CR20140361A - Inhibidores de pde9 con estructura básica de imidazotriazinona - Google Patents

Inhibidores de pde9 con estructura básica de imidazotriazinona

Info

Publication number
CR20140361A
CR20140361A CR20140361A CR20140361A CR20140361A CR 20140361 A CR20140361 A CR 20140361A CR 20140361 A CR20140361 A CR 20140361A CR 20140361 A CR20140361 A CR 20140361A CR 20140361 A CR20140361 A CR 20140361A
Authority
CR
Costa Rica
Prior art keywords
imidazotriazinona
basic structure
pde9 inhibitors
inhibitors
pde9
Prior art date
Application number
CR20140361A
Other languages
English (en)
Inventor
Niels Svenstrup
Klaus Baek Simonsen
Lars Kyhn Rasmussen
Karsten Juhl
Morten Langgard
Kate Wen
Yazhou Wang
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of CR20140361A publication Critical patent/CR20140361A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La invención se refiere a compuestos, que son inhibidores de la enzima PDE9. La invención proporciona una composición farmacéutica que comprende una cantidad terapéuticamente eficaz de un compuesto de la invención y un portador farmacéuticamente aceptable. La presente invención también proporciona procesos para preparar compuestos de fórmula (I).
CR20140361A 2012-01-26 2014-07-24 Inhibidores de pde9 con estructura básica de imidazotriazinona CR20140361A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2012070718 2012-01-26
CN2012080208 2012-08-16
PCT/EP2013/051451 WO2013110768A1 (en) 2012-01-26 2013-01-25 Pde9 inhibitors with imidazo triazinone backbone

Publications (1)

Publication Number Publication Date
CR20140361A true CR20140361A (es) 2014-11-11

Family

ID=47603775

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20140361A CR20140361A (es) 2012-01-26 2014-07-24 Inhibidores de pde9 con estructura básica de imidazotriazinona

Country Status (15)

Country Link
US (3) US9434733B2 (es)
EP (2) EP2807163B1 (es)
CN (2) CN104093720B (es)
AP (1) AP2014007820A0 (es)
AU (2) AU2013213603B2 (es)
BR (1) BR112014018199A8 (es)
CO (1) CO7020913A2 (es)
CR (1) CR20140361A (es)
DO (1) DOP2014000175A (es)
EC (1) ECSP14015609A (es)
HK (1) HK1199879A1 (es)
MX (1) MX351582B (es)
PH (1) PH12014501695B1 (es)
SG (1) SG11201403909RA (es)
WO (1) WO2013110768A1 (es)

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RU2603140C2 (ru) 2010-09-20 2016-11-20 Айронвуд Фармасьютикалз, Инк. Соединения имидазотриазинона
EP4070841B1 (en) 2010-10-08 2025-08-13 Fisher & Paykel Healthcare Limited Mask seal assembly
SG11201502728WA (en) 2011-10-10 2015-05-28 Lundbeck & Co As H Pde9i with imidazo pyrazinone backbone
BR112014018199A8 (pt) 2012-01-26 2021-03-02 H Lundbeck As inibidores da pde9 com cadeia principal imidazo triazinona, composição farmacêutica que os compreende, uso dos referidos inibidores e processo para sua preparação
EP2828262A4 (en) 2012-03-19 2015-09-23 Forum Pharmaceuticals Inc IMIDAZOTRIAZINONVERBINDUNGEN
WO2016006975A2 (en) * 2014-07-11 2016-01-14 St Pharm Co., Ltd. Novel imidazotriazinone or imidazopyrazinone derivatives, and use thereof
KR20160007347A (ko) 2014-07-11 2016-01-20 에스티팜 주식회사 신규한 이미다조트리아지논 또는 이미다조피라지논 유도체, 및 이들의 용도
TW201629064A (zh) 2014-10-10 2016-08-16 Ｈ 朗德貝克公司 作爲ｐｄｅ１抑制劑之三唑並吡酮
JO3627B1 (ar) 2015-04-30 2020-08-27 H Lundbeck As إيميدازو بيرازينونات على هيئة مثبطات pde1
WO2017000276A1 (en) 2015-07-01 2017-01-05 Merck Sharp & Dohme Corp. Bicyclic heterocyclic compounds as pde2 inhibitors
HRP20240082T1 (hr) * 2015-07-07 2024-03-29 H. Lundbeck A/S Inhibitor pde9 s okosnicom imidazopirazinona za liječenje perifernih bolesti
CN105669680B (zh) * 2016-03-24 2018-02-23 南京药捷安康生物科技有限公司 吡咯并[2,1‑f][1,2,4]三嗪‑4(1H)‑酮衍生物类PDE9A抑制剂
TWI729109B (zh) 2016-04-12 2021-06-01 丹麥商Ｈ 朗德貝克公司 作爲PDE1抑制劑的1,5-二氫-4H-吡唑并[3,4-d]嘧啶-4-酮和1,5-二氫-4H-吡唑并[4,3-c]吡啶-4-酮
TN2018000383A1 (en) 2016-07-06 2020-06-15 H Lundbeck As Pde9 inhibitors for treatment of peripheral diseases.
ES2967489T3 (es) 2016-10-18 2024-04-30 H Lundbeck As Imidazopirazinonas, pirazolopirimidinonas y pirazolopiridinonas como inhibidores de PDE1
MX2019004859A (es) 2016-10-28 2019-06-20 H Lundbeck As Tratamientos de combinacion que comprenden la administracion de imidazopirazinonas.
RU2019109039A (ru) 2016-10-28 2020-11-30 Х. Лундбекк А/С Комбинированные средства для лечения, предусматривающего введение имидазопиразинонов, предназначенные для лечения психических и/или когнитивных расстройств
EP3541784B1 (en) * 2016-11-18 2023-09-13 Integrative Research Laboratories Sweden AB Novel azetidine derivatives useful as modulators of cortical catecholaminergic neurotransmission
EP3585392A1 (en) * 2017-02-23 2020-01-01 Boehringer Ingelheim International GmbH New medical use of compound iii
DK3630772T3 (da) * 2017-05-26 2024-02-05 Cardurion Pharmaceuticals Inc Fremgangsmåder til fremstilling og anvendelse af pde9-hæmmere
CN110003213B (zh) * 2018-01-04 2021-10-08 南京农业大学 苯并咪唑并三嗪酮类化合物、制备方法及应用
EP3697423A4 (en) 2018-01-05 2021-08-11 Dicerna Pharmaceuticals, Inc. REDUCED EXPRESSION OF BETA-CATENIN AND IDO TO POTENTIALIZE IMMUNOTHERAPY
FI3801526T3 (fi) 2018-05-25 2024-03-20 Cardurion Pharmaceuticals Inc 6-[(3s,4s)-4-metyyli-1-(pyrimidin-2-yylimetyyli)pyrrolidin-3-yyli]-3-tetrahydropyran-4-yyli-7h-imidatso[1,5-a]pyratsin-8-onin monohydraattimuotoja ja kiteisiä muotoja
EP3843737A4 (en) 2018-08-31 2022-06-01 Imara Inc. PDE9 INHIBITORS FOR THE TREATMENT OF SICKLE CELL DISEASE
CN114072151A (zh) * 2019-05-07 2022-02-18 伊马拉公司 用于治疗地中海贫血的pde9抑制剂
CN113072556B (zh) * 2021-03-30 2022-02-01 牡丹江医学院 一种用于治疗胶质瘤的药物及其制备方法
CN120897742A (zh) * 2022-11-15 2025-11-04 福睿德姆生物科学公司 通过抑制9型磷酸二酯酶增强血清素能致幻药物在治疗或预防某些神经精神障碍中的功效

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CZ20012627A3 (cs) 1999-01-20 2002-01-16 Arzneimittelwerk Dresden Gmbh Pouľití imidazo [1,5-a] pyrido [3,2-e]pyrazinonů jako léčiva
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TW200613306A (en) 2004-07-20 2006-05-01 Osi Pharm Inc Imidazotriazines as protein kinase inhibitors
TW200815436A (en) 2006-05-30 2008-04-01 Elbion Ag 4-amino-pyrido[3,2-e]pyrazines, their use as inhibitors of phosphodiesterase 10, and processes for preparing them
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CN102015684A (zh) 2007-12-10 2011-04-13 葛兰素集团有限公司 联-吡啶基吡啶酮作为黑色素浓缩激素受体1拮抗剂
TWI404721B (zh) 2009-01-26 2013-08-11 Pfizer 胺基－雜環化合物
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RU2603140C2 (ru) 2010-09-20 2016-11-20 Айронвуд Фармасьютикалз, Инк. Соединения имидазотриазинона
US8809345B2 (en) 2011-02-15 2014-08-19 Boehringer Ingelheim International Gmbh 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders
BR112014018199A8 (pt) 2012-01-26 2021-03-02 H Lundbeck As inibidores da pde9 com cadeia principal imidazo triazinona, composição farmacêutica que os compreende, uso dos referidos inibidores e processo para sua preparação

Also Published As

Publication number Publication date
CN104093720B (zh) 2017-04-12
AU2017200886B2 (en) 2018-01-18
CN107082783A (zh) 2017-08-22
EP2807163A1 (en) 2014-12-03
DOP2014000175A (es) 2014-08-31
ECSP14015609A (es) 2015-12-31
AU2017200886A1 (en) 2017-03-02
MX2014008912A (es) 2014-08-26
PH12014501695A1 (en) 2014-10-20
US9850249B2 (en) 2017-12-26
US9434733B2 (en) 2016-09-06
CO7020913A2 (es) 2014-08-11
WO2013110768A1 (en) 2013-08-01
SG11201403909RA (en) 2014-10-30
MX351582B (es) 2017-10-20
CN104093720A (zh) 2014-10-08
US20150045348A1 (en) 2015-02-12
US9533992B2 (en) 2017-01-03
CN107082783B (zh) 2019-03-22
AU2013213603A1 (en) 2014-07-24
PH12014501695B1 (en) 2019-06-03
AU2013213603B2 (en) 2017-02-02
EP3178820B1 (en) 2017-12-20
HK1199879A1 (en) 2015-07-24
BR112014018199A8 (pt) 2021-03-02
US20170081333A1 (en) 2017-03-23
AP2014007820A0 (en) 2014-07-31
EP2807163B1 (en) 2017-03-22
US20160213674A1 (en) 2016-07-28
EP3178820A1 (en) 2017-06-14

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