CN1438016A - Medicine for treating non-gonococcal vaginitis and preparation method - Google Patents
Medicine for treating non-gonococcal vaginitis and preparation method Download PDFInfo
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- CN1438016A CN1438016A CN 03113856 CN03113856A CN1438016A CN 1438016 A CN1438016 A CN 1438016A CN 03113856 CN03113856 CN 03113856 CN 03113856 A CN03113856 A CN 03113856A CN 1438016 A CN1438016 A CN 1438016A
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Abstract
The present invention discloses a Chinese medicine for curing nongonococcal urethritis and its preparation method. Said medicine is made up by using 6 Chinese medicinal materials of gardenia fruit, astragalus root, hedyotis, ophiopogon tuber, mallow seed and picrasma quassioides as raw material through a certain preparation process. Said medicine has the functions of clearing heat, disinhibiting dampness, boosting qi, nourishing yin and inducing diuresis for treating stranguria, and possesses the action of resisting inflammation, resisting bacteria, raising immunity and stopping pain.
Description
Affiliated technical field
The present invention relates to a kind of medicine for the treatment of nongonococcal urethritis, being specifically related to a kind of is the Chinese patent medicine of feedstock production with the Chinese herbal medicine, the invention still further relates to the preparation method of this medicine.
Background technology
Nongonococcal urethritis is a kind of common, multiple urinary system illness, is a kind of sexually transmitted disease (STD) that sickness rate is only second to gonorrhea and condyloma acuminatum.Western medicine thinks that this disease is mainly caused by chlamydia and mycoplasma, infects by sexual intercourse, invades the urogenital organ.The male mainly shows as the scratchy and pain of urinating of urethra clinically, and minority has frequent micturition.Playing urethral orifice morning has a small amount of mucus secretions or only has the crust film to seal.Normal epididymitis, the prostatitis etc. of merging.The women is many to be that the center is diffused into other positions with the cervix uteri.Show as the urogenical infection symptom.Mucus cervicitis person performance has leucorrhoea grow in quantity, edema of cervix or erosion; Urethritis person shows as urethra scorching hot or frequent micturition, checks urethral orifice hyperemia, little red or normal, and the extruding urethra overflows with secretions, and many patients do not have any symptom.The medicine to mycoplasma and chlamydia cosensitize is selected in treatment for use, and as tetracycline, doxycycline, Roxithromycin, ofloxacin etc., but all class medicines all have stronger toxic action, and easily produce drug resistance, and curative effect and prognosis are not satisfactory.
Chinese medicine thinks that the center of stranguria etiology and pathogenesis is damp and hot, and its primary symptom promptly is tangible damp and hot card.For concrete patient, should control with card fully from the integral body of its body.No damp and hot be not stranguria then, grabbed toward this principal contradiction, just be familiar with the general character of this disease.In the actual therapeutic, the product of clear profit should run through in treatment all the time.
Summary of the invention
The object of the present invention is to provide a kind of is the medicine that can effectively treat nongonococcal urethritis that raw material is made with the Chinese herbal medicine, and this medicine has no side effect, taking convenience, and short treating period, evident in efficacy.
Another object of the present invention is to provide the preparation method of this medicine.
The medicine that is used for the treatment of nongonococcal urethritis provided by the invention is the medicament of being made by the following weight proportion raw material:
Fructus Gardeniae 18～30 Radixs Astragali 18～30 Herba Hedyotidis Diffusaes 15～26
Radix Ophiopogonis 15～26 Fructus Malvae, 15～26 Ramulus Et Folium Picrasmaes 8～20.
The above-mentioned medicine material that is used for the treatment of nongonococcal urethritis all meets " the regulation of relevant each kind of Chinese pharmacopoeia version in 2000.
The above-mentioned medicine that is used for the treatment of nongonococcal urethritis can be made said multiple dosage form on the pharmaceutics, as capsule, tablet, powder, oral liquid etc.
The above-mentioned preparation method that is used for the treatment of the medicine of nongonococcal urethritis may further comprise the steps:
(1) get Fructus Gardeniae, Herba Hedyotidis Diffusae, Ramulus Et Folium Picrasmae with 60～80% alcohol heating reflux 2～4 times, each solvent multiple is that 6 times, return time are 1～3 hour; Merging filtrate, medicinal residues device are in addition preserved; Filtrate recycling ethanol, and to be concentrated into relative density be 1.20～1.35, the alcohol extraction clear paste;
(2) get the Radix Astragali, Fructus Malvae, Radix Ophiopogonis and decoct with water 2～4 times after above-mentioned medicinal residues mix, each amount of water is that 8 times, decocting time are 1～3 hour; Merging filtrate is concentrated into relative density 1.10～1.15, adds ethanol and makes and contain the alcohol amount and reach 60～80%, cold preservation 24～96 hours is filtered, and reclaims ethanol and is concentrated into relative density 1.32～1.35, with above-mentioned alcohol extraction clear paste mixing, drying is ground into fine powder, granulate, drying, granulate adds an amount of dry starch mixing, encapsulated, make capsule of the present invention.
The present invention has clearing away heat-damp and promoting diuresis, supplementing QI and nourishing YIN, the effect of inducing diuresis for treating stranguria syndrome.Be used for hold concurrently deficiency of both vital energy and Yin card of nongonococcal urethritis damp-heat in lower-JIAO, disease is seen hot urination not very, and excessive pain is outstanding, drenches drop endlessly, outbreak repeatedly, and soreness of the waist and knees, spiritlessness and weakness, pale tongue, deficient and weak pulse or void are carefully unable.Medicine of the present invention is used for that the nongonococcal urethritis effect is rapid, and effect is remarkable, has no adverse reaction.
The invention will be further described below by embodiment and toxicology and pharmacology experimental result.
Embodiment 1
Get Fructus Gardeniae 260g, Herba Hedyotidis Diffusae 235g, Ramulus Et Folium Picrasmae 150g, with 60% alcohol heating reflux 2 times, the solvent multiple is 8 times, and return time is 2h; Merging filtrate, medicinal residues device are in addition preserved.Filtrate recycling ethanol also is concentrated into the clear paste that relative density is 1.35 (60 ℃), and is standby.Other get Radix Astragali 240g, Fructus Malvae 230g, Radix Ophiopogonis 200g with decoct with water 2 times after above-mentioned medicinal residues mix, amount of water is 8 times, decocting time is 2h; Merging filtrate is concentrated into relative density 1.10 (60 ℃), adds ethanol and makes and contain the alcohol amount and reach 60%, cold preservation 50h filters, and reclaims ethanol, and be concentrated into relative density 1.32 (60 ℃), with above-mentioned alcohol extraction clear paste mixing, in 65 ℃ of dryings, be ground into fine powder, granulate drying, granulate, add the abundant mix homogeneously of an amount of dry starch, encapsulated, make capsule of the present invention.
Embodiment 2
Get Fructus Gardeniae 220g, Herba Hedyotidis Diffusae 230g, Ramulus Et Folium Picrasmae 180g, with 70% alcohol heating reflux 3 times, each solvent multiple is that 6 times, return time are 1h; Merging filtrate, medicinal residues device are in addition preserved.Filtrate recycling ethanol also is concentrated into the clear paste that relative density is 1.32 (60 ℃), and is standby.Other get Radix Astragali 220g, Fructus Malvae 250g, Radix Ophiopogonis 220g with decoct with water 3 times after above-mentioned medicinal residues mix, each amount of water is that 10 times, decocting time are 1h; Merging filtrate is concentrated into relative density 1.15 (60 ℃), adds ethanol and makes and contain the alcohol amount and reach 70%, cold preservation 60h filters, and reclaims ethanol, medicinal liquid is concentrated into relative density 1.33 (60 ℃), with alcohol extraction clear paste mixing, in 65 ℃ of dryings, be ground into fine powder, granulate drying, granulate, add an amount of dry starch mixing, encapsulated, make capsule of the present invention.
The present invention is to provide a kind of natural drug for the treatment of nongonococcal urethritis, for proving its therapeutic effect and safety, the inventor uses the capsule for preparing by the method that provides in the foregoing description 1 to carry out toxicity and pharmacodynamics test, and result of study is as follows: one, acute toxicity test
Studied the acute toxicity of capsule of the present invention to mice.The result shows, after the capsule mouse stomach of the present invention administration, does not find obvious acute toxicity, and mice maximum dosage-feeding on the one is 98.56g crude drug/kg, and 622 times of consumptions every day are equivalent to be grown up.Two, long term toxicity test
The capsular clinical course of treatment according to the present invention according to the specification requirement of new Chinese medicine toxicologic study, has been studied 3 month long term toxicities of capsule of the present invention to rat.The result shows, with three dosage of capsule of the present invention (4.75,9.5,19g crude drug/kg, 30 times, 60 times, 120 times of consumption are equivalent to respectively to be grown up) give rat continuous irrigation stomach 3 months, general situation, hematology, blood biochemical, routine urinalysis, electrocardiogram, system's dissection, organ coefficient and histopathology to rat all do not have obvious influence, do not find toxic reaction, convalescent period does not also have the retardance toxic reaction, and it is 19g crude drug/kg/ day that rat non-toxic reaction dosage is provided.The result shows that capsule of the present invention is not seen obvious accumulative toxicity to rat, estimates to be safe under the clinical dosage condition.Three, pharmacodynamic study
Capsule of the present invention is a compound Chinese medicinal preparation, has the effect of clearing away heat-damp and promoting diuresis, supplementing QI and nourishing YIN, clinically is used for the urinary system infection treatment of chronic phase.According to the present invention capsular effect with cure mainly, according to the principle and the method for " study of tcm new drug guide ", to capsule of the present invention carried out antiinflammatory, antibiotic, Immune Effects, influence, diuresis and analgesia etc. to bladder contraction are cured mainly relevant Pharmacodynamic test of active extract research with function.Result of study shows, capsule of the present invention by 3.22,6.44,12.88g crude drug/kg is to the mouse stomach administration, reaction of chmice acute exudative inflammation and mouse writhing that suppressing acetic acid stimulates react; By 2.3,4.6,9.2g crude drug/kg is to the rat oral gavage administration, suppresses reaction of rat chronic proliferative inflammation and rat in the body bladder contraction; By 1.24,2.48,4.96g crude drug/kg is to the rabbit gastric infusion, obviously increases rabbit urine amount.Immunological testing is the result show, capsule of the present invention by 3.22,6.44,12.88g crude drug/kg is to the mouse stomach administration, and the growth of mouse immune organ is not had obvious influence; Improve the cytophagous phagocytic function of mice, the enhancing body non-specific immunity; Promote the generation and the secretion of mice specific antibody, strengthen the specific humoral immunity function of mice; Promote the mouse spleen lymphocyte breeder reaction, strengthen the specific cellular immunity function of mice.Antibacterial tests result shows, capsule body of the present invention is outer to be had than obvious suppression and deactivation removing from office the blue negative cocci gonococcus of blue positive coccus staphylococcus aureus, staphylococcus epidermidis, streptococcus pyogenes and leather, do not have obvious inhibitory action to removing from office blue negative cocci streptococcus faecalis of blue negative bacillus colon bacillus, Pseudomonas aeruginosa, Salmonella enteritidis, acinetobacter calcoaceticus, Bacillus proteus and leather and fungus saccharomyces albicans, the pH and the bacterial load that change culture fluid do not influence the antibacterial action of capsule of the present invention to streptococcus pyogenes, staphylococcus epidermidis; Gastric infusion; in the body streptococcus pyogenes and staphylococcus epidermidis infecting mouse all there is protective effect; ED50 to the streptococcus pyogenes infecting mouse is 64.15g crude drug/kg; 95% credible 48.41～77.24g crude drug/kg that is limited to; ED50 to epidermis staphy lococcus infection mice is 32.51g crude drug/kg, 95% credible 24.17～43.73g crude drug/kg that is limited to.Presentation of results, capsule of the present invention have antiinflammatory, antibiotic, raise immunity, inhibition bladder contraction and diuresis, analgesic activity.
Claims (4)
1, a kind of medicine for the treatment of nongonococcal urethritis is characterized in that it is the medicament of being made by the following weight proportion raw material:
Fructus Gardeniae 18～30 Radixs Astragali 18～30 Herba Hedyotidis Diffusaes 15～26
Radix Ophiopogonis 15～26 Fructus Malvae, 15～26 Ramulus Et Folium Picrasmaes 8～20.
2, the medicine of treatment nongonococcal urethritis according to claim 1 is characterized in that described medicament is a said dosage form on any pharmaceutics.
3, the medicine of treatment nongonococcal urethritis according to claim 2 is characterized in that described medicament is a capsule.
4, the preparation method of the medicine of the described treatment nongonococcal urethritis of claim 3 may further comprise the steps:
(1) get Fructus Gardeniae, Herba Hedyotidis Diffusae, Ramulus Et Folium Picrasmae with 60～80% alcohol heating reflux 2～4 times, each solvent multiple is that 6 times, return time are 1～3 hour; Merging filtrate, medicinal residues device are in addition preserved; Filtrate recycling ethanol, and to be concentrated into relative density be 1.20～1.35, the alcohol extraction clear paste;
(2) get the Radix Astragali, Fructus Malvae, Radix Ophiopogonis and decoct with water 2～4 times after above-mentioned medicinal residues mix, each amount of water is that 8 times, decocting time are 1～3 hour; Merging filtrate is concentrated into relative density 1.10～1.15, adds ethanol and makes and contain the alcohol amount and reach 60～80%, cold preservation 24～96 hours is filtered, and reclaims ethanol and is concentrated into relative density 1.32～1.35, with above-mentioned alcohol extraction clear paste mixing, drying is ground into fine powder, granulate, drying, granulate adds an amount of dry starch mixing, encapsulated, promptly get capsule of the present invention.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03113856 CN1183951C (en) | 2003-03-05 | 2003-03-05 | Medicine for treating non-gonococcal vaginitis and preparation method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 03113856 CN1183951C (en) | 2003-03-05 | 2003-03-05 | Medicine for treating non-gonococcal vaginitis and preparation method |
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| Publication Number | Publication Date |
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| CN1438016A true CN1438016A (en) | 2003-08-27 |
| CN1183951C CN1183951C (en) | 2005-01-12 |
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| CN 03113856 Expired - Lifetime CN1183951C (en) | 2003-03-05 | 2003-03-05 | Medicine for treating non-gonococcal vaginitis and preparation method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005092329A1 (en) * | 2004-03-12 | 2005-10-06 | Christian Diehl | Topical and intravaginal microbicidal antiparasitic compositions comprising quassinoids or quassinoid-containing plant extracts |
| CN102973791A (en) * | 2012-12-20 | 2013-03-20 | 贵州远程制药有限责任公司 | Drug for treating simplex lower urinary tract infection and preparation method thereof |
| CN103076403A (en) * | 2012-10-07 | 2013-05-01 | 贵州远程制药有限责任公司 | Quality inspection method for capsule for treating lower urinary tract infection |
-
2003
- 2003-03-05 CN CN 03113856 patent/CN1183951C/en not_active Expired - Lifetime
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005092329A1 (en) * | 2004-03-12 | 2005-10-06 | Christian Diehl | Topical and intravaginal microbicidal antiparasitic compositions comprising quassinoids or quassinoid-containing plant extracts |
| US8568794B2 (en) | 2004-03-12 | 2013-10-29 | Life Science Investments, Ltd. | Topical and intravaginal microbicidal and antiparasitic compositions comprising quassinoids or quassinoid-containing plant extracts |
| US8865235B2 (en) | 2004-03-12 | 2014-10-21 | Life Science Investments, Ltd. | Microbicidal and antiparasitic compositions |
| CN103076403A (en) * | 2012-10-07 | 2013-05-01 | 贵州远程制药有限责任公司 | Quality inspection method for capsule for treating lower urinary tract infection |
| CN103076403B (en) * | 2012-10-07 | 2014-10-22 | 贵州远程制药有限责任公司 | Inspection method for capsule for treating lower urinary tract infection |
| CN102973791A (en) * | 2012-12-20 | 2013-03-20 | 贵州远程制药有限责任公司 | Drug for treating simplex lower urinary tract infection and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN1183951C (en) | 2005-01-12 |
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Owner name: GUIZHOU YUANCHENG PHARMACEUTICAL CO. Free format text: FORMER OWNER: WU MEICHUN Effective date: 20040514 |
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Effective date of registration: 20040514 Address after: 550018 national hi tech Industrial Development Zone, Guizhou, Guiyang Applicant after: GUIZHOU REMOTE PHARMACEUTICAL CO.,LTD. Address before: 510610 Guangdong city of Guangzhou province forest and Road No. 150, Room 802 on the eighth floor of Tianyu Garden Plaza Accord Applicant before: Wu Meichun |
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Address after: 550018 No. 5 Gaoxin North Road, Wudang District, Guiyang City, Guizhou Province Patentee after: GUIZHOU REMOTE PHARMACEUTICAL Co.,Ltd. Address before: 550018 national hi tech Industrial Development Zone, Guizhou, Guiyang Patentee before: GUIZHOU REMOTE PHARMACEUTICAL Co.,Ltd. |
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Granted publication date: 20050112 |