CR11345A - Compuestos de [3,2-c] pirazol esteroides con actividad glucocorticoide - Google Patents

Compuestos de [3,2-c] pirazol esteroides con actividad glucocorticoide

Info

Publication number
CR11345A
CR11345A CR11345A CR11345A CR11345A CR 11345 A CR11345 A CR 11345A CR 11345 A CR11345 A CR 11345A CR 11345 A CR11345 A CR 11345A CR 11345 A CR11345 A CR 11345A
Authority
CR
Costa Rica
Prior art keywords
compounds
pirazol
steroids
glucocorticoid activity
glucocorticoid
Prior art date
Application number
CR11345A
Other languages
English (en)
Inventor
Hakan Bladh
Frank Burkamp
Balint Gabos
Peter Hansen
Karolina Lawitz
Svetlana Ivanova
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40328402&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR11345(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CR11345A publication Critical patent/CR11345A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only
    • C07J71/0047—Nitrogen only at position 2(3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invencion proporciona compuestos de formula (I) en donde n, p, R1, R2, X1, X2, X3, X4, X5, R3a, R3b, R4, R5 y R6 son tal como se definen en la memoria descriptiva, un proceso para su preparacion, composiciones farmaceuticas que los contienen y su uso en terapia.
CR11345A 2007-10-04 2010-04-05 Compuestos de [3,2-c] pirazol esteroides con actividad glucocorticoide CR11345A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US97741607P 2007-10-04 2007-10-04

Publications (1)

Publication Number Publication Date
CR11345A true CR11345A (es) 2010-07-15

Family

ID=40328402

Family Applications (1)

Application Number Title Priority Date Filing Date
CR11345A CR11345A (es) 2007-10-04 2010-04-05 Compuestos de [3,2-c] pirazol esteroides con actividad glucocorticoide

Country Status (23)

Country Link
US (2) US8163724B2 (es)
EP (1) EP2207788A1 (es)
JP (1) JP2010540612A (es)
KR (1) KR20100087147A (es)
CN (1) CN101883778A (es)
AR (1) AR068734A1 (es)
AU (1) AU2008306593C1 (es)
BR (1) BRPI0817941A2 (es)
CA (1) CA2700181A1 (es)
CL (1) CL2008002954A1 (es)
CO (1) CO6270214A2 (es)
CR (1) CR11345A (es)
DO (1) DOP2010000094A (es)
EA (1) EA201000436A1 (es)
IL (1) IL204611A0 (es)
MX (1) MX2010003698A (es)
NI (1) NI201000043A (es)
NZ (1) NZ584160A (es)
PE (1) PE20090776A1 (es)
TW (1) TW200918047A (es)
UY (1) UY31375A1 (es)
WO (1) WO2009044200A1 (es)
ZA (1) ZA201002223B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008306593C1 (en) 2007-10-04 2012-10-04 Astrazeneca Ab Steroidal [3, 2-C] pyrazole compounds, with glucocorticoid activity
CA2707618A1 (en) * 2007-12-20 2009-07-02 Astrazeneca Ab Steroid derivatives acting as glucocorticosteroid receptor agonists
UY32520A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides
UY32525A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticosteroides
UY32521A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Combinación para emplear en el tratamiento de enfermedades respiratorias
UY32523A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticosteroides
CA2764830A1 (en) 2009-06-16 2010-12-23 Schering Corporation Novel [3,2-c] heteroaryl steroids as glucocorticoid receptor agonists, compositions and uses thereof
GB0913345D0 (en) 2009-07-31 2009-09-16 Astrazeneca Ab New combination 802
WO2011061527A1 (en) 2009-11-17 2011-05-26 Astrazeneca Ab Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases
TWI471289B (zh) 2010-06-11 2015-02-01 Rhodes Technologies 使三級胺進行ｎ－脫烷反應之方法
GB201016912D0 (en) * 2010-10-07 2010-11-24 Astrazeneca Ab Novel combination
GB201021992D0 (en) 2010-12-23 2011-02-02 Astrazeneca Ab Compound
GB201021979D0 (en) 2010-12-23 2011-02-02 Astrazeneca Ab New compound
CA2821524A1 (en) * 2011-01-07 2012-07-12 Corcept Therapeutics, Inc. Combination steroid and glucocorticoid receptor antagonist therapy
MX350121B (es) 2011-03-18 2017-08-28 Bayer Ip Gmbh Derivados de n-(3-carbamoilfenil)-1h-pirazol-5-carboxamida y el uso de los mismos para el control de plagas de animales.
US9526729B2 (en) * 2013-01-29 2016-12-27 Hsiao Lily Yu Medicament for treating peripheral neuropathies
EP3049089B1 (en) * 2013-09-25 2019-08-21 Van Andel Research Institute Highly potent glucocorticoids
US10954265B2 (en) * 2016-10-14 2021-03-23 Van Andel Research Institute Structures and mechanism for the design of highly potent glucocorticoids

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JP4471404B2 (ja) 1996-02-13 2010-06-02 アストラゼネカ ユーケイ リミテッド Ｖｅｇｆインヒビターとしてのキナゾリン誘導体
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CA2707618A1 (en) 2007-12-20 2009-07-02 Astrazeneca Ab Steroid derivatives acting as glucocorticosteroid receptor agonists
US20110294766A1 (en) 2008-02-27 2011-12-01 Astrazeneca Ab 16 Alpha, 17 Alpha-Acetal Glucocorticosteroidal Derivatives and their Use
UY32523A (es) 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticosteroides
UY32520A (es) 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides
UY32525A (es) 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticosteroides
UY32521A (es) 2009-04-03 2010-10-29 Astrazeneca Ab Combinación para emplear en el tratamiento de enfermedades respiratorias

Also Published As

Publication number Publication date
IL204611A0 (en) 2010-11-30
EP2207788A1 (en) 2010-07-21
AU2008306593C1 (en) 2012-10-04
UY31375A1 (es) 2009-05-29
WO2009044200A1 (en) 2009-04-09
US20090286835A1 (en) 2009-11-19
AU2008306593B2 (en) 2012-04-12
CA2700181A1 (en) 2009-04-09
US20120178726A1 (en) 2012-07-12
AR068734A1 (es) 2009-12-02
NI201000043A (es) 2012-09-10
AU2008306593A1 (en) 2009-04-09
KR20100087147A (ko) 2010-08-03
CL2008002954A1 (es) 2010-01-15
PE20090776A1 (es) 2009-07-23
BRPI0817941A2 (pt) 2015-05-05
TW200918047A (en) 2009-05-01
MX2010003698A (es) 2010-04-21
NZ584160A (en) 2011-05-27
CN101883778A (zh) 2010-11-10
ZA201002223B (en) 2010-12-29
JP2010540612A (ja) 2010-12-24
US8163724B2 (en) 2012-04-24
EA201000436A1 (ru) 2010-10-29
DOP2010000094A (es) 2012-08-15
CO6270214A2 (es) 2011-04-20

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal (granting procedure)