CN209678849U - A functional multilayer hemostatic antibacterial dressing - Google Patents

Abstract

The utility model discloses a functional multi-layer hemostatic and antibacterial dressing, which is a four-layer structure, which sequentially includes a wound contact layer, a liquid absorption layer, a barrier layer and a bandaging and fixing layer according to the contact with the wound surface from the inside to the outside. The wound contact layer is based on degradable natural polymer nanofibers with a diameter of 200-400 nm, and the drug-loaded inorganic materials are distributed in the nanofibers; the liquid absorption layer is made of water-absorbing fibers and The non-woven material layer is composed of superabsorbent resin; the barrier layer is a non-woven material layer composed of hydrophobic fibers; the wrapping and fixing layer is a low-sensitivity elastic medical adhesive tape layer in strip shape. Since the wound surface contact layer is a nanofibrous structure containing inorganic materials, the loaded drug can quickly reach the skin wound surface after being released, so as to realize the effects of hemostasis, antibacterial, and wound healing promotion. The utility model also has the characteristics of good biocompatibility, excellent physical and mechanical properties, simple preparation process and favorable industrial production.

Description

A functional multilayer hemostatic antibacterial dressing

technical field

The utility model belongs to the field of medical dressings, in particular to a functional multilayer hemostatic and antibacterial dressing, which is used for fast and effective hemostasis, antibacterial and accelerated wound healing of skin wounds.

Background technique

There are many types of wounds with different causes. The common wounds in daily life include acute trauma caused by mechanical damage, burns and other reasons. Hemorrhage and bacterial infection are the primary factors of traumatic death, and timely and effective hemostasis and antibacterial treatment are of great significance to save the lives of injured patients.

As a covering for wounds, medical dressings can replace damaged skin to act as a temporary barrier during wound healing, avoid and control wound infection, and provide an environment conducive to wound healing. The medical dressings used in the market still have many deficiencies, such as limited ability to absorb wound exudate, cannot maintain the moist environment required for wound healing during use, delay wound healing, need to be replaced many times, and are easy to adhere to the wound. It is easy to cause secondary injury, etc.; at the same time, people hope to shorten the wound recovery time. Therefore, the demand for multifunctional medical dressings in the world medical and health field will continue to increase.

Contents of the invention

Aiming at the defects of the prior art, the utility model provides a multifunctional medical dressing with good biocompatibility, excellent physical and mechanical properties, hemostatic and antibacterial effects, and accelerated skin wound healing.

In order to achieve the above-mentioned purpose of the invention, the technical solution adopted by the utility model is to provide a functional multilayer hemostatic antibacterial dressing, which is a four-layer structure, which includes a wound contact layer, a liquid absorption layer, and a wound contact layer from the inside to the outside according to the contact with the wound surface. The barrier layer and the dressing and fixing layer are compounded by adhesive or acupuncture; the wound contact layer is based on degradable natural polymer nanofibers with a diameter of 200-400 nm, and the drug-loaded inorganic materials are distributed In nanofibers; the liquid-absorbing layer is a non-woven material layer composed of water-absorbent fibers and superabsorbent resin; the barrier layer is a non-woven material layer composed of hydrophobic fibers, and the size of the barrier layer is larger than that of the wound surface The contact layer; the bandaging and fixing layer is a low-sensitivity elastic medical adhesive tape layer in the shape of a strip.

The degradable natural macromolecule nanofibers adopted in the utility model include silk fibroin and chitosan; 1 to 5%. The drugs contained in organic materials include hemostatic and antibacterial drugs; hemostatic drugs include vitamin K, 6-aminocaproic acid, p-carboxybenzylamine, tranexamic acid, protamine, adrenocortical hormone, immunosuppressant cyclophosphamide, One or more of Yunnan Baiyao, Panax notoginseng, Zhixueling, Agrimony, Bletilla striata, Comfrey, Rubia, Imperatae, Artemisia argyi, Zizhu, blood coagulation factors; antibacterial drugs include penicillins, cephalosporins, ammonia Qunan, vancomycin, fosfomycin, rifamycins, quinolones, aminoglycosides, polymyxins, macrolides, tetracyclines, chloramphenicol, lincomycins, One or more of nitrofurans, sulfonamides, and capreomycin.

The absorbent fibers used include viscose fibers and absorbent cotton fibers.

The hydrophobic fibers used include polypropylene, polyester, and nylon.

The multifunctional medical dressing provided by the utility model has the functions of antibacterial, hemostatic, breathable, and absorbing wound exudate, promoting wound healing and isolating the wound from external germs. Combined with the inorganic material drug-loading system, the administration time is longer and the drug release rate is higher. The wound contact layer directly covers the surface of the wound. The combination of hemostasis, antibacterial drugs and hemostatic inorganic materials can not only achieve rapid hemostasis and sterilization, but also prolong the administration time and increase the utilization rate of drug sustained release. The liquid absorption layer is mainly composed of non-woven materials composed of non-toxic and non-irritating viscose fiber, absorbent cotton and other fibers with good water absorption and superabsorbent resin, which has a water absorption capacity of 100 to 1000 times its own. It can quickly absorb water in blood and wound exudate. The barrier layer is mainly non-woven materials composed of polypropylene, polyester, nylon and other hydrophobic fibers, which can prevent wound exudate from leaking and impregnating the surrounding skin, and can prevent external germs and microorganisms from invading the wound and preventing infection. The bandaging and fixing layer is a low-sensitivity elastic medical adhesive tape with good air permeability and moderate viscosity, which is strip-shaped, and the number of adhesive tapes is selected based on the appropriate dressing size. The bandaging and fixing layer can fix the dressing, avoid falling off, and better protect the wound surface.

Compared with the prior art, the utility model has the following beneficial effects:

1. Non-stick wound: The wound contact layer of this utility model is a nanofiber layer with high porosity, which is beneficial to cell respiration, has good air permeability, and can promote tissue repair.

2. High liquid absorption rate: the use of high water absorption materials can quickly absorb wound exudate without leakage, and can also maintain a moist environment on the wound surface, which is conducive to wound recovery.

3. Effective antibacterial: The natural antibacterial material chitosan and the combination of antibacterial drugs and inorganic materials can improve the drug slow-release efficiency, prolong the drug slow-release time, and achieve effective antibacterial and bactericidal effects.

4. Rapid hemostasis: The inorganic material in the wound contact layer and the hemostatic drug loaded therein have strong hemostatic properties, and the liquid-absorbing layer promotes blood coagulation by rapidly absorbing wound exudate and moisture.

5. Anti-leakage and anti-bacteria: The use of a barrier layer can prevent the leakage of exudate and block the invasion of external bacteria.

6. Environmentally friendly and degradable: no need to change dressings many times, saving resources, and the selected organic raw materials are all degradable materials, which can reduce environmental pollution.

Description of drawings

Fig. 1 is a schematic structural view of a functional multilayer hemostatic antibacterial dressing provided by an embodiment of the present invention.

Wherein, 1 is a wound contact layer, 2 is a liquid absorbing layer, 3 is a barrier layer, and 4 is a dressing and fixing layer.

Detailed ways

The technical solution of the utility model will be further elaborated below in conjunction with the accompanying drawings and embodiments.

Example 1

Referring to Figure 1, it is a schematic structural diagram of a functional multi-layer hemostatic antibacterial dressing provided in this embodiment. It has a four-layer structure, which includes a wound contact layer 1, a liquid absorbing layer 2, a barrier layer 3 and a bandaging and fixing layer 4 in order from the inside to the outside according to the contact with the wound surface, and the layers are compounded by gluing or acupuncture.

Wound contact layer: it is the first layer that is in direct contact with the wound. In this example, vitamin K hemostatic drugs and penicillin antibacterial drugs were loaded onto the outer surface and interior of 0.15 g of the inorganic material halloysite by electrostatic adsorption. , 2.6 g of silk fibroin dry film was dissolved in 17.4 g of formic acid to make a silk fibroin solution with a mass fraction of 13%, and 0.6 g of chitosan was dissolved in 20 mL of acetic acid to make a 3% Chitosan solution, the mixture solution after mixing the above three raw materials is prepared into a nanofiber film by an electrospinning method, and a wound surface contact layer with hemostatic, antibacterial, moisture absorption and air permeability properties is obtained.

The wound contact layer of the functional multilayer hemostatic and antibacterial dressing of this embodiment is detected by scanning electron microscopy and transmission electron microscopy. It can be seen from the transmission electron microscopy that the drug-loaded inorganic material has been compounded into the electrospun fiber; it can be seen from the scanning electron microscopy , nanofibers have a high specific surface area, so they have the characteristics of good absorption. Inorganic materials loaded with hemostatic drugs can effectively improve the speed of wound hemostasis. When wound bacteria contact the dressing, the antibacterial drugs loaded in the inorganic materials The release can effectively inhibit and kill bacteria. Generally, the drug-loaded inorganic material used is 1-5% of the degradable natural polymer material, and the inorganic material includes halloysite, kaolin, and montmorillonite. The hemostatic drugs that can be used include vitamin K, 6-aminocaproic acid, p-carboxybenzylamine, tranexamic acid, protamine, adrenocortical hormone, immunosuppressant cyclophosphamide, Yunnan Baiyao, Panax notoginseng, Zhixueling, Agrimony , Bletilla striata, Comfrey, Rubia, Imperatae, Artemisia argyi, Purple Pearl, blood coagulation factor or one or more; the antibacterial drugs used include penicillins, cephalosporins, aztreonam, vancomycin, fosfomycin rifamycins, quinolones, aminoglycosides, polymyxins, macrolides, tetracyclines, chloramphenicols, lincomycins, nitrofurans, sulfonamides, curly One or more of the mycins.

Liquid absorption layer: It is made of non-woven materials composed of viscose fiber or absorbent cotton and other fibers with good water absorption and super absorbent resin with a water absorption capacity of 100 to 1000 times its own. The water in the wound exudate and blood is quickly absorbed , to promote blood coagulation, which is more conducive to the achievement of hemostasis, and the material after absorbing liquid can provide a moist environment for the wound surface, which is conducive to wound healing.

Barrier layer: non-woven material composed of breathable and impermeable polypropylene, polyester, nylon and other hydrophobic fibers is used as the outermost barrier layer to prevent wound exudate from seeping out and block the invasion of external germs. Its size is larger than that of hemostasis and antibacterial Floor.

Wrapping and fixing layer: Use low-sensitivity elastic medical adhesive tape with good air permeability and moderate viscosity, which is in the shape of a strip. The number of adhesive tapes is selected based on the appropriate dressing size. Better protect the wound surface.

The above wound contact layer, liquid absorption layer, barrier layer and bandage fixation layer are combined by adhesive or acupuncture, and are sutured and cut according to the size and shape of the wound to make a hemostatic, antibacterial, high liquid absorption rate, breathable and waterproof A multi-functional hemostatic and antibacterial dressing that sticks and promotes wound healing.

The dressing provided by the utility model has a simple structure, a correspondingly simple manufacturing process, and is suitable for industrialized production.

Claims (7)

1. A functional multi-layer hemostatic antibacterial dressing, characterized in that: it is a four-layer structure, which includes a wound contact layer (1), a liquid absorption layer (2), and a barrier layer ( 3) and the dressing and fixing layer (4), the layers are combined by adhesive or acupuncture; the wound contact layer uses degradable natural polymer nanofibers with a diameter of 200-400 nm as the base material, and the base material Drug-loaded inorganic materials are distributed in the nanofibers; the liquid-absorbing layer is a non-woven material layer composed of water-absorbent fibers and superabsorbent resin; the barrier layer is a non-woven material layer composed of hydrophobic fibers. The size of the layer is larger than that of the wound contact layer; the bandaging and fixing layer is a low-sensitivity elastic medical adhesive plaster layer in the shape of a strip. 2. A functional multilayer hemostatic antibacterial dressing according to claim 1, characterized in that: said degradable natural polymer nanofibers include silk fibroin and chitosan. 3. A functional multilayer hemostatic and antibacterial dressing according to claim 1, characterized in that: said inorganic material comprises halloysite, kaolin, and montmorillonite. 4. A functional multilayer hemostatic and antibacterial dressing according to claim 1, characterized in that: the medicine carried by the inorganic material is selected from hemostatic and antibacterial medicines. 5. A functional multilayer hemostatic and antibacterial dressing according to claim 1, characterized in that: by mass percentage, the drug-loaded inorganic material is 1-5% of the degradable natural polymer material. 6. A functional multilayer hemostatic and antibacterial dressing according to claim 1, characterized in that: said water-absorbent fibers include viscose fibers and absorbent cotton fibers. 7. A functional multilayer hemostatic and antibacterial dressing according to claim 1, characterized in that: said hydrophobic fibers include polypropylene, polyester, and nylon.