CN1966108A - HIFU tumour ablation system - Google Patents

HIFU tumour ablation system Download PDF

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Publication number
CN1966108A
CN1966108A CNA2005101103877A CN200510110387A CN1966108A CN 1966108 A CN1966108 A CN 1966108A CN A2005101103877 A CNA2005101103877 A CN A2005101103877A CN 200510110387 A CN200510110387 A CN 200510110387A CN 1966108 A CN1966108 A CN 1966108A
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hifu
therapy equipment
magnetic material
tumour ablation
ablation system
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Inventor
蒋继伟
董家贤
马海锦
陈义胜
周勇
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Shanghai A&S Science Technology Development Co Ltd
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Shanghai A&S Science Technology Development Co Ltd
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Priority to CNA2005101103877A priority Critical patent/CN1966108A/en
Priority to PCT/CN2006/000322 priority patent/WO2007056905A1/en
Publication of CN1966108A publication Critical patent/CN1966108A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N7/02—Localised ultrasound hyperthermia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/225—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves
    • A61B17/2256—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves with means for locating or checking the concrement, e.g. X-ray apparatus, imaging means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/38—Systems for generation, homogenisation or stabilisation of the main or gradient magnetic field
    • G01R33/3806—Open magnet assemblies for improved access to the sample, e.g. C-type or U-type magnets
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/4808—Multimodal MR, e.g. MR combined with positron emission tomography [PET], MR combined with ultrasound or MR combined with computed tomography [CT]
    • G01R33/4814—MR combined with ultrasound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/225—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves
    • A61B17/2256—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves with means for locating or checking the concrement, e.g. X-ray apparatus, imaging means
    • A61B17/2258—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves with means for locating or checking the concrement, e.g. X-ray apparatus, imaging means integrated in a central portion of the shock wave apparatus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B90/37—Surgical systems with images on a monitor during operation
    • A61B2090/374—NMR or MRI

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  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • General Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Surgery (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Theoretical Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

本发明公开了一种HIFU肿瘤消融系统，其包括至少一个HIFU治疗装置，还包括一个开放式MRI系统，该开放式MRI系统的磁性材料垂直于地面设置，该HIFU治疗装置设置于该磁性材料之间。本发明将MRI技术和HIFU技术融合为一体，开创性地将MRI系统的磁性材料从传统的水平上下放置改为垂直于水平面设置，使磁性材料间更方便安装HIFU治疗装置，本HIFU肿瘤消融系统的治疗技术更具安全性、可靠性、实用性和可信性，并且其还具有制造成本低、使用方便等优点。

Figure 200510110387

The invention discloses a HIFU tumor ablation system, which includes at least one HIFU treatment device, and also includes an open MRI system, the magnetic material of the open MRI system is arranged perpendicular to the ground, and the HIFU treatment device is arranged on the magnetic material between. The present invention integrates MRI technology and HIFU technology, and creatively changes the magnetic material of the MRI system from the traditional horizontal placement to vertical to the horizontal plane, making it easier to install HIFU treatment devices between the magnetic materials. This HIFU tumor ablation system The treatment technology is more safe, reliable, practical and credible, and it also has the advantages of low manufacturing cost and convenient use.

Figure 200510110387

Description

The HIFU tumour ablation system
Technical field
The present invention relates to a kind of oncotherapy field, particularly the HIFU tumour ablation system.
Background technology
Signal that the magnetic resonance phenomenon produced utilize to be collected and the imaging technique of reconstructed image by MRI (Magnetic Resonance Imaging nuclear magnetic resonance) system.Atomic nucleus in the tissue (contain radix proton or neutron, refer generally to the hydrogen proton) magnetizes in high-intensity magnetic field, after gradient fields gives space orientation, radio-frequency pulse encourages the hydrogen proton of specific precession frequency, and the energy that the hydrogen proton of accepting to encourage discharges in relaxation process is exactly a magnetic resonance signal.By computer magnetic resonance signal is collected, become the black and white GTG by the different switching of signal intensity, opsition dependent is formed two dimension or three-dimensional form, finally forms magnetic resonance image (MRI) (MRI).It has no radiation infringement, the pseudo-shadow of no bone, can many-side, the advantage of multiparameter imaging, soft tissue resolution capability highly.In addition, the parameters relevant with temperature such as the change that utilizes the hydrogen proton resonance frequency among the MRI and spin lattice relaxation time change, and can realize the real-time thermometric of patient's noinvasive.
The building block of MRI system has magnet, spectrometer, patient's bogey, computer analysis software etc.Present employed MRI system, its magnet has two kinds of versions substantially, and a kind of is Open architecture, and a magnetic material respectively is set up and down, and the main stationary magnetic field that is produced is called open MRI systems perpendicular to ground; Another kind of MRI system is a loop configuration, produces main stationary magnetic field at the annular space of a sealing, during use, needs the patient is placed in this annular space.
The element of HIFU (High Intensity Focused Ultrasound high intensity focused ultrasound) tumour ablation system has: HIFU therapy equipment (claiming that again ultrasonic transducer, transducer group, wave source, treatment are first-class), the patient's bogey that is used to carry the patient, computer control software, power generator etc.
Its base therapy principle is to send ultrasonic beam by single or a plurality of ultrasonic transducers, focuses on through media target area in body by the patient is external, makes the ultrasonic sound intensity at focus place, target area reach several thousand even several ten thousand W/cm 2The biological tissue at focus place, target area produces violent mechanical vibration (relaxation) under the synergetic effect of energy, constantly orderly molecular vibration energy is changed into unordered molecular thermalmotion energy, be that mechanical energy is converted to the heat energy in the medium, the temperature of focus place, target area biological tissue was risen to more than 65 ℃ in moment (0.1-ls), make protein that irreversible coagulation necrosis takes place rapidly.Because in the so short time, non-target area is organized and can be subjected to the HIFU damage hardly, " melts " (ablation) purpose of tumor so can reach noinvasive.The tumor therapeuticing method that HIFU tumour ablation treating technology is a kind of noinvasive, have no side effect has become the research focus of international academic community in recent years, and obtains using widely day by day in medical circle.
The HIFU treatment technology has obtained certain clinical practice and has promoted, and has confirmed that China is the country that clinical practice HIFU treatment technology the earliest in the world, quantity is maximum at present, also is to manufacture maximum country of this system product enterprise.
HIFU therapy system in the market all adopts the guiding of B ultrasonic image to implement the location, and system exists fatal defectives such as imaging effect is unintelligible, the tumor-localizing precision is inaccurate, security reliability is relatively poor relatively.In addition, can't carry out noinvasive thermometric, the real-time curative effect assessment of iconography, also become the puzzlement of its clinical practice.
The EXABLTE 2000 type supersonic therapeutic systems that Israel INSIGHTEC company produces adopt the 1.5T magnetic resonance imaging system guiding location of U.S. GE company, and imaging effect is clear, and tumor-localizing is accurate.But because what use is high-field MRI systems, its magnet selects for use superconductor to make, and need use the cooling back installation of liquid nitrogen, makes whole system too expand, operate loaded down with trivial details relatively, the manufacturing cost costliness.And the MRI components of system as directed adopts traditional loop configuration in the HIFU system that they use.
Summary of the invention
The objective of the invention is to overcome the defective of above-mentioned prior art, a kind of brand-new HIFU tumour ablation system is provided.
The objective of the invention is to be achieved through the following technical solutions:
A kind of HIFU tumour ablation system, it comprises at least one HIFU therapy equipment, also comprises an open MRI systems, and the magnetic material of this open MRI systems is provided with perpendicular to ground, and this HIFU therapy equipment is arranged between this magnetic material.
Wherein, the direction of the main stationary magnetic field of this MRI system is parallel to the ground.
Wherein, this HIFU therapy equipment is the overhead HIFU therapy equipment on top between the magnetic material that is located at this open MRI systems.
In addition, this HIFU therapy equipment can also be the underneath type HIFU therapy equipment of bottom between the magnetic material that is located at this open MRI systems.
Perhaps, this HIFU tumour ablation system comprises the underneath type HIFU therapy equipment of bottom between the overhead HIFU therapy equipment on top between the magnetic material that is located at this open MRI systems and the magnetic material that is located at this open MRI systems.
Wherein, the mode of this overhead HIFU therapy equipment employing suspension or support is arranged on the top between this magnetic material.
This underneath type HIFU therapy equipment is carried on the base of this HIFU tumour ablation system.
In addition, this system also comprises patient's bogey, and it links to each other with this base by a lowering or hoisting gear, and links to each other with this underneath type HIFU therapy equipment by encapsulant.
And this patient's bogey is provided with and the corresponding perforate of this underneath type HIFU therapy equipment.
Positive progressive effect of the present invention is: the present invention is an one with MRI technology and HIFU technological incorporation, in a creative way the magnetic material of MRI system is placed up and down from traditional level and changed into perpendicular to the horizontal plane setting, make more convenient installation HIFU therapy equipment between magnetic material, by utilizing MRI system placement technology, the real time temperature change detection techniques, the real-time imaging technology of high-resolution etc., solved the accurate location during puzzlement B ultrasonic formula HIFU system development is used, the noinvasive thermometric, fundamental issues such as curative effect assessment, broken through the development bottleneck of HIFU tumour ablation technology, make the HIFU treatment technology have more safety, reliability, practicality and credibility, and it also has low cost of manufacture, advantage such as easy to use.
Description of drawings
Fig. 1 is the front schematic view of the embodiment of the invention 1.
Fig. 2 is the side schematic view of the embodiment of the invention 1.
The specific embodiment
Embodiment 1
Shown in Fig. 1-2, a kind of HIFU tumour ablation system, comprise an open MRI systems, the magnetic material 5,6 of this open MRI systems is provided with perpendicular to ground, the direction of the main stationary magnetic field of this MRI system is parallel to the ground, also comprise the underneath type HIFU therapy equipment 2 of bottom between the overhead HIFU therapy equipment 1 on top between the magnetic material that is located at this open MRI systems and the magnetic material that is located at this open MRI systems, also comprise patient's bogey 3 that is used to carry the patient.
Magnetic material 5,6 is vertically set on a level and places on the base 4 on ground, and the MRI magnetic resonance imaging system adopts Open architecture, and its opening makes progress, and the HIFU high intensity focused ultrasound system places the opening part of this MRI magnetic resonance imaging system.
Wherein, the mode that this overhead HIFU therapy equipment 1 employing is hung or supported is arranged on the top between this magnetic material 5,6, is positioned at the top of this patient's bogey 3, promptly is positioned at patient's top.
In the present embodiment, this overhead HIFU therapy equipment 1 is connected with two magnetic materials 5,6 by a support 8, is suspended on the top of this patient's bogey 3.This overhead HIFU therapy equipment 1 can be waved along the location of axially and radially the doing of patient's bogey 3＜90 ° through control.
This underneath type HIFU therapy equipment 2 is positioned at the below of patient's bogey 3, is located on this base 4, links to each other with patient's bogey 3 by encapsulant (figure does not show).
Patient's bogey 3 be carried on one with lowering or hoisting gear 9 that the base 4 of HIFU tumour ablation system is connected on.This lowering or hoisting gear 9 is located on the base 4, and this patient's bogey 3 is provided with and underneath type HIFU therapy equipment 2 corresponding perforates, uses during for underneath type HIFU therapy equipment 2 treatments.
During concrete the application, the motion of the top to bottom, left and right, front and rear by control patient bogey 3, the magnetic field central authorities that the magnetic material 5,6 that makes patient 7 be in the MRI magnetic resonance imaging system forms constitute the HIFU tumour ablation system under the incorporate MRI guiding, thereby reach the purpose of treatment tumor.
Embodiment 2
Embodiment 2 difference from Example 1 are: this HIFU therapy equipment is an overhead HIFU therapy equipment that is positioned at patient's bogey top, and figure does not show that other structure of embodiment 2 is all identical with embodiment 1, does not do at this and gives unnecessary details.
Embodiment 3
Embodiment 3 difference from Example 1 are: this HIFU therapy equipment is a underneath type HIFU therapy equipment that is positioned at patient's bogey below, and figure does not show that other structure of embodiment 3 is all identical with embodiment 1, does not do at this and gives unnecessary details.

Claims (9)

1, a kind of HIFU tumour ablation system, it comprises at least one HIFU therapy equipment, it is characterized in that: it also comprises an open MRI systems, and the magnetic material of this open MRI systems is provided with perpendicular to ground, and this HIFU therapy equipment is arranged between this magnetic material.
2, HIFU tumour ablation system according to claim 1, it is characterized in that: the direction of the main stationary magnetic field of this MRI system is parallel to the ground.
3, HIFU tumour ablation system according to claim 1 is characterized in that: this HIFU therapy equipment is the overhead HIFU therapy equipment on top between the magnetic material that is located at this open MRI systems.
4, HIFU tumour ablation system according to claim 1 is characterized in that: this HIFU therapy equipment is the underneath type HIFU therapy equipment of bottom between the magnetic material that is located at this open MRI systems.
5, HIFU tumour ablation system according to claim 1 is characterized in that: it comprises the underneath type HIFU therapy equipment of bottom between the overhead HIFU therapy equipment on top between the magnetic material that is located at this open MRI systems and the magnetic material that is located at this open MRI systems.
6, according to claim 3 or 5 described HIFU tumour ablation systems, it is characterized in that: the mode that this overhead HIFU therapy equipment employing is hung or supported is arranged on the top between this magnetic material.
7, according to claim 4 or 5 described HIFU tumour ablation systems, it is characterized in that: this underneath type HIFU therapy equipment is carried on the base of this HIFU tumour ablation system.
8, HIFU tumour ablation system according to claim 7 is characterized in that, it also comprises patient's bogey, and it links to each other with this base by a lowering or hoisting gear, and links to each other with this underneath type HIFU therapy equipment by encapsulant.
9, HIFU tumour ablation system according to claim 8 is characterized in that, this patient's bogey is provided with and the corresponding perforate of this underneath type HIFU therapy equipment.
CNA2005101103877A 2005-11-16 2005-11-16 HIFU tumour ablation system Pending CN1966108A (en)

Priority Applications (2)

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CNA2005101103877A CN1966108A (en) 2005-11-16 2005-11-16 HIFU tumour ablation system
PCT/CN2006/000322 WO2007056905A1 (en) 2005-11-16 2006-03-03 Hifu tumor ablating system

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101947129A (en) * 2010-10-12 2011-01-19 上海交通大学 Phase-control high-intensity focusing ultrasonic transducer and magnetic resonance breast coil integrating device
CN102333567A (en) * 2009-02-27 2012-01-25 皇家飞利浦电子股份有限公司 Therapeutic apparatus for treating a subject using magnetic nanoparticles
US8942781B2 (en) 2008-04-09 2015-01-27 Universite Pierre Et Marie Curie (Paris 6) Medical system comprising a percutaneous probe
CN108969909A (en) * 2018-07-25 2018-12-11 宋世鹏 The radiotherapy system of therapeutic purpose can be followed
CN110177599A (en) * 2017-01-12 2019-08-27 医视特有限公司 Overcoming sound field and skull inhomogeneities

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US5247935A (en) * 1992-03-19 1993-09-28 General Electric Company Magnetic resonance guided focussed ultrasound surgery
US5275165A (en) * 1992-11-06 1994-01-04 General Electric Company Magnetic resonance guided ultrasound therapy system with inclined track to move transducers in a small vertical space
JP3860227B2 (en) * 1993-03-10 2006-12-20 株式会社東芝 Ultrasonic therapy device used under MRI guide
US5443068A (en) * 1994-09-26 1995-08-22 General Electric Company Mechanical positioner for magnetic resonance guided ultrasound therapy
ATE419789T1 (en) * 1997-05-23 2009-01-15 Prorhythm Inc HIGH INTENSITY DISPOSABLE FOCUSING ULTRASONIC APPLICATOR
US6582381B1 (en) * 2000-07-31 2003-06-24 Txsonics Ltd. Mechanical positioner for MRI guided ultrasound therapy system
US10342558B2 (en) * 2003-09-30 2019-07-09 Koninklijke Philips N.V. Target tracking method and apparatus for radiation treatment planning and delivery

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8942781B2 (en) 2008-04-09 2015-01-27 Universite Pierre Et Marie Curie (Paris 6) Medical system comprising a percutaneous probe
CN102333567A (en) * 2009-02-27 2012-01-25 皇家飞利浦电子股份有限公司 Therapeutic apparatus for treating a subject using magnetic nanoparticles
CN102333567B (en) * 2009-02-27 2014-04-30 皇家飞利浦电子股份有限公司 Therapeutic apparatus for treating a subject using magnetic nanoparticles
CN101947129A (en) * 2010-10-12 2011-01-19 上海交通大学 Phase-control high-intensity focusing ultrasonic transducer and magnetic resonance breast coil integrating device
CN101947129B (en) * 2010-10-12 2012-03-21 上海交通大学 Phase-control high-intensity focusing ultrasonic transducer and magnetic resonance breast coil integrating device
CN110177599A (en) * 2017-01-12 2019-08-27 医视特有限公司 Overcoming sound field and skull inhomogeneities
CN110177599B (en) * 2017-01-12 2022-01-25 医视特有限公司 System for heating the target area
CN108969909A (en) * 2018-07-25 2018-12-11 宋世鹏 The radiotherapy system of therapeutic purpose can be followed

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