CO5540309A2 - Derivados de 4-(fenil-piperazinil-metil) benzamida y sus usos para el tratamiento del dolor, la ansiedad o desordenes gastrointestinales - Google Patents

Derivados de 4-(fenil-piperazinil-metil) benzamida y sus usos para el tratamiento del dolor, la ansiedad o desordenes gastrointestinales

Info

Publication number
CO5540309A2
CO5540309A2 CO03100169A CO03100169A CO5540309A2 CO 5540309 A2 CO5540309 A2 CO 5540309A2 CO 03100169 A CO03100169 A CO 03100169A CO 03100169 A CO03100169 A CO 03100169A CO 5540309 A2 CO5540309 A2 CO 5540309A2
Authority
CO
Colombia
Prior art keywords
independently selected
benzamida
piperazinil
fenil
metil
Prior art date
Application number
CO03100169A
Other languages
English (en)
Spanish (es)
Inventor
William Brown
Christopher Walpole
Niklas Plobeck
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0101772A external-priority patent/SE0101772D0/xx
Priority claimed from SE0103820A external-priority patent/SE0103820D0/xx
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CO5540309A2 publication Critical patent/CO5540309A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/24—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
CO03100169A 2001-05-18 2003-11-12 Derivados de 4-(fenil-piperazinil-metil) benzamida y sus usos para el tratamiento del dolor, la ansiedad o desordenes gastrointestinales CO5540309A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0101772A SE0101772D0 (sv) 2001-05-18 2001-05-18 Novel compounds
SE0103820A SE0103820D0 (sv) 2001-11-15 2001-11-15 Novel compounds

Publications (1)

Publication Number Publication Date
CO5540309A2 true CO5540309A2 (es) 2005-07-29

Family

ID=26655470

Family Applications (1)

Application Number Title Priority Date Filing Date
CO03100169A CO5540309A2 (es) 2001-05-18 2003-11-12 Derivados de 4-(fenil-piperazinil-metil) benzamida y sus usos para el tratamiento del dolor, la ansiedad o desordenes gastrointestinales

Country Status (31)

Country Link
US (3) US7229994B2 (2)
EP (2) EP1395567B1 (2)
JP (2) JP4549024B2 (2)
KR (2) KR100915263B1 (2)
CN (1) CN1269805C (2)
AR (1) AR035974A1 (2)
AT (1) ATE420866T1 (2)
AU (1) AU2002305994B2 (2)
BG (1) BG108333A (2)
BR (1) BR0209678A (2)
CA (1) CA2446326C (2)
CO (1) CO5540309A2 (2)
CY (1) CY1108913T1 (2)
CZ (1) CZ20033092A3 (2)
DE (1) DE60230869D1 (2)
DK (1) DK1395567T3 (2)
EE (1) EE05243B1 (2)
ES (1) ES2319876T3 (2)
HU (1) HUP0401086A3 (2)
IL (2) IL158631A0 (2)
IS (1) IS2625B (2)
MX (1) MXPA03010445A (2)
MY (1) MY140070A (2)
NO (1) NO326632B1 (2)
NZ (2) NZ529401A (2)
PL (1) PL367142A1 (2)
PT (1) PT1395567E (2)
RU (1) RU2297412C2 (2)
SI (1) SI1395567T1 (2)
SK (1) SK287555B6 (2)
WO (1) WO2002094794A1 (2)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1395567E (pt) * 2001-05-18 2009-03-26 Astrazeneca Ab Derivados de 4(fenil-piperazinil-metil)benzamida e sua utilização para o tratamento da ansiedade da dor ou de distúrbios gastrointestinais
CN1596113B (zh) 2001-10-29 2010-05-26 蒙特库克生物科学公司 δ受体激动剂化合物在制备治疗抑郁症的药物中的应用
SE0203300D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203303D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203302D0 (sv) * 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
NZ546834A (en) 2003-10-01 2010-03-26 Adolor Corp Spirocyclic heterocyclic derivatives and methods of their use
SE0401968D0 (sv) * 2004-08-02 2004-08-02 Astrazeneca Ab Diarylmethyl piperazine derivatives, preparations thereof and uses thereof
KR101234421B1 (ko) * 2004-08-02 2013-02-18 아스트라제네카 아베 디아릴메틸 피페라진 유도체, 이의 제조 방법 및 용도
EP1856076A1 (en) * 2005-02-28 2007-11-21 AstraZeneca AB Diarylmethyl piperazine derivatives, preparations thereof and uses thereof
US7598261B2 (en) 2005-03-31 2009-10-06 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
TWI449692B (zh) 2005-05-13 2014-08-21 Otsuka Pharma Co Ltd 吡咯烷化合物（三）
US20080306087A1 (en) * 2005-08-08 2008-12-11 Astrazeneca Ab Therapeutic Agents
US7576207B2 (en) 2006-04-06 2009-08-18 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
US20100029681A1 (en) * 2006-05-26 2010-02-04 Hassan Pajouhesh Heterocyclic compounds as calcium channel blockers
WO2008033299A2 (en) 2006-09-12 2008-03-20 Adolor Corporation Use of n-containing spirocompounds for the enhancement of cognitive function
US20090291966A1 (en) * 2008-05-20 2009-11-26 Astrazeneca Ab Method Of Treating Anxious Major Depressive Disorder
CN102131791B (zh) 2008-06-20 2014-12-24 阿斯利康(瑞典)有限公司 二苯并硫杂氮杂*衍生物及其用途
GB201111705D0 (en) 2011-07-07 2011-08-24 Takeda Pharmaceutical Compounds and their use
GB201111704D0 (en) 2011-07-07 2011-08-24 Takeda Pharmaceutical Novel compounds
JO3115B1 (ar) 2011-08-22 2017-09-20 Takeda Pharmaceuticals Co مركبات بيريدازينون واستخدامها كمثبطات daao
GB201209587D0 (en) 2012-05-30 2012-07-11 Takeda Pharmaceutical Therapeutic compounds
WO2014202999A1 (en) 2013-06-21 2014-12-24 Takeda Cambridge Limited 1-sulfonyl piperidine derivatives as modulators of prokineticin receptors
GB201314286D0 (en) 2013-08-08 2013-09-25 Takeda Pharmaceutical Therapeutic Compounds
GB201318222D0 (en) 2013-10-15 2013-11-27 Takeda Pharmaceutical Novel compounds
GB201320905D0 (en) 2013-11-27 2014-01-08 Takeda Pharmaceutical Therapeutic compounds
TW201613864A (en) 2014-02-20 2016-04-16 Takeda Pharmaceutical Novel compounds
CN104163788A (zh) * 2014-07-07 2014-11-26 湖南华腾制药有限公司 一种吡啶衍生物的制备方法
GB201616839D0 (en) 2016-10-04 2016-11-16 Takeda Pharmaceutical Company Limited Therapeutic compounds
GB201619514D0 (en) 2016-11-18 2017-01-04 Takeda Pharmaceuticals Co Novel compounds
JP2021138648A (ja) 2020-03-04 2021-09-16 武田薬品工業株式会社 経口固形製剤
CN112245432B (zh) * 2020-11-05 2021-12-21 东南大学 一种1-二苯甲基-4-甲基哌嗪类化合物在制备抗抑郁症药物中的应用
GB202414197D0 (en) 2024-09-27 2024-11-13 Addex Pharmaceuticals Sa Novel compounds
GB202414193D0 (en) 2024-09-27 2024-11-13 Addex Pharmaceuticals Sa Novel compounds

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH583713A5 (2) * 1973-06-29 1977-01-14 Cermol Sa
DE2900810A1 (de) 1979-01-11 1980-07-24 Cassella Ag Substituierte n-benzhydryl-n'-p- hydroxybenzyl-piperazine und verfahren zu ihrer herstellung
IT1140978B (it) 1980-05-23 1986-10-10 Selvi & C Spa 1-(4-clorobenzidril)-4-(2,3-diidros sipropil)-piperazina, metodi per la sua preparazione e relative composizione farmaceutiche
GB8320701D0 (en) 1983-08-01 1983-09-01 Wellcome Found Chemotherapeutic agent
IT1196150B (it) 1984-06-19 1988-11-10 Poli Ind Chimica Spa Derivati di 1-(bis-(4-fluorofenil)metil)-4-(3-fenil-2-propenil)-esaidro-1h-1,4-diazepina ad attivita' calcio antagonista,sua preparazione e composizioni che lo contengono
SE8500573D0 (sv) 1985-02-08 1985-02-08 Ferrosan Ab Novel piperazinecarboxamides having a phenoxyalkyl or thiophenoxyalkyl side chain
US5028610A (en) 1987-03-18 1991-07-02 Sankyo Company Limited N-benzhydryl-substituted heterocyclic derivatives, their preparation and their use
US4829065A (en) 1987-04-24 1989-05-09 Syntex Pharmaceuticals, Ltd. Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives
US4826844A (en) 1987-09-30 1989-05-02 American Home Products Corporation Substituted 1-(aralkyl-piperazinoalkyl) cycloalkanols
EP0455789B1 (en) 1989-11-22 1994-03-16 Janssen Pharmaceutica N.V. Method of preventing or limiting reperfusion damage
US5840896A (en) 1989-11-22 1998-11-24 Janssen Pharmaceutica, N.V. Method of preventing or limiting reperfusion damage
DK0546102T3 (da) 1990-08-29 1998-06-02 Upjohn Co Tropolonderivater og farmaceutisk sammensætning deraf til hindring og behandling af iskæmiske sygdomme
KR970005927B1 (ko) 1990-10-10 1997-04-22 쉐링 코포레이션 디아릴메틸피페리딘 또는 피페라진의 피리딘 및 피리딘 n-옥사이드 유도체, 이를 함유하는 약제학적 조성물 및 이의 제조방법
GB9202238D0 (en) * 1992-02-03 1992-03-18 Wellcome Found Compounds
US5985880A (en) 1996-06-05 1999-11-16 Delta Pharmaceuticals Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds
US5574159A (en) * 1992-02-03 1996-11-12 Delta Pharmaceuticals, Inc. Opioid compounds and methods for making therefor
US5807858A (en) * 1996-06-05 1998-09-15 Delta Pharmaceutical, Inc. Compositions and methods for reducing respiratory depression
US5681830A (en) * 1992-02-03 1997-10-28 Delta Pharmaceuticals, Inc. Opioid compounds
SE9201956D0 (sv) * 1992-06-25 1992-06-25 Kabi Pharmacia Ab Novel nicotinicacid esters
FR2696744B1 (fr) 1992-10-12 1994-12-30 Logeais Labor Jacques Dérivés de 2-pyrrolidone, leur procédé de préparation et leurs applications en thérapeutique.
RU2124511C1 (ru) 1993-05-14 1999-01-10 Фармасьютикал Ко., Лтд Производные пиперазина
PT711289E (pt) 1993-07-30 2001-02-28 Delta Pharmaceuticals Inc Compostos piperazina utilizados em terapia
JP3352184B2 (ja) 1993-11-12 2002-12-03 株式会社アズウェル ピペラジン不飽和脂肪酸誘導体
IL117149A0 (en) 1995-02-23 1996-06-18 Schering Corp Muscarinic antagonists
SE9504661D0 (sv) * 1995-12-22 1995-12-22 Astra Pharma Inc New compounds
SE9604786D0 (sv) 1996-12-20 1996-12-20 Astra Pharma Inc New compounds
TW548271B (en) 1996-12-20 2003-08-21 Astra Pharma Inc Novel piperidine derivatives having an exocyclic double bond with analgesic effects
EP1049676B1 (en) 1997-12-24 2005-10-12 Ortho-Mcneil Pharmaceutical, Inc. 4- aryl(piperidin-4-yl)] aminobenzamides which bind to the delta-opioid receptor
US6011035A (en) 1998-06-30 2000-01-04 Neuromed Technologies Inc. Calcium channel blockers
SE9904675D0 (sv) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE9904673D0 (sv) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE9904674D0 (sv) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE0001209D0 (sv) * 2000-04-04 2000-04-04 Astrazeneca Canada Inc Novel compounds
SE0101765D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
PT1395567E (pt) 2001-05-18 2009-03-26 Astrazeneca Ab Derivados de 4(fenil-piperazinil-metil)benzamida e sua utilização para o tratamento da ansiedade da dor ou de distúrbios gastrointestinais
SE0101766D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0103313D0 (sv) 2001-10-03 2001-10-03 Astrazeneca Ab Novel compounds
CN1596113B (zh) * 2001-10-29 2010-05-26 蒙特库克生物科学公司 δ受体激动剂化合物在制备治疗抑郁症的药物中的应用
US8476280B2 (en) 2002-05-09 2013-07-02 Versi Group, Llc Compositions and methods for combating lower urinary tract dysfunctions with delta opioid receptor agonists
SE0203300D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203303D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203302D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0300105D0 (sv) 2003-01-16 2003-01-16 Astrazeneca Ab Diarylmethylidene piperdine derivatives, preparations thereof and uses thereof
SE0400027D0 (sv) 2004-01-09 2004-01-09 Astrazeneca Ab Diarylmethyl piperazine derivatives, preparations thereof and uses thereof
KR101234421B1 (ko) 2004-08-02 2013-02-18 아스트라제네카 아베 디아릴메틸 피페라진 유도체, 이의 제조 방법 및 용도
SE0401968D0 (sv) 2004-08-02 2004-08-02 Astrazeneca Ab Diarylmethyl piperazine derivatives, preparations thereof and uses thereof
EP1856076A1 (en) 2005-02-28 2007-11-21 AstraZeneca AB Diarylmethyl piperazine derivatives, preparations thereof and uses thereof
US20090291966A1 (en) 2008-05-20 2009-11-26 Astrazeneca Ab Method Of Treating Anxious Major Depressive Disorder

Also Published As

Publication number Publication date
DK1395567T3 (da) 2009-04-06
SK13982003A3 (sk) 2004-04-06
IL158631A0 (en) 2004-05-12
EP1395567A1 (en) 2004-03-10
BG108333A (bg) 2004-12-30
WO2002094794A8 (en) 2004-04-22
SI1395567T1 (sl) 2009-04-30
HUP0401086A2 (hu) 2004-08-30
JP2010132670A (ja) 2010-06-17
AU2002305994B2 (en) 2008-06-26
EE200300545A (et) 2004-02-16
US20110039858A1 (en) 2011-02-17
US7915413B2 (en) 2011-03-29
ES2319876T3 (es) 2009-05-14
EP1395567B1 (en) 2009-01-14
RU2297412C2 (ru) 2007-04-20
JP5028500B2 (ja) 2012-09-19
PL367142A1 (en) 2005-02-21
DE60230869D1 (de) 2009-03-05
WO2002094794A1 (en) 2002-11-28
CN1269805C (zh) 2006-08-16
NO326632B1 (no) 2009-01-26
KR20040000471A (ko) 2004-01-03
US7229994B2 (en) 2007-06-12
KR100915263B1 (ko) 2009-09-03
BR0209678A (pt) 2004-09-14
CY1108913T1 (el) 2014-07-02
NO20035120D0 (no) 2003-11-17
MXPA03010445A (es) 2004-03-09
PT1395567E (pt) 2009-03-26
CA2446326C (en) 2010-12-07
CN1527820A (zh) 2004-09-08
JP2005508293A (ja) 2005-03-31
RU2003131964A (ru) 2005-05-10
IS7032A (is) 2003-11-13
HUP0401086A3 (en) 2011-07-28
JP4549024B2 (ja) 2010-09-22
EP2042495A1 (en) 2009-04-01
US8022074B2 (en) 2011-09-20
US20040147526A1 (en) 2004-07-29
EE05243B1 (et) 2009-12-15
IL158631A (en) 2010-12-30
US20070270435A1 (en) 2007-11-22
KR20080106586A (ko) 2008-12-08
SK287555B6 (sk) 2011-01-04
KR100885100B1 (ko) 2009-02-20
CZ20033092A3 (cs) 2004-08-18
IS2625B (is) 2010-05-15
NZ539828A (en) 2007-01-26
MY140070A (en) 2009-11-30
NZ529401A (en) 2005-09-30
CA2446326A1 (en) 2002-11-28
AR035974A1 (es) 2004-07-28
ATE420866T1 (de) 2009-01-15
HK1061237A1 (en) 2004-09-10

Similar Documents

Publication Publication Date Title
CO5540309A2 (es) Derivados de 4-(fenil-piperazinil-metil) benzamida y sus usos para el tratamiento del dolor, la ansiedad o desordenes gastrointestinales
SE0001207D0 (sv) Novel compounds
NO20044063L (no) Pyranoner anvendelige som ATM-inhibitorer
CO5611136A2 (es) Derivados de 4-(fenil-(piperidin-4-iliden-metil)-benzamida y su uso para el tratramiento del dolor, ansiedad o desordenes gastrointestinales
CO5580822A2 (es) Derivados de 4[piperidin-4-iliden-(3-carbamoilfenil)metil] benzamida y sus usos para el tratamiento del dolor, las lesiones en la columna vertebral o desordenes gastrointes- tinales
AR049438A1 (es) Derivados con estructura aroil-o-piperidina, procedimientos para su preparacion, composiciones farmaceuticas que los comprenden y sus aplicaciones terapeuticas
CO5540303A2 (es) Derivados de 4-(fenil-piperidin-4-iliden-metil)-benzamida y su uso para el tratamiento del dolor, ansiedad o desordenes gastrointestinales
AR048875A1 (es) Un proceso para preparar montelukast y compuestos intermedios para el mismo
IS2194B (is) Efnasambönd sem innihalda píperasín sem eru gagnleg til meðhöndlunar á sársauka
ES2236203T3 (es) Derivados de quinolinil-piperidin-4-ilideno-metil-benzamida para el tratamiento del dolor.
SE0001209D0 (sv) Novel compounds
CO5540318A2 (es) Derivados de 4-(fenil-(piperidin-4-il)-amino)-benzamida y sus usos para el tratamiento del dolor, la ansiedad o desordenes gastrointestinales
AR054341A1 (es) Combinaciones sinergicas de compuestos activos fungicidas
CO5540321A2 (es) Derivados de 4-(fenil-piperidin-4-iliden-metil)-benzamida y su uso para el tratamiento del dolor, ansiedad o desordenes gastrointestinales
CO5540319A2 (es) Derivados de 4-(fenil-(piperidin-4-il)-amino)-benzamida y sus usos para el tratamiento del dolor, la ansiedad o desordenes gastrointestinales
CO5540317A2 (es) Derivados de 4-(fenil-(piperidin-4-il)-amino)-benzamida y sus usos para el tratamiento del dolor, la ansiedad o desordenes gastrointestinales
ATE111460T1 (de) 2-(aminoalkyl)-5-(arylalkyl)1,3-dioxanderivate, ihre herstellung und ihre anwendung in der therapeutik.
NO20050871L (no) 6-amino-1H-indazol- og 4-aminobenzofuranforbindelser som fosfodiesterase 4-inhibitorer
HRP20070286T3 (en) Substituted diketopiperazines and their use as oxytocyn antagonists
CO5720994A2 (es) Derivados sustituidos del pirrol
ES2083479T3 (es) Bis(hidroximetil)ciclobutil-purinas y pirimidinas fluoradas.
CO5540304A2 (es) Derivados de 4-(fenil-piperidin-4-iliden-metil)-benzamida y su uso para el tratamiento del dolor, la ansiedad o transtornos gastrointestinales
CO5540320A2 (es) Derivados de 4-(fenil-(piperidin-4-il)-amino)benzamida y sus usos para el tratamiento del dolor, la ansiedad o desordenes gastrointestinales
ATE284379T1 (de) Aminderivate
SE0101772D0 (sv) Novel compounds

Legal Events

Date Code Title Description
FC Application refused