CN1842335A - 用于治疗高眼压的眼用组合物 - Google Patents

用于治疗高眼压的眼用组合物 Download PDF

Info

Publication number
CN1842335A
CN1842335A CNA2004800243370A CN200480024337A CN1842335A CN 1842335 A CN1842335 A CN 1842335A CN A2004800243370 A CNA2004800243370 A CN A2004800243370A CN 200480024337 A CN200480024337 A CN 200480024337A CN 1842335 A CN1842335 A CN 1842335A
Authority
CN
China
Prior art keywords
alkyl
heterocyclyl
aryl
compound
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2004800243370A
Other languages
English (en)
Chinese (zh)
Inventor
M·H·陈
J·B·多赫尔蒂
L·刘
S·纳塔拉彦
R·M·泰内博尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of CN1842335A publication Critical patent/CN1842335A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
CNA2004800243370A 2003-09-04 2004-08-31 用于治疗高眼压的眼用组合物 Pending CN1842335A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50009003P 2003-09-04 2003-09-04
US60/500,090 2003-09-04

Publications (1)

Publication Number Publication Date
CN1842335A true CN1842335A (zh) 2006-10-04

Family

ID=34312180

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2004800243370A Pending CN1842335A (zh) 2003-09-04 2004-08-31 用于治疗高眼压的眼用组合物

Country Status (7)

Country Link
US (1) US7494983B2 (fr)
EP (1) EP1663221A4 (fr)
JP (1) JP2007504236A (fr)
CN (1) CN1842335A (fr)
AU (1) AU2004271978B2 (fr)
CA (1) CA2537430A1 (fr)
WO (1) WO2005025568A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003287481B2 (en) 2002-11-08 2009-04-23 Merck & Co., Inc. Ophthalmic compositions for treating ocular hypertension
DE602004020079D1 (de) * 2003-09-04 2009-04-30 Merck & Co Inc Ophthalmische zusammensetzungen zur behandlung der okularen hypertonie
US8299079B2 (en) 2009-05-22 2012-10-30 Kaufman Herbert E Preparations and methods for ameliorating or reducing presbyopia
WO2010135731A1 (fr) * 2009-05-22 2010-11-25 Kaufman Herbert E Préparations et procédés pour améliorer ou réduire une presbytie

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2534580A1 (fr) 1982-10-13 1984-04-20 Synthelabo Derives de phenyl-1 piperidino-2 propanol, leur preparation, et medicaments qui les contiennent
US5151444B1 (en) 1987-09-18 1999-07-06 R Tech Ueno Ltd Ocular hypotensive agents
AU3693789A (en) 1988-05-10 1989-11-29 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) New ophthalmic preparation for treating glaucoma
US5296504A (en) 1988-09-06 1994-03-22 Kabi Pharmacia Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
DE1300150T1 (de) 1988-09-06 2003-09-18 Pharmacia Ab, Stockholm Prostaglandin-Derivate zur Behandlung von Glaukom oder Augenüberdruck
US5352708A (en) 1992-09-21 1994-10-04 Allergan, Inc. Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
US5922773A (en) 1992-12-04 1999-07-13 The Children's Medical Center Corp. Glaucoma treatment
AU7099194A (en) 1993-06-08 1995-01-03 Vide Pharmaceuticals Methods and compositions for lowering intraocular pressure
US5510383A (en) 1993-08-03 1996-04-23 Alcon Laboratories, Inc. Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension
US5573758A (en) 1995-04-28 1996-11-12 Allergan Method for reducing intraocular pressure in the mammalian eye by administration of potassium channel blockers
US5925342A (en) 1996-11-13 1999-07-20 Allergan Method for reducing intraocular pressure in the mammalian eye by administration of potassium channel blockers
KR20010074981A (ko) 1998-09-14 2001-08-09 우에노 도시오 ω치환된 페닐프로스타그란딘 Ｅ 유도체 및 그 유도체를유효 성분으로 하는 약제
PE20010306A1 (es) * 1999-07-02 2001-03-29 Agouron Pharma Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
TWI262914B (en) * 1999-07-02 2006-10-01 Agouron Pharma Compounds and pharmaceutical compositions for inhibiting protein kinases
GEP20043203B (en) 1999-12-22 2004-03-25 Pfizer Prod Inc EP4 Receptor Selective Agonists in the Treatment of Osteoporosis
WO2001070701A1 (fr) * 2000-03-17 2001-09-27 Alcon, Inc. Derives d'indazole 5-hydroxy permettant de traiter le glaucome
BR0017157A (pt) 2000-03-17 2002-11-26 Alcon Inc Derivados de 6-hidroxi-indazol para o tratamento de glaucoma
CN1366458A (zh) 2000-03-31 2002-08-28 东丽株式会社 毛发生长和毛发形成调节剂
AU2001290250A1 (en) 2000-09-21 2002-04-02 Ono Pharmaceutical Co. Ltd. Ep4 receptor agonists containing 8-azaprostaglandin derivatives as the active ingredient
OA12533A (en) 2000-11-27 2006-06-05 Pfizer Prod Inc Ep4 receptor selective agonists in the treatment of osteoporosis.
CA2447480A1 (fr) * 2001-06-01 2002-12-12 Alcon, Inc. Pyranoindazoles et leur utilisation dans le traitement du glaucome
AU2003287481B2 (en) * 2002-11-08 2009-04-23 Merck & Co., Inc. Ophthalmic compositions for treating ocular hypertension
US7053085B2 (en) 2003-03-26 2006-05-30 Merck & Co. Inc. EP4 receptor agonist, compositions and methods thereof
EP1479675A1 (fr) * 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH Derivés d'indazole en tant qu'inhibiteurs du facteur Xa

Also Published As

Publication number Publication date
JP2007504236A (ja) 2007-03-01
US20070027188A1 (en) 2007-02-01
AU2004271978A1 (en) 2005-03-24
CA2537430A1 (fr) 2005-03-24
EP1663221A1 (fr) 2006-06-07
US7494983B2 (en) 2009-02-24
EP1663221A4 (fr) 2009-04-22
WO2005025568A1 (fr) 2005-03-24
AU2004271978B2 (en) 2009-02-05

Similar Documents

Publication Publication Date Title
CN1816530A (zh) 用于治疗高眼压症的眼用组合物
CN1213026C (zh) N－杂环化合物的羧酸和羧酸电子等排物
CN1249051C (zh) 毒蕈碱性激动剂
CN1127493C (zh) 苯环的2－位被取代的1－(n－苯氨基烷基)－哌嗪衍生物
CN1152030C (zh) 新的杂环化合物
CN1859904A (zh) 用于治疗阿尔茨海默氏病的苄醚和苄氨基β－分泌酶抑制剂
CN1221417A (zh) 具有抗糖尿病、降低血脂、抗高血压性能的噻唑烷二酮化合物,其制备方法及其药物组合物
CN1374082A (zh) 糖原磺酸化酶抑制剂的用途
CN1745077A (zh) 促旋酶抑制剂及其用途
CN1140709A (zh) 被取代的N-(吲哚-2-羰基)-β-丙氨酰胺与作为抗糖尿病药的衍生物
CN1200124A (zh) 作为促性腺激素释放激素拮抗剂的噻吩并吡啶衍生物
TWI250873B (en) Ophthalmic compositions for treating ocular hypertension
CN1845914A (zh) 用于治疗眼压过高的眼用组合物
CN1158610A (zh) 可用于治疗的喹喔啉衍生物
CN1845904A (zh) 用于治疗高眼压的眼用组合物
CN1842335A (zh) 用于治疗高眼压的眼用组合物
CN85108132A (zh) 化合物制备方法
JP2005532363A (ja) 高眼圧を治療するための眼用組成物
US7563816B2 (en) Ophthalmic compositions for treating ocular hypertension
HK1097541A (en) Ophthalmic compositions for treating ocular hypertension
CN1832943A (zh) 趋化因子受体活性的四氢吡喃杂环环戊基杂芳基调制剂
CN1708484A (zh) 用于治疗高眼压症的眼用组合物
US20080097108A1 (en) Ophthalmic Compositions for Treating Ocular Hypertension
CN1217699C (zh) 心律失常的预防剂或药物
HK1048472A1 (en) Sodium-hydrogen exchanger type 1 inhibitor crystals

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C12 Rejection of a patent application after its publication
RJ01 Rejection of invention patent application after publication

Open date: 20061004