CR20140253A - N-(3-{ [ (3- { [ 2 - cloro -5- (metoxi) fenil ] amino } quinoxalin -2- il) amino ] sulfonil } fenil ) -2- metilalaninamida como inhibidor de fosfatidilinositol 3- quinasa para el tratamiento de neoplasias linfoproliferativas - Google Patents

N-(3-{ [ (3- { [ 2 - cloro -5- (metoxi) fenil ] amino } quinoxalin -2- il) amino ] sulfonil } fenil ) -2- metilalaninamida como inhibidor de fosfatidilinositol 3- quinasa para el tratamiento de neoplasias linfoproliferativas

Info

Publication number
CR20140253A
CR20140253A CR20140253A CR20140253A CR20140253A CR 20140253 A CR20140253 A CR 20140253A CR 20140253 A CR20140253 A CR 20140253A CR 20140253 A CR20140253 A CR 20140253A CR 20140253 A CR20140253 A CR 20140253A
Authority
CR
Costa Rica
Prior art keywords
phenyl
amino
treatment
linfoproliferative
phosphytidylinositol
Prior art date
Application number
CR20140253A
Other languages
English (en)
Inventor
Arthur Decillis
Joanne Lager
Original Assignee
Exelixis Inc
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47295148&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR20140253(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Exelixis Inc, Sanofi Sa filed Critical Exelixis Inc
Publication of CR20140253A publication Critical patent/CR20140253A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Se proporciona métodos para el tratamiento de una neoplasia linfoproliferativa a un paciente en necesidad de dicho tratamiento, comprendiendo la administración al paciente de una cantidad efectiva del compuesto A como se describe.
CR20140253A 2011-11-01 2014-05-28 N-(3-{ [ (3- { [ 2 - cloro -5- (metoxi) fenil ] amino } quinoxalin -2- il) amino ] sulfonil } fenil ) -2- metilalaninamida como inhibidor de fosfatidilinositol 3- quinasa para el tratamiento de neoplasias linfoproliferativas CR20140253A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161553990P 2011-11-01 2011-11-01
US201161568189P 2011-12-08 2011-12-08
PCT/US2012/062999 WO2013067141A1 (en) 2011-11-01 2012-11-01 N- (3- { [ (3- { [2-chloro-5- (methoxy) phenyl] amino} quinoxalin- 2 -yl) amino] sulfonyl} phe nyl) - 2 -methylalaninamide as phosphatidylinositol 3 - kinase inhibitor for the treatment of lymphoproliferative malignancies

Publications (1)

Publication Number Publication Date
CR20140253A true CR20140253A (es) 2014-10-28

Family

ID=47295148

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20140253A CR20140253A (es) 2011-11-01 2014-05-28 N-(3-{ [ (3- { [ 2 - cloro -5- (metoxi) fenil ] amino } quinoxalin -2- il) amino ] sulfonil } fenil ) -2- metilalaninamida como inhibidor de fosfatidilinositol 3- quinasa para el tratamiento de neoplasias linfoproliferativas

Country Status (22)

Country Link
US (2) US20140303172A1 (es)
EP (1) EP2773353B1 (es)
JP (1) JP6013498B2 (es)
KR (1) KR20140096083A (es)
CN (2) CN104302294A (es)
AU (2) AU2012332486A1 (es)
BR (1) BR112014010492A2 (es)
CA (1) CA2854159A1 (es)
CL (1) CL2014001138A1 (es)
CR (1) CR20140253A (es)
DO (1) DOP2014000092A (es)
EA (1) EA201490905A1 (es)
EC (1) ECSP14002014A (es)
HK (1) HK1201480A1 (es)
IL (1) IL232398A0 (es)
MX (1) MX2014005249A (es)
NI (1) NI201400037A (es)
PE (1) PE20141794A1 (es)
PH (1) PH12014500973A1 (es)
SG (1) SG11201401961UA (es)
WO (1) WO2013067141A1 (es)
ZA (1) ZA201403258B (es)

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Publication number Priority date Publication date Assignee Title
SG11201401961UA (en) 2011-11-01 2014-05-29 Exelixis Inc N- (3- { [ (3- { [2-chloro-5- (methoxy) phenyl] amino} quinoxalin- 2 -yl) amino] sulfonyl} phe nyl) - 2 -methylalaninamide as phosphatidylinositol 3 - kinase inhibitor for the treatment of lymphoproliferative malignancies
AR092501A1 (es) * 2012-09-13 2015-04-22 Sanofi Sa Compuestos cristalinos
HK1214159A1 (zh) 2012-11-08 2016-07-22 Rhizen Pharmaceuticals S.A. 含有PDE4抑制剂和PI3δ或双重PI3δ-γ激酶抑制剂的药物组合物

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US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
HRP20130902T1 (hr) 2005-10-07 2013-11-08 Exelixis Inc. PIRIDOPIRIMIDINONSKI INHIBITORI PI3Kalfa
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PT1940839E (pt) 2005-10-07 2013-10-10 Exelixis Inc Inibidores de piridopirimidinona pi3k alfa
CA2658725A1 (en) 2006-08-16 2008-02-21 Exelixis, Inc. Using pi3k and mek modulators in treatments of cancer
PT2139484E (pt) 2007-04-10 2013-10-31 Exelixis Inc Métodos de tratamento de cancro usando inibidores piridopirimidinona de pi3k-alfa
UA98141C2 (ru) * 2007-04-11 2012-04-25 Экселиксис, Инк. Способы лечения с применением хинаксолиновых ингибиторов pi3k-альфа
AU2008239655B2 (en) 2007-04-11 2013-06-20 Exelixis, Inc. Pyrido (2, 3-d) pyrimidin-7-one compounds as inhibitors of PI3k-alpha for the treatment of cancer
CA2683820A1 (en) 2007-04-11 2008-10-23 Exelixis, Inc. Pyrido [2, 3-d] pyrimidin-7-one compounds as inhibitors of p13k-alpha for the treatment of cancer
WO2009017838A2 (en) * 2007-08-01 2009-02-05 Exelixis, Inc. Combinations of jak-2 inhibitors and other agents
MX2010007746A (es) * 2008-01-15 2010-08-18 Wyeth Llc Compuestos de 3h-[1,2,3]triazolo[4,5-d]pirimidina, su uso como inhibidores de diana de rapamicina de mamifero quinasa y fosfatidilinositol quinasa y su sintesis.
TW201018685A (en) 2008-09-30 2010-05-16 Exelixis Inc Pyridopyrimidinone inhibitors of PI3Kα and mTOR
ES2439793T3 (es) * 2009-04-17 2014-01-24 Wyeth Llc Compuestos de pirimidina, su uso como inhibidores de la mTOR quinasa y de la PI3 quinasa, y su síntesis
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EP2444084A1 (en) * 2010-10-21 2012-04-25 Centro Nacional de Investigaciones Oncológicas (CNIO) Use of PI3K inibitors for the treatment of obesity
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JP2013544827A (ja) 2010-11-24 2013-12-19 エクセリクシス， インク． ＰＩ３Ｋ／ｍＴＯＲの阻害剤としてのベンゾオキサゼピン類ならびにそれらの使用法および製造法
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JP2013544829A (ja) 2010-11-24 2013-12-19 エクセリクシス， インク． ＰＩ３Ｋ／ｍＴＯＲの阻害剤としてのベンゾオキサゼピンおよびその使用と製造方法
BR112013012961A2 (pt) 2010-11-24 2019-09-24 Exelixis Inc benzoxazepinas como inhibidores de mtor e métodos de seu uso e fabricação
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Also Published As

Publication number Publication date
MX2014005249A (es) 2015-03-05
BR112014010492A2 (pt) 2017-04-25
CL2014001138A1 (es) 2014-08-01
AU2017219131A1 (en) 2017-09-28
EP2773353B1 (en) 2018-09-05
ZA201403258B (en) 2015-11-25
ECSP14002014A (es) 2015-11-30
CN104302294A (zh) 2015-01-21
EP2773353A1 (en) 2014-09-10
AU2012332486A1 (en) 2014-06-19
US20170296529A1 (en) 2017-10-19
PH12014500973A1 (en) 2014-06-16
JP2014532709A (ja) 2014-12-08
HK1201480A1 (en) 2015-09-04
IL232398A0 (en) 2014-06-30
WO2013067141A1 (en) 2013-05-10
NI201400037A (es) 2014-12-22
US20140303172A1 (en) 2014-10-09
DOP2014000092A (es) 2015-02-15
PE20141794A1 (es) 2014-12-17
KR20140096083A (ko) 2014-08-04
US10328069B2 (en) 2019-06-25
CN107375289A (zh) 2017-11-24
CA2854159A1 (en) 2013-05-10
SG11201401961UA (en) 2014-05-29
JP6013498B2 (ja) 2016-10-25
EA201490905A1 (ru) 2014-11-28

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