CO2017006204A2 - Método de producción de derivado de tiazol - Google Patents
Método de producción de derivado de tiazolInfo
- Publication number
- CO2017006204A2 CO2017006204A2 CONC2017/0006204A CO2017006204A CO2017006204A2 CO 2017006204 A2 CO2017006204 A2 CO 2017006204A2 CO 2017006204 A CO2017006204 A CO 2017006204A CO 2017006204 A2 CO2017006204 A2 CO 2017006204A2
- Authority
- CO
- Colombia
- Prior art keywords
- formula
- compound represented
- thiazole derivative
- production method
- migraine
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 150000007979 thiazole derivatives Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 102000007471 Adenosine A2A receptor Human genes 0.000 abstract 1
- 108010085277 Adenosine A2A receptor Proteins 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 208000016285 Movement disease Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 239000000014 opioid analgesic Substances 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 208000019116 sleep disease Diseases 0.000 abstract 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Cephalosporin Compounds (AREA)
Abstract
RESUMEN Se proporciona un método de producción de un derivado de tiazol representado por la fórmula (I), que tiene una acción antagonista del recepto A2A de adenosina y es útil como un agente terapéutico para, por ejemplo, enfermedad de Parkinson, trastornos del sueño, resistencia analgésica a opioides, migraña, trastorno del movimiento, depresión, trastorno de ansiedad y similares. También se proporciona un método de producción de un compuesto representado por la fórmula (C), que contiene (i) una etapa de reacción de un compuesto representado por la fórmula (A) y un compuesto representado por la fórmula (B), y similares: (donde R1 representa furilo, R4, R5 y R6 son los mismos o diferentes y cada uno representa alquilo inferior o arilo, R2 representa piridilo o tetrahidropiranilo, y X1 representa halógeno).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015002964 | 2015-01-09 | ||
| PCT/JP2016/051197 WO2016111381A1 (en) | 2015-01-09 | 2016-01-08 | Production method of thiazole derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2017006204A2 true CO2017006204A2 (es) | 2017-11-10 |
Family
ID=56356063
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2017/0006204A CO2017006204A2 (es) | 2015-01-09 | 2017-06-22 | Método de producción de derivado de tiazol |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US10214523B2 (es) |
| EP (2) | EP3242877B1 (es) |
| JP (2) | JP6770962B2 (es) |
| CN (1) | CN107108602B (es) |
| AR (1) | AR103380A1 (es) |
| AU (1) | AU2016205657B2 (es) |
| BR (1) | BR112017014179A2 (es) |
| CA (2) | CA3080031C (es) |
| CL (1) | CL2017001695A1 (es) |
| CO (1) | CO2017006204A2 (es) |
| DK (1) | DK3242877T3 (es) |
| ES (1) | ES2861050T3 (es) |
| HR (1) | HRP20210385T1 (es) |
| HU (1) | HUE053567T2 (es) |
| IL (2) | IL252906B (es) |
| JO (2) | JO3546B1 (es) |
| MX (2) | MX379107B (es) |
| PL (1) | PL3242877T3 (es) |
| PT (1) | PT3242877T (es) |
| RS (1) | RS61570B1 (es) |
| RU (2) | RU2020141085A (es) |
| SI (1) | SI3242877T1 (es) |
| TW (2) | TWI732748B (es) |
| WO (1) | WO2016111381A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3546B1 (ar) * | 2015-01-09 | 2020-07-05 | Kyowa Kirin Co Ltd | طريقة لإنتاج مشتق ثيازول |
| CN109293652B (zh) * | 2017-07-24 | 2021-10-22 | 四川科伦博泰生物医药股份有限公司 | 一种取代的噻唑衍生物及其用途 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE445350B (sv) * | 1978-04-14 | 1986-06-16 | Roussel Uclaf | Oximderivat av 3-azidometyl-7-amino-tiazolyl-acetamido-cefalosporansyra och dess anvendning som antibiotika |
| JP4638355B2 (ja) * | 2003-12-26 | 2011-02-23 | 協和発酵キリン株式会社 | チアゾール誘導体 |
| CN101031555A (zh) | 2004-07-27 | 2007-09-05 | 安斯泰来制药有限公司 | 具有vap－1抑制活性的噻唑衍生物 |
| EP1894930A4 (en) | 2005-06-23 | 2010-06-23 | Kyowa Hakko Kirin Co Ltd | THIAZOLE DERIVATIVE |
| US7928098B2 (en) | 2005-08-02 | 2011-04-19 | Kyowa Hakko Kirin Co., Ltd. | Therapeutic and/or preventive agents for a sleep disorder |
| WO2007024863A2 (en) | 2005-08-22 | 2007-03-01 | Melior Discovery, Inc. | Methods and formulations for modulating lyn kinase activity and treating related disorders |
| CN101228143A (zh) * | 2005-08-31 | 2008-07-23 | 安斯泰来制药株式会社 | 噻唑衍生物 |
| WO2007026761A1 (ja) * | 2005-08-31 | 2007-03-08 | Astellas Pharma Inc. | チアゾール誘導体 |
| TWI473614B (zh) | 2008-05-29 | 2015-02-21 | Kyowa Hakko Kirin Co Ltd | Anti-analgesic inhibitors |
| KR20110040856A (ko) | 2008-07-23 | 2011-04-20 | 교와 핫꼬 기린 가부시키가이샤 | 편두통 치료제 |
| TWI548411B (zh) | 2009-04-28 | 2016-09-11 | Kyowa Hakko Kirin Co Ltd | Exercise disorder treatment |
| UA110097C2 (uk) * | 2009-09-02 | 2015-11-25 | Терапевтичний агент для лікування розладів настрою | |
| UA113383C2 (xx) | 2009-09-02 | 2017-01-25 | Терапевтичний агент для лікування тривожних розладів | |
| WO2012027965A1 (en) * | 2010-09-01 | 2012-03-08 | Glaxo Group Limited | Novel compounds |
| JP6266270B2 (ja) | 2013-05-20 | 2018-01-24 | セイコーインスツル株式会社 | 運動フォーム解析装置および運動フォーム解析方法 |
| JO3546B1 (ar) | 2015-01-09 | 2020-07-05 | Kyowa Kirin Co Ltd | طريقة لإنتاج مشتق ثيازول |
-
2016
- 2016-01-07 JO JOP/2016/0004A patent/JO3546B1/ar active
- 2016-01-08 TW TW105100553A patent/TWI732748B/zh not_active IP Right Cessation
- 2016-01-08 RS RS20210278A patent/RS61570B1/sr unknown
- 2016-01-08 EP EP16735119.6A patent/EP3242877B1/en active Active
- 2016-01-08 US US15/541,857 patent/US10214523B2/en active Active
- 2016-01-08 JP JP2017535938A patent/JP6770962B2/ja not_active Expired - Fee Related
- 2016-01-08 CN CN201680005378.8A patent/CN107108602B/zh not_active Expired - Fee Related
- 2016-01-08 CA CA3080031A patent/CA3080031C/en active Active
- 2016-01-08 WO PCT/JP2016/051197 patent/WO2016111381A1/en not_active Ceased
- 2016-01-08 DK DK16735119.6T patent/DK3242877T3/da active
- 2016-01-08 MX MX2017009008A patent/MX379107B/es unknown
- 2016-01-08 HU HUE16735119A patent/HUE053567T2/hu unknown
- 2016-01-08 PT PT167351196T patent/PT3242877T/pt unknown
- 2016-01-08 PL PL16735119T patent/PL3242877T3/pl unknown
- 2016-01-08 EP EP20207877.0A patent/EP3822269A1/en not_active Withdrawn
- 2016-01-08 AU AU2016205657A patent/AU2016205657B2/en not_active Ceased
- 2016-01-08 TW TW109116071A patent/TWI729810B/zh not_active IP Right Cessation
- 2016-01-08 HR HRP20210385TT patent/HRP20210385T1/hr unknown
- 2016-01-08 ES ES16735119T patent/ES2861050T3/es active Active
- 2016-01-08 BR BR112017014179-5A patent/BR112017014179A2/pt not_active IP Right Cessation
- 2016-01-08 AR ARP160100039A patent/AR103380A1/es unknown
- 2016-01-08 RU RU2020141085A patent/RU2020141085A/ru unknown
- 2016-01-08 SI SI201631113T patent/SI3242877T1/sl unknown
- 2016-01-08 CA CA2972746A patent/CA2972746C/en active Active
- 2016-01-08 RU RU2017128217A patent/RU2738937C2/ru active
-
2017
- 2017-06-14 IL IL252906A patent/IL252906B/en active IP Right Grant
- 2017-06-22 CO CONC2017/0006204A patent/CO2017006204A2/es unknown
- 2017-06-23 CL CL2017001695A patent/CL2017001695A1/es unknown
- 2017-07-07 MX MX2021000711A patent/MX2021000711A/es unknown
-
2019
- 2019-01-14 US US16/246,988 patent/US10618894B2/en not_active Expired - Fee Related
-
2020
- 2020-02-20 IL IL272811A patent/IL272811A/en unknown
- 2020-03-18 US US16/822,626 patent/US10894790B2/en not_active Expired - Fee Related
- 2020-05-03 JO JOP/2020/0093A patent/JOP20200093A1/ar unknown
- 2020-08-18 JP JP2020138297A patent/JP7068402B2/ja not_active Expired - Fee Related
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