CN209437726U - A kind of quaternized chitin lamination antiseptic dressing - Google Patents
A kind of quaternized chitin lamination antiseptic dressing Download PDFInfo
- Publication number
- CN209437726U CN209437726U CN201821663831.7U CN201821663831U CN209437726U CN 209437726 U CN209437726 U CN 209437726U CN 201821663831 U CN201821663831 U CN 201821663831U CN 209437726 U CN209437726 U CN 209437726U
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- Prior art keywords
- lamination
- dressing
- layer
- sponge
- quaternized
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- 230000002421 anti-septic effect Effects 0.000 title claims abstract description 25
- 238000003475 lamination Methods 0.000 title claims abstract description 25
- 229920002101 Chitin Polymers 0.000 title claims abstract description 22
- 239000002121 nanofiber Substances 0.000 claims abstract description 12
- 238000001523 electrospinning Methods 0.000 claims abstract description 8
- 239000000835 fiber Substances 0.000 claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
- 238000004108 freeze drying Methods 0.000 claims abstract description 7
- 229920001610 polycaprolactone Polymers 0.000 claims abstract description 7
- 239000004632 polycaprolactone Substances 0.000 claims abstract description 7
- 239000004745 nonwoven fabric Substances 0.000 claims abstract description 5
- 230000000844 anti-bacterial effect Effects 0.000 claims description 5
- 230000008961 swelling Effects 0.000 claims description 4
- 241000588724 Escherichia coli Species 0.000 claims description 3
- 241000191967 Staphylococcus aureus Species 0.000 claims description 3
- 238000010521 absorption reaction Methods 0.000 claims description 3
- 230000005540 biological transmission Effects 0.000 claims description 3
- 238000005516 engineering process Methods 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 238000009958 sewing Methods 0.000 claims description 2
- 239000000463 material Substances 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 1
- 230000000845 anti-microbial effect Effects 0.000 abstract description 3
- 230000000474 nursing effect Effects 0.000 abstract description 2
- 230000036560 skin regeneration Effects 0.000 abstract description 2
- 208000027418 Wounds and injury Diseases 0.000 description 18
- 241000894006 Bacteria Species 0.000 description 4
- 239000012530 fluid Substances 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000008929 regeneration Effects 0.000 description 2
- 238000011069 regeneration method Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 206010072170 Skin wound Diseases 0.000 description 1
- 206010048038 Wound infection Diseases 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000004520 agglutination Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 230000019771 cognition Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 238000005213 imbibition Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000009456 molecular mechanism Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 238000005067 remediation Methods 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 230000003685 thermal hair damage Effects 0.000 description 1
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- Materials For Medical Uses (AREA)
Abstract
The utility model relates to medical treatment and nursing instrument fields, and in particular to a kind of quaternized chitin lamination antiseptic dressing.The lamination antiseptic dressing is from top to bottom successively made of layers of nanofibers, sponge dressing layer and basal layer.The layers of nanofibers is made of electrospinning polycaprolactone fiber；The sponge dressing layer is made of quaternized chitin freeze-drying sponge；The basal layer is made of non-woven fabrics.Quaternized chitin lamination antiseptic dressing structure provided by the utility model is simple, and with excellent anti-microbial property and water suction performance of keeping humidity, has biggish application value in skin regeneration field.
Description
Technical field
The utility model relates to medical treatment and nursing instrument fields, and in particular to a kind of quaternized chitin lamination antiseptic dressing.
Background technique
Skin is the maximum histoorgan of human body, and how to improve post-traumatic remediation efficiency is always the hot spot being concerned
Problem.During clinical diagnosis and treatment, the use of wound dressing is very extensive, as hospital gauze can effective flap coverage, prevent
The generation of secondary injury and wound contamination.Bacterium infection is the most common complication of skin wound, frequently results in wound delay
It is not cured, or even endangers the life security of patient.To solve the above problems, research staff has developed miscellaneous antiseptic dressing
To prevent and treat bacterium infection.
Skin histology can generated a large amount of wound fluid by thermal damage such as burnt degree, easily the induction of the pollution surface of a wound
Bacteria breed.Clinician generallys use the modes such as gauze covering or negative pressure drainage and shifts wound fluid and then keep the surface of a wound
Relatively dry.With constantly bringing forth new ideas for life science in recent years, molecular mechanism and regulation of the research staff to regeneration
Strategy has further cognition.With traditional concept on the contrary, the local wound microenvironment that current research discovery moistens can promote epithelium
The proliferation and migration of cell, and then accelerate the agglutination of the surface of a wound.Therefore, traditional wound dressing including antiseptic dressing
Through the demand that cannot fully meet clinical application.Exploitation novel absorbent moisture retention wound dressing has become skin tissue engineering field
One of main flow direction.
In this context, it for the physics and chemistry and biology demand of wound reparation, provides and a kind of has both excellent anti-microbial property
There is biggish application value with the wound dressing of water suction performance of keeping humidity.
Summary of the invention
The purpose of the utility model is to overcome deficiencies in the prior art, provide a kind of quaternized chitin lamination antibacterial
Dressing, structure is simple, and with excellent anti-microbial property and water suction performance of keeping humidity, has biggish push away in skin regeneration field
Wide application value.
To achieve the above object, the utility model uses following technical scheme:
A kind of quaternized chitin lamination antiseptic dressing, which is characterized in that the lamination antiseptic dressing is from top to bottom successively
It is made of layers of nanofibers (1), sponge dressing layer (2) and basal layer (3)；The layers of nanofibers (1) is by electrospinning polycaprolactone
Fiber composition；The sponge dressing layer (2) is made of quaternized chitin freeze-drying sponge；The basal layer (3) is by non-woven fabrics group
At.
Preferably, the diameter of the electrospinning polycaprolactone fiber be 100-300 nm, the fibrous layer with a thickness of 0.1-
0.15 mm。
Preferably, the quaternized chitin freeze-drying sponge with a thickness of 1-3 mm, porosity 95-99%.
Preferably, the layers of nanofibers, sponge dressing layer are identical with basal layer shape, equal in magnitude, pass through sewer
Skill is combined with each other.
Preferably, the water absorption and swelling rate of the lamination antiseptic dressing is 760-1450%, moisture-vapor transmission 2200-
3000 g/m2·24h。
Preferably, the lamination antiseptic dressing is not less than 97% to the bacteriostasis rate of staphylococcus aureus and Escherichia coli.
Compared to the prior art, quaternized chitin compound antiseptic dressing described in the utility model uses above-mentioned technology
Method has reached following technical effect: electrospinning polycaprolactone fiber has good biocompatibility in layers of nanofibers (1),
And tissue is not glued, it can reduce pain of patient during dressing.Sponge is lyophilized in quaternized chitin in sponge dressing layer (2)
With excellent water imbibition, a large amount of wound fluid can be absorbed, maintains surface of a wound relative clean.Freeze-drying sponge sucks in water swelling after
Hydrogel can be formed and slowly evaporate moisture, the moist environment of the surface of a wound is maintained to promote histocyte regeneration.In addition, quaternized first
Shell element is a kind of biomaterial with broad spectrum antibacterial, can effectively inhibit bacteria breed, prevents and treats bacterial wound
Infection.The application of non-woven fabrics can further increase the mechanical property of lamination antiseptic dressing in basal layer (3).
Detailed description of the invention
Fig. 1 is the utility model overall structure diagram.
In attached drawing: 1- layers of nanofibers, 2- sponge dressing layer, 3- basal layer.
Specific embodiment
The utility model is understood and implemented for the ease of those of ordinary skill in the art, it is right with reference to the accompanying drawings and embodiments
The utility model is described in further detail, it should be appreciated that embodiment described herein is only used for describing and explaining this
Utility model is not used to limit the utility model.
As shown in Figure 1, Fig. 1 is the overall structure diagram of the quaternized chitin lamination antiseptic dressing of the utility model.Institute
Lamination antiseptic dressing is stated from top to bottom successively to be made of layers of nanofibers (1), sponge dressing layer (2) and basal layer (3)；It is described to receive
Rice fibrous layer (1) is made of electrospinning polycaprolactone fiber；Sponge group is lyophilized by quaternized chitin in the sponge dressing layer (2)
At；The basal layer (3) is made of non-woven fabrics.The diameter of the electrospinning polycaprolactone fiber is 100-300 nm；The fiber
Layer with a thickness of 0.1-0.15 mm；The quaternized chitin freeze-drying sponge with a thickness of 1-3 mm, porosity 95-99%；
The layers of nanofibers, sponge dressing layer are identical with basal layer shape, equal in magnitude, are combined with each other by sewing technology；Institute
The water absorption and swelling rate for stating lamination antiseptic dressing is 760-1450%, and moisture-vapor transmission is 2200-3000 g/m2·24h；It is described
Lamination antiseptic dressing is not less than 97% to the bacteriostasis rate of staphylococcus aureus and Escherichia coli.The main effect of the utility model
With antibacterial and maintenance surface of a wound moist environment is, to promote wound reparation.
As it will be easily appreciated by one skilled in the art that the above is only the preferred embodiment of the utility model only, not
To limit the utility model, any modification made within the spirit and principle of the present invention, equivalent replacement and change
Into etc., it should be included within the scope of protection of this utility model.
Claims (6)
1. a kind of quaternized chitin lamination antiseptic dressing, which is characterized in that the lamination antiseptic dressing from top to bottom successively by
Layers of nanofibers (1), sponge dressing layer (2) and basal layer (3) composition；The layers of nanofibers (1) is fine by electrospinning polycaprolactone
Dimension composition；The sponge dressing layer (2) is made of quaternized chitin freeze-drying sponge；The basal layer (3) is made of non-woven fabrics.
2. a kind of quaternized chitin lamination antiseptic dressing as described in claim 1, which is characterized in that the electrospinning is gathered in oneself
The diameter of ester fiber be 100-300 nm, the fibrous layer with a thickness of 0.1-0.15 mm.
3. a kind of quaternized chitin lamination antiseptic dressing as described in claim 1, which is characterized in that the quaternized crust
Element freeze-drying sponge with a thickness of 1-3 mm, porosity 95-99%.
4. a kind of quaternized chitin lamination antiseptic dressing as described in claim 1, which is characterized in that the nanofiber
Layer, sponge dressing layer are identical with basal layer shape, equal in magnitude, are combined with each other by sewing technology.
5. a kind of quaternized chitin lamination antiseptic dressing as described in claim 1, which is characterized in that the lamination antibacterial is applied
The water absorption and swelling rate of material is 760-1450%, and moisture-vapor transmission is 2200-3000 g/m2·24h。
6. a kind of quaternized chitin lamination antiseptic dressing as described in claim 1, which is characterized in that the lamination antibacterial is applied
Material is not less than 97% to the bacteriostasis rate of staphylococcus aureus and Escherichia coli.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821663831.7U CN209437726U (en) | 2018-10-15 | 2018-10-15 | A kind of quaternized chitin lamination antiseptic dressing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821663831.7U CN209437726U (en) | 2018-10-15 | 2018-10-15 | A kind of quaternized chitin lamination antiseptic dressing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN209437726U true CN209437726U (en) | 2019-09-27 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201821663831.7U Expired - Fee Related CN209437726U (en) | 2018-10-15 | 2018-10-15 | A kind of quaternized chitin lamination antiseptic dressing |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN209437726U (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111513395A (en) * | 2020-05-18 | 2020-08-11 | 武汉大学 | A new type of anti-microbial environmental protection mask and method for making the same |
| CN111529748A (en) * | 2020-04-16 | 2020-08-14 | 东华大学 | Medical composite dressing for wound repair and preparation method thereof |
| CN114618006A (en) * | 2022-04-11 | 2022-06-14 | 北京服装学院 | Intelligent wound dressing, preparation method and application thereof, and flexible sensor |
| CN114681663A (en) * | 2020-12-31 | 2022-07-01 | 广州迈普再生医学科技股份有限公司 | Multifunctional composite wound dressing and preparation method thereof |
| CN115634305A (en) * | 2022-12-16 | 2023-01-24 | 郑州大学第一附属医院 | A kind of multifunctional electrospinning composite nanofiber material and its preparation method and application |
-
2018
- 2018-10-15 CN CN201821663831.7U patent/CN209437726U/en not_active Expired - Fee Related
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111529748A (en) * | 2020-04-16 | 2020-08-14 | 东华大学 | Medical composite dressing for wound repair and preparation method thereof |
| CN111529748B (en) * | 2020-04-16 | 2021-06-04 | 东华大学 | A kind of composite dressing for medical wound repair and preparation method thereof |
| CN111513395A (en) * | 2020-05-18 | 2020-08-11 | 武汉大学 | A new type of anti-microbial environmental protection mask and method for making the same |
| CN114681663A (en) * | 2020-12-31 | 2022-07-01 | 广州迈普再生医学科技股份有限公司 | Multifunctional composite wound dressing and preparation method thereof |
| CN114681663B (en) * | 2020-12-31 | 2023-05-05 | 广州迈普再生医学科技股份有限公司 | Multifunctional composite wound dressing and preparation method thereof |
| CN114618006A (en) * | 2022-04-11 | 2022-06-14 | 北京服装学院 | Intelligent wound dressing, preparation method and application thereof, and flexible sensor |
| CN114618006B (en) * | 2022-04-11 | 2022-11-25 | 北京服装学院 | Intelligent wound dressing, preparation method and application thereof, and flexible sensor |
| CN115634305A (en) * | 2022-12-16 | 2023-01-24 | 郑州大学第一附属医院 | A kind of multifunctional electrospinning composite nanofiber material and its preparation method and application |
| CN115634305B (en) * | 2022-12-16 | 2023-11-17 | 郑州大学第一附属医院 | Multifunctional electrostatic spinning composite nanofiber material and preparation method and application thereof |
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| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20190927 Termination date: 20201015 |