CR20120108A - ANTIBODIES AGAINST THE EXTODOMINUM OF ERBB3 AND USES OF THE SAME - Google Patents

ANTIBODIES AGAINST THE EXTODOMINUM OF ERBB3 AND USES OF THE SAME

Info

Publication number
CR20120108A
CR20120108A CR20120108A CR20120108A CR20120108A CR 20120108 A CR20120108 A CR 20120108A CR 20120108 A CR20120108 A CR 20120108A CR 20120108 A CR20120108 A CR 20120108A CR 20120108 A CR20120108 A CR 20120108A
Authority
CR
Costa Rica
Prior art keywords
erbb3
receptor
extodominum
same
antibodies against
Prior art date
Application number
CR20120108A
Other languages
Spanish (es)
Inventor
Birgit Schoeberl
Ulrik Nielsen
Michael Feldhaus
Original Assignee
Merrimack Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43607614&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR20120108(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merrimack Pharmaceuticals Inc filed Critical Merrimack Pharmaceuticals Inc
Publication of CR20120108A publication Critical patent/CR20120108A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención proporciona una nueva clase de anticuerpos y fragmentos de unión a antígeno de los mismos que se unen al dominio extracelular del receptor ErbB3 e inhiben diversas funciones de ErbB3. Por ejemplo, los anticuerpos y fragmentos de unión a antígeno descritos en la presente son capaces de unirse al receptor designado ErbB3 e inhibir la fosforilación mediada por ligando similar a EGF del receptor.The present invention provides a new class of antibodies and antigen-binding fragments thereof that bind to the extracellular domain of the ErbB3 receptor and inhibit various functions of ErbB3. For example, the antibodies and antigen binding fragments described herein are capable of binding to the receptor designated ErbB3 and inhibiting EGF-like ligand-mediated phosphorylation of the receptor.

CR20120108A 2009-08-21 2012-03-05 ANTIBODIES AGAINST THE EXTODOMINUM OF ERBB3 AND USES OF THE SAME CR20120108A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23579909P 2009-08-21 2009-08-21

Publications (1)

Publication Number Publication Date
CR20120108A true CR20120108A (en) 2012-06-05

Family

ID=43607614

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20120108A CR20120108A (en) 2009-08-21 2012-03-05 ANTIBODIES AGAINST THE EXTODOMINUM OF ERBB3 AND USES OF THE SAME

Country Status (21)

Country Link
EP (1) EP2467164A2 (en)
JP (1) JP5752687B2 (en)
KR (1) KR20120059568A (en)
CN (1) CN103002912A (en)
AU (1) AU2010284018C1 (en)
BR (1) BR112012003809A2 (en)
CA (1) CA2771744A1 (en)
CR (1) CR20120108A (en)
DO (1) DOP2012000044A (en)
EA (1) EA201200195A1 (en)
EC (1) ECSP12011740A (en)
IL (1) IL218097A0 (en)
IN (1) IN2012DN01518A (en)
MA (1) MA33582B1 (en)
MX (1) MX336091B (en)
NI (1) NI201200027A (en)
PE (1) PE20121585A1 (en)
SG (1) SG178509A1 (en)
TN (1) TN2012000057A1 (en)
WO (1) WO2011022727A2 (en)
ZA (1) ZA201201195B (en)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG178789A1 (en) 2007-02-16 2012-03-29 Merrimack Pharmaceuticals Inc Antibodies against erbb3 and uses thereof
BR112012012160B1 (en) 2009-11-13 2022-04-26 Amgen, Inc. Material and methods to treat or prevent diseases associated with her-3
PH12012501157A1 (en) 2009-12-22 2012-10-29 Roche Glycart Ag Anti-her3 antibodies and uses thereof
KR101798679B1 (en) 2010-03-11 2017-11-16 메리맥 파마슈티컬즈, 인크. Use of erbb3 inhibitors in the treatment of triple negative and basal-like breast cancers
US8481687B2 (en) 2010-04-09 2013-07-09 Aveo Pharmaceuticals, Inc. Anti-ErbB3 antibodies
SG187908A1 (en) 2010-08-20 2013-03-28 Novartis Ag Antibodies for epidermal growth factor receptor 3 (her3)
TW201302793A (en) 2010-09-03 2013-01-16 Glaxo Group Ltd Novel antigen binding protein
IT1402149B1 (en) * 2010-10-04 2013-08-28 Ist Fisioterap Ospitalroma USE OF A PHOSPHOPEPTIDE WHICH IS ABLE TO BLOCK THE HER3 / P85 INTERACTION FOR THE TREATMENT OF HER2 EXPRESSION TUMORS.
KR101862832B1 (en) 2010-11-01 2018-05-30 심포젠 에이/에스 Pan-her antibody composition
BR112013027021A2 (en) 2011-04-19 2016-11-29 Merrimack Pharmaceuticals Inc monospecific and bispecific anti-igf-1r and anti-erbb3 antibodies
KR20140033152A (en) * 2011-06-20 2014-03-17 교와 핫꼬 기린 가부시키가이샤 Anti-erbb3 antibody
PH12014500483A1 (en) 2011-09-30 2014-04-14 Regeneron Pharma Anti-erbb3 antibodies and uses thereof
US9273143B2 (en) 2011-09-30 2016-03-01 Regeneron Pharmaceuticals, Inc. Methods and compositions comprising a combination of an anti-ErbB3 antibody and an anti-EGFR antibody
AU2012318541B2 (en) 2011-10-06 2018-04-12 Aveo Pharmaceuticals, Inc. Predicting tumor response to anti-ERBB3 antibodies
JP6149042B2 (en) * 2011-11-09 2017-06-14 ザ ユーエービー リサーチ ファンデーション HER3 antibody and use thereof
KR102083957B1 (en) 2011-12-05 2020-03-04 노파르티스 아게 Antibodies for epidermal growth factor receptor 3 (her3)
US20150037336A1 (en) * 2012-02-22 2015-02-05 U3 Pharma Gmbh Combination of hb-egf binding protein and egfr inhibitor
AR094403A1 (en) 2013-01-11 2015-07-29 Hoffmann La Roche ANTI-HER3 ANTIBODY COMBINATION THERAPY
WO2015058108A1 (en) * 2013-10-17 2015-04-23 Sanford-Burnham Medical Research Institute Drug sensitivity biomarkers and methods of identifying and using drug sensitivity biomarkers
EP3087394A2 (en) 2013-12-27 2016-11-02 Merrimack Pharmaceuticals, Inc. Biomarker profiles for predicting outcomes of cancer therapy with erbb3 inhibitors and/or chemotherapies
EP3786186A1 (en) 2014-02-28 2021-03-03 Merus N.V. Antibodies that bind egfr and erbb3
CN110642952B (en) * 2014-08-14 2021-05-25 上海生物制品研究所有限责任公司 anti-HER 3 antibody, preparation method and application thereof
WO2016038609A1 (en) * 2014-09-08 2016-03-17 Yeda Research And Development Co. Ltd. Anti-her3 antibodies and uses of same
WO2016038610A1 (en) 2014-09-08 2016-03-17 Yeda Research And Development Co. Ltd. Compositions and methods for treating cancer resistant to a tyrosine kinase inhibitor (tki)
US10184006B2 (en) 2015-06-04 2019-01-22 Merrimack Pharmaceuticals, Inc. Biomarkers for predicting outcomes of cancer therapy with ErbB3 inhibitors
WO2017069628A2 (en) 2015-10-23 2017-04-27 Merus N.V. Binding molecules that inhibit cancer growth
US11780925B2 (en) 2017-03-31 2023-10-10 Merus N.V. ErbB-2 and ErbB3 binding bispecific antibodies for use in the treatment of cells that have an NRG1 fusion gene
US12195551B2 (en) 2017-05-17 2025-01-14 Merus N.V. Combination of an ErbB-2/ErbB-3 bispecific antibody with endocrine therapy for breast cancer
SI3665198T1 (en) 2017-08-09 2025-06-30 Merus N.V. Antibodies that bind egfr and cmet
US11390686B2 (en) 2017-08-09 2022-07-19 University Of Saskatchewan HER3 binding agents and uses thereof
GB201804094D0 (en) * 2018-03-14 2018-04-25 Ultrahuman Thirteen Ltd ERBB3 Binding agents
JP2021534811A (en) * 2018-06-22 2021-12-16 シーアールディー ファーマシューティカルズ インコーポレイティド Anti-HER3 antibody and its uses
CN122011191A (en) * 2020-10-14 2026-05-12 苏州盛迪亚生物医药有限公司 Anti-HER 3 antibody and anti-HER 3 antibody drug conjugate and medical application thereof
KR20230128271A (en) * 2020-11-20 2023-09-04 악티늄 파마슈티컬즈, 인코포레이티드 HER3 radioimmunotherapy for the treatment of solid cancers
IL309337A (en) * 2021-06-15 2024-02-01 Beijing Sinotau Bio Pharmaceuticals Tech Co Ltd Anti-her3 antibody, antibody drug conjugate containing the same, and use thereof
WO2023198138A1 (en) * 2022-04-13 2023-10-19 上海翰森生物医药科技有限公司 Antibody or antigen-binding fragment thereof and medical use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG178789A1 (en) * 2007-02-16 2012-03-29 Merrimack Pharmaceuticals Inc Antibodies against erbb3 and uses thereof

Also Published As

Publication number Publication date
AU2010284018B2 (en) 2014-06-05
IL218097A0 (en) 2012-04-30
WO2011022727A2 (en) 2011-02-24
MA33582B1 (en) 2012-09-01
ECSP12011740A (en) 2013-02-28
EA201200195A1 (en) 2012-12-28
CN103002912A (en) 2013-03-27
DOP2012000044A (en) 2012-06-30
MX2012002172A (en) 2012-05-29
NI201200027A (en) 2013-01-29
AU2010284018A1 (en) 2012-03-22
AU2010284018C1 (en) 2015-10-15
KR20120059568A (en) 2012-06-08
WO2011022727A3 (en) 2013-06-27
BR112012003809A2 (en) 2019-09-24
JP5752687B2 (en) 2015-07-22
ZA201201195B (en) 2015-07-29
TN2012000057A1 (en) 2013-09-19
EP2467164A2 (en) 2012-06-27
MX336091B (en) 2016-01-08
CA2771744A1 (en) 2011-02-24
JP2013506622A (en) 2013-02-28
IN2012DN01518A (en) 2015-06-05
SG178509A1 (en) 2012-04-27
PE20121585A1 (en) 2012-11-29

Similar Documents

Publication Publication Date Title
ECSP12011740A (en) ANTIBODIES AGAINST THE EXTODOMINUM OF ERBB3 AND USES OF THE SAME
ECSP099637A (en) ANTIBODIES AGAINST ERBB3 AND THE USES OF THE SAME
CR20140146A (en) ANTI-BODIES ANTI-CD134 (OX40) AND USES OF THE SAME
CY1118761T1 (en) CODES FOR RECEPTORING GROWTH FACTORS 3 (HER3)
MX2016015263A (en) HUMAN ANTIBODIES AGAINST THE CORONAVIRUS ANCHORAGE PROTEIN CAUSING THE MIDDLE EAST RESPIRATORY SYNDROME.
MX2020004503A (en) HUMANIZED OR CHIMERIC CD3 ANTIBODIES.
PE20171041A1 (en) CD3 / CD38 T-CELL REDIRECTION HETERO-DIMERIC IMMUNOGLOBULINS AND THEIR PRODUCTION METHODS
ECSP17001673A (en) MONOCLONAL ANTIBODIES AGAINST HER2 EPITOPE
CR20110566A (en) IMMUNOCONJUGADOS OF ANTIMESOTELINA AND USES OF THE SAME
PE20160690A1 (en) HUMANIZED ANTI-CD134 (OX40) ANTIBODIES AND USES OF THEM
CO2020006453A2 (en) Anti-cxcr5 antibodies and compositions and uses thereof
MX2018003196A (en) ANTI-PROMIOSTATIN OR LATENT MIOSTATINE ANTIBODIES AND USES OF THE SAME.
MX2014009289A (en) ANTIBODIES C1ORF32 AND USES OF THE SAME FOR THE TREATMENT OF CANCER.
CR20120577A (en) ANTIBODIES TO GDF8 HUMAN
MX2017001597A (en) Anti-pd-l1 antibodies.
CY1119154T1 (en) ANTI-VLA-4 ANTIBODIES
BR112017011234A2 (en) antibodies to the blood-brain barrier receptor and methods of use
BR112016007112A2 (en) ANTIBODIES THAT BINDS HUMAN ANGIOPOIETIN 2 (ANG-2), USES OF AN ANTIBODY THAT BINDS HUMAN ANGIOPOIETIN 2 (ANG-2) AND COMBINATION
CU20140073A7 (en) COMPOSITIONS AND METHODS FOR ANTIBODIES ACTING ON FACTOR P
MX2014013678A (en) Agents for influenza neutralization.
MX2015017863A (en) Modulators of growth hormone receptor.
UA113879C2 (en) HUMANIZED TRK ANTITILE ANTIBODY
CY1120732T1 (en) INHIBITORS H4 RECEPTORS FOR TREATMENT
EA201500995A1 (en) BISPECIFIC ANTIBODIES, SPECIFIC FOR THE FAP AND DR5, ANTIBODIES, THE SPECIFIC FOR THE DR5, AND METHODS OF THEIR APPLICATION
MX2016000344A (en) Immunoglobulin fc conjugate maintaining fcrn binding strength.