CN1969802A - Application of water soluble chitosan as skin care product - Google Patents

Application of water soluble chitosan as skin care product Download PDF

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Publication number
CN1969802A
CN1969802A CN 200510128065 CN200510128065A CN1969802A CN 1969802 A CN1969802 A CN 1969802A CN 200510128065 CN200510128065 CN 200510128065 CN 200510128065 A CN200510128065 A CN 200510128065A CN 1969802 A CN1969802 A CN 1969802A
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China
Prior art keywords
chitosan
water
soluble chitosan
scalp
dandruff
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CN 200510128065
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Chinese (zh)
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王立君
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Individual
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Individual
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Priority to CN 200510128065 priority Critical patent/CN1969802A/en
Publication of CN1969802A publication Critical patent/CN1969802A/en
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Abstract

The invention discloses an application of soluble chitose as antidandruff and antipruritic skin care products, which is characterized by the following: activating scalp cell to form barrier; accelerating microcirculation of scalp cell vessel; controlling the grease of pore; reducing died skin of scalp surface.

Description

Water-soluble chitosan is as the application of skin care item
Technical field
The present invention relates to the application of water-soluble chitosan as skin care item, particularly water-soluble chitosan application as anti-dandruff, the antipruritic expansion skin of scalp product.
Background technology
The water-soluble chitosan water-soluble chitosan be meant can be in neutral water a dissolved class chitosan, mainly contain chitosan, chitosan salt, the carboxymethyl chitosan of moderate deacetylation, obtain through taking off the acetyl post-modification by chitin, very extensive in natural distribution, there are aquatic arthropodan shells such as shrimp, Eriocheir sinensis, in molluscan ectoskeleton and the mushroom.The chitosan that moderate is taken off acetyl is meant the chitosan of its uniform deacetylation about 55% in the intramolecule structure, the crystal habit of this type of chitosan molecule inside is different from chitosan, because be that part is taken off acetyl, so original secondary structure of strand is destroyed, its crystallization almost can't be finalized the design, thereby have the advantages that to be dissolved in neutral water.Chitosan salt is to be the ionomeric characteristics of alkalescence according to chitosan, the water-soluble chitosan of a class that chitosan and acid are made after molten altogether.Chitosan salt can be dissolved by neutral water, and the pH value of its aqueous solution changes little.Carboxymethyl chitosan is to be a kind of modifier that raw material obtains through carboxy methylation with the chitosan, carboxymethyl chitosan can be water-soluble and alkaline aqueous solution in, but insoluble under acid condition, carboxymethyl chitosan has fungistatic effect preferably in the solution under the neutrallty condition.Because the effect of the effect of water-soluble chitosan and chitosan is identical, so water-soluble chitosan has been expanded the application of chitosan greatly.Water-soluble chitosan is the chitosan that a class has the number of chemical structure, and owing to having nothing in common with each other of its structure, its purposes also has nothing in common with each other.
Water-soluble chitosan is a kind of biomaterial that using value is arranged very much, now in food, chemical industry and pharmaceuticals industry, and as adjuvant or directly use,
(1) low deacetylation chitosan, the application of this type of material exploitation now also fewer is mainly used in the agricultural as soil conditioner and as the thickening agent in the field of food etc.
(2) chitosan hydrochlorate can be applicable to field of medicaments, makes some antibacterial medical material, as gauze etc.In bioengineering field, can be used as the biochemical reagents of specific function.
(3) carboxymethyl chitosan is owing to have bacterial inhibition biological body affinity and stronger characteristics such as moisture retention preferably, so it is mainly used in the fields such as medicine and cosmetics.As preparation be used to scald or mechanical damage after wound dressing: employed disinfectant solution and the cosmetics that are used for aspects such as beautifying face, preserving moisture behind the wound infection.Also can be used as food preservative.
At field of food, water-soluble chitosan is the health food as a new generation, it is the unique positively charged edible animal fiber of present occurring in nature, can in time discharge and enter the intravital harmful substance of people every day and recover the impaired function of health, the generation of diseases such as prevent diabetes, hypertension, hepatopathy, arthritis.
Water-soluble chitosan does not also have known to the inventor as the anti-dandruff application that ends overworked skin care item.And chitosan is used to end overworked anti-dandruff, owing to need to add the weak acid dissolving, hair and skin is had certain injury.
Dandruff product in the market is various, a feast for the eyes.Probably can divide two classes in many products in market: a class is shampoo, the shampoo of dandruff, and this class all is chemical products mostly; Another kind of is medicine goods class, Chinese medicine class and Chinese and Western association class.Two kinds of its main drawbacks all are must be clean with flushing with clean water after coating scalp, can not stay on the scalp for a long time, otherwise can cause injury and infringement to scalp and cell, hair.
Summary of the invention
The new purposes that the purpose of this invention is to provide water-soluble chitosan is promptly as the application of dandruff skin care item with as the application that ends the overworked skin care item of scalp.
The present invention uses the water-soluble chitosan self characteristics, makes a kind ofly can remove the dandruff and antipruritic, and the protection hair is submissive, guarantees the expansion skin product of scalp health and no side effects.
Beneficial effect of the present invention solves that head pruritus, the dandruff are many, the problem of scalp inflammation, energy dandruff, stopping head itching, guarantees scalp health and no side effects.
The specific embodiment
The dandruff medically is called " hair pityriasis ", and " head fat leak disease " is that dust filthy in the sebum of excess secretion and the air etc. mixes and forms, and its dandruff can be divided into two kinds, dryness dandruff and oiliness dandruff.The many distributions of dryness are loose on hair, and the squama that is white in color shape easily comes off: oiliness is bonded on the hair more, is the faint yellow bits of oils and fats sample, difficult drop-off.The vigorous person of brain overwork person and metabolism, easy repiece scurf, though or sebum few, because of cuticle cellular abnormality hypertrophy, also can easily produce the dandruff.
Through experiment, the affinity of water-soluble chitosan positive charge cation group oils and fats tool uniqueness, the water-soluble chitosan of 0.1-20% can activate the cell of scalp, can combine with the scalp top layer rapidly and form the barrier barrier film, cover on the scalp, soften cuticle, activate the cell of skin, promote the microcirculation of scalp top layer blood capillary, can evoke the replying of immunocyte of deep layer, promote that pore is smooth and easy, effectively control greasy decomposition and overflowed pore, combine with the cutin of pore mouth is too fast, farthest reduce the dead bark on scalp top layer.
The function of water-soluble chitosan tool sterilizing and itch-relieving, through experiment, the water-soluble chitosan of 0.1-20% all has bactericidal action to Gram-positive, feminine gender, and antibacterial, greasy anion that positively charged cation group all has correct fur hole to grow all have affinity interaction, to reach the effect of sterilization, antibacterial, antiinflammatory.
As the water-soluble chitosan of anti-dandruff, scalp antipruritic skin care preparation, its deacetylation must reach more than 80%.Water-soluble chitosan can water-soluble and neutral solution, just can fine when the water-soluble chitosan concentration of aqueous solution is 0.1-8% anti-dandruff, itching-relieving action.During practical application, make shampoo, protective skin cream or cold cream that water-soluble chitosan content is 1-15%, more convenient like this use is accepted by consumer easily.
The preparation of this water-soluble chitosan stock solution is dissolved in 0.9% with 250g deacetylation 80% water-soluble chitosan, and in the 750ml normal saline, square frame filters, and removes impurity, deacetylation is 80% water-soluble chitosan solution, sterilization, sterilization.
Contain 2.5% water-soluble chitosan anti-dandruff, end overworked skin care liquid, the preparation of cream frost, be 80% water-soluble chitosan 250 grams with deacetylation, add 0.9% physiological saline solution and add deionized water to 1000ml, stir 25% water-soluble chitosan concentrated solution.Get and contain 25% water-soluble chitosan concentrated solution 400ml, add vitamin B1 .3 gram, allantoin 0.6 gram, water-soluble plant camellia oil 3 grams, essence a little, filter sterilization promptly makes and contains 2.55% water-soluble chitosan anti-dandruff, itching-relieve skin-care liquid then, gets anti-dandruff and ends overworked expansion skin cream frost through adding monoglyceride, stearic acid, hexadecanol, octadecanol oil phase, the emulsifying of water high temperature.
The present invention is the biological preparation product of a kind of containing " aminated polysaccharide (water-soluble chitosan) ", vegetable oil, vitamin.Unique effect is arranged, and its advantage is can directly smear, spray, and need not clean and wash off, also be not subjected to the restriction of time, dosage, and product also contains the required nutrition of hair, no side effects, really be dandruff, end overworked germ-resistant product, consumer can relievedly use.
The present invention is good through tens routine experimenters' result of use, and concrete content of the test indicates as follows
Embodiment 1: with this product vacuum tank of packing into, spray into root of hair every day, use through 5 people, do not have the overworked sensation of scalp two days later, wherein 3 people's dandruffs reduce by 80%, 2 people's dandruff and reduce 65%.Oiliness is sent out system improvement rate 60% simultaneously.
Embodiment 2: the cotton mill, and test number 8 people, age 25-42 is exactly a scalp pruritus when next, scalp pruritus when next.
First day, this product 4 people on probation sprayed on the root of hair before the last machine, when next, just had 3 people to feel not itch, and 1 people feels that degree of itching alleviated more than 80% than in the past, and other 4 people do not spray this product, felt that scalp itches very much.
Second day is that 4 people continue to spray this product equally, and sensory effect is all fine when coming off duty, and does not itch.The people that other 4 people do not spray this product feels that scalp is more and more overworked, and the dandruff is more and more, and scalp ached after also feeling of having scratched, but also hyporrhea.At this moment, experiencing of spraying that the people of this product can both be very fast is not only antipruritic, also has a kind of algefacient sensation.Long run test is three days like this, and they feel only overworked in various degree, and the dandruff also obviously reduces, have 2 people's effects best be that scalp is no longer overworked, scurf also reduces 85%.Have the 3 people degree of itching to reduce 85%, the dandruff reduces more than 60%.It is grease type that their hair matter of 2 Mies is arranged, and it is better than in the past that they use this product aftersensation, and general ratio is 60%.
After the embodiment 3:5 people hair washing, this product is dissolved in the 500ml water, with the water-soluble chitosan hair washing, wherein 1 people did not have obvious dandruff in 15 days, and 3 people did not have obvious dandruff in 10 days, and 1 people did not have obvious dandruff in 7 days.
Embodiment 4: person on probation five people, professional builder is between 25 to 55 years old age.
Before the test, they every day occurs scalp pruritus in various degree, and scalp lumps and shaves one's head.
Spray this product before the working, the head pruritus degree is clearly better, and also has the algefacient sensation, and rate of perspiration also reduces, and uses ten days continuously, and their reaction effect is felt quite pleased, and difficult problems such as scalp pruritus can both solve.

Claims (3)

1. water-soluble chitosan is as the application of dandruff skin care item.
2. water-soluble chitosan is as the application of scalp antipruritic skin care preparation.
3. described water-soluble chitosan be meant can be in neutral water a dissolved class chitosan, comprise chitosan, chitosan salt, carboxymethyl chitosan, the oligochitosan (oligo-chitosan) of moderate deacetylation, but be not limited thereto.
CN 200510128065 2005-11-25 2005-11-25 Application of water soluble chitosan as skin care product Pending CN1969802A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN 200510128065 CN1969802A (en) 2005-11-25 2005-11-25 Application of water soluble chitosan as skin care product

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN 200510128065 CN1969802A (en) 2005-11-25 2005-11-25 Application of water soluble chitosan as skin care product

Publications (1)

Publication Number Publication Date
CN1969802A true CN1969802A (en) 2007-05-30

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102018633A (en) * 2010-12-15 2011-04-20 广州潮徽化工科技有限公司 Efficient scurf removing and itch relieving composite as well as preparation method and application thereof in shampoos
US8303997B2 (en) 2008-08-04 2012-11-06 Polichem Sa Film-forming liquid formulations for drug release to hair and scalp
CN103784372A (en) * 2014-02-19 2014-05-14 北京德喜天地科贸有限公司 Cosmetic containing chitosan
CN106821907A (en) * 2017-02-14 2017-06-13 玉林祺钟商贸有限公司 A kind of efficient cosmetic hair care and preparation method
CN110075064A (en) * 2019-05-28 2019-08-02 厦门华言科技有限公司 A kind of prevention and treatment alopecia masking liquid and preparation method thereof
CN114533586A (en) * 2021-11-23 2022-05-27 广州市科能化妆品科研有限公司 Dandruff-removing itching-relieving shampoo composition, and preparation method and application thereof

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8303997B2 (en) 2008-08-04 2012-11-06 Polichem Sa Film-forming liquid formulations for drug release to hair and scalp
CN105194675A (en) * 2008-08-04 2015-12-30 波利化学公司 Film-forming liquid formulations for drug release to hair and scalp
CN102018633A (en) * 2010-12-15 2011-04-20 广州潮徽化工科技有限公司 Efficient scurf removing and itch relieving composite as well as preparation method and application thereof in shampoos
CN102018633B (en) * 2010-12-15 2012-04-25 广州潮徽化工科技有限公司 Dandruff-removing and itching-relieving composition, preparation method thereof and application thereof in shampoo
CN103784372A (en) * 2014-02-19 2014-05-14 北京德喜天地科贸有限公司 Cosmetic containing chitosan
CN106821907A (en) * 2017-02-14 2017-06-13 玉林祺钟商贸有限公司 A kind of efficient cosmetic hair care and preparation method
CN110075064A (en) * 2019-05-28 2019-08-02 厦门华言科技有限公司 A kind of prevention and treatment alopecia masking liquid and preparation method thereof
CN114533586A (en) * 2021-11-23 2022-05-27 广州市科能化妆品科研有限公司 Dandruff-removing itching-relieving shampoo composition, and preparation method and application thereof

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