CR11814A - DERIVATIVES OF AZACARBOLINAS, ITS PREPARATION AND ITS THERAPEUTIC USE - Google Patents

DERIVATIVES OF AZACARBOLINAS, ITS PREPARATION AND ITS THERAPEUTIC USE

Info

Publication number
CR11814A
CR11814A CR11814A CR11814A CR11814A CR 11814 A CR11814 A CR 11814A CR 11814 A CR11814 A CR 11814A CR 11814 A CR11814 A CR 11814A CR 11814 A CR11814 A CR 11814A
Authority
CR
Costa Rica
Prior art keywords
azacarbolinas
derivatives
preparation
therapeutic use
optionally substituted
Prior art date
Application number
CR11814A
Other languages
Spanish (es)
Inventor
Arendt Christopher
Babin Didier
Bedel Olivier
Gouyon Thierry
Levit Mikhail
Mignani Serge
Moorcroft Neil
Papin David
Li Ronghua
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CR11814A publication Critical patent/CR11814A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)

Abstract

Nuevas azacarbolinas de fórmula (I), en la que:R3, R4representan independientemente el uno del otro H; hal; CF3; oxi sustituido; amida opcionalmente sustituido; amino opcionalmente sustituido; etc.New azacarbolins of formula (I), in which: R3, R4 independently represent each other H; hal; CF3; substituted oxy; optionally substituted amide; optionally substituted amino; etc.

CR11814A 2008-06-12 2010-11-25 DERIVATIVES OF AZACARBOLINAS, ITS PREPARATION AND ITS THERAPEUTIC USE CR11814A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0803262 2008-06-12

Publications (1)

Publication Number Publication Date
CR11814A true CR11814A (en) 2011-01-10

Family

ID=40445526

Family Applications (1)

Application Number Title Priority Date Filing Date
CR11814A CR11814A (en) 2008-06-12 2010-11-25 DERIVATIVES OF AZACARBOLINAS, ITS PREPARATION AND ITS THERAPEUTIC USE

Country Status (26)

Country Link
US (1) US20110178053A1 (en)
EP (1) EP2303882A2 (en)
JP (1) JP2011522867A (en)
KR (1) KR20110016998A (en)
CN (1) CN102124007A (en)
AR (1) AR072084A1 (en)
AU (1) AU2009259114B2 (en)
BR (1) BRPI0915204A2 (en)
CA (1) CA2725093A1 (en)
CO (1) CO6280536A2 (en)
CR (1) CR11814A (en)
DO (1) DOP2010000366A (en)
EA (1) EA018945B1 (en)
EC (1) ECSP10010670A (en)
IL (1) IL209840A0 (en)
MA (1) MA32460B1 (en)
MX (1) MX2010013699A (en)
NI (1) NI201000210A (en)
NZ (1) NZ589839A (en)
PE (1) PE20110122A1 (en)
SV (1) SV2010003754A (en)
TW (1) TW201002711A (en)
UA (1) UA101668C2 (en)
UY (1) UY31895A (en)
WO (1) WO2009150381A2 (en)
ZA (1) ZA201008387B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR072092A1 (en) * 2008-06-11 2010-08-04 Genentech Inc DIAZACARBAZOLES AND METHODS OF USE
PE20110061A1 (en) 2008-06-12 2011-01-31 Janssen Pharmaceutica Nv DIAMINE-PYRIDINE, PYRIMIDINE AND PYRIDAZINE DERIVATIVES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR
UY32275A (en) * 2009-03-24 2010-06-30 Sanofi Aventis DERIVATIVES OF AZACARBOLINAS 9H-PIRROLO [2,3-b: 5,4-c '] DIPIRIDINE, ITS PREPARATION AND ITS THERAPEUTIC USE.
FR2950891B1 (en) * 2009-10-06 2012-11-09 Sanofi Aventis AZACARBOLINE DERIVATIVES 9H-PYRROLO [2,3-B: 5,4-C] DIPYRIDINE, THEIR PREPARATION AND THEIR THERAPEUTIC USE
FR2953838B1 (en) * 2009-12-10 2012-02-24 Sanofi Aventis TRISUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDINO [3,4-B] INDOLE) DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
US20110183938A1 (en) * 2009-12-16 2011-07-28 Genentech, Inc. 1,7-diazacarbazoles and methods of use
LT3495367T (en) 2012-06-13 2021-02-25 Incyte Holdings Corporation MODIFIED TRICYCLIC COMPOUNDS AS FGFR INHIBITORS
JP6401773B2 (en) * 2013-03-11 2018-10-10 ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン BET bromodomain inhibitor and therapeutic method using the same
KR101612179B1 (en) * 2013-04-19 2016-04-12 영남대학교 산학협력단 Pharmaceutical composition for preventing or treating cancer comprising amidopyridinol derivative or a pharmaceutically acceptable salt
CN103408573B (en) * 2013-07-12 2015-12-23 上海工程技术大学 Boric acid derivatives and its preparation method and application
CN110198941B (en) * 2017-01-25 2021-09-28 江苏豪森药业集团有限公司 Pyrrolopyridine N-oxide derivative and preparation method and application thereof
JP7365332B2 (en) * 2017-08-07 2023-10-19 ジョイント・ストック・カンパニー “バイオキャド” Novel heterocyclic compounds as CDK8/19 inhibitors
ES3061844T3 (en) 2018-05-04 2026-04-07 Incyte Corp Salts of an fgfr inhibitor
MX2020011718A (en) 2018-05-04 2021-02-15 Incyte Corp SOLID FORMS OF A FIBROBLAST GROWTH FACTOR RECEPTOR (FGFR) INHIBITOR AND PROCESSES FOR PREPARING THEM.
WO2020072675A1 (en) 2018-10-02 2020-04-09 Northwestern University Beta-carbolines as positive allosteric modulators of the human serotonin receptor 2c (5-ht2c)
WO2021113462A1 (en) 2019-12-04 2021-06-10 Incyte Corporation Derivatives of an fgfr inhibitor
CN116693449A (en) 2022-03-04 2023-09-05 上海致根医药科技有限公司 Compounds useful as TYK2 inhibitors, preparation method and application thereof in medicine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8119655B2 (en) * 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
AR072092A1 (en) * 2008-06-11 2010-08-04 Genentech Inc DIAZACARBAZOLES AND METHODS OF USE

Also Published As

Publication number Publication date
AU2009259114A1 (en) 2009-12-17
CN102124007A (en) 2011-07-13
EA018945B1 (en) 2013-11-29
MX2010013699A (en) 2011-02-23
WO2009150381A3 (en) 2010-02-18
ECSP10010670A (en) 2011-01-31
MA32460B1 (en) 2011-07-03
CO6280536A2 (en) 2011-05-20
TW201002711A (en) 2010-01-16
CA2725093A1 (en) 2009-12-17
DOP2010000366A (en) 2010-12-31
BRPI0915204A2 (en) 2019-01-15
US20110178053A1 (en) 2011-07-21
WO2009150381A2 (en) 2009-12-17
SV2010003754A (en) 2011-03-15
UA101668C2 (en) 2013-04-25
AR072084A1 (en) 2010-08-04
EA201170002A1 (en) 2011-08-30
NI201000210A (en) 2011-05-09
EP2303882A2 (en) 2011-04-06
NZ589839A (en) 2012-07-27
PE20110122A1 (en) 2011-03-07
KR20110016998A (en) 2011-02-18
JP2011522867A (en) 2011-08-04
ZA201008387B (en) 2012-02-29
UY31895A (en) 2010-01-29
IL209840A0 (en) 2011-02-28
AU2009259114B2 (en) 2013-05-23

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Legal Events

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FA Abandonment or withdrawal (granting procedure)