CN1554448A - Chitosan gelatine polyvinyl alcohol biological hemostatic dressing - Google Patents
Chitosan gelatine polyvinyl alcohol biological hemostatic dressing Download PDFInfo
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- CN1554448A CN1554448A CNA200310121182XA CN200310121182A CN1554448A CN 1554448 A CN1554448 A CN 1554448A CN A200310121182X A CNA200310121182X A CN A200310121182XA CN 200310121182 A CN200310121182 A CN 200310121182A CN 1554448 A CN1554448 A CN 1554448A
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- polyvinyl alcohol
- chitosan
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- bleeding
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- 229920001661 Chitosan Polymers 0.000 title claims abstract description 32
- 229920000159 gelatin Polymers 0.000 title claims abstract description 26
- 235000019322 gelatine Nutrition 0.000 title claims abstract description 26
- 239000004372 Polyvinyl alcohol Substances 0.000 title claims abstract description 21
- 229920002451 polyvinyl alcohol Polymers 0.000 title claims abstract description 21
- 230000002439 hemostatic effect Effects 0.000 title abstract description 23
- 239000001828 Gelatine Substances 0.000 title 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 41
- 108010010803 Gelatin Proteins 0.000 claims abstract description 25
- 239000008273 gelatin Substances 0.000 claims abstract description 25
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 25
- 229920000742 Cotton Polymers 0.000 claims abstract description 4
- 238000004519 manufacturing process Methods 0.000 claims abstract description 4
- 239000007921 spray Substances 0.000 claims abstract description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 238000004659 sterilization and disinfection Methods 0.000 claims description 8
- 230000001954 sterilising effect Effects 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 5
- 239000002552 dosage form Substances 0.000 claims description 3
- 239000002994 raw material Substances 0.000 claims description 3
- QBUKAFSEUHGMMX-MTJSOVHGSA-N (5z)-5-[[3-(1-hydroxyethyl)thiophen-2-yl]methylidene]-10-methoxy-2,2,4-trimethyl-1h-chromeno[3,4-f]quinolin-9-ol Chemical group C1=CC=2NC(C)(C)C=C(C)C=2C2=C1C=1C(OC)=C(O)C=CC=1O\C2=C/C=1SC=CC=1C(C)O QBUKAFSEUHGMMX-MTJSOVHGSA-N 0.000 claims description 2
- 238000011200 topical administration Methods 0.000 claims description 2
- 238000010521 absorption reaction Methods 0.000 abstract description 4
- 239000003814 drug Substances 0.000 abstract description 2
- 235000011187 glycerol Nutrition 0.000 abstract 1
- 231100000956 nontoxicity Toxicity 0.000 abstract 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 abstract 1
- 238000001179 sorption measurement Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 description 24
- 208000032843 Hemorrhage Diseases 0.000 description 22
- 206010052428 Wound Diseases 0.000 description 16
- 208000027418 Wounds and injury Diseases 0.000 description 16
- 230000023597 hemostasis Effects 0.000 description 12
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 6
- 230000000025 haemostatic effect Effects 0.000 description 6
- 210000000952 spleen Anatomy 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 6
- 230000000740 bleeding effect Effects 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 238000004108 freeze drying Methods 0.000 description 5
- 210000004185 liver Anatomy 0.000 description 5
- 229920002101 Chitin Polymers 0.000 description 4
- 238000005520 cutting process Methods 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 238000012856 packing Methods 0.000 description 4
- 230000000704 physical effect Effects 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 210000000683 abdominal cavity Anatomy 0.000 description 3
- 239000002671 adjuvant Substances 0.000 description 3
- 229910021529 ammonia Inorganic materials 0.000 description 3
- 238000009835 boiling Methods 0.000 description 3
- 239000002075 main ingredient Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 231100000252 nontoxic Toxicity 0.000 description 3
- 230000003000 nontoxic effect Effects 0.000 description 3
- 238000009736 wetting Methods 0.000 description 3
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 2
- 241000628997 Flos Species 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 240000007711 Peperomia pellucida Species 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 210000000589 cicatrix Anatomy 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- 230000029663 wound healing Effects 0.000 description 2
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 1
- 101001018064 Homo sapiens Lysosomal-trafficking regulator Proteins 0.000 description 1
- 102100033472 Lysosomal-trafficking regulator Human genes 0.000 description 1
- 244000038561 Modiola caroliniana Species 0.000 description 1
- 235000010703 Modiola caroliniana Nutrition 0.000 description 1
- 241001597008 Nomeidae Species 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 238000006065 biodegradation reaction Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000109 continuous material Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 229960002442 glucosamine Drugs 0.000 description 1
- 210000000569 greater omentum Anatomy 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000006101 laboratory sample Substances 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000013558 reference substance Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
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- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
Abstract
The biological chitosan-gelatin-polyvinyl alcohol hemostatic dressing is compounded with chitosan, gelatin, polyvinyl alcohol and glycerin, and is prepared into hemostatic cotton, spray and other externally applied medicine forms via conventional production process. The present invention has high adsorption amount, maintained amount, no toxicity, easy absorption by body and high hemostatic function and is superior to available hemostatic dressing.
Description
Technical field:
The present invention relates to the chitosan is the improvement of main material production bleeding-stopping dressing, has further provided the biological bleeding-stopping dressing of a kind of chitosan gelatin polyvinyl alcohol, belongs to medical hemostatic dressing
Technical field.
Background technology
Chitosan (chiosail.cs) is also referred to as chitosan, is the main derivant of chitin, and its preparation is simple, the source is abundant, low price, is nontoxic micromolecular compound glucosamine by biodegradation easily, therefore more and more is subject to people's attention.Developing with chitin and chitosan in recent years in succession is the bleeding-stopping dressing of Main Ingredients and Appearance, materials such as many employing gelfoam, also having with chitin, gelatin is the hemostatic material of Main Ingredients and Appearance, but these materials are desirable not enough what have aspect hydrophilic, film property, tractive and the haemostatic effect.Report as the hemostatic material document is existing with chitosan and gelatin merely, but,, in hemostatic material, only account for about 2%, thereby influenced haemostatic effect, and elasticity is too little, is inconvenient to use because the dissolubility of chitosan is bad because its anastalsis is limited.
Summary of the invention:
The invention provides the biological bleeding-stopping dressing of a kind of chitosan gelatin polyvinyl alcohol, overcome the shortcoming of existing bleeding-stopping dressing aspect hydrophilic, film property, tractive and haemostatic effect, kept original hemostatic function again.
The present invention is made by following raw materials by weight portion ratio:
5～60 parts of chitosans, 5～40 parts in gelatin, 5～60 parts of polyvinyl alcohol, 5～40 parts of glycerol.
Optimum ratio of the present invention is (by weight):
40 parts of chitosans, 35 parts in gelatin, 40 parts of polyvinyl alcohol, 20 parts of glycerol.
Concrete technology is as follows:
At first chitosan is dissolved in the acetic acid solution of 0.2～2% concentration; It is molten respectively polyvinyl alcohol to be added hydro-thermal again, the gelatin heating for dissolving, and glycerol is dissolved in water, and above-mentioned dissolved various solution are mixed, fully stir to make evenly, lyophilization, the cutting packing, sterilization makes product of the present invention.
Utilize bleeding-stopping dressing of the present invention to produce topical administration dosage forms such as styptic cotton, spray by conventional external used medicine dosage form manufacturing technique.
The character of utilizing the hemostasis of chitosan, antibacterial, antibiotic property, biocompatibility, promotion wound healing among the present invention and being easy to form gel cooperates polyvinyl alcohol nontoxic non-stimulated, has extremely strong hydrophilic and fabulous film property.
Gelatin is that the Main Ingredients and Appearance of composition tissue is the main matter that forms the sponge state, thereby improves the elasticity of this product, and for wound provides nutrition, promotes wound healing, prevents that cicatrix from generating.Glycerol plays humidification in this product, makes sthptic sponge easier to be fused with tissue.
Good effect of the present invention is: utilize the mutual compatibility of chitosan, gelatin, polyvinyl alcohol and glycerol, blood had high adsorbance, reservation amount, nontoxic, be easy to be absorbed by body, solved that original biological hemostasis adjuvant hygroscopicity is poor, the shortcoming of weak frangible, the haemostatic effect difference of pulling force.
Below test example is proof result of use of the present invention further:
1, materials and methods
1.1 material
Chitosan is purchased in Qingdao
Gelatin is purchased in Shanghai
Polyvinyl alcohol is purchased in Shanghai
Glycerol is purchased in Shanghai
1.2 method
1) hemostatic material: chitosan, polyvinyl alcohol are dissolved respectively, and glycerol is dissolved in the water, and above three kinds of solution are mixed, and stirs to make evenly, and lyophilization makes biological sthptic sponge.
2) physical property:
For the physical property of hemostatic material, can represent that its meaning and unit are as follows with apparent density, wetting time, absorbtivity, absorbance:
The weight of apparent density (ρ) expression sponge material under unit volume, the mg/cm of unit
3
The every gram sponge material saturated with water of wetting time (t) expression is divided required time, the t/g of unit
The every gram sponge material of water absorption (m) expression absorbs the gram number of moisture, unit water/gram
Water absorption rate (ω) representation unit is in the time, the gram number of every gram moisture that sponge material absorbs, the g of unit water/gram-second
3) haemostatic effect
This experiment is carried out preliminary study to the anthemorrhagic performance and the reliability of biological hemostatic material, and with the chitosan gelfoam in contrast.Used animal is the 2.5-3.0kg large ear rabbit, and male and female are not limit.Laboratory sample is through Co
60The hemorrhage wound surface of 2cm * 1cm size is made in radiation sterilization in rabbit ear portion.20% urethane is anaesthetized rabbit through auricular vein under aseptic condition, the stomach wall preserved skin, and routine disinfection, the medisection stomach wall enters the abdominal cavity.Form the hemorrhage wound surface of oozing of blood at liver, spleen skin cut 1cm * 1cm tissue, apply with autonomous biological hemostasis adjuvant and chitosan gelatin hemostatic material respectively and press hemostasis, the record bleeding stopping period, the bonding situation of observing adjuvant and wound surface is in the hope of the healing state of routine observation wound surface.
4) vivo degradation experiment
Under the aseptic condition, 20% urethane is anaesthetized rabbit (about 5ml/kg) through auricular vein, the stomach wall preserved skin, and routine disinfection, the medisection stomach wall enters the abdominal cavity.Form oozing of blood, hemorrhage wound surface at liver, spleen skin cut 1cm * 0.5cm tissue, after the definite hemostasis of the deposited pressure of hemostatic material, hemostatic material is stayed in the organ, close the conventional raising in abdominal cavity then, put to death animal in 15 days, 30 days, 60 days respectively at postoperative, get liver, spleen is done the pathology inspection, matched group uses the chitosan gelfoam.
2, experimental result
2.1 the physical property of biological sthptic sponge and chitin absorbable gelatin sponge.
The physical property test result of sthptic sponge of the present invention and carapace ammonia absorbable gelatin sponge: table 1
Hemostatic material sthptic sponge chitosan of the present invention gelfoam
1??????????2???????????3?????????????1????????????2???????????3
Density
14.0???????14.32???????13.99?????????13.1?????????13.0????????13.0
mg/m
3
Wetting time
1.0×10
4??1.02×10
4?1.01×10
4????3.35×10
4??3.21×10
4??3.4×10
4
t/g
Water absorption
43?????????42??????????43????????????30???????????31??????????30
gH
2O/v
2.2 haemostatic effect is observed: (table 2)
| Hemostatic material | The example number | Average bleeding stopping period | Hemostasis percentage rate (%) | ||
| Ear | Liver | Spleen | |||
| The present invention's silk floss that stops blooding | ????20 | ????58±4 | ????60±6 | ????62±8 | ??100 |
| Carapace ammonia gelfoam | ????20 | ????60±6 | ????64±13 | ????65±10 | ??100 |
In the table 2, the continuous bleeding stopping period of biological hemostasis is shorter than the chitosan absorbable gelatin sponge, and experiment the present invention continuous wound surface ability that adheres to of stopping blooding is better than the chitosan sthptic sponge.
2) hemostatic reliability
On 20 hemorrhage wound surface of rabbit ear portion making, observed in continuous back 10 minutes, 24 hours, 48 hours with the present invention's tender carapace ammonia gelatin hemostasis of stopping blooding respectively, there is no that hemostatic material comes off and bleeding again.10 livers, spleen wound surface, hemostatic material apply presses hemostasis to observe in back 10 minutes to there is no hemorrhage and oozing phenomenon.Sponge and wound surface adhere to good.Observed result was the same in 24 hours, 48 hours.Hemostatic material and sludged blood form a complete covering on wound surface, see that wound surface has the mauve fibrous membrane of one deck, does not have bleeding again after removing this covering.
3) healing state of wound surface and vivo degradation absorbing state
Hepar Leporis seu Oryctolagi, spleen stopped blooding back 15 days, all observed the partial hemostasis covering of wound surface for two groups and had formed the machine scar tissue, and omentum majus tissue and its adhesion are arranged.After 30 days, the present invention's continuous material that stops blooding partly is absorbed, the local fiber spot that forms of wound surface after 60 days, and hemostatic material all is absorbed.The matched group situation is similar substantially to experimental group, but the local formation of wound surface local organization cicatrix is bigger than experimental group after 60 days.
3, discuss
From above experiment as can be seen, sea of blood silk floss of the present invention has good hygroscopicity, and the short more performance of tissue intersolubility and hemostasis compares to similar product, and not only traction force strengthens convenient the use, and effect is better than reference substance.
The specific embodiment:
The following example is intended to further describe for example the present invention, rather than limit the present invention by any way, under the prerequisite that does not deviate from the spirit and principles in the present invention, any change or change that those of ordinary skills that the present invention did are realized easily all will fall within the claim scope that awaits the reply of the present invention.
Embodiment 1
Chitosan 20g is dissolved in the acetic acid solution of 600ml 0.2% concentration, gets polyvinyl alcohol 20g and add boiling water and make dissolving, gelatin 15g heating is dissolved, glycerol 15g is dissolved in water, and merges above-mentioned solution, fully stirs to make evenly, lyophilization, the cutting packing, the Co60 sterilization makes bleeding-stopping dressing.
Embodiment 2
Chitosan 40g is dissolved in the acetic acid solution of 1000ml 1.2% concentration, gets polyvinyl alcohol 55g and add boiling water and make dissolving, gelatin 30g heating is dissolved, glycerol 40g is dissolved in water, and merges above-mentioned solution, fully stirs to make evenly, lyophilization, the cutting packing, sterilization makes bleeding-stopping dressing.
Embodiment 3
Chitosan 60g is dissolved in the acetic acid solution of 800ml 0.8% concentration, polyvinyl alcohol 40g adds boiling water makes dissolving, and gelatin 10g heating is dissolved, glycerol 10g is dissolved in water, and merges above-mentioned solution, fully stirs to make evenly, lyophilization, the cutting packing, the Co60 sterilization makes bleeding-stopping dressing.
Embodiment 4
Embodiment 1～3 is made bleeding-stopping dressing be adsorbed on equably that to make biological hemostasis on the cotton wool continuous.
Embodiment 5
Embodiment 1～3 is made an amount of powder of waving of bleeding-stopping dressing adding make spray.
Claims (4)
1, the biological bleeding-stopping dressing of a kind of chitosan gelatin polyvinyl alcohol is characterized in that it being to be made by following raw materials by weight portion ratio:
5～60 parts of chitosans, 5～40 parts in gelatin, 5～60 parts of polyvinyl alcohol, 5～40 parts of glycerol.
2, bleeding-stopping dressing according to claim 1 is characterized in that being made by following raw materials by weight portion ratio:
40 parts of chitosans, 35 parts in gelatin, 40 parts of polyvinyl alcohol, 20 parts of glycerol.
3, the production method of the biological bleeding-stopping dressing of a kind of chitosan gelatin polyvinyl alcohol, it is characterized in that: at first chitosan is dissolved in the acetic acid solution of 0.2～2% concentration, it is molten respectively polyvinyl alcohol to be added hydro-thermal again, the gelatin heating is dissolved, glycerol is dissolved in water, above-mentioned dissolved various solution are mixed, and fully stirring makes evenly, and sterilization makes product of the present invention.
4, biological bleeding-stopping dressing according to claim 1 and 2 is produced topical administration dosage forms such as styptic cotton, spray.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200310121182XA CN1554448A (en) | 2003-12-23 | 2003-12-23 | Chitosan gelatine polyvinyl alcohol biological hemostatic dressing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200310121182XA CN1554448A (en) | 2003-12-23 | 2003-12-23 | Chitosan gelatine polyvinyl alcohol biological hemostatic dressing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1554448A true CN1554448A (en) | 2004-12-15 |
Family
ID=34338422
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA200310121182XA Pending CN1554448A (en) | 2003-12-23 | 2003-12-23 | Chitosan gelatine polyvinyl alcohol biological hemostatic dressing |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1554448A (en) |
Cited By (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1327849C (en) * | 2005-03-05 | 2007-07-25 | 汕头市金丰医疗器械科技有限公司 | Hemostatic agent and its preparing method |
| CN100348272C (en) * | 2006-06-23 | 2007-11-14 | 华南理工大学 | Method for preparing astringent sponge of soluble cellulose |
| CN101879324A (en) * | 2010-07-02 | 2010-11-10 | 西南大学 | Preparation method of chitosan composite medical dressing |
| CN101912634A (en) * | 2010-08-06 | 2010-12-15 | 华南理工大学 | A kind of preparation method of antibacterial biological dressing containing nano-silver/nanometer silicon dioxide |
| CN101927029A (en) * | 2010-08-06 | 2010-12-29 | 华南理工大学 | A kind of preparation method of chitosan/polyvinyl alcohol sponge dressing containing nanometer silver |
| CN102108138B (en) * | 2009-12-28 | 2012-07-25 | 沈阳鑫盛生物科技有限公司 | Method for preparing chitosan collagen gel |
| CN102671232A (en) * | 2012-05-18 | 2012-09-19 | 成都理工大学 | Tourmaline/chitosan hydrochloride compound spray-type aqueous dressing and preparation method thereof |
| CN103007339A (en) * | 2012-12-06 | 2013-04-03 | 浙江医鼎医用敷料有限公司 | Biological powder medical dressing and preparation method thereof |
| CN103239753A (en) * | 2013-04-28 | 2013-08-14 | 华南理工大学 | Hydroxypropyl-beta-cyclodextrin/chitosan medical dressing and preparation method thereof |
| CN103316377A (en) * | 2013-06-27 | 2013-09-25 | 华南理工大学 | Beta-cyclodextrin/carboxymethyl chitosan medical dressing and preparation method thereof |
| CN103705968A (en) * | 2013-12-30 | 2014-04-09 | 深圳先进技术研究院 | Medical chitosan compound moisturizing dressing and preparation method thereof |
| CN103736135A (en) * | 2013-12-12 | 2014-04-23 | 深圳先进技术研究院 | Medicinal composite dressing and preparation method thereof |
| CN104524624A (en) * | 2014-12-17 | 2015-04-22 | 安徽省健源医疗器械设备有限公司 | Chitosan hemostatic gauze and preparation method thereof |
| WO2015187103A1 (en) * | 2014-05-21 | 2015-12-10 | Punyanitya Sittiporn | Surgical hemostatic based rice starch |
| US9283187B2 (en) | 2011-04-27 | 2016-03-15 | Biom'up | Hemostatic compositions |
| CN106344080A (en) * | 2016-08-30 | 2017-01-25 | 宗兆文 | Hemostasis device for closed abdominal cavity bleeding |
| CN107469138A (en) * | 2017-10-09 | 2017-12-15 | 常州金艺广告传媒有限公司 | A kind of preparation method of high imbibition promoting healing type compound hemostatic material |
| WO2020021499A1 (en) * | 2018-07-26 | 2020-01-30 | Azista Industries Pvt Ltd | Haemostatic gel composition and its process of preparation |
| RU2720627C1 (en) * | 2019-09-09 | 2020-05-12 | Общество с ограниченной ответственностью "Химико-фармацевтические технологии" (ООО "ХимФармТех") | Haemostatic composition with reparative properties (versions) |
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- 2003-12-23 CN CNA200310121182XA patent/CN1554448A/en active Pending
Cited By (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1327849C (en) * | 2005-03-05 | 2007-07-25 | 汕头市金丰医疗器械科技有限公司 | Hemostatic agent and its preparing method |
| CN100348272C (en) * | 2006-06-23 | 2007-11-14 | 华南理工大学 | Method for preparing astringent sponge of soluble cellulose |
| CN102108138B (en) * | 2009-12-28 | 2012-07-25 | 沈阳鑫盛生物科技有限公司 | Method for preparing chitosan collagen gel |
| CN101879324A (en) * | 2010-07-02 | 2010-11-10 | 西南大学 | Preparation method of chitosan composite medical dressing |
| CN101927029B (en) * | 2010-08-06 | 2013-06-12 | 华南理工大学 | Preparation method of chitosan/polyvinyl alcohol sponge dressing containing nano-silver |
| CN101912634A (en) * | 2010-08-06 | 2010-12-15 | 华南理工大学 | A kind of preparation method of antibacterial biological dressing containing nano-silver/nanometer silicon dioxide |
| CN101927029A (en) * | 2010-08-06 | 2010-12-29 | 华南理工大学 | A kind of preparation method of chitosan/polyvinyl alcohol sponge dressing containing nanometer silver |
| CN101912634B (en) * | 2010-08-06 | 2013-09-25 | 华南理工大学 | Method for preparing nanosilver/nano silicon dioxide-containing antibacterial biological dressing |
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| US9283187B2 (en) | 2011-04-27 | 2016-03-15 | Biom'up | Hemostatic compositions |
| US10342856B2 (en) | 2011-04-27 | 2019-07-09 | Biom'up | Hemostatic compostions |
| US9662374B2 (en) | 2011-04-27 | 2017-05-30 | Biom'up | Hemostatic compositions |
| CN102671232A (en) * | 2012-05-18 | 2012-09-19 | 成都理工大学 | Tourmaline/chitosan hydrochloride compound spray-type aqueous dressing and preparation method thereof |
| CN102671232B (en) * | 2012-05-18 | 2014-08-13 | 成都理工大学 | Tourmaline/chitosan hydrochloride compound spray-type aqueous dressing and preparation method thereof |
| CN103007339A (en) * | 2012-12-06 | 2013-04-03 | 浙江医鼎医用敷料有限公司 | Biological powder medical dressing and preparation method thereof |
| CN103007339B (en) * | 2012-12-06 | 2014-11-26 | 浙江医鼎医用敷料有限公司 | Biological powder medical dressing and preparation method thereof |
| CN103239753A (en) * | 2013-04-28 | 2013-08-14 | 华南理工大学 | Hydroxypropyl-beta-cyclodextrin/chitosan medical dressing and preparation method thereof |
| CN103316377A (en) * | 2013-06-27 | 2013-09-25 | 华南理工大学 | Beta-cyclodextrin/carboxymethyl chitosan medical dressing and preparation method thereof |
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