell differentiation inducer |
| BR9810378A (pt) * | 1997-07-01 | 2000-08-29 | Novo Nordisk As | Composto,uso do mesmo, composição farmacêutica, e, processos de tratar a diabete do tipo i ou do tipo ii, de tratar a hiperglicemia, e de diminuir a glicose do sangue em um mamìfero |
| US6613942B1 (en) * | 1997-07-01 | 2003-09-02 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
| DE60023492T2 (de) * | 1999-05-17 | 2006-07-20 | Novo Nordisk A/S | Glucagon antagonisten/inverse agonisten |
-
2001
- 2001-06-21 HU HU0301501A patent/HUP0301501A2/hu unknown
- 2001-06-21 KR KR1020027017276A patent/KR20030029061A/ko not_active Withdrawn
- 2001-06-21 CZ CZ20024105A patent/CZ20024105A3/cs unknown
- 2001-06-21 MX MXPA02012273A patent/MXPA02012273A/es not_active Application Discontinuation
- 2001-06-21 PL PL01359619A patent/PL359619A1/xx not_active Application Discontinuation
- 2001-06-21 BR BR0111908-7A patent/BR0111908A/pt not_active Application Discontinuation
- 2001-06-21 WO PCT/DK2001/000435 patent/WO2002000612A1/fr not_active Ceased
- 2001-06-21 JP JP2002505360A patent/JP2004501897A/ja active Pending
- 2001-06-21 IL IL15318101A patent/IL153181A0/xx unknown
- 2001-06-21 AU AU2001265834A patent/AU2001265834A1/en not_active Abandoned
- 2001-06-21 CN CN01811591A patent/CN1437581A/zh active Pending
- 2001-06-21 EP EP01943189A patent/EP1296942A1/fr not_active Withdrawn
- 2001-06-21 CA CA002411552A patent/CA2411552A1/fr not_active Abandoned
-
2002
- 2002-12-20 NO NO20026149A patent/NO20026149L/no not_active Application Discontinuation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101312963B (zh) * | 2005-11-23 | 2012-03-14 | 伊莱利利公司 | 胰高血糖素受体拮抗剂、制备和治疗用途 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1296942A1 (fr) | 2003-04-02 |
| HUP0301501A2 (hu) | 2003-08-28 |
| KR20030029061A (ko) | 2003-04-11 |
| WO2002000612A1 (fr) | 2002-01-03 |
| MXPA02012273A (es) | 2003-04-25 |
| JP2004501897A (ja) | 2004-01-22 |
| NO20026149L (no) | 2003-02-21 |
| CZ20024105A3 (cs) | 2003-05-14 |
| CA2411552A1 (fr) | 2002-01-03 |
| NO20026149D0 (no) | 2002-12-20 |
| IL153181A0 (en) | 2003-06-24 |
| BR0111908A (pt) | 2003-04-01 |
| AU2001265834A1 (en) | 2002-01-08 |
| PL359619A1 (en) | 2004-08-23 |
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