CR11562A - Bis-piridilpiridonas como antagonistas del receptor 1 de la hormona concentradora de melanina - Google Patents

Bis-piridilpiridonas como antagonistas del receptor 1 de la hormona concentradora de melanina

Info

Publication number
CR11562A
CR11562A CR11562A CR11562A CR11562A CR 11562 A CR11562 A CR 11562A CR 11562 A CR11562 A CR 11562A CR 11562 A CR11562 A CR 11562A CR 11562 A CR11562 A CR 11562A
Authority
CR
Costa Rica
Prior art keywords
antagonists
bis
piridilpiridonas
melanina
concentrating hormone
Prior art date
Application number
CR11562A
Other languages
English (en)
Inventor
Allen Scott
C Blackwell Ii William
Boros Eric
L Collins Jon
Hertzog Don
Liang Xi
Ray John
Michael Reister Steven
Samano Vicente
Sherrill Ron
Original Assignee
Glaxosmithkline Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Llc filed Critical Glaxosmithkline Llc
Publication of CR11562A publication Critical patent/CR11562A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invencion provee bis-piridilpiridonas novedosas que son antagonistas en el receptor 1 de la hormona concentradora de melanina (MCHR1), composiciones farmmaceuticas que las contienen, procedimientos para su preparacion , y su uso en terapia y para el tratamiento de la obesidad y/o diabetes.
CR11562A 2007-12-10 2010-07-09 Bis-piridilpiridonas como antagonistas del receptor 1 de la hormona concentradora de melanina CR11562A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1252507P 2007-12-10 2007-12-10

Publications (1)

Publication Number Publication Date
CR11562A true CR11562A (es) 2010-09-23

Family

ID=40469812

Family Applications (1)

Application Number Title Priority Date Filing Date
CR11562A CR11562A (es) 2007-12-10 2010-07-09 Bis-piridilpiridonas como antagonistas del receptor 1 de la hormona concentradora de melanina

Country Status (15)

Country Link
US (1) US20110118261A1 (es)
EP (1) EP2231646A1 (es)
JP (1) JP2011506462A (es)
KR (1) KR20100117059A (es)
CN (1) CN102015684A (es)
AU (1) AU2008335187B2 (es)
CA (1) CA2708741A1 (es)
CO (1) CO6280470A2 (es)
CR (1) CR11562A (es)
EA (1) EA201070725A1 (es)
IL (1) IL206237A0 (es)
MA (1) MA31941B1 (es)
MX (1) MX2010006388A (es)
WO (1) WO2009076387A1 (es)
ZA (1) ZA201004010B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120077795A1 (en) * 2009-06-03 2012-03-29 Glaxsmithkline Llc Bis-pyridylpyridones as melanin-concentrating hormone receptor 1 antagonists
US20120077794A1 (en) * 2009-06-03 2012-03-29 Glaxsmithkline Llc Bis-pyridylpyridones as melanin-concentrating hormone receptor 1 antagonists
BR112014018199A8 (pt) 2012-01-26 2021-03-02 H Lundbeck As inibidores da pde9 com cadeia principal imidazo triazinona, composição farmacêutica que os compreende, uso dos referidos inibidores e processo para sua preparação
WO2014028829A1 (en) 2012-08-16 2014-02-20 The Scripps Research Institute Novel kappa opioid ligands
CN103044394A (zh) * 2012-12-20 2013-04-17 北京理工大学 一种苯基氨基嘧啶衍生物及其制备方法和用途
DE102015011861B4 (de) 2015-09-10 2018-03-01 Rudolf Schindler Neue cyclische Carboxamide als NMDA NR2B Rezeptor Inhibitoren
ES2926533T3 (es) * 2017-03-17 2022-10-26 Scripps Research Inst Antagonistas del receptor opioideo kappa y productos y métodos relacionados con los mismos
KR20200011946A (ko) 2017-06-01 2020-02-04 수미토모 케미칼 컴퍼니 리미티드 복소환 화합물 및 그것을 함유하는 조성물
WO2020048830A1 (en) 2018-09-03 2020-03-12 Bayer Aktiengesellschaft 5-aryl-3,9-diazaspiro[5.5]undecan-2-one compounds
WO2020048831A1 (en) 2018-09-03 2020-03-12 Bayer Aktiengesellschaft 5-aryl-3,9-diazaspiro[5.5]undecan-2-one compounds
WO2020048828A1 (en) 2018-09-03 2020-03-12 Bayer Pharma Aktiengesellschaft 5-heteroaryl-3,9-diazaspiro[5.5]undecane compounds
CN109851542A (zh) * 2019-01-28 2019-06-07 爱斯特（成都）生物制药股份有限公司 一种(s)-n-甲基-n-(吡咯烷-3-基)乙酰胺二盐酸盐及其合成方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1930126A (zh) * 2004-03-05 2007-03-14 万有制药株式会社 吡啶酮衍生物

Also Published As

Publication number Publication date
JP2011506462A (ja) 2011-03-03
KR20100117059A (ko) 2010-11-02
CO6280470A2 (es) 2011-05-20
CN102015684A (zh) 2011-04-13
EA201070725A1 (ru) 2011-02-28
IL206237A0 (en) 2010-12-30
AU2008335187B2 (en) 2012-03-29
AU2008335187A1 (en) 2009-06-18
CA2708741A1 (en) 2009-06-18
MX2010006388A (es) 2010-06-25
ZA201004010B (en) 2011-03-30
US20110118261A1 (en) 2011-05-19
WO2009076387A1 (en) 2009-06-18
MA31941B1 (fr) 2010-12-01
EP2231646A1 (en) 2010-09-29

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal (granting procedure)