CO2017005201A2 - Ácido benzóico, derivados de ácido benzóico y conjugados heteroarilcarboxílico de la oxicodona - Google Patents

Ácido benzóico, derivados de ácido benzóico y conjugados heteroarilcarboxílico de la oxicodona

Info

Publication number
CO2017005201A2
CO2017005201A2 CONC2017/0005201A CO2017005201A CO2017005201A2 CO 2017005201 A2 CO2017005201 A2 CO 2017005201A2 CO 2017005201 A CO2017005201 A CO 2017005201A CO 2017005201 A2 CO2017005201 A2 CO 2017005201A2
Authority
CO
Colombia
Prior art keywords
oxycodone
benzoic acid
conjugates
heteroarylcarboxylic
acid derivatives
Prior art date
Application number
CONC2017/0005201A
Other languages
English (en)
Inventor
Travis Mickle
Sven Guenther
Sanjib Bera
Bindu Bera
Jaroslaw Kanski
Andrea K Martin
Original Assignee
Kempharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kempharm Inc filed Critical Kempharm Inc
Publication of CO2017005201A2 publication Critical patent/CO2017005201A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C07D489/04—Salts; Organic complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La a tecnología actualmente descrita proporciona composiciones que comprenden ácidos arilcarboxílicos y, por ejemplo, AINES, químicamente conjugados a la oxicodona (4,5-α-epoxi-14-hidroxi-17-metilmorfinan-6-ona) para formar nuevos profármacos/composiciones de la oxicodona, incluyendo benzoatos, salicilatos, propionatos, fenamatos y acetatos, que tienen un menor potencial de abuso de la oxicodona. La presente tecnología también proporciona métodos para el tratamiento de pacientes, kits farmacéuticos y métodos para sintetizar conjugados de la presente tecnología.
CONC2017/0005201A 2014-11-25 2017-05-25 Ácido benzóico, derivados de ácido benzóico y conjugados heteroarilcarboxílico de la oxicodona CO2017005201A2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462084216P 2014-11-25 2014-11-25
US201462084246P 2014-11-25 2014-11-25
PCT/US2015/062637 WO2016086113A1 (en) 2014-11-25 2015-11-25 Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxycodone

Publications (1)

Publication Number Publication Date
CO2017005201A2 true CO2017005201A2 (es) 2017-08-31

Family

ID=56075034

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2017/0005201A CO2017005201A2 (es) 2014-11-25 2017-05-25 Ácido benzóico, derivados de ácido benzóico y conjugados heteroarilcarboxílico de la oxicodona

Country Status (18)

Country Link
US (3) US9850252B2 (es)
EP (1) EP3223819A4 (es)
JP (2) JP6400848B2 (es)
KR (2) KR20190049944A (es)
CN (1) CN106999486A (es)
AU (1) AU2015353502B2 (es)
BR (1) BR112017011069A2 (es)
CA (1) CA2967424C (es)
CL (1) CL2017001353A1 (es)
CO (1) CO2017005201A2 (es)
IL (1) IL252470B (es)
MX (1) MX2017006520A (es)
NZ (1) NZ731591A (es)
PH (1) PH12017500963A1 (es)
RU (1) RU2683317C2 (es)
SG (1) SG11201704178UA (es)
WO (1) WO2016086113A1 (es)
ZA (1) ZA201703154B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
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UA102916C2 (uk) 2009-07-02 2013-08-27 Кемфарм, Інк. Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
US10849981B2 (en) 2009-07-02 2020-12-01 KemPham, Inc. Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof
NZ731591A (en) 2014-11-25 2018-06-29 Kempharm Inc Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxycodone
WO2018071879A1 (en) * 2016-10-14 2018-04-19 Kempharm, Inc. Immediate-release abuse deterrent compositions or medicaments for treating pain, add, adhd and other syndromes or disorders
WO2019018638A1 (en) * 2017-07-20 2019-01-24 Suzhou Runxindatai Pharmaceutics Ltd Co. PRODRUGS OF EXTENDED RELEASE OPIOID OPIOIDS RESISTANT TO ABUSE
EP3755704A1 (en) * 2018-02-23 2020-12-30 Rhodes Technologies Inc. Novel opioid compounds and uses thereof

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GB320749A (es)
US1731152A (en) 1925-10-27 1929-10-08 Firm C H Boehringer Sohn Process for the manufacture of derivatives of dihydrocodeinone or its substitution products
AT229496B (de) 1961-03-08 1963-09-25 Lannacher Heilmittel Verfahren zur Darstellung des neuen Nicotinsäureesters des Dihydrohydroxycodeinons
US4668685A (en) 1984-07-05 1987-05-26 E.I. Du Pont De Nemours And Company Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists
SE9003665D0 (sv) 1990-11-16 1990-11-16 Kabivitrum Ab Morphine prodrugs
GB9423542D0 (en) 1994-11-22 1995-01-11 Marples Brian A Pharmaceutical compounds
US5869669A (en) * 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
IL150929A0 (en) 2000-01-28 2003-06-24 Rohm & Haas Pharmaceutical compounds comprising a pharmaceutically active moiety and a moiety comprising a substituent that enhances its properties
KR20040014544A (ko) 2001-06-05 2004-02-14 컨트롤 딜리버리 시스템즈 인코포레이티드 서방 진통제 화합물
US7375082B2 (en) 2002-02-22 2008-05-20 Shire Llc Abuse-resistant hydrocodone compounds
CA2477004C (en) 2002-02-22 2011-05-10 Thomas Piccariello Novel sustained release pharmaceutical compounds to prevent abuse of controlled substances
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EP1782834A3 (en) * 2003-03-13 2007-08-01 Controlled Chemicals, Inc. Oxycodone conjugates with lower abuse potential and extended duration of action
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Also Published As

Publication number Publication date
JP6400848B2 (ja) 2018-10-03
KR101976101B1 (ko) 2019-05-09
AU2015353502A1 (en) 2017-05-25
RU2017122144A (ru) 2018-12-26
NZ731591A (en) 2018-06-29
MX2017006520A (es) 2017-08-09
KR20170094249A (ko) 2017-08-17
US20180065975A1 (en) 2018-03-08
RU2017122144A3 (es) 2018-12-26
EP3223819A4 (en) 2018-04-25
US10144740B2 (en) 2018-12-04
SG11201704178UA (en) 2017-06-29
ZA201703154B (en) 2019-03-27
CL2017001353A1 (es) 2018-01-05
IL252470B (en) 2019-08-29
WO2016086113A1 (en) 2016-06-02
PH12017500963A1 (en) 2017-10-18
JP2018199719A (ja) 2018-12-20
CA2967424A1 (en) 2016-06-02
RU2683317C2 (ru) 2019-03-28
BR112017011069A2 (pt) 2018-07-10
US20190048018A1 (en) 2019-02-14
EP3223819A1 (en) 2017-10-04
US9850252B2 (en) 2017-12-26
CA2967424C (en) 2023-05-02
US10544153B2 (en) 2020-01-28
JP2017535593A (ja) 2017-11-30
IL252470A0 (en) 2017-07-31
AU2015353502B2 (en) 2018-09-27
CN106999486A (zh) 2017-08-01
KR20190049944A (ko) 2019-05-09
US20160168160A1 (en) 2016-06-16

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